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Article ; Online: SARS-CoV-2 vaccination in primary antibody deficiencies: an overview on efficacy, immunogenicity, durability of immune response and safety.

Cusa, Gabriella / Sardella, Germano / Garzi, Giulia / Firinu, Davide / Milito, Cinzia

Current opinion in allergy and clinical immunology

2023 Volume 24, Issue 1, Page(s) 37–43

Abstract: Purpose of review: This review aims to summarize the current best knowledge on the efficacy of COVID-19 vaccination in vulnerable patients affected by primary antibody deficiencies (PADs), both in patients previously infected and vaccine-immunized, ... ...

Abstract	Purpose of review: This review aims to summarize the current best knowledge on the efficacy of COVID-19 vaccination in vulnerable patients affected by primary antibody deficiencies (PADs), both in patients previously infected and vaccine-immunized, focusing also on the durability, on the need for multiple booster doses and on the safety of anti-SARS-CoV-2 vaccines. Recent findings: Patients vaccinated for SARS-CoV2 have variable humoral response, still showing a tendency towards an increase in antibody titers, with factors such as booster doses, previous infections, age and specific genetic mutations influencing the outcome. Long-lasting cellular responses to SARS-CoV-2 vaccination instead, mostly of the T-cell type, have been observed. Overall, the duration of protection given by vaccinations is sufficient and increased upon further simulations. Furthermore, the safety profile in PID patients is excellent, with most adverse events being transient and mild and no major adverse event reported. Summary: Several studies have emphasized the benefit of vaccinating patients with PADs against the SARS-CoV-2 virus and the necessity of administering booster doses. This review, by gathering the most recent and significant data from the scientific literature, could be helpful in clinical practice in the management of disease prevention in patients affected by primary immunodeficiency and also serve as inspiration for further in-depth clinical research.
MeSH term(s)	Humans ; COVID-19/prevention & control ; COVID-19 Vaccines/immunology ; Immunity ; Primary Immunodeficiency Diseases ; RNA, Viral ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines ; RNA, Viral
Language	English
Publishing date	2023-11-14
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	2088710-3
ISSN	1473-6322 ; 1528-4050
ISSN (online)	1473-6322
ISSN	1528-4050
DOI	10.1097/ACI.0000000000000955
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Article ; Online: Clinical management of patients with primary immunodeficiencies during the COVID-19 pandemic.

Quinti, Isabella / Mezzaroma, Ivano / Milito, Cinzia

Expert review of clinical immunology

2021 Volume 17, Issue 2, Page(s) 163–168

Abstract: ... ...

Abstract	Introduction
MeSH term(s)	COVID-19/diagnosis ; COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19/therapy ; Humans ; Immunization, Passive ; Practice Guidelines as Topic ; Primary Immunodeficiency Diseases/epidemiology ; Primary Immunodeficiency Diseases/therapy ; Remote Consultation ; SARS-CoV-2/isolation & purification
Language	English
Publishing date	2021-01-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2274260-8
ISSN	1744-8409 ; 1744-666X
ISSN (online)	1744-8409
ISSN	1744-666X
DOI	10.1080/1744666X.2021.1873767
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Article ; Online: Genetic stability of Campylobacter coli in patients with primary antibody deficiencies.

Milito, Cinzia / Quinti, Isabella

The journal of allergy and clinical immunology. In practice

2019 Volume 7, Issue 5, Page(s) 1707

MeSH term(s)	Adult ; Campylobacter Infections ; Campylobacter coli ; Humans ; Primary Immunodeficiency Diseases
Language	English
Publishing date	2019-03-27
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	2843237-X
ISSN	2213-2201 ; 2213-2198
ISSN (online)	2213-2201
ISSN	2213-2198
DOI	10.1016/j.jaip.2019.02.033
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Zs.A 7086: Show issues

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Article: Non-Infectious Pneumonitis and Acute Respiratory Distress Syndrome in a Patient on Ustekinumab Treatment: Case Report and Literature Review.

Cioffi, Valentina / Di Napoli, Giulia / Tozzi, Pierfrancesco / Martelli, Sabina / Bruno, Katia / Longo, Andrea / Buso, Helena / Pugliese, Francesco / Milito, Cinzia

Life (Basel, Switzerland)

2024 Volume 14, Issue 3

Abstract: Ustekinumab is a monoclonal antibody targeting the p40 subunit of IL-12 and IL-23, approved for treating psoriasis, psoriatic arthritis, and inflammatory bowel disease. Despite a remarkable success in treating chronic inflammatory conditions and a ... ...

Abstract	Ustekinumab is a monoclonal antibody targeting the p40 subunit of IL-12 and IL-23, approved for treating psoriasis, psoriatic arthritis, and inflammatory bowel disease. Despite a remarkable success in treating chronic inflammatory conditions and a generally favorable safety profile, its role in inducing rare adverse events, such as interstitial pneumonia and acute respiratory distress syndrome (ARDS), remains largely uncharted. We report a case of a 66-year-old male patient treated with Ustekinumab for severe psoriasis who, after almost two years of treatment, developed dyspnea, asthenia, and fever progressing to non-infectious pneumonia and ARDS leading to ICU admission. Moreover, we conducted a literature review on Ustekinumab-associated pulmonary complications. Our case underscores the importance of appropriate and long-term clinical monitoring in patients on Ustekinumab treatment, particularly considering the potential lung complications. The possibility of non-infectious pneumonitis should be considered alongside infectious causes, facilitating prompt management in the case of negative infectious screening. Additionally, the severity of ARDS underscores the importance of timely recognition and proper management. Further investigations are recommended to investigate the immunological basis of Ustekinumab-induced ARDS for designing appropriate monitoring strategies.
Language	English
Publishing date	2024-03-16
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2662250-6
ISSN	2075-1729
ISSN	2075-1729
DOI	10.3390/life14030394
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Article: Insights into Facilitated Subcutaneous Immunoglobulin Use in Patients with Secondary Immunodeficiency Diseases: A FIGARO Subgroup Analysis.

Dimou, Maria / Speletas, Matthaios / Milito, Cinzia / Pyzik, Aleksandra / Huscher, Dörte / Kamieniak, Marta / Pittrow, David / Borte, Michael

Cancers

2023 Volume 15, Issue 18

Abstract: The Facilitated Immunoglobulin Administration Registry And Outcomes (FIGARO) Study was a European, multicenter, prospective, observational study conducted across Europe designed to provide insights on the clinical use and tolerability of facilitated ... ...

Abstract	The Facilitated Immunoglobulin Administration Registry And Outcomes (FIGARO) Study was a European, multicenter, prospective, observational study conducted across Europe designed to provide insights on the clinical use and tolerability of facilitated subcutaneous immunoglobulin (fSCIG). Data herein are reported for the cohort of patients with secondary immunodeficiency (SID), with a subgroup analysis by age. The SID cohort included 31 patients: 1 pediatric, 15 adult, and 15 older adult patients. Over the 36-month observation period, the median monthly dose of fSCIG (30 g) and median monthly infusion volume per patient (300 mL) remained constant in both adult-age cohorts. Serum trough levels tended to increase over time. Most patients required only one infusion site and could receive the full dose every 3-4 weeks. There was a trend toward self-administration at home. In the adult group, infusion site inflammation and headache were reported at the inclusion visit (
Language	English
Publishing date	2023-09-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15184524
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Article ; Online: COVID-19 in complex common variable immunodeficiency patients affected by lung diseases.

Milito, Cinzia / Soccodato, Valentina / Auria, Stefania / Pulvirenti, Federica / Quinti, Isabella

Current opinion in allergy and clinical immunology

2021 Volume 21, Issue 6, Page(s) 535–544

Abstract: Purpose of review: In the general population, the risk of severe COVID-19 is associated with old age, male sex, hypertension, obesity and chronic diseases. Chronic lung diseases are listed as additional risk factors for hospitalization and ICU admission. ...

Abstract	Purpose of review: In the general population, the risk of severe COVID-19 is associated with old age, male sex, hypertension, obesity and chronic diseases. Chronic lung diseases are listed as additional risk factors for hospitalization and ICU admission. The purpose of this review is to define whether chronic lung diseases, such as bronchiectasis and interstitial diseases, represent a risk for a severe SARS-CoV-2 infection in patients affected by common variable immunodeficiency (CVID), the most common symptomatic primary antibody defect. Recent findings: CVID patients with SARS-CoV-2 infection have been reported since the beginning of the pandemic with a wide range of clinical presentations ranging from asymptomatic to mild/moderate and severe COVID-19. The meta-analysis of 88 CVID cases described in large cohorts and case reports demonstrated that CVID patients with chronic lung involvement have an increased risk for severe COVID-19 in comparison to CVID without lung diseases (50 vs. 28%, relative risk 1.75, 95% confidence interval 1.04--2.92, P = 0.043). Differently from the general population, age and metabolic comorbidities did not represent a risk factor for severe course in this patient's population. Summary: Underlying chronic lung diseases but not age represent a risk factor for severe COVID-19 in CVID. Prompt therapeutic intervention should be adopted in SARS-CoV-2 positive CVID patients with chronic lung diseases independently of their age.
MeSH term(s)	Age Factors ; Bronchiectasis/epidemiology ; Bronchiectasis/immunology ; COVID-19/diagnosis ; COVID-19/immunology ; COVID-19/virology ; Chronic Disease/epidemiology ; Common Variable Immunodeficiency/complications ; Common Variable Immunodeficiency/immunology ; Disease Susceptibility ; Humans ; Lung Diseases, Interstitial/epidemiology ; Lung Diseases, Interstitial/immunology ; Risk Factors ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Severity of Illness Index
Language	English
Publishing date	2021-09-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2088710-3
ISSN	1473-6322 ; 1528-4050
ISSN (online)	1473-6322
ISSN	1528-4050
DOI	10.1097/ACI.0000000000000789
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Article ; Online: Clinical impact of transient lymphopenia.

Petramala, Luigi / Milito, Cinzia / Sarlo, Francesca / Servello, Adriana / Circosta, Francesco / Marino, Luca / Sardella, Germano / Trapani, Piero / D'aguanno, Giulio / Cimo', Antonino / Galardo, Gioacchino / Letizia, Claudio

Clinical and experimental medicine

2024 Volume 24, Issue 1, Page(s) 77

Abstract: Transient or persistent immunosuppression is a known risk factor for morbidity and mortality in critically ill patients. Aim of the present study is to evaluate the lymphopenia in patients admitted to the Emergency Unit of AOU Policlinico Umberto I, to ... ...

Abstract	Transient or persistent immunosuppression is a known risk factor for morbidity and mortality in critically ill patients. Aim of the present study is to evaluate the lymphopenia in patients admitted to the Emergency Unit of AOU Policlinico Umberto I, to investigate its prevalence at admission and the persistence during hospitalization until discharge. Possible correlations were evaluated between lymphopenia, diagnosis of admission, comorbidities and chronic treatments. In this study, 240 patients (142 men; 98 female; mean age 75.1 ± 15.1) were enrolled. Patients were divided into two groups according to the lymphocytes count at hospital admission, namely "Group A" with lymphopenia and "Group B" with values in the normal range. Moreover, the patients in group A were distinguished in relation to the regression or persistence of the lymphopenia assessed at the time of hospital discharge (Group A1: persistence; Group A2: normalization). Prevalence of lymphopenia at admission was 57%; Group A showed higher mean age and percentage of patients over 65 years of age; and none differences were observed regarding gender. Prevalence of lymphopenia at admission was 57%; Group A showed higher mean age and percentage of patients over 65 years of age; no differences were observed regarding gender. All subsets of the lymphocytes (CD4
MeSH term(s)	Male ; Humans ; Female ; Middle Aged ; Aged ; Aged, 80 and over ; Lymphopenia/epidemiology ; Patient Discharge ; Emergency Service, Hospital ; Risk Factors
Language	English
Publishing date	2024-04-17
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2053018-3
ISSN	1591-9528 ; 1591-8890
ISSN (online)	1591-9528
ISSN	1591-8890
DOI	10.1007/s10238-024-01340-0
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Article: Reply to Özdemir, Ö. Allergic Disease with Selective IgA Deficiency. Comment on "Cinicola et al. The Allergic Phenotype of Children and Adolescents with Selective IgA Deficiency: A Longitudinal Monocentric Study.

Cinicola, Bianca Laura / Brindisi, Giulia / Capponi, Martina / Gori, Alessandra / Loffredo, Lorenzo / De Castro, Giovanna / Anania, Caterina / Spalice, Alberto / Guido, Cristiana Alessia / Milito, Cinzia / Duse, Marzia / Quinti, Isabella / Pulvirenti, Federica / Zicari, Anna Maria

Journal of clinical medicine

2023 Volume 12, Issue 23

Abstract: We carefully read the correspondence [ ... ]. ...

Abstract	We carefully read the correspondence [...].
Language	English
Publishing date	2023-11-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12237224
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Article ; Online: Age-dependent NK cell dysfunctions in severe COVID-19 patients.

Fionda, Cinzia / Ruggeri, Silvia / Sciumè, Giuseppe / Laffranchi, Mattia / Quinti, Isabella / Milito, Cinzia / Palange, Paolo / Menichini, Ilaria / Sozzani, Silvano / Frati, Luigi / Gismondi, Angela / Santoni, Angela / Stabile, Helena

Frontiers in immunology

2022 Volume 13, Page(s) 1039120

Abstract: Natural Killer (NK) cells are key innate effectors of antiviral immune response, and their activity changes in ageing and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we investigated the age-related changes of NK cell ... ...

Abstract	Natural Killer (NK) cells are key innate effectors of antiviral immune response, and their activity changes in ageing and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we investigated the age-related changes of NK cell phenotype and function during SARS-CoV-2 infection, by comparing adult and elderly patients both requiring mechanical ventilation. Adult patients had a reduced number of total NK cells, while elderly showed a peculiar skewing of NK cell subsets towards the CD56
MeSH term(s)	Humans ; COVID-19 ; SARS-CoV-2 ; Skin Diseases ; Killer Cells, Natural ; Transforming Growth Factor beta
Chemical Substances	Transforming Growth Factor beta
Language	English
Publishing date	2022-11-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2022.1039120
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Article ; Online: IgA Antibodies and IgA Deficiency in SARS-CoV-2 Infection.

Quinti, Isabella / Mortari, Eva Piano / Fernandez Salinas, Ane / Milito, Cinzia / Carsetti, Rita

Frontiers in cellular and infection microbiology

2021 Volume 11, Page(s) 655896

Abstract: A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, ... ...

Abstract	A large repertoire of IgA is produced by B lymphocytes with T-independent and T-dependent mechanisms useful in defense against pathogenic microorganisms and to reduce immune activation. IgA is active against several pathogens, including rotavirus, poliovirus, influenza virus, and SARS-CoV-2. It protects the epithelial barriers from pathogens and modulates excessive immune responses in inflammatory diseases. An early SARS-CoV-2 specific humoral response is dominated by IgA antibodies responses greatly contributing to virus neutralization. The lack of anti-SARS-Cov-2 IgA and secretory IgA (sIgA) might represent a possible cause of COVID-19 severity, vaccine failure, and possible cause of prolonged viral shedding in patients with Primary Antibody Deficiencies, including patients with Selective IgA Deficiency. Differently from other primary antibody deficiency entities, Selective IgA Deficiency occurs in the vast majority of patients as an asymptomatic condition, and it is often an unrecognized, Studies are needed to clarify the open questions raised by possible consequences of a lack of an IgA response to SARS-CoV-2.
MeSH term(s)	Antibodies, Neutralizing/blood ; Antibodies, Viral/blood ; COVID-19/immunology ; Humans ; IgA Deficiency ; Immunoglobulin A/blood ; SARS-CoV-2/immunology ; Virus Shedding
Chemical Substances	Antibodies, Neutralizing ; Antibodies, Viral ; Immunoglobulin A
Language	English
Publishing date	2021-04-06
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2619676-1
ISSN	2235-2988 ; 2235-2988
ISSN (online)	2235-2988
ISSN	2235-2988
DOI	10.3389/fcimb.2021.655896
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