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Article ; Online: Reply to S. Tan et al.

Rini, Brian I / Moslehi, Javid J / Hariharan, Subramanian

Journal of clinical oncology : official journal of the American Society of Clinical Oncology

2022 Volume 40, Issue 29, Page(s) 3469

Language	English
Publishing date	2022-06-16
Publishing country	United States
Document type	Journal Article ; Comment
ZDB-ID	604914-x
ISSN	1527-7755 ; 0732-183X
ISSN (online)	1527-7755
ISSN	0732-183X
DOI	10.1200/JCO.22.01108
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Article ; Online: Physician burnout in ophthalmology: U.S. survey.

Sedhom, Jessica A / Patnaik, Jennifer L / McCourt, Emily A / Liao, Sophie / Subramanian, Prem S / Davidson, Richard S / Palestine, Alan G / Kahook, Malik Y / Seibold, Leonard K

Journal of cataract and refractive surgery

2021 Volume 48, Issue 6, Page(s) 723–729

Abstract: ... exhibited a high degree of self-reported burnout in the U.S. This study highlights sex, employment autonomy ...

Abstract	Purpose: To determine the prevalence of physician burnout among ophthalmologists in the United States and identify associated risks. Setting: All practice types within the United States. Design: Cross-sectional study. Methods: A survey was distributed through email listservs to several national ophthalmology societies. Participants completed a modified Mini Z Burnout Survey, a 10-item questionnaire measured in 5-point Likert scales, followed by demographic questions. The Mini Z Burnout survey assessed 3 main outcomes: stress, burnout, and work satisfaction. The percentage of subgroups experiencing burnout were presented and comparisons made with odds ratios from logistic regression modeling. Results: Of the 592 ophthalmologists responding to the survey, 37.8% (224) self-reported symptoms of burnout with a low of 30.8% (12/39) for vitreoretinal specialists to a high of 45.4% (30/66) for uveitis specialists. Most of those reporting burnout were categorized as mild (65.2% [146/224]), followed by moderate (29.5% [66/224]) and severe (5.4% [12/224]). Women had almost twice the odds of reporting burnout (odds ratio [OR] = 1.9 [95% CI: 1.3-2.7]; P = .0005). Physicians employed in academic (OR = 2.0 [95% CI: 1.2-3.2]; P = 0.007) and hospital facilities (OR = 2.4 [95% CI: 1.3-4.6]; P = .008) reported higher rates of burnout compared with those in large private groups. Burnout was associated with self-reported low work control, insufficient time for documentation, and misalignment with departmental leaders (P < .0001). Conclusions: Ophthalmologists exhibited a high degree of self-reported burnout in the U.S. This study highlights sex, employment autonomy, and practice type as major factors associated with burnout.
MeSH term(s)	Burnout, Professional/epidemiology ; Cross-Sectional Studies ; Female ; Humans ; Ophthalmology ; Physicians ; Surveys and Questionnaires ; United States/epidemiology
Language	English
Publishing date	2021-09-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1097/j.jcrs.0000000000000837
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Article: Prevalence of depressive symptoms in U.S. adults during the COVID-19 pandemic: A systematic review.

Ettman, Catherine K / Fan, Alice Y / Subramanian, Maya / Adam, Gaelen P / Badillo Goicoechea, Elena / Abdalla, Salma M / Stuart, Elizabeth A / Galea, Sandro

SSM - population health

2023 Volume 21, Page(s) 101348

Abstract: The COVID-19 pandemic has led to a worsening of mental health among U.S. adults. However, no review ... to date has synthesized the overall prevalence of population depressive symptoms in the U.S. over ... in nationally representative samples of U.S. adults from March 2020 to June 2021. First, we found ...

Abstract	The COVID-19 pandemic has led to a worsening of mental health among U.S. adults. However, no review to date has synthesized the overall prevalence of population depressive symptoms in the U.S. over the COVID-19 pandemic. We aimed to document the population prevalence of depressive symptoms and psychological distress across time since the start of the COVID-19 pandemic, both to identify patterns that emerged in the literature and to assess the data sources, methods, sampling, and measurement used to examine population mental health during the pandemic. In a systematic review of the peer review literature, we identified 49 articles reporting 88 prevalence points of depressive symptoms and related constructs in nationally representative samples of U.S. adults from March 2020 to June 2021. First, we found that the average prevalence of poor mental health across studies was 12.9% for severe depression, 26.0% for at least moderate depression, and 36.0% for at least mild depression. Second, we found that women reported significantly higher prevalence of probable depression than men in 63% of studies that reported depression levels by gender and that results on statistically significant differences between racial and ethnic groups were mixed. Third, we found that the 49 articles published were based on 12 studies; the most common sources were the Household Pulse Survey (n = 15, 31%), the AmeriSpeak panel (n = 8, 16%), the Qualtrics panel (n = 8, 16%), and the Understanding America Study (n = 5, 10%). Prevalence estimates varied based on mental health screening instruments and cutoffs used. The most commonly used instruments were the Patient Health Questionnaire (PHQ) (n = 36, 73%) and the Kessler (n = 8, 16%) series. While the prevalence of population depression varied over time depending on the survey instruments, severity, and constructs reported, the overall prevalence of depression remained high from March 2020 through June 2021 across instruments and severity. Understanding the scope of population mental health can help policymakers and providers address and prepare to meet the ongoing and future mental health needs of U.S. adults in the post-COVID-19 context and beyond.
Language	English
Publishing date	2023-01-28
Publishing country	England
Document type	Journal Article ; Review
ISSN	2352-8273
ISSN	2352-8273
DOI	10.1016/j.ssmph.2023.101348
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Article ; Online: Assets and depression in U.S. adults during the COVID-19 pandemic: a systematic review.

Ettman, Catherine K / Subramanian, Maya / Fan, Alice Y / Adam, Gaelen P / Abdalla, Salma M / Galea, Sandro / Stuart, Elizabeth A

Social psychiatry and psychiatric epidemiology

2023 Volume 59, Issue 4, Page(s) 571–583

Abstract: ... marital status, educational attainment) assets and depression in U.S. adults. For each asset type, we created ...

Abstract	Purpose: Mental health is shaped by social and economic contexts, which were altered during the COVID-19 pandemic. No study has systematically reviewed the literature on the relation between different assets and depression during the COVID-19 pandemic. Methods: We conducted a systematic review of the literature on financial (e.g. income/savings), physical (e.g., home ownership), and social (e.g., marital status, educational attainment) assets and depression in U.S. adults. For each asset type, we created binary comparisons to report on the direction of the relationship and described if each study reported insignificant, positive, negative, or mixed associations. Results: Among the 41 articles identified, we found that income was the most studied asset (n=34), followed by education (n=25), marital status (n=18), home ownership (n=5), and savings (n=4). 88%, 100%, and 100% of articles reported a significant association of higher income, home ownership, and higher savings, respectively, with less depression. The association between marital status and education with depression was more nuanced: 72% (13 of 18) studies showed that unmarried persons had greater risk of depression than married or cohabitating persons and 52% (13 of 25) of studies reported no significant difference in depression across educational groups. Conclusion: This work adds to the literature a deeper understanding of how different assets relate to depression. In the context of largescale traumatic events, policies that maintain and protect access to social, physical, and financial assets may help to protect mental health.
MeSH term(s)	Adult ; Humans ; Socioeconomic Factors ; Depression/epidemiology ; Depression/psychology ; Pandemics ; COVID-19/epidemiology ; Income
Language	English
Publishing date	2023-10-15
Publishing country	Germany
Document type	Systematic Review ; Journal Article ; Review
ZDB-ID	623071-4
ISSN	1433-9285 ; 0037-7813 ; 0933-7954
ISSN (online)	1433-9285
ISSN	0037-7813 ; 0933-7954
DOI	10.1007/s00127-023-02565-2
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Article ; Online: The Eye as a Diagnostic Tool for Alzheimer’s Disease

Ahsan Hussain / Zahra Sheikh / Manju Subramanian

Life, Vol 13, Iss 726, p

2023 Volume 726

Abstract: Alzheimer’s disease (AD) is a progressive neurodegenerative disorder impacting cognition, function ... morbidity and life expectancy. Currently, the diagnosis of Alzheimer’s disease is a clinical one, often ... capabilities. This review summarizes current research for detecting biomarkers of Alzheimer’s disease in ocular ...

Abstract	Alzheimer’s disease (AD) is a progressive neurodegenerative disorder impacting cognition, function, and behavior in the elderly population. While there are currently no disease-modifying agents capable of curing AD, early diagnosis and management in the preclinical stage can significantly improve patient morbidity and life expectancy. Currently, the diagnosis of Alzheimer’s disease is a clinical one, often supplemented by invasive and expensive biomarker testing. Over the last decade, significant advancements have been made in our understanding of AD and the role of ocular tissue as a potential biomarker. Ocular biomarkers hold the potential to provide noninvasive and easily accessible diagnostic and monitoring capabilities. This review summarizes current research for detecting biomarkers of Alzheimer’s disease in ocular tissue.
Keywords	Alzheimer’s disease ; dementia ; ocular biomarkers ; Science ; Q
Language	English
Publishing date	2023-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Improved accuracy of S-value-based dosimetry: a guide to transition from Cristy-Eckerman to ICRP adult phantoms.

Subramanian, Shalini / He, Bin / Frey, Eric / Jokisch, Derek W / Bolch, Wesley / Sgouros, George

EJNMMI physics

2022 Volume 9, Issue 1, Page(s) 57

Abstract: Background: In 2016, the International Commission on Radiological Protection (ICRP) published the results of Monte Carlo simulations performed using updated and anatomically realistic voxelized phantoms. The resulting specific absorbed fractions are ... ...

Abstract	Background: In 2016, the International Commission on Radiological Protection (ICRP) published the results of Monte Carlo simulations performed using updated and anatomically realistic voxelized phantoms. The resulting specific absorbed fractions are based on more realistic human anatomy than those computed in the stylized, geometrical Cristy-Eckerman (CE) phantom. Despite this development, the ICRP-absorbed fractions have not been widely adopted for radiopharmaceutical dosimetry. To help make the transition, we have established a correspondence between source and target tissues defined in the CE phantom and those defined in the ICRP phantoms. Results: The ICRP phantom has 79 source regions and 43 target regions in comparison with the 23 source and 18 target tissue regions defined in the CE phantom. The ICRP phantom provides tissue regions with greater anatomical detail. Some of this additional detail is focused on radiation protection and dosimetry of inhaled/ingested radioactivity. Some, but not all, of this detail is useful and appropriate for radiopharmaceutical therapy. We have established the correspondence between CE and ICRP phantom source and target regions and attempted to highlight the ICRP source tissues relevant to radiopharmaceutical therapy (RPT). This paper provides tables and figures highlighting the correspondences established. Conclusion: The results provide assistance in transitioning from CE-stylized phantoms to the anatomically accurate voxelized ICRP phantoms. It provides specific guidance for porting the total absorbed activity for regions as defined in the CE phantom to regions within the ICRP phantoms.
Language	English
Publishing date	2022-08-26
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-022-00485-9
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Article: Development of Wunderlich syndrome following a Russell’s viper bite

Senthilkumaran, Subramanian / Miller, Stephen W. / Williams, Harry F. / Savania, Ravi / Thirumalaikolundusubramanian, Ponniah / Patel, Ketan / Vaiyapuri, Sakthivel

Toxicon. 2022 Aug., v. 215

2022

Abstract: Snakebite envenomation is a high priority neglected tropical disease that predominantly affects rural communities living in developing countries. Due to myriad of complications including coagulopathies, neurotoxicity, nephrotoxicity and local tissue ... ...

Abstract	Snakebite envenomation is a high priority neglected tropical disease that predominantly affects rural communities living in developing countries. Due to myriad of complications including coagulopathies, neurotoxicity, nephrotoxicity and local tissue destruction, treating snakebite victims is a major challenge for clinicians. Russell's viper (Daboia russelii) is one of the ‘Big Four’ venomous snakes in India, and it is responsible for the most snakebite-induced deaths and disabilities. Acute kidney injury occurs frequently following Russell's viper bites and it is a critical factor contributing to disabilities, deaths and excessive treatment costs. In addition to commonly observed envenomation effects, Russell's viper bites induce some rare complications such as priapism, sialolithiasis and splenic rupture. Here, we report a case of Wunderlich syndrome that developed in a 22-year-old male following a Russell's viper bite. The patient displayed severe coagulopathies, abdominal tenderness, and hypotension. Notably, a peri-nephric haematoma was identified through ultrasound and computerised tomographic imaging. The haemorrhage was successfully treated using angioembolisation, and the patient recovered without any difficulties. Although a clinical condition such as this is rare, it is important to create awareness among treating clinicians about its occurrence, diagnosis and clinical management.
Keywords	Daboia russelii ; acute kidney injury ; hematoma ; hypotension ; males ; nephrotoxicity ; neurotoxicity ; patients ; snake bites ; tomography ; tropical diseases ; ultrasonics ; India
Language	English
Dates of publication	2022-08
Size	p. 11-16.
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	204479-1
ISSN	1879-3150 ; 0041-0101
ISSN (online)	1879-3150
ISSN	0041-0101
DOI	10.1016/j.toxicon.2022.06.004
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Article ; Online: Effect of Diethyl Ether Additive on Reformulated Bio-Mix Blends from a Mixture of Different FEED Stock’s

Subhash, G. V. / Sivapirakasam, S. P. / Mohan, Sreejith / Subramanian, Nandakumar / Harisivasri Phanindra, K.

Waste Biomass Valor. 2023 Jan., v. 14, no. 1 p.261-276

2023

Abstract: The current study focuses on the use of diethyl ether as a fuel additive to enhance the properties of bio-mixture test samples. In this research, the raw bio-mix oil was extracted from a mixture of various raw feedstocks of borassus flabellifer oil (non- ... ...

Abstract	The current study focuses on the use of diethyl ether as a fuel additive to enhance the properties of bio-mixture test samples. In this research, the raw bio-mix oil was extracted from a mixture of various raw feedstocks of borassus flabellifer oil (non-edible) and waste cooking oil (edible) to obtain the optimum raw bio-mix blends based on their acid value. The optimum raw bio-mix fuels were converted to purified bio-mixture test fuel through a transesterification reaction process. Transesterified bio-mix samples were selected as optimum blends and mixed with 5% Diethyl ether for further investigations. The fatty acid composition of samples was identified using gas chromatography-mass spectrometry (GC–MS). The results of the study revealed that adding the diethyl ether additive to the bio-mix fuels could improve the fuel quality and meet the standards set forth by the Bureau of Indian standards, American standard for testing and material, European standards of test methods and norms when compared to all the individual biodiesel and bio-mix fuel samples. The experimental analysis also concluded that saturated fatty acids, oxidation stability, and cetane number were enhanced while flash point, viscosity, iodine number, density, free fatty acid and heating value were reduced as compared to individual non-edible biodiesel. From the experimental results, it was concluded that the addition of 5% diethyl ether into bio-mix fuel resulted in a significant enhancement of saturated fatty acid by 12.5 and 11.8% while unsaturated fatty acid decreased by 13.2 and 12.9% as compared to bio-mix blends without additive.
Keywords	Borassus flabellifer ; acid value ; biodiesel ; biomass ; ethyl ether ; fatty acid composition ; feedstocks ; free fatty acids ; gas chromatography-mass spectrometry ; iodine value ; oils ; oxidative stability ; saturated fatty acids ; transesterification ; viscosity ; wastes
Language	English
Dates of publication	2023-01
Size	p. 261-276.
Publishing place	Springer Netherlands
Document type	Article ; Online
ZDB-ID	2541900-6
ISSN	1877-265X ; 1877-2641
ISSN (online)	1877-265X
ISSN	1877-2641
DOI	10.1007/s12649-022-01871-1
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Article ; Online: Memory-Based Integral Sliding-Mode Control for T-S Fuzzy Systems With PMSM via Disturbance Observer.

Kuppusamy, Subramanian / Joo, Young Hoon

IEEE transactions on cybernetics

2021 Volume 51, Issue 5, Page(s) 2457–2465

Abstract: ... through the Takagi-Sugeno (T-S) fuzzy approach. Different from the previous studies, a memory-based ISMC scheme ... that has a constant delay is taken for the first time to design the ISMC for the T-S fuzzy systems. The DOB ... the disturbance. To fully abide by the model characteristics of the PMSM-based T-S fuzzy systems and DOB ...

Abstract	In this article, the disturbance observer (DOB)-based memory integral sliding-mode control (ISMC) is designed for the permanent magnet synchronous motor (PMSM) model subject to mismatched disturbance through the Takagi-Sugeno (T-S) fuzzy approach. Different from the previous studies, a memory-based ISMC scheme that has a constant delay is taken for the first time to design the ISMC for the T-S fuzzy systems. The DOB is given to estimate the disturbances, which are incorporated in the controller design to counteract the disturbance. To fully abide by the model characteristics of the PMSM-based T-S fuzzy systems and DOB, an integral-type fuzzy switching surface function (IFSSF), which involves state-dependent input matrix and memory parameter simultaneously, is defined. From the IFSSF, the fuzzy ISMC is designed to ensure the reachability condition in finite time. Besides that, the designed fuzzy ISMC can effectively attenuate the mismatched disturbances based on the H
Language	English
Publishing date	2021-04-15
Publishing country	United States
Document type	Journal Article
ISSN	2168-2275
ISSN (online)	2168-2275
DOI	10.1109/TCYB.2019.2953567
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Article ; Online: Do health trajectories predict neighborhood outcomes? Evidence of health selection in a diverse sample of U.S. adults.

Rolheiser, Lyndsey / Zacher, Meghan / Subramanian, S V / Arcaya, Mariana C

Health & place

2021 Volume 73, Page(s) 102713

Abstract: ... a longitudinal survey of U.S. households. Using ordinary least squares linear regression, we estimated the effect ...

Abstract	Across the United States, residents of lower income neighborhoods evince poorer health, on average, than residents of more affluent areas. Studies aiming to explain this pattern have focused largely on the effects of neighborhood characteristics on residents' health, often overlooking the possibility that the reverse causal process-that a person's health impacts where they live, or "health selection into neighborhoods"-also plays a role. We investigated processes of health selection using the Panel Study of Income Dynamics, a longitudinal survey of U.S. households. Using ordinary least squares linear regression, we estimated the effect of householders' self-rated health on their neighborhood socioeconomic status (SES, the Census tract-level family poverty rate) in 2013, adjusting for neighborhood SES and health in 2001 as well as sociodemographic characteristics and residential mobility. Poorer health was associated with residence in higher poverty neighborhoods overall. Stratified models indicated that while health selection was observed across both race/ethnicity and class boundaries, the relationship between poor health and neighborhood poverty was stronger among non-Hispanic Black respondents, those with low income, and respondents who either moved moderate distances or did not move at all during the study period. We conclude with a call for future work exploring the mechanisms leading those in worse health to reside in higher poverty neighborhoods, and for public health policies that seek not only to improve health supporting conditions in economically disadvantaged neighborhoods, but that also support the economic and social needs of residents struggling with health problems.
MeSH term(s)	Adult ; Humans ; Income ; Poverty ; Residence Characteristics ; Social Class ; Socioeconomic Factors ; United States ; Vulnerable Populations
Language	English
Publishing date	2021-11-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1262540-1
ISSN	1873-2054 ; 1353-8292
ISSN (online)	1873-2054
ISSN	1353-8292
DOI	10.1016/j.healthplace.2021.102713
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