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  1. Book ; Online: Q-Diffusion

    Li, Xiuyu / Liu, Yijiang / Lian, Long / Yang, Huanrui / Dong, Zhen / Kang, Daniel / Zhang, Shanghang / Keutzer, Kurt

    Quantizing Diffusion Models

    2023  

    Abstract: ... The code is available at https://github.com/Xiuyu-Li/q-diffusion ...

    Abstract Diffusion models have achieved great success in image synthesis through iterative noise estimation using deep neural networks. However, the slow inference, high memory consumption, and computation intensity of the noise estimation model hinder the efficient adoption of diffusion models. Although post-training quantization (PTQ) is considered a go-to compression method for other tasks, it does not work out-of-the-box on diffusion models. We propose a novel PTQ method specifically tailored towards the unique multi-timestep pipeline and model architecture of the diffusion models, which compresses the noise estimation network to accelerate the generation process. We identify the key difficulty of diffusion model quantization as the changing output distributions of noise estimation networks over multiple time steps and the bimodal activation distribution of the shortcut layers within the noise estimation network. We tackle these challenges with timestep-aware calibration and split shortcut quantization in this work. Experimental results show that our proposed method is able to quantize full-precision unconditional diffusion models into 4-bit while maintaining comparable performance (small FID change of at most 2.34 compared to >100 for traditional PTQ) in a training-free manner. Our approach can also be applied to text-guided image generation, where we can run stable diffusion in 4-bit weights with high generation quality for the first time.

    Comment: The code is available at https://github.com/Xiuyu-Li/q-diffusion
    Keywords Computer Science - Computer Vision and Pattern Recognition ; Computer Science - Machine Learning
    Publishing date 2023-02-08
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Feasibility of 3D-EIT in identifying lung perfusion defect and V/Q mismatch in a patient with VA-ECMO.

    Gao, Yelin / Zhang, Ke / Li, Maokun / Yuan, Siyi / Wang, Qianlin / Chi, Yi / Long, Yun / Zhao, Zhanqi / He, Huaiwu

    Critical care (London, England)

    2024  Volume 28, Issue 1, Page(s) 90

    MeSH term(s) Humans ; Extracorporeal Membrane Oxygenation ; Feasibility Studies ; Lung ; Perfusion ; Ventilation-Perfusion Ratio
    Language English
    Publishing date 2024-03-20
    Publishing country England
    Document type Letter
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-024-04865-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Two-dimensional electronic spectroscopy of the Q

    Do, Thanh Nhut / Nguyen, Hoang Long / Caffarri, Stefano / Tan, Howe-Siang

    The Journal of chemical physics

    2022  Volume 156, Issue 14, Page(s) 145102

    Abstract: Using two-dimensional electronic spectroscopy, we measured the Q ...

    Abstract Using two-dimensional electronic spectroscopy, we measured the Q
    MeSH term(s) Chlorophyll/chemistry ; Chlorophyll A ; Electronics ; Light-Harvesting Protein Complexes ; Photosystem II Protein Complex/chemistry ; Spectrum Analysis/methods
    Chemical Substances Light-Harvesting Protein Complexes ; Photosystem II Protein Complex ; Chlorophyll (1406-65-1) ; Chlorophyll A (YF5Q9EJC8Y)
    Language English
    Publishing date 2022-04-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0079500
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Chemical profiling and quality evaluation of Liuweizhiji Gegen-Sangshen oral liquid by UPLC-Q-TOF-MS and HPLC-diode array detector fingerprinting.

    Wei, Shulin / Jiang, Yu / Li, Mingxing / Zhao, Long / Wang, Tiangang / Wei, Mei / Zhao, Qianyun / Zeng, Jiuping / Zhao, Yueshui / Shen, Jing / Du, Fukuan / Chen, Yu / Deng, Shuai / Xiao, Zhangang / Li, Zhi / Wu, Xu

    Phytochemical analysis : PCA

    2024  

    Abstract: ... UPLC-Q-TOF-MS) and fingerprint analysis by high-performance liquid chromatography with diode array ... negative ion modes based on the UPLC-Q-TOF-MS results. Of these, 37 were confirmed ...

    Abstract Introduction: Liuweizhiji Gegen-Sangshen (LGS) oral liquid is a Chinese patent medicine that is widely used for the prevention and treatment of alcoholic liver disease in clinical practice. However, the chemical complexity of LGS has not yet been investigated.
    Objective: The aim of this study was to rapidly identify chemical constituents of LGS and establish a quality control method based on fingerprint and quantitative analysis.
    Methodology: A comprehensive strategy was used by combining qualitative analysis by ultra-performance liquid chromatography tandem quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) and fingerprint analysis by high-performance liquid chromatography with diode array detection (HPLC-DAD).
    Results: A total of 162 chemical components in LGS, including 91 flavonoids, 31 organic acids, and 20 phenolic compounds, were identified or preliminarily characterized in both positive and negative ion modes based on the UPLC-Q-TOF-MS results. Of these, 37 were confirmed with the reference standards. In fingerprint analysis, 23 peaks were chosen as common peaks and used to evaluate the similarity of different batches of LGS. Subsequently, a rapid quantification method was optimized and validated for the simultaneous determination of multiple chemical markers in LGS. The validated quantitative method was successfully used to analyze different batches of LGS samples.
    Conclusion: The proposed comprehensive strategy combining HPLC-DAD fingerprinting and multi-component quantification demonstrated satisfactory results with high efficiency, accuracy, and reliability. This can be used as a reference for the overall quality consistency evaluation of Chinese patent medicines.
    Language English
    Publishing date 2024-02-15
    Publishing country England
    Document type Journal Article
    ZDB-ID 1073576-8
    ISSN 1099-1565 ; 0958-0344
    ISSN (online) 1099-1565
    ISSN 0958-0344
    DOI 10.1002/pca.3333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Chemical constituents and mechanism of Chuanzhi Tongluo Capsules based on UPLC-Q-Exactive Orbitrap-MS and network pharmacology].

    Yang, Ke-Nan / Guan, Yong-Xia / Fan, Jian-Wei / Yuan, Xiao-Mei / Zhang, Long-Fei / Liu, Qian / Li, Jing

    Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

    2023  Volume 48, Issue 19, Page(s) 5216–5234

    Abstract: ... mass spectrometry(UPLC-Q-Exactive Orbitrap-MS) to clarify the pharmacological substance basis. In addition, network ...

    Abstract The chemical constituents of Chuanzhi Tongluo Capsules were analyzed and identified using ultra-high performance liquid chromatography-quadrupole/electrostatic field orbitrap high-resolution mass spectrometry(UPLC-Q-Exactive Orbitrap-MS) to clarify the pharmacological substance basis. In addition, network pharmacology was employed to explore the mechanism of Chuanzhi Tongluo Capsules in the treatment of cerebral infarction. Gradient elution was performed using acetonitrile and 1% acetic acid in water as the mobile phase. Mass spectrometry was performed in positive and negative ion modes. Xcalibur 4.2 software was used for compound analysis, including accurate mass-to-charge ratio and MS/MS fragment information, combined with the comparison of reference standards and literature data. A total of 152 compounds were identified, including 32 organic acids, 35 flavonoids and their glycosides, 33 diterpenes, 13 phthalides, 12 triterpenes and triterpene saponins, 23 nitrogen-containing compounds, and 4 other compounds, and their fragmentation patterns were analyzed. SwissTargetPrediction, GeneCards, DAVID, and other databases were used to predict and analyze the core targets and mechanism of Chuanzhi Tongluo Capsules. Protein-protein interaction(PPI) network topology analysis identified 10 core targets, including TNF, VEGFA, EGFR, IL1B, and CTNNB1. KEGG enrichment analysis showed that Chuanzhi Tongluo Capsules mainly exerted their effects through the regulation of lipid and atherosclerosis, glycoproteins in cancer, MicroRNAs in cancer, fluid shear stress, and atherosclerosis-related pathways. Molecular docking was performed between the key constituents and core targets, and the results demonstrated a strong binding affinity between the key constituents of Chuanzhi Tongluo Capsules and the core targets. This study comprehensively elucidated the chemical constituents of Chuanzhi Tongluo Capsules and explored the core targets and mechanism in the treatment of cerebral infarction based on network pharmacology, providing a scientific reference for the study of the pharmacological substance basis and formulation quality standards of Chuanzhi Tongluo Capsules.
    MeSH term(s) Humans ; Tandem Mass Spectrometry/methods ; Chromatography, High Pressure Liquid/methods ; Molecular Docking Simulation ; Network Pharmacology ; Drugs, Chinese Herbal/pharmacology ; Capsules ; Atherosclerosis ; Cerebral Infarction ; Neoplasms
    Chemical Substances tongluo ; Drugs, Chinese Herbal ; Capsules
    Language Chinese
    Publishing date 2023-12-17
    Publishing country China
    Document type English Abstract ; Journal Article
    ZDB-ID 1004649-5
    ISSN 1001-5302 ; 0254-0029
    ISSN 1001-5302 ; 0254-0029
    DOI 10.19540/j.cnki.cjcmm.20230614.302
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Q-switching Yb

    Zhan, Yi / Wang, Yimeng / Long, Jinlin / Zu, Jifeng / Wang, Li / Wang, Congcong / Qu, Ting / Liu, Qian

    Optics letters

    2017  Volume 42, Issue 13, Page(s) 2619–2622

    Abstract: Copper(II) chalcogenide nanocrystals, including ... ...

    Abstract Copper(II) chalcogenide nanocrystals, including Cu
    Language English
    Publishing date 2017-07-01
    Publishing country United States
    Document type Journal Article
    ISSN 1539-4794
    ISSN (online) 1539-4794
    DOI 10.1364/OL.42.002619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Preclinical Animal Models for Q Fever Vaccine Development.

    Tesfamariam, Mahelat / Binette, Picabo / Long, Carrie Mae

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 828784

    Abstract: ... Coxiella ... ...

    Abstract Coxiella burnetii
    MeSH term(s) Animals ; Bacterial Vaccines ; Coxiella burnetii ; Mammals ; Models, Animal ; Q Fever/prevention & control ; Vaccine Development
    Chemical Substances Bacterial Vaccines
    Language English
    Publishing date 2022-02-10
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.828784
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Relationship between Q-Tip Test and Urethral Hypermobility on Perineal Ultrasound.

    Long, Cheng-Yu / Loo, Zi-Xi / Wu, Ching-Hu / Lin, Kun-Ling / Yeh, Chang-Lin / Feng, Chien-Wei / Wu, Pei-Chi

    Journal of clinical medicine

    2023  Volume 12, Issue 14

    Abstract: ... distance measured by transperineal ultrasound (TPUS) and Q-tip test angle in women with urodynamic stress ... recruited. UH was defined as a Q-tip angle more than or equal to 30 degrees. Ultrasonic measurement ... coefficient between the overall rest-stress distance in TPUS and Q-tip test angle was 0.9104 (95% CI, 0.8758-0 ...

    Abstract Background: The aim of this study was to assess the correlation between the overall rest-stress distance measured by transperineal ultrasound (TPUS) and Q-tip test angle in women with urodynamic stress incontinence (USI), and determine a cut-off value of rest-stress distance for predicting urethral hypermobility (UH).
    Methods: Women with USI scheduled for mid-urethral sling surgery were retrospectively recruited. UH was defined as a Q-tip angle more than or equal to 30 degrees. Ultrasonic measurement of the overall rest-stress distance was defined as the linear distance of bladder-neck position change from resting status to maximal strain.
    Results: Among the 132 enrolled women, the Pearson correlation coefficient between the overall rest-stress distance in TPUS and Q-tip test angle was 0.9104 (95% CI, 0.8758-0.9357,
    Conclusions: The overall rest-stress distance in TPUS correlated well with the Q-tip test angle, indicating that it can be an alternative method for the assessment of USI. A rest-stress distance of more than 13.3 mm was an optimal cut-off value to predict UH in women with USI.
    Language English
    Publishing date 2023-07-24
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12144863
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Book ; Online: Gradient Q$(\sigma, \lambda)$

    Yang, Long / Zhang, Yu / Zheng, Qian / Li, Pengfei / Pan, Gang

    A Unified Algorithm with Function Approximation for Reinforcement Learning

    2019  

    Abstract: Full-sampling (e.g., Q-learning) and pure-expectation (e.g., Expected Sarsa) algorithms are ... efficient and frequently used techniques in reinforcement learning. Q$(\sigma,\lambda)$ is the first ... to the tabular case, for large-scale learning, the Q$(\sigma,\lambda)$ is too expensive to require a huge ...

    Abstract Full-sampling (e.g., Q-learning) and pure-expectation (e.g., Expected Sarsa) algorithms are efficient and frequently used techniques in reinforcement learning. Q$(\sigma,\lambda)$ is the first approach unifies them with eligibility trace through the sampling degree $\sigma$. However, it is limited to the tabular case, for large-scale learning, the Q$(\sigma,\lambda)$ is too expensive to require a huge volume of tables to accurately storage value functions. To address above problem, we propose a GQ$(\sigma,\lambda)$ that extends tabular Q$(\sigma,\lambda)$ with linear function approximation. We prove the convergence of GQ$(\sigma,\lambda)$. Empirical results on some standard domains show that GQ$(\sigma,\lambda)$ with a combination of full-sampling with pure-expectation reach a better performance than full-sampling and pure-expectation methods.
    Keywords Computer Science - Machine Learning ; Statistics - Machine Learning
    Subject code 670
    Publishing date 2019-09-06
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Q Fever Vaccine Development

    Carrie Mae Long

    Pathogens, Vol 10, Iss 1223, p

    Current Strategies and Future Considerations

    2021  Volume 1223

    Abstract: Q fever is a zoonotic disease caused by the intracellular pathogen Coxiella burnetii . This disease ... typically manifests as a self-limiting, febrile illness known as acute Q fever. Due to the aerosol ... bioterrorism threat. Despite extensive efforts to develop next-generation human Q fever vaccines, only one ...

    Abstract Q fever is a zoonotic disease caused by the intracellular pathogen Coxiella burnetii . This disease typically manifests as a self-limiting, febrile illness known as acute Q fever. Due to the aerosol transmissibility, environmental persistence, and infectivity of C. burnetii , this pathogen is a notable bioterrorism threat. Despite extensive efforts to develop next-generation human Q fever vaccines, only one vaccine, Q-Vax®, is commercially available. Q-Vax® is a phase I whole-cell vaccine, and its licensed use is limited to Australia, presumably due to the potential for a post-vaccination hypersensitivity response. Pre-clinical Q fever vaccine development is a major area of interest, and diverse approaches have been undertaken to develop an improved Q fever vaccine. Following a brief history of Q fever vaccine development, current approaches will be discussed along with future considerations for an improved Q fever vaccine.
    Keywords Coxiella burnetii ; bacterial vaccines ; vaccine ; intracellular pathogen ; Q-Vax ; hypersensitivity ; Medicine ; R
    Language English
    Publishing date 2021-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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