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  1. Article ; Online: Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0).

    Li, Taisheng

    Emerging microbes & infections

    2020  Volume 9, Issue 1, Page(s) 582–585

    Abstract: Since December 2019, China has been experiencing an outbreak of a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical features include fever, coughing, shortness of breath, and inflammatory lung ... ...

    Abstract Since December 2019, China has been experiencing an outbreak of a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical features include fever, coughing, shortness of breath, and inflammatory lung infiltration. China rapidly listed SARS-CoV-2-related pneumonia as a statutory infectious disease. To standardize the diagnosis and treatment of this new infectious disease, an operational recommendation for the diagnosis and management of SARS-CoV-2 infection is developed by Peking Union Medical College Hospital.
    MeSH term(s) COVID-19 ; Coronavirus Infections/diagnosis ; Coronavirus Infections/prevention & control ; Coronavirus Infections/therapy ; Coronavirus Infections/transmission ; Health Personnel ; Hospitals ; Humans ; Occupational Exposure ; Patient Isolation ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/prevention & control ; Pneumonia, Viral/therapy ; Pneumonia, Viral/transmission ; Practice Guidelines as Topic
    Keywords covid19
    Language English
    Publishing date 2020-03-14
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2681359-2
    ISSN 2222-1751 ; 2222-1751
    ISSN (online) 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2020.1735265
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: HIV DNA positively correlates with HLA-DR+CD8+ T lymphocytes over 8-year suppressive antiretroviral therapy.

    Zhu, Tianyuan / Cao, Wei / Li, Taisheng

    AIDS (London, England)

    2023  Volume 37, Issue 8, Page(s) 1335–1337

    Abstract: We studied the relationship between HIV DNA and CD8 + T-cell activation in a retrospective cohort. We observed that the expression level of HLA-DR remained high in CD8 + T-cells and was positively correlated with total HIV DNA [odds ratio (OR)  =  1.86, ... ...

    Abstract We studied the relationship between HIV DNA and CD8 + T-cell activation in a retrospective cohort. We observed that the expression level of HLA-DR remained high in CD8 + T-cells and was positively correlated with total HIV DNA [odds ratio (OR)  =  1.86, P  = 0.028) during 8 years of suppressive antiretroviral therapy (ART). This study illustrated the long-term interplay between HIV DNA reservoir and host inflammatory state despite viral suppression.
    MeSH term(s) Humans ; HIV Infections/drug therapy ; Retrospective Studies ; HLA-DR Antigens ; CD8-Positive T-Lymphocytes ; DNA ; CD4-Positive T-Lymphocytes ; Lymphocyte Activation
    Chemical Substances HLA-DR Antigens ; DNA (9007-49-2)
    Language English
    Publishing date 2023-04-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000003587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2228: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection

    Li, Taisheng

    Emerging Microbes & Infections

    an operational recommendation of Peking Union Medical College Hospital (V2.0) ; Working Group of 2019 Novel Coronavirus, Peking Union Medical College Hospital

    2020  Volume 9, Issue 1, Page(s) 582–585

    Keywords Immunology ; Epidemiology ; Microbiology ; Drug Discovery ; Parasitology ; Virology ; Infectious Diseases ; General Medicine ; covid19
    Language English
    Publisher Informa UK Limited
    Publishing country uk
    Document type Article ; Online
    ZDB-ID 2681359-2
    ISSN 2222-1751
    ISSN 2222-1751
    DOI 10.1080/22221751.2020.1735265
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Development and validation of an HPLC method for quantification of dolutegravir in human plasma.

    Li, Dongsheng / Fu, Qiang / Du, Xiaoli / Li, Taisheng

    Biomedical chromatography : BMC

    2023  Volume 37, Issue 10, Page(s) e5708

    Abstract: Dolutegravir (DTG) has been the first-line drug in many human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) guidelines for the treatment of naïve and experienced HIV-infected individuals, which calls for cost-effective and ... ...

    Abstract Dolutegravir (DTG) has been the first-line drug in many human immunodeficiency virus/acquired immunodeficiency syndrome (HIV/AIDS) guidelines for the treatment of naïve and experienced HIV-infected individuals, which calls for cost-effective and convenient methods for quantitative detection of DTG in human plasma for pharmacokinetic studies and patient adherence evaluation. Here, an HPLC-ultraviolet method in combination with liquid-liquid extraction with isocratic elution was developed for the first time. The analysis was performed on a CLC-ODS column (6 mm internal diameter × 15 cm, 5 μm) using a mixture of acetonitrile and phosphate buffer (40:60, v/v) as the mobile phase at the flow rate of 1 mL/min. Using triamcinolone as the internal standard, 100 μL of plasma sample was extracted by methyl tert-butyl ether, followed by evaporating under nitrogen stream, re-dissolving with 100 μL mobile phase, and injection of 20-40 μL of supernatant into the chromatographic system. The linearity of DTG was good in the range of 0.05-10 μg/mL (r = 0.9995), and the inter- and intra-day variabilities were 0.4%-4.3% (n = 10) and 1.2%-6.2% (n = 10) for the lower limit of quantification, low-, medium-, and high-concentration quality control samples (0.05, 0.1, 0.8, and 8 μg/mL), respectively, while the methodological and extraction recoveries were 98.0%-103.0% (n = 20) and 65.2%-75.7% (n = 3), respectively. This method was successfully applied to analyze DTG plasma concentration in 84 Chinese patients with HIV.
    MeSH term(s) Humans ; Chromatography, High Pressure Liquid ; Heterocyclic Compounds, 3-Ring ; Oxazines ; HIV Infections
    Chemical Substances dolutegravir (DKO1W9H7M1) ; Heterocyclic Compounds, 3-Ring ; Oxazines
    Language English
    Publishing date 2023-08-22
    Publishing country England
    Document type Journal Article
    ZDB-ID 632848-9
    ISSN 1099-0801 ; 0269-3879
    ISSN (online) 1099-0801
    ISSN 0269-3879
    DOI 10.1002/bmc.5708
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2166: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: COVID-19: towards understanding of pathogenesis.

    Cao, Wei / Li, Taisheng

    Cell research

    2020  Volume 30, Issue 5, Page(s) 367–369

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus ; Coronavirus Infections ; Genomics ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-04-28
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 1319303-x
    ISSN 1748-7838 ; 1001-0602
    ISSN (online) 1748-7838
    ISSN 1001-0602
    DOI 10.1038/s41422-020-0327-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5283: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection: an operational recommendation of Peking Union Medical College Hospital (V2.0)

    Li, Taisheng

    Emerg Microbes Infect

    Abstract: Since December 2019, China has been experiencing an outbreak of a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical features include fever, coughing, shortness of breath, and inflammatory lung ... ...

    Abstract Since December 2019, China has been experiencing an outbreak of a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical features include fever, coughing, shortness of breath, and inflammatory lung infiltration. China rapidly listed SARS-CoV-2-related pneumonia as a statutory infectious disease. To standardize the diagnosis and treatment of this new infectious disease, an operational recommendation for the diagnosis and management of SARS-CoV-2 infection is developed by Peking Union Medical College Hospital.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #400832
    Database COVID19

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  7. Article ; Online: Diagnosis and clinical management of severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) infection

    Li, Taisheng

    Emerging Microbes & Infections, 9(1):582-585

    an operational recommendation of Peking Union Medical College Hospital (V2.0)

    2020  

    Abstract: Since December 2019, China has been experiencing an outbreak of a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical features include fever, coughing, shortness of breath, and inflammatory lung ... ...

    Abstract Since December 2019, China has been experiencing an outbreak of a new infectious disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The clinical features include fever, coughing, shortness of breath, and inflammatory lung infiltration. China rapidly listed SARS-CoV-2-related pneumonia as a statutory infectious disease. To standardize the diagnosis and treatment of this new infectious disease, an operational recommendation for the diagnosis and management of SARS-CoV-2 infection is developed by Peking Union Medical College Hospital.
    Keywords Coronavirus disease 2019 ; COVID-19 ; pneumonia ; treatment ; SARS-CoV-2 ; diagnosis ; covid19
    Language English
    Publishing country de
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: [The changes in subjective visual vertical after otolith reduction in patients with BPPV].

    Li, Peihong / Liu, Qiang / Wang, Wei / Chen, Taisheng

    Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery

    2022  Volume 36, Issue 11, Page(s) 816–821

    Abstract: Objective: ...

    Abstract Objective:
    MeSH term(s) Humans ; Otolithic Membrane/physiology ; Semicircular Canals ; Face
    Language Chinese
    Publishing date 2022-11-08
    Publishing country China
    Document type English Abstract ; Journal Article
    ISSN 2096-7993
    ISSN 2096-7993
    DOI 10.13201/j.issn.2096-7993.2022.11.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: A preliminary study on plasma concentration, short-term efficacy, and safety profile of dolutegravir in Chinese people with HIV.

    Li, Dongsheng / Xiao, Ran / Fu, Qiang / Song, Xiaojing / Han, Yang / Du, Xiaoli / Li, Taisheng

    Expert review of clinical pharmacology

    2024  , Page(s) 1–7

    Abstract: Background: This study examined the plasma concentration, clinical efficacy, and safety of dolutegravir (DTG) in Chinese people with HIV (PWH).: Methods: In this observational study, HIV-positive individuals on DTG-based regimens for at least 6 ... ...

    Abstract Background: This study examined the plasma concentration, clinical efficacy, and safety of dolutegravir (DTG) in Chinese people with HIV (PWH).
    Methods: In this observational study, HIV-positive individuals on DTG-based regimens for at least 6 months were included. Plasma DTG concentrations were measured 1 month after initiating treatment. Viral loads (VL) and CD4+ T cell counts were evaluated at baseline and after 1 and 6 months of therapy. High-performance liquid chromatography was used for measuring DTG concentrations, polymerase chain reaction for VL, and flow cytometry for CD4+ T cell counts. Safety assessments included monitoring liver enzymes, serum creatinine estimated glomerular filtration rate, and adverse reactions.
    Results: Eighty-two Chinese PWH were enrolled. Average VL decreased significantly from baseline by 3.1 log at 1 month and 3.5 log at 6 months. CD4+ T cell counts increased from 273 cells/mm
    Conclusion: Preliminary findings suggest higher DTG plasma concentrations in Chinese PWH compared to Western populations, with promising short-term efficacy and safety.
    Language English
    Publishing date 2024-01-22
    Publishing country England
    Document type Journal Article
    ISSN 1751-2441
    ISSN (online) 1751-2441
    DOI 10.1080/17512433.2024.2308664
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Coexisting of Primary Central Nervous System Lymphoma and

    Liu, Xinchao / Xing, Hao / Lin, Jing / Sun, Jian / Wang, Yu / Liu, Yaxu / Cao, Wei / Liu, Zhengyin / Li, Taisheng

    Infection and drug resistance

    2024  Volume 17, Page(s) 709–718

    Abstract: Background: Talaromyces marneffei: Case presentation: We reported a very rare case of a 19-year-old man with HIV infection who suffered from a brain mass and lymphadenopathy. His blood culture, bone marrow culture and sputum culture all grew : ... ...

    Abstract Background: Talaromyces marneffei
    Case presentation: We reported a very rare case of a 19-year-old man with HIV infection who suffered from a brain mass and lymphadenopathy. His blood culture, bone marrow culture and sputum culture all grew
    Conclusion: Based on a case report of a traveller who suffered from a brain mass of
    Language English
    Publishing date 2024-02-22
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2494856-1
    ISSN 1178-6973
    ISSN 1178-6973
    DOI 10.2147/IDR.S432697
    Database MEDical Literature Analysis and Retrieval System OnLINE

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