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Article ; Online: Likelihood of 'falling through the net' relates to contemporary prevalence of gestational diabetes. Reply to Ikomi A, Mannan S, Anthony R, Kiss S [letter].

Meek, Claire L / Lewis, Hannah B / Patient, Charlotte / Murphy, Helen R / Simmons, David

2015 Volume 58, Issue 11, Page(s) 2673–2675

MeSH term(s)	Diabetes, Gestational/diagnosis ; Female ; Humans ; Pregnancy
Language	English
Publishing date	2015-08-29
Publishing country	Germany
Document type	Letter ; Research Support, Non-U.S. Gov't ; Comment
ZDB-ID	1694-9
ISSN	1432-0428 ; 0012-186X
ISSN (online)	1432-0428
ISSN	0012-186X
DOI	10.1007/s00125-015-3737-y
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Article ; Online: Evaluation of a Proportional Response Addition Approach to Mixture Risk Assessment and Predictive Toxicology Using Data on Four Trihalomethanes from the U.S. EPA's Multiple-Purpose Design Study.

Teuschler, Linda K / Hertzberg, Richard C / McDonald, Anthony / Sey, Yusupha Mahtarr / Simmons, Jane Ellen

Toxics

2024 Volume 12, Issue 4

Abstract: In this study, proportional response addition (Prop-RA), a model for predicting response from chemical mixture exposure, is demonstrated and evaluated by statistically analyzing data on all possible binary combinations of the four regulated ... ...

Abstract	In this study, proportional response addition (Prop-RA), a model for predicting response from chemical mixture exposure, is demonstrated and evaluated by statistically analyzing data on all possible binary combinations of the four regulated trihalomethanes (THMs). These THMs were the subject of a multipurpose toxicology study specifically designed to evaluate Prop-RA. The experimental design used a set of doses common to all components and mixtures, providing hepatotoxicity data on the four single THMs and the binary combinations. In Prop-RA, the contribution of each component to mixture toxicity is proportional to its fraction in the mixture based on its response at the total mixture dose. The primary analysis consisted of 160 evaluations. Statistically significant departures from the Prop-RA prediction were found for seven evaluations, with three predications that were greater than and four that were less than the predicted response; interaction magnitudes (n-fold difference in response vs. prediction) ranged from 1.3 to 1.4 for the former and 2.6 to 3.8 for the latter. These predictions support the idea that Prop-RA works best with chemicals where the effective dose ranges overlap. Prop-RA does not assume the similarity of toxic action or independence, but it can be applied to a mixture of components that affect the same organ/system, with perhaps unknown toxic modes of action.
Language	English
Publishing date	2024-03-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2733883-6
ISSN	2305-6304 ; 2305-6304
ISSN (online)	2305-6304
ISSN	2305-6304
DOI	10.3390/toxics12040240
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Article ; Online: Abaloparatide (Tymlos) for Osteoporosis.

Simmons, Benjamin F / Caprio, Anthony J

American family physician

2019 Volume 99, Issue 4, Page(s) 260–261

MeSH term(s)	Bone Density/drug effects ; Bone Density Conservation Agents/administration & dosage ; Bone Density Conservation Agents/economics ; Bone Density Conservation Agents/pharmacology ; Female ; Humans ; Injections, Subcutaneous ; Osteoporosis, Postmenopausal/drug therapy ; Parathyroid Hormone-Related Protein/administration & dosage ; Parathyroid Hormone-Related Protein/economics ; Parathyroid Hormone-Related Protein/pharmacology
Chemical Substances	Bone Density Conservation Agents ; Parathyroid Hormone-Related Protein ; abaloparatide (AVK0I6HY2U)
Language	English
Publishing date	2019-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	412694-4
ISSN	1532-0650 ; 0002-838X ; 0572-3612
ISSN (online)	1532-0650
ISSN	0002-838X ; 0572-3612
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Article ; Online: Acute Effects of Training Loads on Muscle Damage Markers and Performance in Semi-elite and Elite Athletes: A Systematic Review and Meta-analysis.

Simmons, Ryan / Doma, Kenji / Sinclair, Wade / Connor, Jonathan / Leicht, Anthony

Sports medicine (Auckland, N.Z.)

2021 Volume 51, Issue 10, Page(s) 2181–2207

Abstract: Background: The relationship between exercise-induced muscle damage (EIMD) indicators and acute training loads (TL) is yet to be reviewed extensively in semi-elite and elite athlete populations.: Objectives: The objectives of this systematic review ... ...

Abstract	Background: The relationship between exercise-induced muscle damage (EIMD) indicators and acute training loads (TL) is yet to be reviewed extensively in semi-elite and elite athlete populations. Objectives: The objectives of this systematic review and meta-analysis were threefold: (1) to evaluate studies of EIMD following the initial period of the preseason in semi-elite and elite athletes: (2) to examine acute physiological and performance responses across two periods of the season with similar TL; and (3) to examine acute physiological and performance responses to acute changes in TL during the season. Methods: The CINAHL, PubMed, Scopus, SPORTDiscus and Web of Science databases were systematically searched for studies that investigated: (1) semi-elite or elite athletes in team or individual sports following a periodised training programme; and (2) measured acute responses to training. Studies were excluded if: (1) conducted in animals; (2) non-English language; or (3) a conference abstract, review or case report. The Kmet Quality Scoring of Quantitative Studies tool was used for study appraisal. Synthesis methods: Data were quantitatively analysed by generating forest plots to report test statistics for statistical significance and inter-trial heterogeneity. Results: Of the included studies (n = 32), athletes experienced greater creatine kinase (CK) concentrations (Z = 4.99, p < 0.00001, I Limitations: This review included varying age, sex, sports and competition levels. The group level meta-analysis failed to identify within-athlete or position-specific differences across time. Conclusion: Blood biomarkers of EIMD may not differ across periods of similar TL, however can be considered a sensitive monitoring tool for assessing responses following acute TL changes in semi-elite and elite athletes.
MeSH term(s)	Athletes ; Biomarkers ; Creatine Kinase ; Humans ; Muscles ; Sports
Chemical Substances	Biomarkers ; Creatine Kinase (EC 2.7.3.2)
Language	English
Publishing date	2021-06-07
Publishing country	New Zealand
Document type	Case Reports ; Meta-Analysis ; Systematic Review
ZDB-ID	605911-9
ISSN	1179-2035 ; 0112-1642
ISSN (online)	1179-2035
ISSN	0112-1642
DOI	10.1007/s40279-021-01486-x
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Article: Using Computed Tomography (CT) Data to Build 3D Resources for Forensic Craniofacial Identification.

Simmons-Ehrhardt, Terrie / Falsetti, Catyana R S / Falsetti, Anthony B

Advances in experimental medicine and biology

2021 Volume 1317, Page(s) 53–74

Abstract: Forensic craniofacial identification encompasses the practices of forensic facial approximation (aka facial reconstruction) and craniofacial superimposition within the field of forensic art in the United States. Training in forensic facial approximation ... ...

Abstract	Forensic craniofacial identification encompasses the practices of forensic facial approximation (aka facial reconstruction) and craniofacial superimposition within the field of forensic art in the United States. Training in forensic facial approximation methods historically has used plaster copies, high-cost commercially molded skulls, and photographs. Despite the increased accessibility of computed tomography (CT) and the numerous studies utilizing CT data to better inform facial approximation methods, 3D CT data have not yet been widely used to produce interactive resources or reference catalogs aimed at forensic art practitioner use or method standardization. There are many free, open-source 3D software packages that allow engagement in immersive studies of the relationships between the craniofacial skeleton and facial features and facilitate collaboration between researchers and practitioners. 3D CT software, in particular, allows the bone and soft tissue to be visualized simultaneously with tools such as transparency, clipping, and volume rendering of underlying tissues, allowing for more accurate analyses of bone to soft tissue relationships. Analyses and visualization of 3D CT data can not only facilitate basic research into facial variation and anatomical relationships relevant for reconstructions but can also lead to improved facial reconstruction guidelines. Further, skull and face surface models exported in digital 3D formats allow for 3D printing of custom reference models and novel training materials and modalities for practitioners. This chapter outlines the 3D resources that can be built from CT data for forensic craniofacial identification methods, including how to view 3D craniofacial CT data and modify surface models for 3D printing.
MeSH term(s)	Face/diagnostic imaging ; Forensic Medicine ; Imaging, Three-Dimensional ; Skull/diagnostic imaging ; Tomography, X-Ray Computed
Language	English
Publishing date	2021-05-04
Publishing country	United States
Document type	Journal Article
ISSN	2214-8019 ; 0065-2598
ISSN (online)	2214-8019
ISSN	0065-2598
DOI	10.1007/978-3-030-61125-5_4
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Article ; Online: The association between provider characteristics and post-catheterization interventions.

Powell, Adam C / Goldstein, Jason P / Long, James W / Simmons, Jeffrey D / DeFrance, Anthony

PloS one

2022 Volume 17, Issue 4, Page(s) e0266544

Abstract: Objectives: To examine whether the demographics of providers' prior year patient cohorts, providers' historic degree of catheter-based fractional flow reserve (FFR) utilization, and other provider characteristics were associated with post- ... ...

Abstract	Objectives: To examine whether the demographics of providers' prior year patient cohorts, providers' historic degree of catheter-based fractional flow reserve (FFR) utilization, and other provider characteristics were associated with post-catheterization performance of percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). Study design: A retrospective, observational analysis of outpatient claims data was performed. Methods: All 2018 outpatient catheterization claims from a national organization offering commercial and Medicare Advantage health plans were examined. Claims were excluded if the patient had a prior catheterization in 2018, had any indications of CABG or valvular heart disease in the prior year of claims, or if the provider had ≤10 catheterization claims in 2017. Downstream PCI and CABG were determined by examining claims 0-30 days post-catheterization. Using multivariate mixed effects logistic regression with provider identity random effects, the association between post-catheterization procedures and provider characteristics was assessed, controlling for patient characteristics. Results: The sample consisted of 31,920 catheterization claims pertaining to procedures performed by 964 providers. Among the catheterization claims, 8,554 (26.8%) were followed by PCI and 1,779 (5.6%) were followed by CABG. Catheterizations performed by providers with older prior year patient cohorts were associated with higher adjusted odds of PCI (1.78; CI: 1.26-2.53), even after controlling for patient age. Catheterizations performed by providers with greater historic use of FFR had significantly higher adjusted odds of being followed by PCI (1.73; CI: 1.26-2.37). Conclusion: Provider characteristics may impact whether patients receive a procedure post-catheterization. Further research is needed to characterize this relationship.
MeSH term(s)	Aged ; Cardiac Catheterization ; Coronary Artery Disease ; Fractional Flow Reserve, Myocardial ; Humans ; Medicare ; Percutaneous Coronary Intervention/methods ; Retrospective Studies ; Risk Factors ; Treatment Outcome ; United States
Language	English
Publishing date	2022-04-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0266544
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Article: New frontiers in intraoperative neurophysiologic monitoring: a narrative review.

Oliva, Anthony M / Montejano, Julio / Simmons, Colby G / Vogel, Scott A / Isaza, Carlos F / Clavijo, Claudia F

Annals of translational medicine

2023 Volume 11, Issue 11, Page(s) 388

Abstract: Background and objective: Neurological insults during surgery arise from anatomic and/or physiologic perturbations. Intraoperative neurophysiologic monitoring (IONM) fills a critical role of ensuring that any neurological insults during certain surgical ...

Abstract	Background and objective: Neurological insults during surgery arise from anatomic and/or physiologic perturbations. Intraoperative neurophysiologic monitoring (IONM) fills a critical role of ensuring that any neurological insults during certain surgical procedures are caught in real-time to prevent patient harm. IONM provides immediate feedback to the surgeon and anesthesiologist about the need for an intervention to prevent a neurologic deficit postoperatively. As important as it seems to have IONM available to any patient having surgery where a neurological injury is possible, the truth is that IONM is unavailable to large swaths of people around the world. This review is intended to bring attention to all of the ways IONM is critically important for a variety of surgeries and highlight the barriers preventing most patients around the world from benefiting from the technology. Expansion of IONM to benefit patients from all over the world is the new frontier. Methods: We searched all English language original papers and reviews using Embase and MEDLINE/PubMed databases published from 1995 to 2022. Different combinations of the following search terms were used: intraoperative neuromonitoring, neurosurgery, low-income countries, cost, safety, and efficacy. Key content and findings: We describe common IONM modalities used during surgery as well as explore barriers to implementation of IONM in resource-limited regions. Additionally, we describe ongoing efforts to establish IONM capabilities in new locations around the world. Conclusions: In this paper, we performed a review of the literature on IONM with an emphasis on the basic understanding of clinical applications and the barriers for expansion into resource-limited settings. Finally, we provide our interpretation of "new frontiers" in IONM quite literally facilitating access to the tools and education so a hospital in Sub-Saharan Africa can incorporate IONM for their high-risk surgeries.
Language	English
Publishing date	2023-07-26
Publishing country	China
Document type	Journal Article ; Review
ZDB-ID	2893931-1
ISSN	2305-5847 ; 2305-5839
ISSN (online)	2305-5847
ISSN	2305-5839
DOI	10.21037/atm-22-4586
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Article ; Online: Immunomagnetic Isolation and Enrichment of Microvascular Endothelial Cells from Human Adipose Tissue.

Antonyshyn, Jeremy A / Mazzoli, Vienna / McFadden, Meghan J / Gramolini, Anthony O / Hofer, Stefan O P / Simmons, Craig A / Santerre, Paul J

Bio-protocol

2022 Volume 12, Issue 10

Abstract: Human adipose tissue-resident microvascular endothelial cells are not only garnering attention for their emergent role in the pathogenesis of obesity-related metabolic disorders, but are also of considerable interest for vascular tissue engineering due, ... ...

Abstract	Human adipose tissue-resident microvascular endothelial cells are not only garnering attention for their emergent role in the pathogenesis of obesity-related metabolic disorders, but are also of considerable interest for vascular tissue engineering due, in part, to the abundant, accessible, and uniquely dispensable nature of the tissue. Here, we delineate a protocol for the acquisition of microvascular endothelial cells from human fat. A cheaper, smaller, and simpler alternative to fluorescence-assisted cell sorting for the immunoselection of cells, our protocol adapts magnet-assisted cell sorting for the isolation of endothelial cells from enzymatically digested adipose tissue and the subsequent enrichment of their primary cultures. Strategies are employed to mitigate the non-specific uptake of immunomagnetic microparticles, enabling the reproducible acquisition of human adipose tissue-resident microvascular endothelial cells with purities ≥98%. They exhibit morphological, molecular, and functional hallmarks of endothelium, yet retain a unique proteomic signature when compared with endothelial cells derived from different vascular beds. Their cultures can be expanded for >10 population doublings and can be maintained at confluence for at least 28 days without being overgrown by residual stromal cells from the cell sorting procedure. The isolation of human adipose tissue-resident microvascular endothelial cells can be completed within 6 hours and their enrichment within 2 hours, following approximately 7 days in culture. Graphical abstract.
Language	English
Publishing date	2022-05-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.4422
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Article ; Online: Stereocontrolled Radical Thiophosphorylation.

Nassir, Molhm / Ociepa, Michał / Zhang, Hai-Jun / Grant, Lauren N / Simmons, Bryan J / Oderinde, Martins S / Kawamata, Yu / Cauley, Anthony N / Schmidt, Michael A / Eastgate, Martin D / Baran, Phil S

Journal of the American Chemical Society

2023 Volume 145, Issue 28, Page(s) 15088–15093

Abstract: The first practical, fully stereoselective P(V)-radical hydrophosphorylation is presented herein by using simple, limonene-derived reagent systems. A set of reagents have been developed that upon radical initiation react smoothly with olefins and other ... ...

Abstract	The first practical, fully stereoselective P(V)-radical hydrophosphorylation is presented herein by using simple, limonene-derived reagent systems. A set of reagents have been developed that upon radical initiation react smoothly with olefins and other radical acceptors to generate
Language	English
Publishing date	2023-07-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.3c05655
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Article: Characterizing Cardiac Catheterization Utilization in a US Population with Commercial or Medicare Advantage Health Plans.

Powell, Adam C / Lugo, Christopher T / Long, James W / Simmons, Jeffrey D / DeFrance, Anthony

American health & drug benefits

2021 Volume 14, Issue 3, Page(s) 91–100

Abstract: Background: Health plans and health systems need to understand the demand for common healthcare services to ensure adequate access to care. Utilization of cardiac catheterization is of particular interest, because it is relatively common and has the ... ...

Abstract	Background: Health plans and health systems need to understand the demand for common healthcare services to ensure adequate access to care. Utilization of cardiac catheterization is of particular interest, because it is relatively common and has the potential for variation across subpopulations, similar to the level of geographical variation in heart disease in the United States. Objectives: To illustrate how the utilization of cardiac catheterization has changed over time in a US population with commercial and Medicare Advantage health plans, and how it differs between subpopulations. Methods: Cardiac catheterization claims data from 2012 to 2018 were extracted from the database of a national healthcare organization offering commercial and Medicare Advantage health plans. Contemporaneous health plan enrollment data and government data were used to determine the patients' characteristics. Annual catheterizations per 1000 patients for the population as a whole and for subpopulations were determined using claims data. Spearman's rank-order correlation was used to assess the monotonicity of trends. Catheterization utilization for each subpopulation was compared with that of the population average. A second, patient-level analysis was used to determine the factors predictive of patients' catheterization utilization in 2018. Results: Across the overall population, the rate of cardiac catheterization was stable from 2012 to 2018. An adjusted analysis of 2018 data showed that catheterization utilization was significantly associated with older age, male sex, residence in a rural zip code, residence in a lower-income zip code, and residence in a state with a high obesity rate. The trendlines of the relative utilization of catheterization in subpopulations over time revealed similar patterns. Conclusion: Marked differences were observed in the rates of cardiac catheterization utilization between the subpopulations in our study. Overall, these data show a direct correlation between geographic residence, obesity level, wealth, and the rate of cardiac catheterization utilization. To ensure adequate access to care, health plans and health systems should explore the implications of disproportionately high demand for cardiac catheterization in populations from lower-income areas, higher obesity rate states, rural patients, and older patients.
Language	English
Publishing date	2021-09-25
Publishing country	United States
Document type	Journal Article
ZDB-ID	2853721-X
ISSN	1942-2970 ; 1942-2962
ISSN (online)	1942-2970
ISSN	1942-2962
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