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Article: The sternocostoclavicular joint: normal and abnormal features.

Le Loët, Xavier / Vittecoq, Olivier

2002 Volume 69, Issue 2, Page(s) 161–169

Abstract: Many physicians are unfamiliar with the characteristics of the sternocostoclavicular joint (SCCJ). Disorders of the SCCJ, although common, frequently escape recognition. Computed tomography (CT) with thin slices and no gap is at presentthe best means of ... ...

Abstract	Many physicians are unfamiliar with the characteristics of the sternocostoclavicular joint (SCCJ). Disorders of the SCCJ, although common, frequently escape recognition. Computed tomography (CT) with thin slices and no gap is at presentthe best means of investigating the SCCJ. CTfeatures in normal subjects have been described in detail; some are misleading. The most common SCCJ disorder is degenerative disease manifesting as osteoarthritis or as periarticular lesions causing antero-medial dislocation of the clavicle. Septic arthritis is the most severe disorder and can lead to mediastinitis. All inflammatory joint diseases, including spondyloarthropathies, can affect the SCCJ. SCCJ involvement is a typical component of the osteoarticular manifestations seen in patients with palmoplantar pustulosis.
MeSH term(s)	Arthritis, Infectious/complications ; Arthritis, Infectious/diagnostic imaging ; Female ; Humans ; Joint Dislocations/diagnostic imaging ; Joint Dislocations/etiology ; Male ; Sternoclavicular Joint/anatomy & histology ; Sternoclavicular Joint/diagnostic imaging ; Sternoclavicular Joint/microbiology ; Tomography, X-Ray Computed
Language	English
Publishing date	2002-03
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2020487-5
ISSN	1778-7254 ; 1297-319X
ISSN (online)	1778-7254
ISSN	1297-319X
DOI	10.1016/s1297-319x(02)00362-7
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Article: Approche multidisciplinaire de la polyarthrite rhumatoïde.

Le Loët, X / Vittecoq, O

Annales de medecine interne

2001 Volume 152, Issue 8, Page(s) 513–517

Abstract: The main objectives of team management of rheumatoid arthritis are to stop structural damage of joints and to reduce functional, psychological, socioprofessional and economic consequences. Team management requires the collaboration, around the patient, ... ...

Title translation	Team management of rheumatoid arthritis.
Abstract	The main objectives of team management of rheumatoid arthritis are to stop structural damage of joints and to reduce functional, psychological, socioprofessional and economic consequences. Team management requires the collaboration, around the patient, of a rheumatologist, a nurse, a psychologist, a physiotherapist, an occupational therapist, an orthopaedic surgeon at the same time, in the same place. More and more patients wish to manage their disease by themselves. Team care should not be proposed to every patient; it must be reserved to patients whose condition required such an approach because of the severity of the disease, comorbidity, psychological or socioprofessionnal difficulties. Team management should be personalized. Utility of team management is now accepted; out-patient administration is as effective as in-patient one. A good educational program is very important. However, search is still needed to define optimal modalities of team management and tools to measure the efficiency of this approach.
MeSH term(s)	Arthritis, Rheumatoid/psychology ; Arthritis, Rheumatoid/therapy ; Attitude to Health ; Humans ; Patient Care Team ; Patient Compliance ; Stress, Psychological
Language	French
Publishing date	2001-12
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	215082-7
ISSN	0003-410X
ISSN	0003-410X
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Article ; Online: Fcγ receptor type IIIA polymorphism influences treatment outcomes in patients with rheumatoid arthritis treated with rituximab.

Ruyssen-Witrand, A / Rouanet, S / Combe, B / Dougados, M / Le Loët, X / Sibilia, J / Tebib, J / Mariette, X / Constantin, A

Annals of the rheumatic diseases

2012 Volume 71, Issue 6, Page(s) 875–877

Abstract: Objective: To assess the association between a single nucleotide polymorphism in the gene of FCGR3A and the response to treatment with rituximab (RTX) in rheumatoid arthritis (RA).: Methods: SMART is a randomised open trial assessing two strategies ... ...

Abstract	Objective: To assess the association between a single nucleotide polymorphism in the gene of FCGR3A and the response to treatment with rituximab (RTX) in rheumatoid arthritis (RA). Methods: SMART is a randomised open trial assessing two strategies of re-treatment in patients responding to 1 g infusion of RTX with methotrexate on days 1 and 15 after failure, intolerance or contraindication to tumour necrosis factor (TNF) blockers. Among the 224 patients included, 111 could be genotyped and were included in an ancillary study of SMART. Univariate and multivariate analyses adjusted on disease activity score on 28 joints were performed to assess whether FCGR3A-158V/F polymorphism was associated with European League Against Rheumatism response at week 24. Results: Among the 111 patients, 90 (81%) were responders of whom 30 (27%) were good responders. V allele carriage was significantly associated with a higher response rate (91% of responders vs 70%, OR 4.6 (95% CI 1.5 to 13.6), p=0.006). These results were also confirmed in rheumatoid factor-positive patients (93% vs 74%, p=0.025). In multivariate analysis, V allele carriage was independently associated with response to RTX (OR 3.8 (95% CI 1.2 to 11.7), p=0.023). Conclusion: The 158V/F polymorphism of FCGR3A seems to influence the response to RTX in patients with RA after failure, intolerance or contraindication to TNF blockers.
MeSH term(s)	Adult ; Aged ; Antibodies, Monoclonal, Murine-Derived/administration & dosage ; Antirheumatic Agents/administration & dosage ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/genetics ; Drug Resistance/genetics ; Drug Therapy, Combination ; Female ; Humans ; Male ; Methotrexate/administration & dosage ; Middle Aged ; Polymorphism, Single Nucleotide/genetics ; Receptors, IgG/genetics ; Rituximab ; Treatment Outcome ; Tumor Necrosis Factor-alpha/antagonists & inhibitors
Chemical Substances	Antibodies, Monoclonal, Murine-Derived ; Antirheumatic Agents ; FCGR3A protein, human ; Receptors, IgG ; Tumor Necrosis Factor-alpha ; Rituximab (4F4X42SYQ6) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2012-06
Publishing country	England
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	7090-7
ISSN	1468-2060 ; 0003-4967
ISSN (online)	1468-2060
ISSN	0003-4967
DOI	10.1136/annrheumdis-2011-200337
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Article: Evaluation de l'activité clinique du lupus érythémateux disséminé.

Le Loët, X

Annales de medecine interne

1990 Volume 141, Issue 3, Page(s) 261–264

Abstract: It is difficult to measure clinical disease activity in systemic lupus erythematosus because many organs can be involved simultaneously and the corresponding symptoms are not easy to quantify. Disease activity is poorly defined and there is no consensus ... ...

Title translation	Evaluation of the clinical activity of systemic lupus erythematosus.
Abstract	It is difficult to measure clinical disease activity in systemic lupus erythematosus because many organs can be involved simultaneously and the corresponding symptoms are not easy to quantify. Disease activity is poorly defined and there is no consensus on what disease activity means or how it should be measured. More than 60 systems have been devised but none of them is commonly used because they do not have the 3 characteristics necessary for such a tool: validity, reliability and sensitivity. Three recent systems, BILAG (British Isles Lupus Assessment Group), SLEDAI (Systemic Lupus Erythematosus Disease Activity Index) and SLAM (Systemic Lupus Activity Measures) are very valid. Comparisons of their reproducibility are in progress; however, more information is needed concerning their sensitivity and the feasibility of making these systems easy to manage for physicians.
MeSH term(s)	Humans ; Lupus Erythematosus, Systemic/complications ; Lupus Erythematosus, Systemic/diagnosis ; Lupus Erythematosus, Systemic/physiopathology ; Severity of Illness Index
Language	French
Publishing date	1990
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	215082-7
ISSN	0003-410X
ISSN	0003-410X
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Article: Pathologie synoviale de la hanche.

Le Loët, Xavier / Pouplin, Sophie / Vittecoq, Olivier

La Revue du praticien

2002 Volume 52, Issue 6, Page(s) 611–615

Abstract: Synovial diseases of the hip are often overlooked because they are far less frequent that osteoarthritis and because this joint is deep and so difficult to examine. The more important cause is septic arthritis; it requires an hospitalization in emergency. ...

Title translation	Synovial diseases of the hip.
Abstract	Synovial diseases of the hip are often overlooked because they are far less frequent that osteoarthritis and because this joint is deep and so difficult to examine. The more important cause is septic arthritis; it requires an hospitalization in emergency. Synovial tissue may also be at the beginning of the spondylarthropathy or, more rarely, of rheumatoid arthritis. In acute forms, diagnosis must be done before any radiological destructive changes. Aspiration of the hip and synovial biopsy are necessary for the diagnosis. In subacute or chronic forms, computed tomography and/or magnetic resonance imaging are useful tools to suspect the diagnosis and to guide a biopsy.
MeSH term(s)	Arthritis, Infectious/diagnosis ; Arthritis, Infectious/pathology ; Arthritis, Rheumatoid/diagnosis ; Arthritis, Rheumatoid/pathology ; Biopsy ; Diagnosis, Differential ; Hip Joint/pathology ; Humans ; Joint Diseases/diagnosis ; Joint Diseases/pathology ; Magnetic Resonance Imaging ; Spondylarthritis/diagnosis ; Spondylarthritis/pathology ; Synovial Membrane/pathology ; Tomography, X-Ray Computed
Language	French
Publishing date	2002-03-15
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	205365-2
ISSN	2101-017X ; 0035-2640
ISSN (online)	2101-017X
ISSN	0035-2640
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Article ; Online: Usefulness of monitoring of B cell depletion in rituximab-treated rheumatoid arthritis patients in order to predict clinical relapse: a prospective observational study.

Trouvin, A-P / Jacquot, S / Grigioni, S / Curis, E / Dedreux, I / Roucheux, A / Boulard, H / Vittecoq, O / Le Loët, X / Boyer, O / Goëb, V

Clinical and experimental immunology

2015 Volume 180, Issue 1, Page(s) 11–18

Abstract: Our objective was to evaluate the contribution of monitoring B cell subset depletion after rituximab in patients with rheumatoid arthritis (RA) in order to guide reintroduction to forestall relapse. This prospective, monocentre study included all RA ... ...

Abstract	Our objective was to evaluate the contribution of monitoring B cell subset depletion after rituximab in patients with rheumatoid arthritis (RA) in order to guide reintroduction to forestall relapse. This prospective, monocentre study included all RA patients receiving two 1-g rituximab infusions at a 15-day interval. The patients were followed clinically and biologically every 2 months until rituximab reintroduction. The physician was blinded to lymphocyte-typing results to diagnose relapse and, hence, retreatment. Among the 39 patients included between March 2010 and December 2011 and followed until April 2013, seven received two rituximab cycles, yielding a total of 46 cycles for analysis. After the two rituximab cycles, the total number of CD19(+) B cells decreased significantly (0·155 versus 0·0002 G/l, P < 0·0001), with complete depletions in all patients of CD19(+) CD38(++) CD24(++) (transitional) (P < 0·0001) and CD19(+) CD27(+) (memory) B lymphocytes. A significant majority of patients relapsed within the 4 months following repopulation of total B (P = 0·036), B transitional (P = 0·007) and B memory (P = 0·01) lymphocytes. CD19(+) B lymphocyte repopulation preceded clinical RA relapse and enabled its prediction 4 months in advance. Hence, monitoring of CD19(+) B lymphocytes could serve as a tool to predict those relapses.
MeSH term(s)	Aged ; Antibodies, Monoclonal, Murine-Derived/administration & dosage ; Antigens, CD/immunology ; Antirheumatic Agents/administration & dosage ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/immunology ; B-Lymphocytes ; Female ; Follow-Up Studies ; Humans ; Lymphocyte Depletion/methods ; Male ; Middle Aged ; Monitoring, Physiologic/methods ; Prospective Studies ; Rituximab
Chemical Substances	Antibodies, Monoclonal, Murine-Derived ; Antigens, CD ; Antirheumatic Agents ; Rituximab (4F4X42SYQ6)
Language	English
Publishing date	2015-04
Publishing country	England
Document type	Journal Article
ZDB-ID	218531-3
ISSN	1365-2249 ; 0009-9104 ; 0964-2536
ISSN (online)	1365-2249
ISSN	0009-9104 ; 0964-2536
DOI	10.1111/cei.12481
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Article: Treatment of eosinophilic fasciitis with methotrexate.

Pouplin, S / Daragon, A / Le Loët, X

The Journal of rheumatology

1998 Volume 25, Issue 3, Page(s) 606–607

MeSH term(s)	Antirheumatic Agents/therapeutic use ; Eosinophilia/drug therapy ; Fasciitis/drug therapy ; Humans ; Male ; Methotrexate/therapeutic use ; Middle Aged
Chemical Substances	Antirheumatic Agents ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	1998-03
Publishing country	Canada
Document type	Case Reports ; Letter
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
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Article: Combinations of second-line drugs for rheumatoid arthritis: is remission induction a reasonable goal?

Le Loët, X / Vittecoq, O / Daragon, A

Revue du rhumatisme (English ed.)

1998 Volume 65, Issue 3, Page(s) 161–164

MeSH term(s)	Antirheumatic Agents/therapeutic use ; Arthritis, Rheumatoid/drug therapy ; Drug Evaluation ; Drug Synergism ; Drug Therapy, Combination ; Humans ; Remission Induction
Chemical Substances	Antirheumatic Agents
Language	English
Publishing date	1998-03
Publishing country	France
Document type	Editorial ; Review
ZDB-ID	1236379-0
ISSN	1169-8446 ; 0035-2659
ISSN	1169-8446 ; 0035-2659
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Article ; Online: Anti-Carbamylated Fibrinogen Antibodies Might Be Associated With a Specific Rheumatoid Phenotype and Include a Subset Recognizing

Brevet, Pauline / Lattard, Claire / Guillou, Clément / Rottenberg, Pascal / Fardellone, Patrice / Le-Loët, Xavier / Lequerré, Thierry / Cosette, Pascal / Boyer, Olivier / Fréret, Manuel / Vittecoq, Olivier

Frontiers in immunology

2021 Volume 12, Page(s) 733511

Abstract: To identify the targets recognized by anti-carbamylated protein antibodies (anti-CarP) in patients with early Rheumatoid Arthritis (RA), to study the cross-reactivity between anti-CarP and anti-citrullinated protein antibodies (ACPA) and to evaluate ... ...

Abstract	To identify the targets recognized by anti-carbamylated protein antibodies (anti-CarP) in patients with early Rheumatoid Arthritis (RA), to study the cross-reactivity between anti-CarP and anti-citrullinated protein antibodies (ACPA) and to evaluate their prognostic value. 331 patients (184 RA and 147 other rheumatisms) from the Very Early Arthritis (VErA) French cohort were analyzed. We performed mass spectrometry analysis of RA sera displaying anti-CarP activity and epitope mapping of the carbamylated fibrinogen γ chain to identify immunodominant peptides. The specificity of these targets was studied using competition assays with the major antigens recognized by ACPA. The prognostic value of anti-carbamylated fibrinogen IgG antibodies (ACa-Fib IgG) was compared to that of anti-cyclic citrullinated peptide antibodies (anti-CCP) and anti-CarP using an in-house ELISA. Besides the α chain, the γ chain of fibrinogen, particularly one immunodominant epitope that has a specific reactivity, was identified as a circulating carbamylated target in sera. The prevalence of ACa-Fib was 37% at baseline and 10.9% for anti-CCP-negative RA. In anti-CCP-negative patients, ACa-Fib positivity was associated with a more inflammatory and erosive disease at baseline but not with rapid radiological progression, which remains strongly related to anti-CCP antibodies. Fibrinogen seems to be one of the antigens recognized
MeSH term(s)	Anti-Citrullinated Protein Antibodies/metabolism ; Arthritis, Rheumatoid/immunology ; Autoantibodies/metabolism ; Autoantigens/immunology ; Cohort Studies ; Cross Reactions ; Enzyme-Linked Immunosorbent Assay ; Epitope Mapping ; Fibrinogen/chemistry ; Fibrinogen/genetics ; Fibrinogen/immunology ; Humans ; Immunodominant Epitopes/genetics ; Immunodominant Epitopes/immunology ; Phenotype ; Protein Carbamylation
Chemical Substances	Anti-Citrullinated Protein Antibodies ; Autoantibodies ; Autoantigens ; FGG protein, human ; Immunodominant Epitopes ; Fibrinogen (9001-32-5)
Language	English
Publishing date	2021-10-07
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.733511
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Article: Visual hallucinations induced by intraarticular injection of steroids.

Daragon, A / Vittecoq, O / Le Loët, X

The Journal of rheumatology

1997 Volume 24, Issue 2, Page(s) 411

MeSH term(s)	Aged ; Anti-Inflammatory Agents/adverse effects ; Hallucinations/chemically induced ; Humans ; Injections, Intra-Articular ; Knee Joint/drug effects ; Male ; Osteoarthritis/drug therapy ; Triamcinolone Acetonide/adverse effects ; Triamcinolone Acetonide/analogs & derivatives ; Visual Perception
Chemical Substances	Anti-Inflammatory Agents ; Triamcinolone Acetonide (F446C597KA) ; triamcinolone hexacetonide (I7GT1U99Y9)
Language	English
Publishing date	1997-02
Publishing country	Canada
Document type	Case Reports ; Letter
ZDB-ID	194928-7
ISSN	1499-2752 ; 0315-162X
ISSN (online)	1499-2752
ISSN	0315-162X
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