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Article ; Online: Microsolvation in V

Carnegie, Prosser D / Marks, Joshua H / Brathwaite, Antonio D / Ward, Timothy B / Duncan, Michael A

The journal of physical chemistry. A

2020 Volume 124, Issue 6, Page(s) 1093–1103

Abstract: Gas-phase ion-molecule clusters of the form V ...

Abstract	Gas-phase ion-molecule clusters of the form V
Language	English
Publishing date	2020-01-31
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.9b11275
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Article ; Online: mHealth application for improving treatment outcomes for patients with multidrug-resistant tuberculosis in Vietnam: an economic evaluation protocol for the V-SMART trial.

Cheng, Qinglu / Dang, Tho / Nguyen, Thu-Anh / Velen, Kavindhran / Nguyen, Viet Nhung / Nguyen, Binh Hoa / Vu, Dinh Hoa / Long, Chuong Huynh / Do, Thu Thuong / Vu, Truong-Minh / Marks, Guy B / Yapa, Manisha / Fox, Gregory J / Wiseman, Virginia

BMJ open

2023 Volume 13, Issue 12, Page(s) e076778

Abstract: Introduction: The Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V ... of this mHealth intervention from a healthcare provider and societal perspective.: Methods and analysis: The V ...

Abstract	Introduction: The Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART) trial is a randomised controlled trial of using mobile health (mHealth) technologies to improve adherence to medications and management of adverse events (AEs) in people with multidrug-resistant tuberculosis (MDR-TB) undergoing treatment in Vietnam. This economic evaluation seeks to quantify the cost-effectiveness of this mHealth intervention from a healthcare provider and societal perspective. Methods and analysis: The V-SMART trial will recruit 902 patients treated for MDR-TB across seven participating provinces in Vietnam. Participants in both intervention and control groups will receive standard community-based therapy for MDR-TB. Participants in the intervention group will also have a purpose-designed App installed on their smartphones to report AEs to health workers and to facilitate timely management of AEs. This economic evaluation will compare the costs and health outcomes between the intervention group (mHealth) and the control group (standard of care). Costs associated with delivering the intervention and health service utilisation will be recorded, as well as patient out-of-pocket costs. The health-related quality of life (HRQoL) of study participants will be captured using the 36-Item Short Form Survey (SF-36) questionnaire and used to calculate quality-adjusted life-years (QALYs). Incremental cost-effectiveness ratios (ICERs) will be based on the primary outcome (proportion of patients with treatment success after 24 months) and QALYs gained. Sensitivity analysis will be conducted to test the robustness of the ICERs. A budget impact analysis will be conducted from a payer perspective to provide an estimate of the total budget required to scale-up delivery of the intervention. Ethics and dissemination: Ethical approval for the study was granted by the University of Sydney Human Research Ethics Committee (2019/676), the Scientific Committee of the Ministry of Science and Technology, Vietnam (08/QD-HDQL-NAFOSTED) and the Institutional Review Board of the National Lung Hospital, Vietnam (13/19/CT-HDDD). Study findings will be published in peer-reviewed journals and conference proceedings. Trial registration number: ACTRN12620000681954.
MeSH term(s)	Humans ; Mobile Applications ; Cost-Benefit Analysis ; Vietnam ; Quality of Life ; Tuberculosis, Multidrug-Resistant/drug therapy ; Treatment Outcome ; Telemedicine ; Randomized Controlled Trials as Topic
Language	English
Publishing date	2023-12-11
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-076778
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Article ; Online: First Observation of the Decay B_{s}^{0}→K^{-}μ^{+}ν_{μ} and a Measurement of |V_{ub}|/|V_{cb}|.

Aaij, R / Abellán Beteta, C / Ackernley, T / Adeva, B / Adinolfi, M / Afsharnia, H / Aidala, C A / Aiola, S / Ajaltouni, Z / Akar, S / Albrecht, J / Alessio, F / Alexander, M / Alfonso Albero, A / Aliouche, Z / Alkhazov, G / Alvarez Cartelle, P / Amato, S / Amhis, Y /

An, L / Anderlini, L / Andreianov, A / Andreotti, M / Archilli, F / Artamonov, A / Artuso, M / Arzymatov, K / Aslanides, E / Atzeni, M / Audurier, B / Bachmann, S / Bachmayer, M / Back, J J / Baker, S / Baladron Rodriguez, P / Balagura, V / Baldini, W / Baptista Leite, J / Barlow, R J / Barsuk, S / Barter, W / Bartolini, M / Baryshnikov, F / Basels, J M / Bassi, G / Batsukh, B / Battig, A / Bay, A / Becker, M / Bedeschi, F / Bediaga, I / Beiter, A / Belavin, V / Belin, S / Bellee, V / Belous, K / Belov, I / Belyaev, I / Bencivenni, G / Ben-Haim, E / Berezhnoy, A / Bernet, R / Berninghoff, D / Bernstein, H C / Bertella, C / Bertholet, E / Bertolin, A / Betancourt, C / Betti, F / Bettler, M O / Bezshyiko, Ia / Bhasin, S / Bhom, J / Bian, L / Bieker, M S / Bifani, S / Billoir, P / Birch, M / Bishop, F C R / Bizzeti, A / Bjørn, M / Blago, M P / Blake, T / Blanc, F / Blusk, S / Bobulska, D / Boelhauve, J A / Boente Garcia, O / Boettcher, T / Boldyrev, A / Bondar, A / Bondar, N / Borghi, S / Borisyak, M / Borsato, M / Borsuk, J T / Bouchiba, S A / Bowcock, T J V / Boyer, A / Bozzi, C / Bradley, M J / Braun, S / Brea Rodriguez, A / Brodski, M / Brodzicka, J / Brossa Gonzalo, A / Brundu, D / Buonaura, A / Burr, C / Bursche, A / Butkevich, A / Butter, J S / Buytaert, J / Byczynski, W / Cadeddu, S / Cai, H / Calabrese, R / Calefice, L / Calero Diaz, L / Cali, S / Calladine, R / Calvi, M / Calvo Gomez, M / Camargo Magalhaes, P / Camboni, A / Campana, P / Campora Perez, D H / Campoverde Quezada, A F / Capelli, S / Capriotti, L / Carbone, A / Carboni, G / Cardinale, R / Cardini, A / Carli, I / Carniti, P / Carus, L / Carvalho Akiba, K / Casais Vidal, A / Casse, G / Cattaneo, M / Cavallero, G / Celani, S / Cerasoli, J / Chadwick, A J / Chapman, M G / Charles, M / Charpentier, Ph / Chatzikonstantinidis, G / Chavez Barajas, C A / Chefdeville, M / Chen, C / Chen, S / Chernov, A / Chitic, S-G / Chobanova, V / Cholak, S / Chrzaszcz, M / Chubykin, A / Chulikov, V / Ciambrone, P / Cicala, M F / Cid Vidal, X / Ciezarek, G / Clarke, P E L / Clemencic, M / Cliff, H V / Closier, J / Cobbledick, J L / Coco, V / Coelho, J A B / Cogan, J / Cogneras, E / Cojocariu, L / Collins, P / Colombo, T / Congedo, L / Contu, A / Cooke, N / Coombs, G / Corti, G / Costa Sobral, C M / Couturier, B / Craik, D C / Crkovská, J / Cruz Torres, M / Currie, R / Da Silva, C L / Dall'Occo, E / Dalseno, J / D'Ambrosio, C / Danilina, A / d'Argent, P / Davis, A / De Aguiar Francisco, O / De Bruyn, K / De Capua, S / De Cian, M / De Miranda, J M / De Paula, L / De Serio, M / De Simone, D / De Simone, P / de Vries, J A / Dean, C T / Dean, W / Decamp, D / Del Buono, L / Delaney, B / Dembinski, H-P / Dendek, A / Denysenko, V / Derkach, D / Deschamps, O / Desse, F / Dettori, F / Dey, B / Di Nezza, P / Didenko, S / Dieste Maronas, L / Dijkstra, H / Dobishuk, V / Donohoe, A M / Dordei, F / Dos Reis, A C / Douglas, L / Dovbnya, A / Downes, A G / Dreimanis, K / Dudek, M W / Dufour, L / Duk, V / Durante, P / Durham, J M / Dutta, D / Dziewiecki, M / Dziurda, A / Dzyuba, A / Easo, S / Egede, U / Egorychev, V / Eidelman, S / Eisenhardt, S / Ek-In, S / Eklund, L / Ely, S / Ene, A / Epple, E / Escher, S / Eschle, J / Esen, S / Evans, T / Falabella, A / Fan, J / Fan, Y / Fang, B / Farley, N / Farry, S / Fazzini, D / Fedin, P / Féo, M / Fernandez Declara, P / Fernandez Prieto, A / Fernandez-Tenllado Arribas, J M / Ferrari, F / Ferreira Lopes, L / Ferreira Rodrigues, F / Ferreres Sole, S / Ferrillo, M / Ferro-Luzzi, M / Filippov, S / Fini, R A / Fiorini, M / Firlej, M / Fischer, K M / Fitzpatrick, C / Fiutowski, T / Fleuret, F / Fontana, M / Fontanelli, F / Forty, R / Franco Lima, V / Franco Sevilla, M / Frank, M / Franzoso, E / Frau, G / Frei, C / Friday, D A / Fu, J / Fuehring, Q / Funk, W / Gabriel, E / Gaintseva, T / Gallas Torreira, A / Galli, D / Gambetta, S / Gan, Y / Gandelman, M / Gandini, P / Gao, Y / Garau, M / Garcia Martin, L M / Garcia Moreno, P / García Pardiñas, J / Garcia Plana, B / Garcia Rosales, F A / Garrido, L / Gaspar, C / Geertsema, R E / Gerick, D / Gerken, L L / Gersabeck, E / Gersabeck, M / Gershon, T / Gerstel, D / Ghez, Ph / Gibson, V / Giovannetti, M / Gioventù, A / Gironella Gironell, P / Giubega, L / Giugliano, C / Gizdov, K / Gkougkousis, E L / Gligorov, V V / Göbel, C / Golobardes, E / Golubkov, D / Golutvin, A / Gomes, A / Gomez Fernandez, S / Goncalves Abrantes, F / Goncerz, M / Gong, G / Gorbounov, P / Gorelov, I V / Gotti, C / Govorkova, E / Grabowski, J P / Graciani Diaz, R / Grammatico, T / Granado Cardoso, L A / Graugés, E / Graverini, E / Graziani, G / Grecu, A / Greeven, L M / Griffith, P / Grillo, L / Gromov, S / Gruberg Cazon, B R / Gu, C / Guarise, M / Günther, P A / Gushchin, E / Guth, A / Guz, Y / Gys, T / Hadavizadeh, T / Haefeli, G / Haen, C / Haimberger, J / Halewood-Leagas, T / Hamilton, P M / Han, Q / Han, X / Hancock, T H / Hansmann-Menzemer, S / Harnew, N / Harrison, T / Hasse, C / Hatch, M / He, J / Hecker, M / Heijhoff, K / Heinicke, K / Hennequin, A M / Hennessy, K / Henry, L / Heuel, J / Hicheur, A / Hill, D / Hilton, M / Hollitt, S E / Hu, J / Hu, W / Huang, W / Huang, X / Hulsbergen, W / Hunter, R J / Hushchyn, M / Hutchcroft, D / Hynds, D / Ibis, P / Idzik, M / Ilin, D / Ilten, P / Inglessi, A / Ishteev, A / Ivshin, K / Jacobsson, R / Jakobsen, S / Jans, E / Jashal, B K / Jawahery, A / Jevtic, V / Jezabek, M / Jiang, F / John, M / Johnson, D / Jones, C R / Jones, T P / Jost, B / Jurik, N / Kandybei, S / Kang, Y / Karacson, M / Karpov, M / Kazeev, N / Keizer, F / Kenzie, M / Ketel, T / Khanji, B / Kharisova, A / Kholodenko, S / Kim, K E / Kirn, T / Kirsebom, V S / Kitouni, O / Klaver, S / Klimaszewski, K / Koliiev, S / Kondybayeva, A / Konoplyannikov, A / Kopciewicz, P / Kopecna, R / Koppenburg, P / Korolev, M / Kostiuk, I / Kot, O / Kotriakhova, S / Kravchenko, P / Kravchuk, L / Krawczyk, R D / Kreps, M / Kress, F / Kretzschmar, S / Krokovny, P / Krupa, W / Krzemien, W / Kucewicz, W / Kucharczyk, M / Kudryavtsev, V / Kuindersma, H S / Kunde, G J / Kvaratskheliya, T / Lacarrere, D / Lafferty, G / Lai, A / Lampis, A / Lancierini, D / Lane, J J / Lane, R / Lanfranchi, G / Langenbruch, C / Langer, J / Lantwin, O / Latham, T / Lazzari, F / Le Gac, R / Lee, S H / Lefèvre, R / Leflat, A / Legotin, S / Leroy, O / Lesiak, T / Leverington, B / Li, H / Li, L / Li, P / Li, Y / Li, Z / Liang, X / Lin, T / Lindner, R / Lisovskyi, V / Litvinov, R / Liu, G / Liu, H / Liu, S / Liu, X / Loi, A / Lomba Castro, J / Longstaff, I / Lopes, J H / Loustau, G / Lovell, G H / Lu, Y / Lucchesi, D / Luchuk, S / Lucio Martinez, M / Lukashenko, V / Luo, Y / Lupato, A / Luppi, E / Lupton, O / Lusiani, A / Lyu, X / Ma, L / Maccolini, S / Machefert, F / Maciuc, F / Macko, V / Mackowiak, P / Maddrell-Mander, S / Madejczyk, O / Madhan Mohan, L R / Maev, O / Maevskiy, A / Maisuzenko, D / Majewski, M W / Malczewski, J J / Malde, S / Malecki, B / Malinin, A / Maltsev, T / Malygina, H / Manca, G / Mancinelli, G / Manera Escalero, R / Manuzzi, D / Marangotto, D / Maratas, J / Marchand, J F / Marconi, U / Mariani, S / Marin Benito, C / Marinangeli, M / Marino, P / Marks, J / Marshall, P J / Martellotti, G / Martinazzoli, L / Martinelli, M / Martinez Santos, D / Martinez Vidal, F / Massafferri, A / Materok, M / Matev, R / Mathad, A / Mathe, Z / Matiunin, V / Matteuzzi, C / Mattioli, K R / Mauri, A / Maurice, E / Mauricio, J / Mazurek, M / McCann, M / Mcconnell, L / Mcgrath, T H / McNab, A / McNulty, R / Mead, J V / Meadows, B / Meaux, C / Meier, G / Meinert, N / Melnychuk, D / Meloni, S / Merk, M / Merli, A / Meyer Garcia, L / Mikhasenko, M / Milanes, D A / Millard, E / Milovanovic, M / Minard, M-N / Minzoni, L / Mitchell, S E / Mitreska, B / Mitzel, D S / Mödden, A / Mohammed, R A / Moise, R D / Mombächer, T / Monroy, I A / Monteil, S / Morandin, M / Morello, G / Morello, M J / Moron, J / Morris, A B / Morris, A G / Mountain, R / Mu, H / Muheim, F / Mukherjee, M / Mulder, M / Müller, D / Müller, K / Murphy, C H / Murray, D / Muzzetto, P / Naik, P / Nakada, T / Nandakumar, R / Nanut, T / Nasteva, I / Needham, M / Neri, I / Neri, N / Neubert, S / Neufeld, N / Newcombe, R / Nguyen, T D / Nguyen-Mau, C / Niel, E M / Nieswand, S / Nikitin, N / Nolte, N S / Nunez, C / Oblakowska-Mucha, A / Obraztsov, V / O'Hanlon, D P / Oldeman, R / Olivares, M E / Onderwater, C J G / Ossowska, A / Otalora Goicochea, J M / Ovsiannikova, T / Owen, P / Oyanguren, A / Pagare, B / Pais, P R / Pajero, T / Palano, A / Palutan, M / Pan, Y / Panshin, G / Papanestis, A / Pappagallo, M / Pappalardo, L L / Pappenheimer, C / Parker, W / Parkes, C / Parkinson, C J / Passalacqua, B / Passaleva, G / Pastore, A / Patel, M / Patrignani, C / Pawley, C J / Pearce, A / Pellegrino, A / Pepe Altarelli, M / Perazzini, S / Pereima, D / Perret, P / Petridis, K / Petrolini, A / Petrov, A / Petrucci, S / Petruzzo, M / Pham, T T H / Philippov, A / Pica, L / Piccini, M / Pietrzyk, B / Pietrzyk, G / Pili, M / Pinci, D / Pisani, F / Piucci, A / P K, Resmi / Placinta, V / Plews, J / Plo Casasus, M / Polci, F / Poli Lener, M / Poliakova, M / Poluektov, A / Polukhina, N / Polyakov, I / Polycarpo, E / Pomery, G J / Ponce, S / Popov, D / Popov, S / Poslavskii, S / Prasanth, K / Promberger, L / Prouve, C / Pugatch, V / Pullen, H / Punzi, G / Qian, W / Qin, J / Quagliani, R / Quintana, B / Raab, N V / Rabadan Trejo, R I / Rachwal, B / Rademacker, J H / Rama, M / Ramos Pernas, M / Rangel, M S / Ratnikov, F / Raven, G / Reboud, M / Redi, F / Reiss, F / Remon Alepuz, C / Ren, Z / Renaudin, V / Ribatti, R / Ricciardi, S / Rinnert, K / Robbe, P / Robert, A / Robertson, G / Rodrigues, A B / Rodrigues, E / Rodriguez Lopez, J A / Rollings, A / Roloff, P / Romanovskiy, V / Romero Lamas, M / Romero Vidal, A / Roth, J D / Rotondo, M / Rudolph, M S / Ruf, T / Ruiz Vidal, J / Ryzhikov, A / Ryzka, J / Saborido Silva, J J / Sagidova, N / Sahoo, N / Saitta, B / Sanchez Gonzalo, D / Sanchez Gras, C / Santacesaria, R / Santamarina Rios, C / Santimaria, M / Santovetti, E / Saranin, D / Sarpis, G / Sarpis, M / Sarti, A / Satriano, C / Satta, A / Saur, M / Savrina, D / Sazak, H / Scantlebury Smead, L G / Schael, S / Schellenberg, M / Schiller, M / Schindler, H / Schmelling, M / Schmelzer, T / Schmidt, B / Schneider, O / Schopper, A / Schubiger, M / Schulte, S / Schune, M H / Schwemmer, R / Sciascia, B / Sciubba, A / Sellam, S / Semennikov, A / Senghi Soares, M / Sergi, A / Serra, N / Sestini, L / Seuthe, A / Seyfert, P / Shangase, D M / Shapkin, M / Shchemerov, I / Shchutska, L / Shears, T / Shekhtman, L / Shen, Z / Shevchenko, V / Shields, E B / Shmanin, E / Shupperd, J D / Siddi, B G / Silva Coutinho, R / Simi, G / Simone, S / Skiba, I / Skidmore, N / Skwarnicki, T / Slater, M W / Smallwood, J C / Smeaton, J G / Smetkina, A / Smith, E / Smith, I T / Smith, M / Snoch, A / Soares, M / Soares Lavra, L / Sokoloff, M D / Soler, F J P / Solovev, A / Solovyev, I / Souza De Almeida, F L / Souza De Paula, B / Spaan, B / Spadaro Norella, E / Spradlin, P / Stagni, F / Stahl, M / Stahl, S / Stefko, P / Steinkamp, O / Stemmle, S / Stenyakin, O / Stevens, H / Stone, S / Stramaglia, M E / Straticiuc, M / Strekalina, D / Strokov, S / Suljik, F / Sun, J / Sun, L / Sun, Y / Svihra, P / Swallow, P N / Swientek, K / Szabelski, A / Szumlak, T / Szymanski, M / Taneja, S / Teubert, F / Thomas, E / Thomson, K A / Tilley, M J / Tisserand, V / T'Jampens, S / Tobin, M / Tolk, S / Tomassetti, L / Torres Machado, D / Tou, D Y / Traill, M / Tran, M T / Trifonova, E / Trippl, C / Tuci, G / Tully, A / Tuning, N / Ukleja, A / Unverzagt, D J / Ursov, E / Usachov, A / Ustyuzhanin, A / Uwer, U / Vagner, A / Vagnoni, V / Valassi, A / Valenti, G / Valls Canudas, N / van Beuzekom, M / Van Dijk, M / van Herwijnen, E / Van Hulse, C B / van Veghel, M / Vazquez Gomez, R / Vazquez Regueiro, P / Vázquez Sierra, C / Vecchi, S / Velthuis, J J / Veltri, M / Venkateswaran, A / Veronesi, M / Vesterinen, M / Vieira, D / Vieites Diaz, M / Viemann, H / Vilasis-Cardona, X / Vilella Figueras, E / Vincent, P / Vitali, G / Vollhardt, A / Vom Bruch, D / Vorobyev, A / Vorobyev, V / Voropaev, N / Waldi, R / Walsh, J / Wang, C / Wang, J / Wang, M / Wang, R / Wang, Y / Wang, Z / Wark, H M / Watson, N K / Weber, S G / Websdale, D / Weisser, C / Westhenry, B D C / White, D J / Whitehead, M / Wiedner, D / Wilkinson, G / Wilkinson, M / Williams, I / Williams, M / Williams, M R J / Wilson, F F / Wislicki, W / Witek, M / Witola, L / Wormser, G / Wotton, S A / Wu, H / Wyllie, K / Xiang, Z / Xiao, D / Xie, Y / Xu, A / Xu, J / Xu, L / Xu, M / Xu, Q / Xu, Z / Yang, D / Yang, Y / Yang, Z / Yao, Y / Yeomans, L E / Yin, H / Yu, J / Yuan, X / Yushchenko, O / Zaffaroni, E / Zarebski, K A / Zavertyaev, M / Zdybal, M / Zenaiev, O / Zeng, M / Zhang, D / Zhang, L / Zhang, S / Zhang, Y / Zhelezov, A / Zheng, Y / Zhou, X / Zhou, Y / Zhu, X / Zhukov, V / Zonneveld, J B / Zucchelli, S / Zuliani, D / Zunica, G

Physical review letters

2021 Volume 126, Issue 8, Page(s) 81804

Abstract: ... matrix elements |V_{ub}|/|V_{cb}| at low and high B_{s}^{0}→K^{-} momentum transfer. ...

Abstract	The first observation of the suppressed semileptonic B_{s}^{0}→K^{-}μ^{+}ν_{μ} decay is reported. Using a data sample recorded in pp collisions in 2012 with the LHCb detector, corresponding to an integrated luminosity of 2 fb^{-1}, the branching fraction B(B_{s}^{0}→K^{-}μ^{+}ν_{μ}) is measured to be [1.06±0.05(stat)±0.08(syst)]×10^{-4}, where the first uncertainty is statistical and the second one represents the combined systematic uncertainties. The decay B_{s}^{0}→D_{s}^{-}μ^{+}ν_{μ}, where D_{s}^{-} is reconstructed in the final state K^{+}K^{-}π^{-}, is used as a normalization channel to minimize the experimental systematic uncertainty. Theoretical calculations on the form factors of the B_{s}^{0}→K^{-} and B_{s}^{0}→D_{s}^{-} transitions are employed to determine the ratio of the Cabibbo-Kobayashi-Maskawa matrix elements \|V_{ub}\|/\|V_{cb}\| at low and high B_{s}^{0}→K^{-} momentum transfer.
Language	English
Publishing date	2021-03-13
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.126.081804
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Article ; Online: Cyclotrimerization of Acetylene in Gas Phase V

Marks, Joshua H / Ward, Timothy B / Brathwaite, Antonio D / Ferguson, Sojourna / Duncan, Michael A

The journal of physical chemistry. A

2019 Volume 123, Issue 31, Page(s) 6733–6743

Abstract: ... of the form V ...

Abstract	Infrared laser spectroscopy and mass spectrometry were used to determine the structures of intermediates and products in the single-atom-catalyzed trimerization of acetylene to form benzene. Complexes of the form V
Language	English
Publishing date	2019-07-25
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.9b04962
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Article ; Online: Harnessing new mHealth technologies to Strengthen the Management of Multidrug-Resistant Tuberculosis in Vietnam (V-SMART trial): a protocol for a randomised controlled trial.

Velen, Kavindhran / Nguyen, Viet Nhung / Nguyen, Binh Hoa / Dang, Tho / Nguyen, Hoang Anh / Vu, Dinh Hoa / Do, Thu Thuong / Pham Duc, Cuong / Nguyen, Huu Lan / Pham, Huu Thuong / Marais, Ben J / Johnston, James / Britton, Warwick / Beardsley, Justin / Negin, Joel / Wiseman, Virginia / Marks, Guy Barrington / Nguyen, Thu Anh / Fox, Greg J

BMJ open

2022 Volume 12, Issue 6, Page(s) e052633

Abstract: Introduction: Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem globally. Long, complex treatment regimens coupled with frequent adverse events have resulted in poor treatment adherence and patient outcomes. Smartphone- ... ...

Abstract	Introduction: Multidrug-resistant tuberculosis (MDR-TB) remains a major public health problem globally. Long, complex treatment regimens coupled with frequent adverse events have resulted in poor treatment adherence and patient outcomes. Smartphone-based mobile health (mHealth) technologies offer national TB programmes an appealing platform to improve patient care and management; however, clinical trial evidence to support their use is lacking. This trial will test the hypothesis that an mHealth intervention can improve treatment success among patients with MDR-TB and is cost-effective compared with standard practice. Methods and analysis: A community-based, open-label, parallel-group randomised controlled trial will be conducted among patients treated for MDR-TB in seven provinces of Vietnam. Patients commencing therapy for microbiologically confirmed rifampicin-resistant or multidrug-resistant tuberculosis within the past 30 days will be recruited to the study. Participants will be individually randomised to an intervention arm, comprising use of an mHealth application for treatment support, or a 'standard care' arm. In both arms, patients will be managed by the national TB programme according to current national treatment guidelines. The primary outcome measure of effectiveness will be the proportion of patients with treatment success (defined as treatment completion and/or bacteriological cure) after 24 months. A marginal Poisson regression model estimated via a generalised estimating equation will be used to test the effect of the intervention on treatment success. A prospective microcosting of the intervention and within-trial cost-effectiveness analysis will also be undertaken from a societal perspective. Cost-effectiveness will be presented as an incremental cost per patient successfully treated and an incremental cost per quality-adjusted life-year gained. Ethics: Ethical approval for the study was granted by The University of Sydney Human Research Ethics Committee (2019/676). Dissemination: Study findings will be disseminated to participants and published in peer-reviewed journals and conference proceedings. Trial registration number: ACTRN12620000681954.
MeSH term(s)	Cost-Benefit Analysis ; Humans ; Prospective Studies ; Quality-Adjusted Life Years ; Randomized Controlled Trials as Topic ; Telemedicine ; Tuberculosis, Multidrug-Resistant/drug therapy ; Vietnam
Language	English
Publishing date	2022-06-22
Publishing country	England
Document type	Clinical Trial Protocol ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2021-052633
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Article: 25. Symposium des AKTX-Pflege e. V.

Marks, Lara / Pohl, Marei

Dialyse aktuell

2021 Volume 25, Issue 10, Page(s) 388–389

Abstract: Auch in diesem Jahr hat der Arbeitskreis Transplantationspflege (AKTX-Pflege e. V.) das jährliche ... 25. Symposium des AKTX-Pflege e. V. am 7. und 8. Oktober 2021 ausgerichtet. Wie bereits ...

Abstract	Auch in diesem Jahr hat der Arbeitskreis Transplantationspflege (AKTX-Pflege e. V.) das jährliche 25. Symposium des AKTX-Pflege e. V. am 7. und 8. Oktober 2021 ausgerichtet. Wie bereits in den zurückliegenden Jahren, geschah dies in guter Kooperation zusammen mit der Deutschen Transplantationsgesellschaft (DTG), welche ihre Jahrestagung ebenfalls im Oktober veranstaltete.:
Language	German
Publishing date	2021-12-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2146225-2
ISSN	1860-3300 ; 1434-0704
ISSN (online)	1860-3300
ISSN	1434-0704
DOI	10.1055/a-1672-7106
Database	Thieme publisher's database

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Article: 24. Pflegesymposium des AKTX-Pflege e. V.

Reddig, Iris / Marks, Lara

Dialyse aktuell

2020 Volume 24, Issue 10, Page(s) 391–393

Abstract: Das 24. Symposium des AKTX-Pflege e. V. hat auch dieses Jahr im Rahmen der Jahrestagung der DTG ... Deutsche Transplantationsgesellschaft e. V.) am 15. und 16. Oktober in Köln stattgefunden (Abb. 1 ... die 29. DTG-Jahrestagung und das dazu fest angebundene Pflegesymposium des AKTX-Pflege e. V. ausgerichtet werden.: ...

Abstract	Das 24. Symposium des AKTX-Pflege e. V. hat auch dieses Jahr im Rahmen der Jahrestagung der DTG (Deutsche Transplantationsgesellschaft e. V.) am 15. und 16. Oktober in Köln stattgefunden (Abb. 1). Es waren dieses Jahr durch die Situation rund um COVID-19 besondere Umstände, die viel Planung, Information, ein Hygienekonzept und dessen ständige Aktualisierung bzw. der Auflagen erforderten. Nur so konnte letztendlich die 29. DTG-Jahrestagung und das dazu fest angebundene Pflegesymposium des AKTX-Pflege e. V. ausgerichtet werden.:
Language	German
Publishing date	2020-12-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2146225-2
ISSN	1860-3300 ; 1434-0704
ISSN (online)	1860-3300
ISSN	1434-0704
DOI	10.1055/a-1298-6889
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Article ; Online: Flexible complementary circuits operating at sub-0.5 V via hybrid organic-inorganic electrolyte-gated transistors.

Yao, Yao / Huang, Wei / Chen, Jianhua / Wang, Gang / Chen, Hongming / Zhuang, Xinming / Ying, Yibin / Ping, Jianfeng / Marks, Tobin J / Facchetti, Antonio

Proceedings of the National Academy of Sciences of the United States of America

2021 Volume 118, Issue 44

Abstract: ... voltage gain and ultralow driving voltage (<0.5 V) are currently unrealized, because achieving balanced ... HCIN) achieves ultrahigh voltage gains (>110) under a supply voltage of only 0.7 V. Furthermore, NAND ... logic response with driving voltages as low as 0.2 V but also impressive mechanical flexibility down ...

Abstract	Electrolyte-gated transistors (EGTs) hold great promise for next-generation printed logic circuitry, biocompatible integrated sensors, and neuromorphic devices. However, EGT-based complementary circuits with high voltage gain and ultralow driving voltage (<0.5 V) are currently unrealized, because achieving balanced electrical output for both the p- and n-type EGT components has not been possible with current materials. Here we report high-performance EGT complementary circuits containing p-type organic electrochemical transistors (OECTs) fabricated with an ion-permeable organic semiconducting polymer (DPP-g2T) and an n-type electrical double-layer transistor (EDLT) fabricated with an ion-impermeable inorganic indium-gallium-zinc oxide (IGZO) semiconductor. Adjusting the IGZO composition enables tunable EDLT output which, for In:Ga:Zn = 10:1:1 at%, balances that of the DPP-g2T OECT. The resulting hybrid electrolyte-gated inverter (HCIN) achieves ultrahigh voltage gains (>110) under a supply voltage of only 0.7 V. Furthermore, NAND and NOR logic circuits on both rigid and flexible substrates are realized, enabling not only excellent logic response with driving voltages as low as 0.2 V but also impressive mechanical flexibility down to 1-mm bending radii. Finally, the HCIN was applied in electrooculographic (EOG) signal monitoring for recording eye movement, which is critical for the development of wearable medical sensors and also interfaces for human-computer interaction; the high voltage amplification of the present HCIN enables EOG signal amplification and monitoring in which a small ∼1.5 mV signal is amplified to ∼30 mV.
Language	English
Publishing date	2021-10-29
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2111790118
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Article ; Online: Effect of Recombinant Human Perlecan Domain V Tethering Method on Protein Orientation and Blood Contacting Activity on Polyvinyl Chloride.

Chandrasekar, Keerthana / Farrugia, Brooke L / Johnson, Lacey / Marks, Denese / Irving, David / Elgundi, Zehra / Lau, Kieran / Kim, Ha Na / Rnjak-Kovacina, Jelena / Bilek, Marcela M / Whitelock, John M / Lord, Megan S

Advanced healthcare materials

2021 Volume 10, Issue 14, Page(s) e2100388

Abstract: ... interactions with perlecan by establishing that platelets utilize domains III and V of the core protein ... for adhesion. Polyvinyl chloride (PVC) is functionalized with recombinant human perlecan domain V (rDV ...

Abstract	Surface modification of biomaterials is a promising approach to control biofunctionality while retaining the bulk biomaterial properties. Perlecan is the major proteoglycan in the vascular basement membrane that supports low levels of platelet adhesion but not activation. Thus, perlecan is a promising bioactive for blood-contacting applications. This study furthers the mechanistic understanding of platelet interactions with perlecan by establishing that platelets utilize domains III and V of the core protein for adhesion. Polyvinyl chloride (PVC) is functionalized with recombinant human perlecan domain V (rDV) to explore the effect of the tethering method on proteoglycan orientation and bioactivity. Tethering of rDV to PVC is achieved via either physisorption or covalent attachment via plasma immersion ion implantation (PIII) treatment. Both methods of rDV tethering reduce platelet adhesion and activation compared to the pristine PVC, however, the mechanisms are unique for each tethering method. Physisorption of rDV on PVC orientates the molecule to hinder access to the integrin-binding region, which inhibits platelet adhesion. In contrast, PIII treatment orientates rDV to allow access to the integrin-binding region, which is rendered antiadhesive to platelets via the glycosaminoglycan (GAG) chain. These effects demonstrate the potential of rDV biofunctionalization to modulate platelet interactions for blood contacting applications.
MeSH term(s)	Extracellular Matrix Proteins ; Glycosaminoglycans ; Heparan Sulfate Proteoglycans ; Humans ; Polyvinyl Chloride
Chemical Substances	Extracellular Matrix Proteins ; Glycosaminoglycans ; Heparan Sulfate Proteoglycans ; perlecan (143972-95-6) ; Polyvinyl Chloride (9002-86-2)
Language	English
Publishing date	2021-04-23
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2649576-4
ISSN	2192-2659 ; 2192-2640
ISSN (online)	2192-2659
ISSN	2192-2640
DOI	10.1002/adhm.202100388
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Article ; Online: Identifying and enriching platelet-producing human stem cell-derived megakaryocytes using factor V uptake.

Sim, Xiuli / Jarocha, Danuta / Hayes, Vincent / Hanby, Hayley A / Marks, Michael S / Camire, Rodney M / French, Deborah L / Poncz, Mortimer / Gadue, Paul

Blood

2017 Volume 130, Issue 2, Page(s) 192–204

Abstract: Stem cell-derived platelets have the potential to replace donor platelets for transfusion. Defining the platelet-producing megakaryocytes (MKs) within the heterogeneous MK culture may help to optimize the in vitro generation of platelets. Using 2 human ... ...

Abstract	Stem cell-derived platelets have the potential to replace donor platelets for transfusion. Defining the platelet-producing megakaryocytes (MKs) within the heterogeneous MK culture may help to optimize the in vitro generation of platelets. Using 2 human stem cell models of megakaryopoiesis, we identified novel MK populations corresponding to distinct maturation stages. An immature, low granular (LG) MK pool (defined by side scatter on flow cytometry) gives rise to a mature high granular (HG) pool, which then becomes damaged by apoptosis and glycoprotein Ib α chain (CD42b) shedding. We define an undamaged HG/CD42b
MeSH term(s)	Animals ; Apoptosis/drug effects ; Arterioles/drug effects ; Arterioles/immunology ; Arterioles/injuries ; Biomarkers/blood ; Blood Platelets/cytology ; Blood Platelets/immunology ; Bone Marrow Cells/cytology ; Bone Marrow Cells/drug effects ; Bone Marrow Cells/immunology ; Cell Differentiation ; Cell Lineage/immunology ; Endocytosis ; Factor V/genetics ; Factor V/immunology ; Factor V/pharmacology ; Flow Cytometry ; Gene Expression ; Humans ; Immunophenotyping ; Lasers ; Megakaryocyte Progenitor Cells/cytology ; Megakaryocyte Progenitor Cells/immunology ; Megakaryocytes/cytology ; Megakaryocytes/immunology ; Mice ; Mice, SCID ; Platelet Glycoprotein GPIb-IX Complex/genetics ; Platelet Glycoprotein GPIb-IX Complex/immunology
Chemical Substances	Biomarkers ; Platelet Glycoprotein GPIb-IX Complex ; Factor V (9001-24-5)
Language	English
Publishing date	2017-04-28
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	80069-7
ISSN	1528-0020 ; 0006-4971
ISSN (online)	1528-0020
ISSN	0006-4971
DOI	10.1182/blood-2017-01-761049
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