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  1. Article: Updating the Knowledge on the Secretory Machinery of Hops (

    Ramos, Felipe Paulino / Iwamoto, Lucas / Piva, Vítor Hélio / Teixeira, Simone Pádua

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 6

    Abstract: Cannabaceae species garner attention in plant research due to their diverse secretory structures and pharmacological potential associated with the production of secondary metabolites. This study aims to update our understanding of the secretory system in ...

    Abstract Cannabaceae species garner attention in plant research due to their diverse secretory structures and pharmacological potential associated with the production of secondary metabolites. This study aims to update our understanding of the secretory system in Hops (
    Language English
    Publishing date 2024-03-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13060864
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  2. Article ; Online: Author's response: "Long-term physical impairments in survivors of COVID-19-associated ARDS compared with classic ARDS: A two-center study".

    Piva, Simone / Pozzi, Matteo / Calza, Stefano / Latronico, Nicola

    Journal of critical care

    2023  Volume 77, Page(s) 154329

    MeSH term(s) Humans ; COVID-19/complications ; Quality of Life ; Survivors ; Respiratory Distress Syndrome/therapy ; Respiratory Distress Syndrome/complications
    Language English
    Publishing date 2023-06-05
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2023.154329
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    Zs.A 2152: Show issues Location:
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  3. Article ; Online: Anticipating ICU discharge and long-term follow-up.

    Rosa, Regis Goulart / Teixeira, Cassiano / Piva, Simone / Morandi, Alessandro

    Current opinion in critical care

    2024  Volume 30, Issue 2, Page(s) 157–164

    Abstract: Purpose of review: This review aims to summarize recent literature findings on long-term outcomes following critical illness and to highlight potential strategies for preventing and managing health deterioration in survivors of critical care.: Recent ... ...

    Abstract Purpose of review: This review aims to summarize recent literature findings on long-term outcomes following critical illness and to highlight potential strategies for preventing and managing health deterioration in survivors of critical care.
    Recent findings: A substantial number of critical care survivors experience new or exacerbated impairments in their physical, cognitive or mental health, commonly named as postintensive care syndrome (PICS). Furthermore, those who survive critical illness often face an elevated risk of adverse outcomes in the months following their hospital stay, including infections, cardiovascular events, rehospitalizations and increased mortality. These findings underscore the need for effective prevention and management of long-term health deterioration in the critical care setting. While robust evidence from well designed randomized clinical trials is limited, potential interventions encompass sedation limitation, early mobilization, delirium prevention and family presence during intensive care unit (ICU) stay, as well as multicomponent transition programs (from ICU to ward, and from hospital to home) and specialized posthospital discharge follow-up.
    Summary: In this review, we offer a concise overview of recent insights into the long-term outcomes of critical care survivors and advancements in the prevention and management of health deterioration after critical illness.
    MeSH term(s) Humans ; Patient Discharge ; Intensive Care Units ; Critical Illness/therapy ; Follow-Up Studies ; Quality of Life ; Critical Care
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001136
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  4. Article ; Online: Publisher Correction to: Critical Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long‑term outcomes.

    Latronico, Nicola / Rasulo, Frank A / Eikermann, Matthias / Piva, Simone

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 469

    Language English
    Publishing date 2023-11-30
    Publishing country England
    Document type Published Erratum
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04757-3
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  5. Article ; Online: Outcomes Among Patients With 1-Year Survival After Intensive Care Unit Treatment for COVID-19.

    Latronico, Nicola / Rasulo, Frank A / Piva, Simone

    JAMA

    2022  Volume 327, Issue 21, Page(s) 2149

    MeSH term(s) COVID-19 ; Critical Care ; Critical Illness ; Humans ; Intensive Care Units ; SARS-CoV-2
    Language English
    Publishing date 2022-06-07
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2958-0
    ISSN 1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
    ISSN (online) 1538-3598
    ISSN 0254-9077 ; 0002-9955 ; 0098-7484
    DOI 10.1001/jama.2022.5886
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  6. Article ; Online: Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes.

    Latronico, Nicola / Rasulo, Frank A / Eikermann, Matthias / Piva, Simone

    Critical care (London, England)

    2023  Volume 27, Issue 1, Page(s) 439

    Abstract: Background: Severe weakness associated with critical illness (CIW) is common. This narrative review summarizes the latest scientific insights and proposes a guide for clinicians to optimize the diagnosis and management of the CIW during the various ... ...

    Abstract Background: Severe weakness associated with critical illness (CIW) is common. This narrative review summarizes the latest scientific insights and proposes a guide for clinicians to optimize the diagnosis and management of the CIW during the various stages of the disease from the ICU to the community stage.
    Main body: CIW arises as diffuse, symmetrical weakness after ICU admission, which is an important differentiating factor from other diseases causing non-symmetrical muscle weakness or paralysis. In patients with adequate cognitive function, CIW can be easily diagnosed at the bedside using manual muscle testing, which should be routinely conducted until ICU discharge. In patients with delirium or coma or those with prolonged, severe weakness, specific neurophysiological investigations and, in selected cases, muscle biopsy are recommended. With these exams, CIW can be differentiated into critical illness polyneuropathy or myopathy, which often coexist. On the general ward, CIW is seen in patients with prolonged previous ICU treatment, or in those developing a new sepsis. Respiratory muscle weakness can cause neuromuscular respiratory failure, which needs prompt recognition and rapid treatment to avoid life-threatening situations. Active rehabilitation should be reassessed and tailored to the new patient's condition to reduce the risk of disease progression. CIW is associated with long-term physical, cognitive and mental impairments, which emphasizes the need for a multidisciplinary model of care. Follow-up clinics for patients surviving critical illness may serve this purpose by providing direct clinical support to patients, managing referrals to other specialists and general practitioners, and serving as a platform for research to describe the natural history of post-intensive care syndrome and to identify new therapeutic interventions. This surveillance should include an assessment of the activities of daily living, mood, and functional mobility. Finally, nutritional status should be longitudinally assessed in all ICU survivors and incorporated into a patient-centered nutritional approach guided by a dietician.
    Conclusions: Early ICU mobilization combined with the best evidence-based ICU practices can effectively reduce short-term weakness. Multi-professional collaborations are needed to guarantee a multi-dimensional evaluation and unitary community care programs for survivors of critical illnesses.
    MeSH term(s) Humans ; Critical Illness/rehabilitation ; Intensive Care Units ; Activities of Daily Living ; Muscular Diseases/complications ; Muscular Diseases/diagnosis ; Muscular Diseases/therapy ; Muscle Weakness/diagnosis ; Muscle Weakness/etiology ; Muscle Weakness/therapy ; Frailty/complications ; Polyneuropathies/complications ; Polyneuropathies/diagnosis ; Polyneuropathies/therapy
    Language English
    Publishing date 2023-11-13
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/s13054-023-04676-3
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    Zs.A 5517: Show issues Location:
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  7. Article ; Online: Hemodynamic Insights From Simultaneous Common Carotid and Internal Jugular Doppler Ultrasonography in a Patient With Hypoxemia and Multiple Organ Dysfunction.

    Kenny, Jon-Émile S / Eibl, Joseph K / Horner, Christine / Arcozzi, Daniele / Bonomi, Federico / Fanelli, Vito / Visioli, Antonio / Goffi, Alberto / Piva, Simone

    Chest

    2024  Volume 165, Issue 4, Page(s) e107–e112

    MeSH term(s) Humans ; Multiple Organ Failure ; Ultrasonography ; Hemodynamics ; Ultrasonography, Doppler ; Hypoxia/etiology ; Jugular Veins/diagnostic imaging
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Case Reports
    ZDB-ID 1032552-9
    ISSN 1931-3543 ; 0012-3692
    ISSN (online) 1931-3543
    ISSN 0012-3692
    DOI 10.1016/j.chest.2023.11.023
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    Zs.MO 349: Show issues

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  8. Article ; Online: Comparison of resting energy expenditure measured with metabolic cart and calculated with predictive formulas in critically ill patients on mechanical ventilation.

    Taboni, Anna / Vinetti, Giovanni / Piva, Simone / Gorghelli, Giulia / Ferretti, Guido / Fagoni, Nazzareno

    Respiratory physiology & neurobiology

    2023  Volume 311, Page(s) 104025

    Abstract: Introduction: The purpose was to compare the resting energy expenditure (REE) measured with the Q-NRG™+ metabolic-cart (MREE) with REE predicted by equations (the Harris-Benedict formula and an equation developed in ward, REE-HB and REE-W, respectively). ...

    Abstract Introduction: The purpose was to compare the resting energy expenditure (REE) measured with the Q-NRG™+ metabolic-cart (MREE) with REE predicted by equations (the Harris-Benedict formula and an equation developed in ward, REE-HB and REE-W, respectively). We also aimed to assess the agreement of the measurements of oxygen consumption (V̇O
    Methods: 27 mechanically ventilated ICU patients were enrolled. V̇O
    Results: V̇O
    Conclusions: This new metabolic cart Q-NRG™+ provides a concordance of values for V̇O
    MeSH term(s) Humans ; Respiration, Artificial ; Critical Illness ; Calorimetry, Indirect ; Energy Metabolism ; Critical Care ; Basal Metabolism
    Language English
    Publishing date 2023-02-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2077867-3
    ISSN 1878-1519 ; 1569-9048
    ISSN (online) 1878-1519
    ISSN 1569-9048
    DOI 10.1016/j.resp.2023.104025
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    Zs.A 519: Show issues Location:
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  9. Article ; Online: Neurological complications of sepsis.

    Piva, Simone / Bertoni, Michele / Gitti, Nicola / Rasulo, Francesco A / Latronico, Nicola

    Current opinion in critical care

    2023  Volume 29, Issue 2, Page(s) 75–84

    Abstract: Purpose of review: Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of hospital and ICU admission. The central and peripheral nervous system may be the first organ system to ... ...

    Abstract Purpose of review: Sepsis, defined as life-threatening organ dysfunction caused by a dysregulated host response to infection, is a leading cause of hospital and ICU admission. The central and peripheral nervous system may be the first organ system to show signs of dysfunction, leading to clinical manifestations such as sepsis-associated encephalopathy (SAE) with delirium or coma and ICU-acquired weakness (ICUAW). In the current review, we want to highlight developing insights into the epidemiology, diagnosis, prognosis, and treatment of patients with SAE and ICUAW.
    Recent findings: The diagnosis of neurological complications of sepsis remains clinical, although the use of electroencephalography and electromyography can support the diagnosis, especially in noncollaborative patients, and can help in defining disease severity. Moreover, recent studies suggest new insights into the long-term effects associated with SAE and ICUAW, highlighting the need for effective prevention and treatment.
    Summary: In this manuscript, we provide an overview of recent insights and developments in the prevention, diagnosis, and treatment of patients with SAE and ICUAW.
    MeSH term(s) Humans ; Sepsis/complications ; Sepsis/therapy ; Sepsis-Associated Encephalopathy/diagnosis ; Sepsis-Associated Encephalopathy/epidemiology ; Prognosis ; Coma ; Hospitalization
    Language English
    Publishing date 2023-02-15
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 1235629-3
    ISSN 1531-7072 ; 1070-5295
    ISSN (online) 1531-7072
    ISSN 1070-5295
    DOI 10.1097/MCC.0000000000001022
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  10. Article ; Online: Long-term complications of COVID-19 in ICU survivors: what do we know?

    Rasulo, Frank A / Piva, Simone / Latronico, Nicola

    Minerva anestesiologica

    2021  Volume 88, Issue 1-2, Page(s) 72–79

    Abstract: Coronavirus disease 2019 (COVID-19) has caused more than 175 million persons infected and 3.8 million deaths so far and is having a devastating impact on both low and high-income countries, in particular on hospitals and Intensive Care Units (ICU). The ... ...

    Abstract Coronavirus disease 2019 (COVID-19) has caused more than 175 million persons infected and 3.8 million deaths so far and is having a devastating impact on both low and high-income countries, in particular on hospitals and Intensive Care Units (ICU). The ICU mortality during the first pandemic wave ranged from 40% to 85% during the busiest ICU period for admissions around the peak of the surge, and those surviving are frequently faced with impairments affecting physical, cognitive, and mental health status, complicating the postacute phase of COVID-19, which in the pre-COVID period, were defined collectively as postintensive care syndrome (PICS). Long COVID is defined as four weeks of persisting symptoms after the acute illness, and post-COVID syndrome and chronic COVID-19 are the proposed terms to describe continued symptomatology for more than 12 weeks. Overall, 50% of ICU survivors suffer from new physical, mental, and/or cognitive problems at 1 year after ICU discharge. The prevalence, severity, and duration of the various impairments in ICU survivors are poorly defined, with substantial variations among published series, and may reflect differences in the timing of assessment, the outcome measured, the instruments utilized, and thresholds adopted to establish the diagnosis, the qualification of personnel delivering the tests, the resource availability as well diversity in patients' case-mix. Future longitudinal studies of adequate sample size with repeated assessments of validated outcomes and comparison with non-COVID-19 ICU patients are needed to fully explore the long-term outcome of ICU patients with COVID-19. In this article, we focus on chronic COVID-19 in ICU survivors and present state-of-the-art data regarding long-term complications related to critical illness and the treatments and organ support received.
    MeSH term(s) COVID-19/complications ; Critical Care/psychology ; Critical Illness ; Humans ; Intensive Care Units ; SARS-CoV-2 ; Survivors/psychology
    Language English
    Publishing date 2021-10-28
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.21.16032-8
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