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  1. Article ; Online: Why now and not later? An exploration into the neurocognitive correlates of delay discounting in bipolar disorder.

    Gold, Alexandra K / Otto, Michael W

    Psychiatry research communications

    2023  Volume 3, Issue 2

    Abstract: Increased delay discounting is evident in bipolar disorder, though there is minimal research on the factors that impact delay discounting in this population. We evaluated neurocognitive correlates of delay discounting among relatively euthymic ... ...

    Abstract Increased delay discounting is evident in bipolar disorder, though there is minimal research on the factors that impact delay discounting in this population. We evaluated neurocognitive correlates of delay discounting among relatively euthymic participants with bipolar disorder (N = 76) with (
    Language English
    Publishing date 2023-03-11
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2772-5987
    ISSN (online) 2772-5987
    DOI 10.1016/j.psycom.2023.100114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: An Experimental Therapeutics Focus on Novel Mechanistic Targets in Cognitive Behavioral Treatments: Introduction to the Special Section.

    Otto, Michael W / Birk, Jeffrey L

    Behavior therapy

    2023  Volume 54, Issue 4, Page(s) 605–609

    Abstract: This article introduces the special section, "An Experimental Therapeutics Focus on Novel Mechanistic Targets in Cognitive Behavioral Treatments." The purpose of this special section is to highlight research that follows the recommended Science of ... ...

    Abstract This article introduces the special section, "An Experimental Therapeutics Focus on Novel Mechanistic Targets in Cognitive Behavioral Treatments." The purpose of this special section is to highlight research that follows the recommended Science of Behavior Change (SOBC) developmental progression for an experimental medicine approach to identifying and testing mechanisms of behavior change. Emphasis was placed on the earlier stage "pipeline" of investigations of novel mechanisms for behavior change: mechanisms that are undergoing the initial stages of validation. In this series, seven empirical articles are presented and are followed by an article detailing a checklist for reporting mechanistic research studies in order to improve communication of findings in the field. The final article in this series discusses the history, current status, and future directions for the SOBC approach to mechanistic science as viewed by National Institute of Health program officials.
    MeSH term(s) Humans ; Biomedical Research ; Cognitive Behavioral Therapy ; Cognition
    Language English
    Publishing date 2023-02-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 211996-1
    ISSN 1878-1888 ; 0005-7894
    ISSN (online) 1878-1888
    ISSN 0005-7894
    DOI 10.1016/j.beth.2023.02.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Editorial: Quorum-sensing in Gram-positive pathogens - mechanisms, role in infection, and potential as a therapeutic target.

    Otto, Michael / Dickey, Seth W / Wolz, Christiane

    Frontiers in cellular and infection microbiology

    2023  Volume 13, Page(s) 1236705

    MeSH term(s) Humans ; Quorum Sensing ; Staphylococcal Infections
    Language English
    Publishing date 2023-06-19
    Publishing country Switzerland
    Document type Editorial ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2023.1236705
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Impaired risk avoidance in bipolar disorder and substance use disorders.

    Gold, Alexandra K / Otto, Michael W

    Journal of psychiatric research

    2022  Volume 152, Page(s) 335–342

    Abstract: Comorbid substance use disorders are highly prevalent in bipolar disorder, and research suggests that individuals with the comorbid presentation typically have worse outcomes than individuals with bipolar disorder without this comorbidity. However, ... ...

    Abstract Comorbid substance use disorders are highly prevalent in bipolar disorder, and research suggests that individuals with the comorbid presentation typically have worse outcomes than individuals with bipolar disorder without this comorbidity. However, psychosocial treatments for the comorbid presentation have not demonstrated effectiveness for both mood and substance use symptom domains, suggesting novel treatments are needed. An alternative path to treatment development is to identify mechanisms that underlie comorbid bipolar disorder and substance use disorders that can subsequently be targeted in treatment. We evaluated neurocognitive markers for impairments in risk avoidance (the tendency to engage in a persistent pattern of problematic behaviors despite negative outcomes resulting from such behaviors) as potential mechanistic variables underlying negative illness outcomes in the comorbid population. Participants with bipolar disorder (n = 45) or comorbid bipolar disorder and substance use disorders (n = 31) in a relatively euthymic mood state completed clinical risk behavior assessments, task-based risk avoidance assessments, and neurocognitive assessments. Results indicated a lack of notable between-group differences in the clinical risk composite score, task-based risk avoidance assessments, and neurocognitive assessments, with the exception of self-reported executive dysfunction which was elevated among the comorbid sample. Collapsing across group, we found that increased discounting of delayed rewards, older age, and an earlier age of (hypo)mania onset predicted an increased clinical risk composite score. These findings underscore the potential importance of delay discounting as a novel mechanistic target for reducing clinical risk behaviors among individuals with bipolar disorder both with and without comorbid substance use disorders.
    MeSH term(s) Bipolar Disorder/complications ; Bipolar Disorder/drug therapy ; Bipolar Disorder/epidemiology ; Comorbidity ; Humans ; Substance-Related Disorders/epidemiology ; Substance-Related Disorders/therapy
    Language English
    Publishing date 2022-05-26
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 3148-3
    ISSN 1879-1379 ; 0022-3956
    ISSN (online) 1879-1379
    ISSN 0022-3956
    DOI 10.1016/j.jpsychires.2022.05.019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Climate change views examined through a behavioral medicine frame: are there potential target mechanisms for change beyond political ideology?

    Lubin, Rebecca E / Edmondson, Donald / Otto, Michael W

    Psychology, health & medicine

    2023  Volume 28, Issue 7, Page(s) 1938–1949

    Abstract: The threat of climate change is associated with both profound health consequences and failures by many individuals to take preventive actions. Behavioral science research on health behavior engagement may serve as a lens through which to better ... ...

    Abstract The threat of climate change is associated with both profound health consequences and failures by many individuals to take preventive actions. Behavioral science research on health behavior engagement may serve as a lens through which to better understand attitudes associated with the threat of climate change. This study was designed to examine individual differences in attitudinal responses to climate change, understanding the degree to which these responses can be predicted by both political beliefs and more readily modified psychological factors commonly associated with health behavior engagement: locus of control, anxiety sensitivity, delay discounting, and intolerance of uncertainty. Participants (
    MeSH term(s) Adult ; Humans ; Male ; Female ; Climate Change ; Behavioral Medicine ; Attitude ; Health Behavior ; Anxiety
    Language English
    Publishing date 2023-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 1477841-5
    ISSN 1465-3966 ; 1354-8506
    ISSN (online) 1465-3966
    ISSN 1354-8506
    DOI 10.1080/13548506.2023.2185644
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  6. Book: Stopping anxiety medication

    Otto, Michael W. / Pollack, Mark H.

    therapist guide

    (Treatments that work)

    2009  

    Author's details Michael W. Otto ; Mark H. Pollack
    Series title Treatments that work
    Keywords Panic disorders/Treatment ; Benzodiazepines ; Drugs/Dosage/Reduction ; Tranquilizing drugs
    Subject code 616.8522306
    Language English
    Size XI, 176 S. : Ill.
    Edition 2. ed.
    Publisher Oxford Univ. Press
    Publishing place Oxford u.a.
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references. - Previous ed.: San Antonio, Tex.: Psychological Corp., 1996
    HBZ-ID HT015909319
    ISBN 978-0-19-533854-6 ; 0-19-533854-5
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    2009 A 1690 order for loan Magazin

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  7. Book: Avoiding treatment failures in the anxiety disorders

    Otto, Michael W. / Hofmann, Stefan G.

    (Series in anxiety and related disorders)

    2011  

    Author's details Michael W. Otto ; Stefan G. Hofmann ed
    Series title Series in anxiety and related disorders
    Keywords Anxiety Disorders / therapy ; Treatment Failure
    Language English
    Size XIII, 405 S. : Ill., graph. Darst.
    Edition 1. softcover print.
    Publisher Springer
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    Note Formerly CIP Uk. - Includes bibliographical references and index
    HBZ-ID HT016694811
    ISBN 978-1-4419-0611-3 ; 978-1-4419-8169-1 ; 1-4419-0611-8 ; 9781441906120 ; 1-4419-8169-1 ; 1441906126
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2011 A 525 order for loan Magazin

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  8. Article: The Role of Functional Health Literacy in terms of Harmful Alcohol Use in Adults with Probable Posttraumatic Stress Disorder and Alcohol Use Disorder.

    Gould, Dylan A / Lubin, Rebecca E / McGrew, Shelby J / Smit, Tanya / Vujanovic, Anka A / Otto, Michael W / Zvolensky, Michael J

    Research square

    2024  

    Abstract: Purpose: The current study examined functional health literacy (FHL) in regard to hazardous drinking among a sample with probable posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD).: Methods: Participants were 565 adults with ... ...

    Abstract Purpose: The current study examined functional health literacy (FHL) in regard to hazardous drinking among a sample with probable posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD).
    Methods: Participants were 565 adults with probable PTSD and hazardous alcohol use (52.2% female, 68.8% Non-Hispanic White, average age = 39.2 years ± 10.9 years).
    Results: FHL literacy maintained statistically significant role in terms of hazardous drinking (
    Conclusion: FHL may be important to better understand hazardous drinking among persons with comorbid PTSD and AUD.
    Language English
    Publishing date 2024-03-26
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-4144996/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Staphylococcus aureus

    Wang, Xiaogang / Uppu, Divakara Ssm / Dickey, Seth W / Burgin, Dylan J / Otto, Michael / Lee, Jean C

    bioRxiv : the preprint server for biology

    2023  

    Abstract: Staphylococcus aureus: Importance: Extracellular membrane vesicles (MVs) produced ... ...

    Abstract Staphylococcus aureus
    Importance: Extracellular membrane vesicles (MVs) produced by
    Language English
    Publishing date 2023-03-23
    Publishing country United States
    Document type Preprint
    DOI 10.1101/2023.03.23.533957
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Initial assessment of the feasibility and efficacy of a scalable digital CBT for generalized anxiety and associated health behaviors in a cardiovascular disease population.

    Parsons, E Marie / Hiserodt, Michele / Otto, Michael W

    Contemporary clinical trials

    2022  Volume 124, Page(s) 107018

    Abstract: Generalized anxiety disorder (GAD) is a significant yet modifiable risk factor for worse cardiovascular disease (CVD) outcomes. The treatment of GAD in an accessible manner represents an unmet need in CVD, given that patients with CVD experience numerous ...

    Abstract Generalized anxiety disorder (GAD) is a significant yet modifiable risk factor for worse cardiovascular disease (CVD) outcomes. The treatment of GAD in an accessible manner represents an unmet need in CVD, given that patients with CVD experience numerous barriers to in-person treatment engagement. This paper presents the rationale and design for an investigation of a strategy to enhance care for patients with CVD by introducing a scalable, affordable, and system-friendly digital intervention that targets a prominent modifiable risk factor (generalized anxiety and associated worry) for negative health behaviors in CVD. In the context of a randomized clinical trial design, we describe an experimental medicine approach for evaluating the degree to which a digital cognitive behavior therapy (dCBT), relative to a waitlist control group, engages anxiety and worry outcomes in a sample of 90 adults who have experienced an acute CVD event and who have comorbid GAD symptoms. We also investigate the degree to which dCBT leads to greater changes in GAD symptoms compared to the control condition and whether reductions in these symptoms are associated with corresponding reductions in cardiac anxiety and cardiac health behaviors (including smoking, physical activity, heart-healthy diet, and medication adherence). We propose that by targeting GAD symptoms in CVD in a way that does not tax ongoing medical care provision, we have the potential to improve the uptake of effective care and address both GAD and associated health behaviors.
    MeSH term(s) Adult ; Humans ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/therapy ; Feasibility Studies ; Anxiety/therapy ; Anxiety/psychology ; Cognitive Behavioral Therapy ; Health Behavior ; Treatment Outcome
    Language English
    Publishing date 2022-11-19
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2022.107018
    Database MEDical Literature Analysis and Retrieval System OnLINE

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