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  1. Article ; Online: Clinical placements for medical students in the time of COVID-19.

    Halbert, Julie A / Jones, Alison / Ramsey, Liam P

    The Medical journal of Australia

    2020  Volume 213, Issue 2, Page(s) 69–69.e1

    MeSH term(s) Betacoronavirus ; COVID-19 ; Clinical Competence ; Coronavirus Infections/epidemiology ; Curriculum/trends ; Education, Distance/trends ; Education, Medical, Undergraduate/trends ; Humans ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Students, Medical/statistics & numerical data ; Teaching/trends
    Keywords covid19
    Language English
    Publishing date 2020-06-25
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.50686
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.398: Show issues Location:
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  3. Article ; Online: Clinical placements for medical students in the time of COVID ‐19

    Halbert, Julie A / Jones, Alison / Ramsey, Liam P

    Medical Journal of Australia

    2020  Volume 213, Issue 2, Page(s) 69

    Keywords General Medicine ; covid19
    Language English
    Publisher AMPCo
    Publishing country au
    Document type Article ; Online
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja2.50686
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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    Ua VI Zs.398: Show issues Location:
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  4. Article: Remarks for the Clive Granger memorial, july 31, 2009

    White, Halbert L

    Journal of financial econometrics Vol. 8, No. 2 , p. 160-161

    2010  Volume 8, Issue 2, Page(s) 160–161

    Author's details Halbert L. White
    Language English
    Publisher Univ. Press
    Publishing place Oxford
    Document type Article
    ZDB-ID 2160581-6
    ISSN 1479-8409
    Database ECONomics Information System

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  5. Article ; Online: Ethical, legal, and social implications (ELSI) and challenges in the design of a randomized controlled trial to test the online return of cancer genetic research results to U.S. Black women.

    Wang, Catharine / Bertrand, Kimberly A / Trevino-Talbot, Michelle / Flynn, Maureen / Ruderman, Maggie / Cabral, Howard J / Bowen, Deborah J / Hughes-Halbert, Chanita / Palmer, Julie R

    Contemporary clinical trials

    2023  Volume 132, Page(s) 107309

    Abstract: Background: A central challenge to precision medicine research efforts is the return of genetic research results in a manner that is effective, ethical, and efficient. Formal tests of alternate modalities are needed, particularly for racially ... ...

    Abstract Background: A central challenge to precision medicine research efforts is the return of genetic research results in a manner that is effective, ethical, and efficient. Formal tests of alternate modalities are needed, particularly for racially marginalized populations that have historically been underserved in this context.
    Methods: We are conducting a randomized controlled trial (RCT) to test scalable modalities for results return and to examine the clinical utility of returning genetic research results to a research cohort of Black women. The primary aim is to compare the efficacy of two communication modalities for results return: 1) a conventional modality that entails telephone disclosure by a Board-certified genetic counselor, and 2) an online self-guided modality that entails results return directly to participants, with optional genetic counselor follow-up via telephone. The trial is being conducted among participants in the Black Women's Health Study (BWHS), where targeted sequencing of 4000 participants was previously completed.
    Results: Several ethical, legal, and social implications (ELSI) and challenges presented, which necessitated substantial revision of the original study protocol. Challenges included chain of custody, re-testing of research results in a CLIA lab, exclusion of VUS results, and digital literacy. Bioethical principles of autonomy, justice, non-maleficence, and beneficence were considered in the design of the study protocol.
    Conclusion: This study is uniquely situated to provide critical evidence on the effectiveness of alternative models for genetic results return and provide further insight into the factors influencing access and uptake of genetic information among U.S. Black women.
    Clinicaltrials: gov: NCT04407611.
    MeSH term(s) Female ; Humans ; Genetic Testing ; Neoplasms/genetics ; Disclosure ; Communication ; Genetic Research
    Language English
    Publishing date 2023-07-27
    Publishing country United States
    Document type Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2182176-8
    ISSN 1559-2030 ; 1551-7144
    ISSN (online) 1559-2030
    ISSN 1551-7144
    DOI 10.1016/j.cct.2023.107309
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1581: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Rapid scale-up and production of active-loaded PEGylated liposomes.

    Roces, Carla B / Port, Emily Charlotte / Daskalakis, Nikolaos N / Watts, Julie A / Aylott, Jonathan W / Halbert, Gavin W / Perrie, Yvonne

    International journal of pharmaceutics

    2020  Volume 586, Page(s) 119566

    Abstract: Manufacturing of liposomal nanomedicines (e.g. Doxil®/Caelyx®) is a challenging and slow process based on multiple-vessel and batch processing techniques. As a result, the translation of these nanomedicines from bench to bedside has been limited. ... ...

    Abstract Manufacturing of liposomal nanomedicines (e.g. Doxil®/Caelyx®) is a challenging and slow process based on multiple-vessel and batch processing techniques. As a result, the translation of these nanomedicines from bench to bedside has been limited. Microfluidic-based manufacturing offers the opportunity to address this issue, and de-risk the wider adoption of nanomedicines. Here we demonstrate the applicability of microfluidics for continuous manufacturing of PEGylated liposomes encapsulating ammonium sulfate (250 mM). Doxorubicin was subsequently active-loaded into these pre-formed liposomes. Critical process parameters and material considerations demonstrated to influence the liposomal product attributes included solvent selection and lipid concentration, flow rate ratio, and temperature and duration used for drug loading. However, the total flow rate did not affect the liposome product characteristics, allowing high production speeds to be adopted. The final liposomal product comprised of 80-100 nm vesicles (PDI < 0.2) encapsulating ≥ 90% doxorubicin, with matching release profiles to the innovator product and is stable for at least 6 months. Additionally, vincristine and acridine orange were active-loaded into these PEGylated liposomes (≥ 90% and ~100 nm in size) using the same process. These results demonstrate the ability to produce active-loaded PEGylated liposomes with high encapsulation efficiencies and particle sizes which support tumour targeting.
    MeSH term(s) Acridine Orange/administration & dosage ; Acridine Orange/chemistry ; Ammonium Sulfate/chemistry ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/chemistry ; Doxorubicin/administration & dosage ; Doxorubicin/analogs & derivatives ; Doxorubicin/chemistry ; Drug Liberation ; Drug Stability ; Drug Storage ; Lipids/chemistry ; Liposomes ; Microfluidics ; Nanoparticles ; Particle Size ; Polyethylene Glycols/administration & dosage ; Polyethylene Glycols/chemistry ; Solvents/chemistry ; Vincristine/administration & dosage ; Vincristine/chemistry
    Chemical Substances Antibiotics, Antineoplastic ; Lipids ; Liposomes ; Solvents ; liposomal doxorubicin ; Polyethylene Glycols (3WJQ0SDW1A) ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Acridine Orange (F30N4O6XVV) ; Ammonium Sulfate (SU46BAM238)
    Language English
    Publishing date 2020-07-02
    Publishing country Netherlands
    Document type Comparative Study ; Journal Article
    ZDB-ID 428962-6
    ISSN 1873-3476 ; 0378-5173
    ISSN (online) 1873-3476
    ISSN 0378-5173
    DOI 10.1016/j.ijpharm.2020.119566
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1409: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Comparison of dystrophin expression following gene editing and gene replacement in an aged preclinical DMD animal model.

    Bengtsson, Niclas E / Crudele, Julie M / Klaiman, Jordan M / Halbert, Christine L / Hauschka, Stephen D / Chamberlain, Jeffrey S

    Molecular therapy : the journal of the American Society of Gene Therapy

    2022  Volume 30, Issue 6, Page(s) 2176–2185

    Abstract: Gene editing has shown promise for correcting or bypassing dystrophin mutations in Duchenne muscular dystrophy (DMD). However, preclinical studies have focused on young animals with limited muscle fibrosis and wasting, thereby favoring muscle ... ...

    Abstract Gene editing has shown promise for correcting or bypassing dystrophin mutations in Duchenne muscular dystrophy (DMD). However, preclinical studies have focused on young animals with limited muscle fibrosis and wasting, thereby favoring muscle transduction, myonuclear editing, and prevention of disease progression. Here, we explore muscle-specific dystrophin gene editing following intramuscular delivery of AAV6:CK8e-CRISPR/SaCas9 in 3- and 8-year-old dystrophic CXMD dogs and provide a qualitative comparison to AAV6:CK8e-micro-dystrophin gene replacement at 6 weeks post-treatment. Gene editing restored the dystrophin reading frame in ∼1.3% of genomes and in up to 4.0% of dystrophin transcripts following excision of a 105-kb mutation containing region spanning exons 6-8. However, resulting dystrophin expression levels and effects on muscle pathology were greater with the use of micro-dystrophin gene transfer. This study demonstrates that our muscle-specific multi-exon deletion strategy can correct a frequently mutated region of the dystrophin gene in an aged large animal DMD model, but underscores that further enhancements are required to reach efficiencies comparable to AAV micro-dystrophin. Our observations also indicate that treatment efficacy and state of muscle pathology at the time of intervention are linked, suggesting the need for additional methodological optimizations related to age and disease progression to achieve relevant clinical translation of CRISPR-based therapies to all DMD patients.
    MeSH term(s) Aging ; Animals ; CRISPR-Cas Systems ; Disease Models, Animal ; Disease Progression ; Dogs ; Dystrophin/genetics ; Gene Editing/methods ; Muscle, Skeletal/metabolism ; Muscular Dystrophy, Duchenne/genetics ; Muscular Dystrophy, Duchenne/therapy
    Chemical Substances Dystrophin
    Language English
    Publishing date 2022-02-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2010592-7
    ISSN 1525-0024 ; 1525-0016
    ISSN (online) 1525-0024
    ISSN 1525-0016
    DOI 10.1016/j.ymthe.2022.02.003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5640: Show issues Location:
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  8. Article: Driving assessment and rehabilitation after stroke.

    Allen, Zoe A / Halbert, Julie / Huang, Lydia

    The Medical journal of Australia

    2007  Volume 187, Issue 10, Page(s) 599

    MeSH term(s) Aged ; Australia ; Automobile Driver Examination ; Automobile Driving/standards ; Humans ; New Zealand ; Stroke Rehabilitation
    Language English
    Publishing date 2007-10-25
    Publishing country Australia
    Document type Letter
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/j.1326-5377.2007.tb01437.x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.398: Show issues Location:
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  9. Article: The distribution of health services for older people in Australia: where does transition care fit?

    Giles, Lynne C / Halbert, Julie A / Gray, Len C / Cameron, Ian D / Crotty, Maria

    Australian health review : a publication of the Australian Hospital Association

    2010  Volume 33, Issue 4, Page(s) 572–582

    Abstract: Introduction: The purpose of this study was to describe the distribution of hospital and aged care services for older people, with a particular focus on transition care places, across Australia and to determine the relationships between the provision of ...

    Abstract Introduction: The purpose of this study was to describe the distribution of hospital and aged care services for older people, with a particular focus on transition care places, across Australia and to determine the relationships between the provision of these services.
    Methods: Aggregation of health and aged care service indicators by Aged Care Assessment Team (ACAT) region including: public and private acute and subacute (rehabilitation and geriatric evaluation and management) hospital beds, flexible and mainstream aged care places as at 30 June 2006.
    Results: There was marked variation in the distribution of acute and subacute hospital beds among the 79 ACAT regions. Aged care places were more evenly distributed. However, the distribution of transition care places was uneven. Rural areas had poorer provision of all beds. There was no evidence of coordination in the allocation of hospital and aged care services between the Commonwealth and state/territory governments. There was a weak relationship between the allocation of transition care places and the distribution of health and aged care services.
    Discussion: Overall, the distribution of services available to older persons is uneven across Australia. While the Transition Care Program is flexible and is providing rural communities with access to rehabilitation, it will not be adequate to address the increasing needs associated with the ageing of the Australian population. An integrated national plan for aged care and rehabilitation services should be considered.
    MeSH term(s) Aged ; Australia ; Health Services for the Aged/supply & distribution ; Hospitals/supply & distribution ; Humans ; Middle Aged ; Rehabilitation Centers/supply & distribution
    Language English
    Publishing date 2010-02-05
    Publishing country Australia
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 639155-2
    ISSN 0156-5788 ; 0159-5709
    ISSN 0156-5788 ; 0159-5709
    DOI 10.1071/ah090572
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 3099: Show issues Location:
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  10. Article: Evaluation of a real-time quantitative polymerase chain reaction assay for detection and quantitation of virulent Rhodococcus equi. [Erratum: 2005 July, v. 66, no. 7, p. 1139.]

    Harrington, J.R / Golding, M.C / Martens, R.J / Halbert, N.D / Cohen, N.D

    American journal of veterinary research. 2005 May, v. 66, no. 5

    2005  

    Keywords Rhodococcus equi ; bacterial pneumonia ; polymerase chain reaction ; disease detection ; quantitative analysis ; virulence ; strains ; disease diagnosis ; trachea (vertebrates) ; bronchi ; accuracy ; rapid methods ; reliability ; foals ; horse diseases
    Language English
    Dates of publication 2005-05
    Size p. 755-761.
    Document type Article
    ZDB-ID 390796-x
    ISSN 1943-5681 ; 0002-9645
    ISSN (online) 1943-5681
    ISSN 0002-9645
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

    Z 3312: Show issues

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