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Article ; Online: IgG4-assoziierte Erkrankung.

Schirmer, Jan H / Hoyer, Bimba F

Deutsche medizinische Wochenschrift (1946)

2019 Volume 144, Issue 24, Page(s) 1726–1730

Abstract: IgG4-related disease (IgG4-RD) is an entity first described less than 20 years ago, characterized by tumorous swelling of affected organs. Differentiation from malignant disease, systemic infections and other systemic autoimmune diseases can be ... ...

Title translation	IgG4-related disease.
Abstract	IgG4-related disease (IgG4-RD) is an entity first described less than 20 years ago, characterized by tumorous swelling of affected organs. Differentiation from malignant disease, systemic infections and other systemic autoimmune diseases can be challenging. Typical histopathologic findings facilitate a diagnosis in a compatible clinical context. Because nearly every organ system can be affected, management of IgG4-RD is a challenging task requiring multidisciplinary work-up and treatment. Medical treatment usually consists of glucocorticoids, which may be combined with other immunosuppressives. Surgical or interventional treatment may be necessary if complications arise. Since high-quality evidence is lacking for most aspects of the management of IgG4-RD, international collaborative studies are urgently needed.
MeSH term(s)	Glucocorticoids/therapeutic use ; Humans ; Immunoglobulin G4-Related Disease/diagnosis ; Immunoglobulin G4-Related Disease/pathology ; Immunoglobulin G4-Related Disease/therapy ; Immunosuppressive Agents/therapeutic use
Chemical Substances	Glucocorticoids ; Immunosuppressive Agents
Language	German
Publishing date	2019-12-02
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/a-0857-1007
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Article ; Online: Update: Polyarteriitis nodosa.

Schirmer, Jan H / Moosig, Frank

Zeitschrift fur Rheumatologie

2018 Volume 77, Issue 5, Page(s) 397–408

Abstract: Polyarteritis nodosa (PAN) is a necrotizing arteritis of medium-sized vessels, which is often fatal if untreated. It frequently affects the skin (nodules and ulcers), the peripheral nervous system (mononeuritis multiplex) and the visceral vessels ( ... ...

Title translation	Update: polyarteritis nodosa.
Abstract	Polyarteritis nodosa (PAN) is a necrotizing arteritis of medium-sized vessels, which is often fatal if untreated. It frequently affects the skin (nodules and ulcers), the peripheral nervous system (mononeuritis multiplex) and the visceral vessels (stenoses and microaneurysms). The complex diagnostic work-up requires discriminating PAN from infectious, malignant, drug-induced and other inflammatory conditions. It can be subclassified into further variants (idiopathic, associated with hepatitis B, associated with hereditary inflammatory diseases or isolated cutaneous disease). While idiopathic and hereditary inflammatory variants require immunosuppressive treatment, the hepatitis B-associated variant is treated with virustatic agents and plasmapheresis. The isolated cutaneous variant has a good prognosis and rarely requires highly potent immunosuppressives.
MeSH term(s)	Hepatitis B/complications ; Humans ; Immunosuppressive Agents ; Plasmapheresis ; Polyarteritis Nodosa/complications ; Polyarteritis Nodosa/diagnosis ; Polyarteritis Nodosa/therapy
Chemical Substances	Immunosuppressive Agents
Language	German
Publishing date	2018-04-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	124985-x
ISSN	1435-1250 ; 0340-1855 ; 0301-6382
ISSN (online)	1435-1250
ISSN	0340-1855 ; 0301-6382
DOI	10.1007/s00393-018-0469-7
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Article ; Online: NT-ProBNP and high-sensitivity troponin T as screening tests for subclinical chronic heart failure in a general population.

Averina, Maria / Stylidis, Michael / Brox, Jan / Schirmer, Henrik

ESC heart failure

2022 Volume 9, Issue 3, Page(s) 1954–1962

Abstract: Aims: The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as ... ...

Abstract	Aims: The aim of this study was to establish age-specific and sex-specific cut-off values for N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitivity troponin T (hs-troponin T) in healthy subjects and assess cardiac biomarkers as screening tools for subclinical heart failure (HF) in a general population. Methods and results: Altogether, 1936 participants were randomly selected from the general population Tromsø 7 study in Northern Norway. Diagnostic accuracy (sensitivity, specificity, and negative and positive predictive value) of cardiac markers for echocardiographically defined subclinical HF was evaluated. The receiver-operating characteristic analysis showed that areas under the curve were relatively low (under 0.75) for both NT-proBNP and hs-troponin T, suggesting that the diagnostic accuracy of these biomarkers for subclinical HF was not excellent, especially for mild forms of HF and younger age group 40-49 years. Sex-specific and age-specific cut-offs for hs-troponin T (99th percentiles) and NT-proBNP (97.5th percentiles) were established in healthy subjects from the same general population. The sex-specific and age-specific cut-offs for NT-proBNP had higher specificity for subclinical HF compared with the previously established single cut-off 125 pg/mL. Age-specific cut-off for hs-troponin T (18 ng/L) for men ≥60 years had also higher specificity than the single cut-off 14 ng/L. These cut-offs had high specificity, but low sensitivity, that makes hs-troponin T and NT-proBNP good biomarkers to rule in HF in case of a positive test, but not good enough to rule out all unrecognized HF due to false negative results. Conclusions: N-terminal pro-brain natriuretic peptide and hs-troponin T are suboptimal screening tools for subclinical HF in a general population due to low sensitivity.
MeSH term(s)	Adult ; Biomarkers ; Chronic Disease ; Female ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Humans ; Male ; Middle Aged ; Natriuretic Peptide, Brain ; Peptide Fragments ; Troponin T
Chemical Substances	Biomarkers ; Peptide Fragments ; Troponin T ; pro-brain natriuretic peptide (1-76) ; Natriuretic Peptide, Brain (114471-18-0)
Language	English
Publishing date	2022-03-23
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2814355-3
ISSN	2055-5822 ; 2055-5822
ISSN (online)	2055-5822
ISSN	2055-5822
DOI	10.1002/ehf2.13906
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Article ; Online: S1-Leitlinie Diagnostik und Therapie der ANCA-assoziierten Vaskulitiden.

Schirmer, Jan H / Moosig, Frank

Zeitschrift fur Rheumatologie

2017 Volume 76, Issue Suppl 3, Page(s) 75–76

Title translation	S1 guidelines on diagnostics and treatment of ANCA-associated vasculitis.
MeSH term(s)	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/diagnosis ; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis/therapy ; Antibodies, Antineutrophil Cytoplasmic ; Humans
Chemical Substances	Antibodies, Antineutrophil Cytoplasmic
Language	German
Publishing date	2017-10-25
Publishing country	Germany
Document type	Editorial
ZDB-ID	124985-x
ISSN	1435-1250 ; 0340-1855 ; 0301-6382
ISSN (online)	1435-1250
ISSN	0340-1855 ; 0301-6382
DOI	10.1007/s00393-017-0393-2
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Article: IgG4-assoziierte Erkrankung

Schirmer, Jan H. / Hoyer, Bimba F.

DMW - Deutsche Medizinische Wochenschrift

2019 Volume 144, Issue 24, Page(s) 1726–1730

Abstract: Übersicht und Nomenklatur: Die IgG4-assoziierte Erkrankung (IgG4-RD) ist eine erst kürzlich beschriebene heterogene Krankheitsentität, der viele vorher als eigenständige Einzelorganerkrankungen interpretierte Manifestationen zugerechnet werden. ... ...

Abstract	Übersicht und Nomenklatur: Die IgG4-assoziierte Erkrankung (IgG4-RD) ist eine erst kürzlich beschriebene heterogene Krankheitsentität, der viele vorher als eigenständige Einzelorganerkrankungen interpretierte Manifestationen zugerechnet werden. Hauptsymptom ist die Schwellung oder Vergrößerung betroffener Organe. Diagnose und Klassifikation: Die Diagnose wird in Zusammenschau von Anamnese, klinischem Bild, Bildgebung, Histopathologie und IgG4-spezifischen Tests in Labor und Histologie gestellt. Labor und Bildgebung: Häufige Laborbefunde sind: erhöhtes Serum-IgG4, IgE und CRP, Hypergammaglobulinämie, Hypokomplementämie und Eosinophilie. Histopathologie.: Das typische Bild umfasst folgende Hauptcharakteristika: dichte lymphoplasmazelluläre Infiltrate, storiforme Fibrose und obliterative Phlebitis. Ferner treten vermehrte IgG4-positive Plasmazellen auf. Differenzialdiagnostische Abgrenzung: Diverse andere Krankheitsbilder können die IgG4-RD imitieren. Medikamentöse Therapie: Neu sind eine Studie zu Mycophenolat-Mofetil und Daten zu Rituximab bei sonst weitgehend fehlender Evidenz aus Studien zur Behandlung der IgG4-RD. Glukokortikoide: Glukokortikoide (GC) sind die Grundlage der medikamentösen Therapie. Konventionelle Immunsuppressiva: Es herrscht weiterhin kein Konsens, ob konventionelle Immunsuppressiva als GC-sparende Therapie immer oder nur in besonderen Fällen Teil der medikamentösen Therapie sein sollten. Biologika: Rituximab ist eine etablierte Reservetherapie. Interventionelle und chirurgische Verfahren: Mechanische Obstruktionen und Kompressionen können chirurgische und interventionelle Verfahren notwendig machen.
Keywords	Immunsuppression ; Plasmablasten ; Diagnostik ; Therapie ; immunosuppression ; plasmablasts ; diagnostics ; therapy
Language	German
Publishing date	2019-12-01
Publisher	© Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	200446-x
ISSN	1439-4413 ; 0012-0472
ISSN (online)	1439-4413
ISSN	0012-0472
DOI	10.1055/a-0857-1007
Database	Thieme publisher's database

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Article: Inhibition of TRIF-Dependent Inflammation Decelerates Afterload-Induced Myocardial Remodeling.

Bettink, Stephanie I / Reil, Jan-Christian / Kazakov, Andrey / Körbel, Christina / Millenaar, Dominic / Laufs, Ulrich / Scheller, Bruno / Böhm, Michael / Schirmer, Stephan H

Biomedicines

2022 Volume 10, Issue 10

Abstract: Pressure-overload-induced cardiac hypertrophy represents one cause of the development of heart failure. The aim of this study is to characterize the influence of the TIR-domain-containing adapter-inducing interferon-β (TRIF) during afterload-induced ... ...

Abstract	Pressure-overload-induced cardiac hypertrophy represents one cause of the development of heart failure. The aim of this study is to characterize the influence of the TIR-domain-containing adapter-inducing interferon-β (TRIF) during afterload-induced myocardial remodeling. After trans-aortic constriction (TAC), cardiac pressure overload leads to an early increase in MyD88- (Myeloid differentiation primary response gene 88) and TRIF-dependent cytokines. The maximum cytokine expression appeared within the first week and decreased to its control level within five weeks. While cardiomyocyte hypertrophy was comparable, the myocardial accumulation of the inflammatory cells was lower in TRIF
Language	English
Publishing date	2022-10-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2720867-9
ISSN	2227-9059
ISSN	2227-9059
DOI	10.3390/biomedicines10102636
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Article ; Online: Endovascular therapy for anterior circulation emergent large vessel occlusion stroke in patients with large ischemic cores: a report of the SNIS Standards and Guidelines Committee.

Al-Mufti, Fawaz / Marden, Franklin A / Burkhardt, Jan Karl / Raper, Daniel / Schirmer, Clemens M / Baker, Amanda / Chen, Peng Roc / Bulsara, Ketan R / Narsinh, Kazim H / Amans, Matthew Robert / Cooper, Jared / Yaghi, Shadi / Al-Kawaz, Mais / Hetts, Steven W

Journal of neurointerventional surgery

2024

Abstract: Background: Early clinical trials validating endovascular therapy (EVT) for emergent large vessel occlusion (ELVO) ischemic stroke in the anterior circulation initially focused on patients with small or absent completed infarctions (ischemic cores) to ... ...

Abstract	Background: Early clinical trials validating endovascular therapy (EVT) for emergent large vessel occlusion (ELVO) ischemic stroke in the anterior circulation initially focused on patients with small or absent completed infarctions (ischemic cores) to maximize the probability of detecting a clinically meaningful and statistically significant benefit of EVT. Subsequently, real-world experience suggested that patients with large core ischemic strokes (LCS) at presentation may also benefit from EVT. Several large, retrospective, and prospective randomized clinical trials have recently been published that further validate this approach. These guidelines aim to provide an update for endovascular treatment of LCS. Methods: A structured literature review of LCS studies available since 2019 and grading the strength and quality of the evidence was performed. Recommendations were made based on these new data by consensus of the authors, with additional input from the full SNIS Standards and Guidelines Committee and the SNIS Board of Directors. Results: The management of ELVO strokes with large ischemic cores continues to evolve. The expert panel agreed on several recommendations: Recommendation 1: In patients with anterior circulation ELVO who present within 24 hours of last known normal with large infarct core (70-149 mL or ASPECTS 3-5) and meet other criteria of RESCUE-Japan LIMIT, SELECT2, ANGEL-ASPECT, TESLA, TENSION, or LASTE trials, thrombectomy is indicated (Class I, Level A). Recommendations 2-7 flow directly from recommendation 1. Recommendation 2: EVT in patients with LCS aged 18-85 years is beneficial (Class I, Level A). Recommendation 3: EVT in patients with LCS >85 years of age may be beneficial (Class I, Level B-R). Recommendation 4: Patients with LCS and NIHSS score 6-30 benefit from EVT in LCS (Class I, Level A). Recommendation 5: Patients with LCS and NIHSS score <6 and >30 may benefit from EVT in LCS (Class IIa, Level A). Recommendation 6: Patients with LCS and low baseline mRS (0-1) benefit from EVT (Class I, Level A). Recommendation 7: Patients with LCS and time of last known well 0-24 hours benefit from EVT (Class I, Level A). Recommendation 8: It is recommended that patients with ELVO LCS who also meet the criteria for on-label or guideline-directed use of IV thrombolysis receive IV thrombolysis, irrespective of whether endovascular treatments are being considered (Class I, Level B-NR). Conclusions: The indications for endovascular treatment of ELVO strokes continue to expand and now include patients with large ischemic cores on presentation. Further prospective randomized studies, including follow-up to assess the population-based efficacy of treating patients with LCS, are warranted.
Language	English
Publishing date	2024-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/jnis-2023-021444
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Article ; Online: A prospective, randomized, controlled, multicentre trial for secondary prevention in patients with chronic coronary syndrome using a smartphone application for digital therapy: the CHANGE study protocol.

Düsing, Philip / Eckardt, Irina / Schirmer, Stephan H / Sinning, Jan-Malte / Werner, Nikos / Bönner, Florian / Krogmann, Alexander / Schäfer, Sebastian / Sedaghat, Alexander / Müller, Cornelius / Nickenig, Georg / Zietzer, Andreas

European heart journal. Digital health

2023 Volume 4, Issue 3, Page(s) 207–215

Abstract: Aims: Coronary artery disease (CAD) remains the leading cause of death worldwide. 'Stable' CAD is a chronic progressive condition, which recent European guidelines recommend referring to as 'chronic coronary syndrome' (CCS). Despite therapeutic advances, ...

Abstract	Aims: Coronary artery disease (CAD) remains the leading cause of death worldwide. 'Stable' CAD is a chronic progressive condition, which recent European guidelines recommend referring to as 'chronic coronary syndrome' (CCS). Despite therapeutic advances, morbidity and mortality among patients with CCS remain high. Optimal secondary prevention in patients with CCS includes optimization of modifiable risk factors with behavioural changes and pharmacological therapy. The CHANGE study aims to provide evidence for optimization of secondary prevention in CCS patients by using a smartphone application (app). Methods and results: The CHANGE study is designed as a prospective, randomized, controlled trial with a 1:1 allocation ratio, which is currently performed in nine centres in Germany in a parallel group design. 210 patients with CCS will be randomly allocated either to the control group (standard-of-care) or to the intervention group, who will be provided the VantisTherapy* app in addition to standard-of-care to incorporate secondary prevention into their daily life. The study will be performed in an open design. Outcomes will be assessed using objective data from three in-person visits (0, 12, and 24 weeks). Primary outcomes will involve adherence to secondary prevention recommendations and quality of life (QoL). The recruitment process started in July 2022. Conclusion: The CHANGE study will investigate whether a smartphone-guided secondary prevention app, combined with a monitor function compared with standard-of-care, has beneficial effects on overall adherence to secondary prevention guidelines and QoL in patients with CCS. Trial registration: The study is listed at the German study registry (DRKS) under the registered number DRKS00028081.
Language	English
Publishing date	2023-02-15
Publishing country	England
Document type	Journal Article
ISSN	2634-3916
ISSN (online)	2634-3916
DOI	10.1093/ehjdh/ztad012
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Article: Prevention of peri-interventional hypothermia during endoscopic retrograde cholangiopancreatography using a forced-air heating system.

Stahl, Klaus / Schuette, Eloise / Schirmer, Paul / Fuge, Jan / Weber, Anna-Lena / Heidrich, Benjamin / Schneider, Andrea / Pape, Thorben / Krauss, Terence / Wedemeyer, Heiner / Lenzen, Henrike

Endoscopy international open

2024 Volume 12, Issue 1, Page(s) E59–E67

Abstract: Background and study ... ...

Abstract	Background and study aims
Language	English
Publishing date	2024-01-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2761052-4
ISSN	2196-9736 ; 2364-3722
ISSN (online)	2196-9736
ISSN	2364-3722
DOI	10.1055/a-2210-4799
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Article ; Online: Contraction pressure analysis using optical imaging in normal and MYBPC3-mutated hiPSC-derived cardiomyocytes grown on matrices with tunable stiffness.

Snelders, Matthijs / Koedijk, Iris H / Schirmer, Julia / Mulleners, Otto / van Leeuwen, Juancito / de Wagenaar, Nathalie P / Bartulos, Oscar / Voskamp, Pieter / Braam, Stefan / Guttenberg, Zeno / Danser, A H Jan / Majoor-Krakauer, Danielle / Meijering, Erik / van der Pluijm, Ingrid / Essers, Jeroen

Biomaterials and biosystems

2022 Volume 8, Page(s) 100068

Abstract: ... ...

Abstract	Current
Language	English
Publishing date	2022-10-17
Publishing country	England
Document type	Journal Article
ISSN	2666-5344
ISSN (online)	2666-5344
DOI	10.1016/j.bbiosy.2022.100068
Database	MEDical Literature Analysis and Retrieval System OnLINE

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