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  1. Book: Laborwerte im Beratungsgespräch

    Findeisen, Peter

    Fragen in der Apotheke kompetent beantworten

    (Govi)

    2023  

    Author's details Prof. Dr. Peter Findeisen studierte Medizin und Pharmazie an der Universität in Frankfurt. Seit 2015 leitet der Facharzt für Laboratoriumsmedizin am MVZ Labor Dr. Limbach & Kollegen in Heidelberg die Abteilung Laboratoriumsmedizin
    Series title Govi
    Keywords Blut ; Blutdruckmessung ; Blutwerte ; Blutzuckermessung ; Cholesterin ; Diabetes ; Govi ; Harn ; Kenngrößen ; Laborparameter ; Laborwerte ; Normwerte ; POCT ; Point of Care Tests ; SARS-CoV-2 ; Schilddrüsendiagnostik ; Stufendiagnostik ; Tumormarker
    Language German
    Size 239 p.
    Edition 7
    Publisher Avoxa - Mediengruppe Deutscher Apotheker
    Document type Book
    Note PDA Manuell_22
    Format 172 x 241 x 15
    ISBN 9783774117006 ; 3774117004
    Database PDA

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  2. Article: Bernstorff, Andreas Petrus (Peter), Graf von

    Findeisen, Jörg-Peter

    Lexikon zum Aufgeklärten Absolutismus in Europa : Herrscher - Denker - Sachbegriffe , p. 155-159

    2005  , Page(s) 155–159

    Author's details Jörg-Peter Findeisen
    Language German
    Publisher Böhlau
    Publishing place Wien [u.a.]
    Document type Article
    ISBN 978-382-52831-6-2 ; 382-52831-6-X
    Database Former special subject collection: coastal and deep sea fishing

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  3. Book: Laborwerte im Beratungsgespräch

    Findeisen, Peter / Zylka-Menhorn, Vera

    Patienten fragen - Apotheker antworten

    2013  

    Author's details [Vera Zylka-Menhorn] ; Peter Findeisen
    Keywords Laborparameter
    Subject Parameter ; Laborwert
    Language German
    Size 221 S. : graph. Darst.
    Edition 5., völlig neu bearb. Aufl.
    Publisher Govi
    Publishing place Eschborn
    Publishing country Germany
    Document type Book
    HBZ-ID HT017593369
    ISBN 978-3-7741-1159-2 ; 3-7741-1159-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 10679 order for loan Magazin

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  4. Article: Die Zukunft der Massenspektrometrie: Werden Immunoassays bald ersetzt?

    Gebauer, Julian / Findeisen, Peter

    Trillium-Diagnostik

    2023  Volume 21, Issue 3, Page(s) 202

    Language German
    Document type Article
    ZDB-ID 2741151-5
    ISSN 2198-1310
    Database Current Contents Medicine

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    Zs.A 7236: Show issues Location:
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  5. Article: Das heilsame Herz

    Findeisen, Peter

    Deutsche Heilpraktiker-Zeitschrift

    2020  Volume 15, Issue 01, Page(s) 62–66

    Abstract: Wohlwollen, Präsenz, Liebe: Qualitäten des Herzens in der Therapie und wie wir sie entwickeln und verwirklichen können. ...

    Abstract Wohlwollen, Präsenz, Liebe: Qualitäten des Herzens in der Therapie und wie wir sie entwickeln und verwirklichen können.
    Keywords Psychotherapie ; Herz ; Therapie ; Sinnbild ; Herzensqualität ; Patient ; Therapeut ; Liebe ; Wohlwollen ; Empathie
    Language German
    Publishing date 2020-01-01
    Publisher © Karl F. Haug Verlag in Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 2266301-0
    ISSN 1862-2275 ; 1862-2267
    ISSN (online) 1862-2275
    ISSN 1862-2267
    DOI 10.1055/a-1092-6973
    Database Thieme publisher's database

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  6. Article ; Online: Fluoxetine Enhances Synaptic Vesicle Trafficking and Energy Metabolism in the Hippocampus of Socially Isolated Rats.

    Filipović, Dragana / Costina, Victor / Findeisen, Peter / Inta, Dragos

    International journal of molecular sciences

    2022  Volume 23, Issue 23

    Abstract: Chronic social isolation (CSIS)-induced alternation in synaptic and mitochondrial function of specific brain regions is associated with major depressive disorder (MDD). Despite the wide number of available medications, treating MDD remains an important ... ...

    Abstract Chronic social isolation (CSIS)-induced alternation in synaptic and mitochondrial function of specific brain regions is associated with major depressive disorder (MDD). Despite the wide number of available medications, treating MDD remains an important challenge. Although fluoxetine (Flx) is the most frequently prescribed antidepressant, its mode of action is still unknown. To delineate affected molecular pathways of depressive-like behavior and identify potential targets upon Flx treatment, we performed a comparative proteomic analysis of hippocampal purified synaptic terminals (synaptosomes) of rats exposed to six weeks of CSIS, an animal model of depression, and/or followed by Flx treatment (lasting three weeks of six-week CSIS) to explore synaptic protein profile changes. Results showed that Flx in controls mainly induced decreased expression of proteins involved in energy metabolism and the redox system. CSIS led to increased expression of proteins that mainly participate in Ca
    Language English
    Publishing date 2022-12-05
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms232315351
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book: Laborwerte im Beratungsgespräch

    Zylka-Menhorn, Vera / Findeisen, Peter

    Patienten fragen - Apotheker antworten

    2007  

    Author's details Vera Zylka-Menhorn ; Peter Findeisen
    Keywords Laborparameter
    Subject Parameter ; Laborwert
    Subject code 616.0756
    Language German
    Size 205 S. : graph. Darst., 24 cm
    Edition 4., überarb. Aufl.
    Publisher Govi-Verl
    Publishing place Eschborn
    Publishing country Germany
    Document type Book
    HBZ-ID HT015357813
    ISBN 978-3-7741-1065-6 ; 3-7741-1065-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2005 A 7975 order for loan Magazin

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  8. Article: Highly sensitive therapeutic drug monitoring of infliximab in serum by targeted mass spectrometry in comparison to ELISA data.

    Hentschel, Andreas / Piontek, Gina / Dahlmann, Rob / Findeisen, Peter / Sakson, Roman / Carbow, Phil / Renné, Thomas / Reinders, Yvonne / Sickmann, Albert

    Clinical proteomics

    2024  Volume 21, Issue 1, Page(s) 16

    Abstract: Background: Presently, antibody concentration measurements for patients undergoing treatment are predominantly determined by ELISA, which still comes with known disadvantages. Therefore, our aim was to establish a targeted mass-spectrometric assay ... ...

    Abstract Background: Presently, antibody concentration measurements for patients undergoing treatment are predominantly determined by ELISA, which still comes with known disadvantages. Therefore, our aim was to establish a targeted mass-spectrometric assay enabling the reproducible absolute quantification of peptides from the hypervariable and interaction regions of infliximab.
    Methods: Peptides of infliximab were measured post-trypsin digestion and subsequent separation on a Vanquish Horizon UHPLC coupled to a TSQ Altis Triple-Quad mass spectrometer. Normalization and absolute quantification were conducted using stable isotope-synthesized peptides. Calibration curves covering a range of 0.25-50 µg/ml were employed for quantitation.
    Results: We demonstrated the substantial influence of peptide selection, choice of hydrolase for digestion, and digestion time on absolute peptide yield (28-44% for peptide 1 and 64-97% for peptide 2). Furthermore, we showed that the generated calibration curves for absolute quantification were highly reproducible and robust (LLOQ1 0.72 µg/ml and LLOQ2 1.00 µg/ml) over several months. In comparison to ELISA values, the absolute values obtained by mass spectrometry often yielded lower results for both targeted peptides.
    Conclusions: In this study, a semi-automated workflow was employed and tested with 8 patients and corresponding replicates (n = 3-4). We demonstrated the robust implementation of calibration curves for the absolute quantification of infliximab in patient samples, with coefficients of variation ranging from 0.5 to 9%. Taken together, we have developed a platform enabling the rapid (2 days of sample preparation and 30 min of measurement time per sample) and robust quantification of Infliximab antibody concentration in patients. The use of mass spectrometry also facilitates the straightforward expansion of the method to include additional antibody peptides.
    Language English
    Publishing date 2024-02-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2205154-5
    ISSN 1542-6416
    ISSN 1542-6416
    DOI 10.1186/s12014-024-09464-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6222: Show issues Location:
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  9. Article ; Online: Endogenous BAX and BAK form mosaic rings of variable size and composition on apoptotic mitochondria.

    Schweighofer, Sarah V / Jans, Daniel C / Keller-Findeisen, Jan / Folmeg, Anne / Ilgen, Peter / Bates, Mark / Jakobs, Stefan

    Cell death and differentiation

    2024  Volume 31, Issue 4, Page(s) 469–478

    Abstract: One hallmark of apoptosis is the oligomerization of BAX and BAK to form a pore in the mitochondrial outer membrane, which mediates the release of pro-apoptotic intermembrane space proteins into the cytosol. Cells overexpressing BAX or BAK fusion proteins ...

    Abstract One hallmark of apoptosis is the oligomerization of BAX and BAK to form a pore in the mitochondrial outer membrane, which mediates the release of pro-apoptotic intermembrane space proteins into the cytosol. Cells overexpressing BAX or BAK fusion proteins are a powerful model system to study the dynamics and localization of these proteins in cells. However, it is unclear whether overexpressed BAX and BAK form the same ultrastructural assemblies following the same spatiotemporal hierarchy as endogenously expressed proteins. Combining live- and fixed-cell STED super-resolution microscopy, we show that overexpression of BAK results in novel BAK structures, which are virtually absent in non-overexpressing apoptotic cells. We further demonstrate that in wild type cells, BAK is recruited to apoptotic pores before BAX. Both proteins together form unordered, mosaic rings on apoptotic mitochondria in immortalized cell culture models as well as in human primary cells. In BAX- or BAK- single-knockout cells, the remaining protein is able to form rings independently. The heterogeneous nature of these rings in both wild type as well as single-knockout cells corroborates the toroidal apoptotic pore model.
    MeSH term(s) Animals ; Humans ; Mice ; Apoptosis ; bcl-2 Homologous Antagonist-Killer Protein/metabolism ; bcl-2 Homologous Antagonist-Killer Protein/genetics ; bcl-2-Associated X Protein/metabolism ; bcl-2-Associated X Protein/genetics ; Mitochondria/metabolism ; Mitochondrial Membranes/metabolism
    Chemical Substances BAK1 protein, human ; bcl-2 Homologous Antagonist-Killer Protein ; bcl-2-Associated X Protein ; BAX protein, human
    Language English
    Publishing date 2024-03-19
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1225672-9
    ISSN 1476-5403 ; 1350-9047
    ISSN (online) 1476-5403
    ISSN 1350-9047
    DOI 10.1038/s41418-024-01273-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4230: Show issues Location:
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    Zs.MG 80: Show issues

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  10. Book ; Thesis: In-vitro-Untersuchungen zur Wirkungsweise der Kombinations-Chemotherapie mit N-Methylformamid und dem Perhydrothiazinyl-Phosphamidester SUM4 an menschlichen und murinen Leukämiezellen

    Findeisen, Peter Steffen

    1994  

    Author's details vorgelegt von Peter Steffen Findeisen
    Language German
    Size 78 Bl. : Ill., graph. Darst.
    Edition [Mikrofiche-Ausg.]
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Frankfurt (Main), Univ., Diss., 1995
    Note Mikrofiche-Ausg.: 2 Mikrofiches : 24x
    HBZ-ID HT007186153
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 MB 1523 order for loan Magazin

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