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Article: HBV "Viral Elimination" in the Asia-Pacific region: Current status and challenges.

Chen, Jing / Lau, George

2024 Volume 23, Issue 1, Page(s) e0132

Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2657644-2
ISSN	2046-2484
ISSN	2046-2484
DOI	10.1097/CLD.0000000000000132
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Shortening HCV therapy: science meets public health.

Lau, George

The lancet. Gastroenterology & hepatology

2017 Volume 2, Issue 11, Page(s) 771–772

Language	English
Publishing date	2017-11
Publishing country	Netherlands
Document type	Journal Article
ISSN	2468-1253
ISSN (online)	2468-1253
DOI	10.1016/S2468-1253(17)30215-7
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Reply: Safety and effectiveness comparison of a new cohesive ophthalmic viscosurgical device.

Packer, Mark / Shultz, Mitchell / Loden, James / Lau, George

Journal of cataract and refractive surgery

2023 Volume 49, Issue 9, Page(s) 998–999

MeSH term(s)	Humans ; Chondroitin Sulfates ; Eye ; Hyaluronic Acid/therapeutic use ; Phacoemulsification
Chemical Substances	Chondroitin Sulfates (9007-28-7) ; Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Letter ; Comment
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1097/j.jcrs.0000000000001244
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Zs.A 1806: Show issues

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bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Impact of Regulatory Approval Status on CADTH Reimbursement of Oncology Drugs and Role of Real-World Evidence on Conditional Approvals from 2019 to 2021.

Lau, Catherine / Dranitsaris, George

Current oncology (Toronto, Ont.)

2022 Volume 29, Issue 11, Page(s) 8031–8042

Abstract: Real-world evidence (RWE) is health and outcomes data generated from a patient's journey through the health care system or disease process (i.e., real-world data). RWE is now having an increasingly important role in regulatory/reimbursement decisions. ... ...

Abstract	Real-world evidence (RWE) is health and outcomes data generated from a patient's journey through the health care system or disease process (i.e., real-world data). RWE is now having an increasingly important role in regulatory/reimbursement decisions. This article examines reimbursement recommendations by the Canadian Agency for Drugs and Technology in Health (CADTH) on oncology drugs approved between 2019 and 2021. Oncology drugs with a Summary Basis of Decision (SBD) for original marketing approvals were used to generate a corresponding list of CADTH final clinical recommendations for review. Of the 45 oncology drugs approved by Health Canada, CADTH granted positive funding recommendations to all 11 drugs that had priority review approvals. Two of the 17 drugs with standard reviews did not file to CADTH and 3 received a negative recommendation. Of the 17 drugs with Notice of Compliance with Conditions (NOCc) status, three were not filed to CADTH and four were under active reviews. Of the ten completed NOCc reviews, all contained RWE from sponsors and six received a negative decision on their first review. No significant differences in review times were found between the three approval statuses. Regulatory approval status appeared to influence reimbursement outcomes in Canada and evaluation of 10 NOCc approvals provided little insight regarding robustness of RWE required for more favorable considerations.
MeSH term(s)	Humans ; Canada ; Drug Approval ; Evidence-Based Practice
Language	English
Publishing date	2022-10-26
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	1236972-x
ISSN	1718-7729 ; 1198-0052
ISSN (online)	1718-7729
ISSN	1198-0052
DOI	10.3390/curroncol29110635
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Article: An international survey exploring the adoption and utility of diagnostic lung ultrasound by physiotherapists and respiratory therapists in intensive care.

Lau, Yin Hung / Hayward, Simon / Ntoumenopoulos, George

Journal of the Intensive Care Society

2023 Volume 24, Issue 4, Page(s) 364–371

Abstract: Introduction: Lung ultrasound (LUS) is an emerging assessment tool for intensive care unit (ICU) therapists (physiotherapists, physical therapists and respiratory therapists) to aid pathology identification, intervention selection, clinical reasoning ... ...

Abstract	Introduction: Lung ultrasound (LUS) is an emerging assessment tool for intensive care unit (ICU) therapists (physiotherapists, physical therapists and respiratory therapists) to aid pathology identification, intervention selection, clinical reasoning and as an outcome measure to assess intervention efficacy. However, the extent of LUS adoption and use by ICU therapists internationally has not been described in the literature. Objectives: This survey explored the interest in LUS amongst ICU therapists internationally. In addition, LUS training, use in clinical practice and barriers to implementation were also explored. The survey findings were used to facilitate recommendations for future adoption. Methods: International ICU therapists were invited to answer a 37 question cross-sectional open e-survey, distributed using the online survey tool REDCap Results: Three hundred twenty ICU therapists from 30 countries responded with most respondents coming from either the United Kingdom ( Conclusions: To the authors' knowledge this is the first study to explore the international adoption and utility of LUS by ICU therapists. LUS is a growing technique with widespread interest from ICU therapists internationally with a desire to adopt LUS into their assessments and upskill their practice. ICU therapists' use of LUS could allow more targetted and appropriate treatment for patients on ICU. Barriers to LUS adoption could be mitigated by having access to quality training programmes and mentorship. Development of profession specific guidance and policies within local infrastructure should facilitate growth and ensure robust quality assurance and governance processes.
Language	English
Publishing date	2023-02-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2701626-2
ISSN	1751-1437 ; 1751-1437
ISSN (online)	1751-1437
ISSN	1751-1437
DOI	10.1177/17511437221148920
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Article ; Online: Safety and effectiveness comparison of a new cohesive ophthalmic viscosurgical device.

Packer, Mark / Shultz, Mitchell / Loden, James / Lau, George

Journal of cataract and refractive surgery

2023 Volume 49, Issue 8, Page(s) 804–811

Abstract: Purpose: To evaluate the safety and effectiveness of a new cohesive ophthalmic viscosurgical device (OVD) (StableVisc) compared with a marketed cohesive OVD (ProVisc) in patients undergoing cataract surgery.: Setting: 22 sites in the United States.!## ...

Abstract	Purpose: To evaluate the safety and effectiveness of a new cohesive ophthalmic viscosurgical device (OVD) (StableVisc) compared with a marketed cohesive OVD (ProVisc) in patients undergoing cataract surgery. Setting: 22 sites in the United States. Design: Prospective multicenter controlled double-masked and randomized 1:1 (StableVisc:ProVisc; stratified by site, age group, and cataract severity). Methods: Adults (≥45 years) with age-related noncomplicated cataract considered amenable to treatment with standard phacoemulsification cataract extraction and intraocular lens implantation were included. Patients were randomized to receive either StableVisc or ProVisc during standard cataract surgery. Postoperative visits occurred at 6 hours, 24 hours, 7 days, 1 month, and 3 months. The primary effectiveness outcome was the change in endothelial cell density (ECD) from baseline to 3 months. The primary safety endpoint was the proportion of patients who experienced at least 1 intraocular pressure (IOP) measurement ≥30 mm Hg at any follow-up visit. Noninferiority between the devices was tested. Inflammation and adverse events were evaluated. Results: 390 patients were randomized; 187 patients with StableVisc and 193 patients with ProVisc completed the study. StableVisc was noninferior to ProVisc in mean ECD loss from baseline to 3 months (17.5% and 16.9%, respectively). StableVisc was noninferior to ProVisc in the proportion of patients with postoperative IOP ≥30 mm Hg at any follow-up visit (5.2% and 8.2%, respectively). Conclusions: The StableVisc cohesive OVD, which provides both mechanical and chemical protection, was safe and effective when used in cataract surgery and provides surgeons with a new cohesive OVD.
MeSH term(s)	Adult ; Humans ; Lens Implantation, Intraocular ; Prospective Studies ; Hyaluronic Acid/therapeutic use ; Eye ; Phacoemulsification ; Cataract/chemically induced ; Intraocular Pressure
Chemical Substances	Hyaluronic Acid (9004-61-9)
Language	English
Publishing date	2023-04-20
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1097/j.jcrs.0000000000001201
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1806: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: John II Komnenos (1118–1143)

Maximilian Christopher George Lau

Encyclopedia, Vol 2, Iss 46, Pp 669-

2022 Volume 678

Abstract: John II Komnenos was the son of Emperor Alexios I Komnenos and Eirene Doukaina, and brother of Princess Anna Komnene, the author of the Alexiad . Born in 1087, he was crowned soon after his fifth birthday as co-emperor with his father, and in 1105, he ... ...

Abstract	John II Komnenos was the son of Emperor Alexios I Komnenos and Eirene Doukaina, and brother of Princess Anna Komnene, the author of the Alexiad . Born in 1087, he was crowned soon after his fifth birthday as co-emperor with his father, and in 1105, he was married to Piroska Árpád, daughter of King Ladislaus I of Hungary and Adelaide of Rheinfelden. He is principally known for continuing his father’s work of stabilising Byzantium after the crises of the eleventh century. This included major wars of defence and conquest in both the Balkans and Anatolia, and especially a major eastern expedition in 1137–1139. During this campaign, he conquered Cilicia, but he was recalled to defend his borders against the Turks before he could make further conquests in Syria and bring the crusader states under his aegis. He died in a hunting accident just before he returned to Syria, with intentions to go to Jerusalem as well. His best-known iconographic representation is a mosaic of him and his wife in the Great Church of Sophia. Whilst there is also an image of him in a contemporary ornate gospel book, his most common representations are found on his many coin issues and seals.
Keywords	royal images ; royal iconography ; Byzantium ; Komnenos ; John II Komnenos ; Science ; Q
Subject code	941
Language	English
Publishing date	2022-03-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Synthesis of Liver Associations Recommendations for Hepatology and Liver Transplant Care During the COVID-19 Pandemic.

Lau, George / Ward, John W

Clinical liver disease

2020 Volume 15, Issue 5, Page(s) 204–209

Keywords	covid19
Language	English
Publishing date	2020-05-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2657644-2
ISSN	2046-2484
ISSN	2046-2484
DOI	10.1002/cld.972
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Clinical Conundrums: Differentiating Monkeypox From Similarly Presenting Infections.

Hussain, Azhar / Kaler, Jasndeep / Lau, George / Maxwell, Tyler

Cureus

2022 Volume 14, Issue 10, Page(s) e29929

Abstract: Post the coronavirus disease 2019 (COVID-19) pandemic, there arises the concern of a new epidemic as cases of monkeypox are being confirmed, globally. With the initial clinical manifestation of monkeypox resembling that of the common cold or seasonal flu, ...

Abstract	Post the coronavirus disease 2019 (COVID-19) pandemic, there arises the concern of a new epidemic as cases of monkeypox are being confirmed, globally. With the initial clinical manifestation of monkeypox resembling that of the common cold or seasonal flu, recognizing alternative differential diagnoses is imperative as a medical health practitioner. The characteristic monkeypox maculopapular rash with the progression to vesicles and pustules before scabbing can be described in several other infections. Understanding the disease progression and distinct clinical presentation of monkeypox in its various stages may allow for a more expedient diagnosis among healthcare providers. Though eradicated, the clinical presentation of smallpox is the most similar to that of monkeypox; however, smallpox is no longer a concern for the general population. Other conditions such as molluscum contagiosum, syphilis, varicella zoster, measles, rickettsialpox, and scabies can present with rashes that may resemble singular or multiple states of the monkeypox rash progression. The ability to correctly diagnose an individual's condition promptly may allow healthcare providers to provide correct supportive therapies or treatments.
Language	English
Publishing date	2022-10-04
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.29929
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Book ; Online: Quantum Finite Automata and Quiver Algebras

Jeffreys, George / Lau, Siu-Cheong

2022

Abstract: We find an application in quantum finite automata for the ideas and results of [JL21] and [JL22]. We reformulate quantum finite automata with multiple-time measurements using the algebraic notion of near-ring. This gives a unified understanding towards ... ...

Abstract	We find an application in quantum finite automata for the ideas and results of [JL21] and [JL22]. We reformulate quantum finite automata with multiple-time measurements using the algebraic notion of near-ring. This gives a unified understanding towards quantum computing and deep learning. When the near-ring comes from a quiver, we have a nice moduli space of computing machines with metric that can be optimized by gradient descent.
Keywords	Computer Science - Formal Languages and Automata Theory ; Computer Science - Machine Learning ; Mathematics - Algebraic Geometry ; Quantum Physics
Publishing date	2022-03-14
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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