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Book ; Online: Classifying Rhoticity of /r/ in Speech Sound Disorder using Age-and-Sex Normalized Formants

Benway, Nina R / Preston, Jonathan L / Salekin, Asif / Xiao, Yi / Sharma, Harshit / McAllister, Tara

2023

Abstract: ... impacting, e.g., /r/. We show age-and-sex normalized formant estimation outperforms cepstral representation ... for detection of fully rhotic vs. derhotic /r/ in the PERCEPT-R Corpus. Gated recurrent neural networks trained ...

Abstract	Mispronunciation detection tools could increase treatment access for speech sound disorders impacting, e.g., /r/. We show age-and-sex normalized formant estimation outperforms cepstral representation for detection of fully rhotic vs. derhotic /r/ in the PERCEPT-R Corpus. Gated recurrent neural networks trained on this feature set achieve a mean test participant-specific F1-score =.81 ({\sigma}x=.10, med = .83, n = 48), with post hoc modeling showing no significant effect of child age or sex. Comment: To appear in Proceedings of the Annual Conference of the International Speech Communication Association, INTERSPEECH 2023
Keywords	Electrical Engineering and Systems Science - Audio and Speech Processing
Publishing date	2023-05-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Tutorial: Motor-Based Treatment Strategies for /r/ Distortions.

Preston, Jonathan L / Benway, Nina R / Leece, Megan C / Hitchcock, Elaine R / McAllister, Tara

Language, speech, and hearing services in schools

2020 Volume 51, Issue 4, Page(s) 966–980

Abstract: Purpose This tutorial summarizes current best practices in treating American English /r ... and feedback, the phonetics of /r/ production is reviewed. Principles of acquisition, which can inform ... how to practice /r/ in the early stages of therapy, are explained. Elements of therapy that lack ...

Abstract	Purpose This tutorial summarizes current best practices in treating American English /r/ distortions in children with residual speech errors. Method To enhance the effectiveness of clinicians' cueing and feedback, the phonetics of /r/ production is reviewed. Principles of acquisition, which can inform how to practice /r/ in the early stages of therapy, are explained. Elements of therapy that lack scientific support are also mentioned. Results Although there is significant variability in /r/ production, the common articulatory requirements include an oral constriction, a pharyngeal constriction, tongue body lowering, lateral bracing, and slight lip rounding. Examples of phonetic cues and shaping strategies are provided to help clinicians elicit these movements to evoke correct /r/ productions. Principles of acquisition (e.g., blocked practice, frequent knowledge of performance feedback) are reviewed to help clinicians structure the earliest stages of treatment to establish /r/. Examples of approaches that currently lack scientific support include nonspeech oral motor exercises, tactile cues along the mylohyoid muscle, and heterogeneous groupings in group therapy. Conclusion Treatment strategies informed by phonetic science and motor learning theory can be implemented by all clinicians to enhance acquisition of /r/ for children with residual errors. Supplemental Material https://doi.org/10.23641/asha.12771329.
MeSH term(s)	Child ; Cues ; Exercise ; Humans ; Language ; Phonetics ; Speech/physiology ; Speech Production Measurement/methods ; Speech Sound Disorder/therapy ; Speech Therapy/methods ; Tongue/physiology
Language	English
Publishing date	2020-08-12
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	2067619-0
ISSN	1558-9129 ; 0161-1461
ISSN (online)	1558-9129
ISSN	0161-1461
DOI	10.1044/2020_LSHSS-20-00012
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Article ; Online: Timing of high-dose methotrexate CNS prophylaxis in DLBCL: an analysis of toxicity and impact on R-CHOP delivery.

Blood advances

2020 Volume 4, Issue 15, Page(s) 3586–3593

Abstract: ... limited evidence to guide whether to intercalate HD-MTX (i-HD-MTX) between R-CHOP-21 (rituximab ... of treatment (EOT) with R-CHOP-21. We conducted a retrospective, multicenter analysis of 334 patients ... were R-CHOP delay rates and HD-MTX toxicity. Secondary end points were CNS relapse rate ...

Abstract	High-dose methotrexate (HD-MTX) is increasingly used as prophylaxis for patients with diffuse large B-cell lymphoma (DLBCL) at high risk of central nervous system (CNS) relapse. However, there is limited evidence to guide whether to intercalate HD-MTX (i-HD-MTX) between R-CHOP-21 (rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone given at 21-day intervals) or to give it at the end of treatment (EOT) with R-CHOP-21. We conducted a retrospective, multicenter analysis of 334 patients with DLBCL who received CNS prophylaxis with i-HD-MTX (n = 204) or EOT HD-MTX (n = 130). Primary end points were R-CHOP delay rates and HD-MTX toxicity. Secondary end points were CNS relapse rate, progression-free survival, and overall survival. The EOT group had more patients with a high CNS international prognostic index (58% vs 39%; P < .001) and more concurrent intrathecal prophylaxis (56% vs 34%; P < .001). Of the 409 cycles of i-HD-MTX given, 82 (20%) were associated with a delay of next R-CHOP (median, 7 days). Delays were significantly increased when i-HD-MTX was given after day 9 post-R-CHOP (26% vs 16%; P = .01). On multivariable analysis, i-HD-MTX was independently associated with increased R-CHOP delays. Increased mucositis, febrile neutropenia, and longer median inpatient stay were recorded with i-HD-MTX delivery. Three-year cumulative CNS relapse incidence was 5.9%, with no differences between groups. There was no difference in survival between groups. We report increased toxicity and R-CHOP delay with i-HD-MTX compared with EOT delivery but no difference in CNS relapse or survival. Decisions on HD-MTX timing should be individualized and, where i-HD-MTX is favored, we recommend scheduling before day 10 of R-CHOP cycles.
MeSH term(s)	Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Central Nervous System Neoplasms/drug therapy ; Cyclophosphamide/adverse effects ; Doxorubicin/adverse effects ; Humans ; Lymphoma, Large B-Cell, Diffuse/drug therapy ; Methotrexate/adverse effects ; Neoplasm Recurrence, Local/drug therapy ; Retrospective Studies ; Rituximab/adverse effects ; Vincristine/adverse effects
Chemical Substances	Rituximab (4F4X42SYQ6) ; Vincristine (5J49Q6B70F) ; Doxorubicin (80168379AG) ; Cyclophosphamide (8N3DW7272P) ; Methotrexate (YL5FZ2Y5U1)
Language	English
Publishing date	2020-08-06
Publishing country	United States
Document type	Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
ZDB-ID	2915908-8
ISSN	2473-9537 ; 2473-9529
ISSN (online)	2473-9537
ISSN	2473-9529
DOI	10.1182/bloodadvances.2020002421
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Article: Longitudinal diffusion and volumetric kinetics of head and neck cancer magnetic resonance on a 1.5T MR-Linear accelerator hybrid system: A prospective R-IDEAL Stage 2a imaging biomarker characterization/ pre-qualification study.

El-Habashy, Dina M / Wahid, Kareem A / He, Renjie / McDonald, Brigid / Rigert, Jillian / Mulder, Samuel J / Lim, Tze Yee / Wang, Xin / Yang, Jinzhong / Ding, Yao / Naser, Mohamed A / Ng, Sweet Ping / Bahig, Houda / Salzillo, Travis C / Preston, Kathryn E / Abobakr, Moamen / Shehata, Mohamed A / Elkhouly, Enas A / Alagizy, Hagar A /

Hegazy, Amira H / Mohammadseid, Mustefa / Terhaard, Chris / Philippens, Marielle / Rosenthal, David I / Wang, Jihong / Lai, Stephen Y / Dresner, Alex / Christodouleas, John C / Mohamed, Abdallah Sherif Radwan / Fuller, Clifton D

medRxiv : the preprint server for health sciences

2023

Abstract: ... for head and neck squamous cell carcinoma (HNSCC) patients as part of a programmatic R-IDEAL biomarker ...

Abstract	Objectives: We aim to characterize the serial quantitative apparent diffusion coefficient (ADC) changes of the target disease volume using diffusion-weighted imaging (DWI) acquired weekly during radiation therapy (RT) on a 1.5T MR-Linac and correlate these changes with tumor response and oncologic outcomes for head and neck squamous cell carcinoma (HNSCC) patients as part of a programmatic R-IDEAL biomarker characterization effort. Methods: Thirty patients with pathologically confirmed HNSCC who received curative-intent RT at the University of Texas MD Anderson Cancer Center, were included in this prospective study. Baseline and weekly Magnetic resonance imaging (MRI) (weeks 1-6) were obtained, and various ADC parameters (mean, 5 Results: There was an overall significant rise in all ADC parameters during different time points of RT compared to baseline values for both gross primary disease volume (GTV-P) and gross nodal disease volumes (GTV-N). The increased ADC values for GTV-P were statistically significant only for primary tumors achieving complete remission (CR) during RT. RPA identified GTV-P ΔADC 5 Conclusion: Assessment of ADC kinetics at regular intervals throughout RT seems to be correlated with RT response. Further studies with larger cohorts and multi-institutional data are needed for validation of ΔADC as a model for prediction of response to RT.
Language	English
Publishing date	2023-05-05
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.05.04.23289527
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Article: A Rare Case of Nodular Mantle Cell Lymphoma of the Gastrointestinal Tract Discovered During a Routine Colonoscopy With a Positive Response to R-CHOP Chemotherapy Regimen.

Chauhan, Sukhjinder / Valenta, Jordan / Dhillon, Gundip S / Phan, Preston / Huh, Yongwoon / Manov, Andre E / Wierman, Ann

Cureus

2023 Volume 15, Issue 7, Page(s) e42516

Abstract: ... vincristine, and prednisone (R-CHOP) chemotherapy, resulting in tumor reduction and adenopathy resolution ... appropriate treatment which in our case was R-CHOP, and personalized management approaches in addressing MCL. ...

Abstract	This report describes the case of a 73-year-old female patient who presented with abdominal symptoms. A colonoscopy identified a cecal mass confirmed as mantle cell lymphoma (MCL). Imaging showed extensive lymph node involvement. The patient received rituximab, cyclophosphamide, hydroxydaunorubicin, vincristine, and prednisone (R-CHOP) chemotherapy, resulting in tumor reduction and adenopathy resolution. Despite a typically unfavorable prognosis associated with a high Ki-67 index, the patient responded well to chemotherapy and achieved a favorable outcome. This case highlights the importance of early detection, appropriate treatment which in our case was R-CHOP, and personalized management approaches in addressing MCL.
Language	English
Publishing date	2023-07-26
Publishing country	United States
Document type	Case Reports
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.42516
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Article ; Online: IgE epitopes of Ara h 9, Jug r 3, and Pru p 3 in peanut-allergic individuals from Spain and the US.

Kronfel, Christina M / Cheng, Hsiaopo / McBride, Jane K / Nesbit, Jacqueline B / Krouse, Rebecca / Burns, Preston / Cabanillas, Beatriz / Crespo, Jesus F / Ryan, Robert / Simon, Reyna J / Maleki, Soheila J / Hurlburt, Barry K

Frontiers in allergy

2023 Volume 3, Page(s) 1090114

Abstract: ... in immunoglobulin (Ig) E binding patterns to the peanut allergen Ara h 9 and two homologous LTPs (walnut Jug r 3 and ... Synthetic overlapping 15-amino acid-long peptides offset by five amino acids from Ara h 9, Jug r 3, and Pru ... from Spain were also tested. Similar IgE binding profiles for Ara h 9, Jug r 3, and Pru p 3 were identified ...

Abstract	Non-specific lipid transfer proteins (LTPs) are well studied allergens that can lead to severe reactions, but often cause oral allergy syndrome in the Mediterranean area and other European countries. However, studies focused on LTP reactivity in allergic individuals from the United States are lacking because they are not considered major allergens. The goal of this study is to determine if differences in immunoglobulin (Ig) E binding patterns to the peanut allergen Ara h 9 and two homologous LTPs (walnut Jug r 3 and peach Pru p 3) between the US and Spain contribute to differences observed in allergic reactivity. Synthetic overlapping 15-amino acid-long peptides offset by five amino acids from Ara h 9, Jug r 3, and Pru p 3 were synthesized, and the intact proteins were attached to microarray slides. Sera from 55 peanut-allergic individuals from the US were tested for IgE binding to the linear peptides and IgE binding to intact proteins using immunofluorescence. For comparison, sera from 17 peanut-allergic individuals from Spain were also tested. Similar IgE binding profiles for Ara h 9, Jug r 3, and Pru p 3 were identified between the US and Spain, with slight differences. Certain regions of the proteins, specifically helices 1 and 2 and the C-terminal coil, were recognized by the majority of the sera more often than other regions of the proteins. While serum IgE from peanut-allergic individuals in the US binds to peptides of Ara h 9 and its homologs, only IgE from the Spanish subjects bound to the intact LTPs. This study identifies Ara h 9, Jug r 3, and Pru p 3 linear epitopes that were previously unidentified using sera from peanut-allergic individuals from the US and Spain. Certain regions of the LTPs are recognized more often in US subjects, indicating that they represent conserved and possible cross-reactive regions. The location of the epitopes in 3D structure models of the LTPs may predict the location of potential conformational epitopes bound by a majority of the Spanish patient sera. These findings are potentially important for development of peptide or protein-targeting diagnostic and therapeutic tools for food allergy.
Language	English
Publishing date	2023-01-09
Publishing country	Switzerland
Document type	Journal Article
ISSN	2673-6101
ISSN (online)	2673-6101
DOI	10.3389/falgy.2022.1090114
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Book ; Online: Acoustic-to-Articulatory Speech Inversion Features for Mispronunciation Detection of /r/ in Child Speech Sound Disorders

Benway, Nina R / Siriwardena, Yashish M / Preston, Jonathan L / Hitchcock, Elaine / McAllister, Tara / Espy-Wilson, Carol

2023

Abstract: Acoustic-to-articulatory speech inversion could enhance automated clinical mispronunciation detection to provide detailed articulatory feedback unattainable by formant-based mispronunciation detection algorithms; however, it is unclear the extent to ... ...

Abstract	Acoustic-to-articulatory speech inversion could enhance automated clinical mispronunciation detection to provide detailed articulatory feedback unattainable by formant-based mispronunciation detection algorithms; however, it is unclear the extent to which a speech inversion system trained on adult speech performs in the context of (1) child and (2) clinical speech. In the absence of an articulatory dataset in children with rhotic speech sound disorders, we show that classifiers trained on tract variables from acoustic-to-articulatory speech inversion meet or exceed the performance of state-of-the-art features when predicting clinician judgment of rhoticity. Index Terms: rhotic, speech sound disorder, mispronunciation detection Comment: *denotes equal contribution. To appear in Proceedings of the Annual Conference of the International Speech Communication Association, INTERSPEECH 2023
Keywords	Electrical Engineering and Systems Science - Audio and Speech Processing
Publishing date	2023-05-25
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites.

Pugh, C Preston / Pouncey, Dakota L / Hartman, Jessica H / Nshimiyimana, Robert / Desrochers, Linda P / Goodwin, Thomas E / Boysen, Gunnar / Miller, Grover P

Archives of biochemistry and biophysics

2014 Volume 564, Page(s) 244–253

Abstract: The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 ... glucuronidation of R- and S-7-hydroxywarfarin. Both compounds underwent glucuronidation at C4 and C7 hydroxyl ... efficient for R-7-hydroxywarfarin due to higher affinity and rates of turnover. The use of these mechanisms ...

Abstract	The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 into hydroxywarfarins that subsequently become conjugated for excretion in urine. Hydroxywarfarins may modulate warfarin metabolism transcriptionally or through direct inhibition of cytochromes P450 and thus, UGT action toward hydroxywarfarin elimination may impact levels of the parent drugs and patient responses. Nevertheless, relatively little is known about conjugation by UDP-glucuronosyltransferases in warfarin metabolism. Herein, we identified probable conjugation sites, kinetic mechanisms and hepatic UGT isoforms involved in microsomal glucuronidation of R- and S-7-hydroxywarfarin. Both compounds underwent glucuronidation at C4 and C7 hydroxyl groups based on elution properties and spectral characteristics. Their formation demonstrated regio- and enantioselectivity by UGTs and resulted in either Michaelis-Menten or substrate inhibition kinetics. Glucuronidation at the C7 hydroxyl group occurred more readily than at the C4 group, and the reaction was overall more efficient for R-7-hydroxywarfarin due to higher affinity and rates of turnover. The use of these mechanisms and parameters to model in vivo clearance demonstrated that contributions of substrate inhibition would lead to underestimation of metabolic clearance than that predicted by Michaelis-Menten kinetics. Lastly, these processes were driven by multiple UGTs indicating redundancy in glucuronidation pathways and ultimately metabolic clearance of R- and S-7-hydroxywarfarin.
MeSH term(s)	Anticoagulants/chemistry ; Anticoagulants/pharmacokinetics ; Anticoagulants/pharmacology ; Glucuronosyltransferase/metabolism ; Humans ; Kinetics ; Microsomes, Liver/enzymology ; Warfarin/chemistry ; Warfarin/pharmacokinetics ; Warfarin/pharmacology
Chemical Substances	Anticoagulants ; Warfarin (5Q7ZVV76EI) ; Glucuronosyltransferase (EC 2.4.1.17)
Language	English
Publishing date	2014-12-15
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2014.10.006
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: An eight-channel T/R head coil for parallel transmit MRI at 3T using ultra-low output impedance amplifiers.

Moody, Katherine Lynn / Hollingsworth, Neal A / Zhao, Feng / Nielsen, Jon-Fredrik / Noll, Douglas C / Wright, Steven M / McDougall, Mary Preston

Journal of magnetic resonance (San Diego, Calif. : 1997)

2014 Volume 246, Page(s) 62–68

Abstract: Parallel transmit is an emerging technology to address the technical challenges associated with MR imaging at high field strengths. When developing arrays for parallel transmit systems, one of the primary factors to be considered is the mechanism to ... ...

Abstract	Parallel transmit is an emerging technology to address the technical challenges associated with MR imaging at high field strengths. When developing arrays for parallel transmit systems, one of the primary factors to be considered is the mechanism to manage coupling and create independently operating channels. Recent work has demonstrated the use of amplifiers to provide some or all of the channel-to-channel isolation, reducing the need for on-coil decoupling networks in a manner analogous to the use of isolation preamplifiers with receive coils. This paper discusses an eight-channel transmit/receive head array for use with an ultra-low output impedance (ULOI) parallel transmit system. The ULOI amplifiers eliminated the need for a complex lumped element network to decouple the eight-rung array. The design and construction details of the array are discussed in addition to the measurement considerations required for appropriately characterizing an array when using ULOI amplifiers. B1 maps and coupling matrices are used to verify the performance of the system.
MeSH term(s)	Amplifiers, Electronic ; Electric Conductivity ; Equipment Design ; Equipment Failure Analysis ; Image Enhancement/instrumentation ; Magnetic Resonance Imaging/instrumentation ; Magnetics/instrumentation ; Phantoms, Imaging ; Reproducibility of Results ; Sensitivity and Specificity ; Signal-To-Noise Ratio ; Transducers
Language	English
Publishing date	2014-07-03
Publishing country	United States
Document type	Evaluation Study ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	1469665-4
ISSN	1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
ISSN (online)	1096-0856 ; 1557-8968
ISSN	1090-7807 ; 0022-2364
DOI	10.1016/j.jmr.2014.06.019
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Article: Multiple UDP-glucuronosyltransferases in human liver microsomes glucuronidate both R- and S-7-hydroxywarfarin into two metabolites

Preston Pugh, C / Pouncey, Dakota L / Hartman, Jessica H / Nshimiyimana, Robert / Desrochers, Linda P / Goodwin, Thomas E / Boysen, Gunnar / Miller, Grover P

Archives of biochemistry and biophysics. 2014 Dec. 15, v. 564

2014

Abstract	The widely used anticoagulant Coumadin (R/S-warfarin) undergoes oxidation by cytochromes P450 into hydroxywarfarins that subsequently become conjugated for excretion in urine. Hydroxywarfarins may modulate warfarin metabolism transcriptionally or through direct inhibition of cytochromes P450 and thus, UGT action toward hydroxywarfarin elimination may impact levels of the parent drugs and patient responses. Nevertheless, relatively little is known about conjugation by UDP-glucuronosyltransferases in warfarin metabolism. Herein, we identified probable conjugation sites, kinetic mechanisms and hepatic UGT isoforms involved in microsomal glucuronidation of R- and S-7-hydroxywarfarin. Both compounds underwent glucuronidation at C4 and C7 hydroxyl groups based on elution properties and spectral characteristics. Their formation demonstrated regio- and enantioselectivity by UGTs and resulted in either Michaelis–Menten or substrate inhibition kinetics. Glucuronidation at the C7 hydroxyl group occurred more readily than at the C4 group, and the reaction was overall more efficient for R-7-hydroxywarfarin due to higher affinity and rates of turnover. The use of these mechanisms and parameters to model in vivo clearance demonstrated that contributions of substrate inhibition would lead to underestimation of metabolic clearance than that predicted by Michaelis–Menten kinetics. Lastly, these processes were driven by multiple UGTs indicating redundancy in glucuronidation pathways and ultimately metabolic clearance of R- and S-7-hydroxywarfarin.
Keywords	anticoagulants ; cytochrome P-450 ; enantioselectivity ; enzyme kinetics ; excretion ; human cell lines ; liver microsomes ; metabolism ; metabolites ; models ; moieties ; oxidation ; patients ; spectral analysis ; transcription (genetics) ; transferases ; urine ; warfarin
Language	English
Dates of publication	2014-1215
Size	p. 244-253.
Publishing place	Elsevier Inc.
Document type	Article
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2014.10.006
Database	NAL-Catalogue (AGRICOLA)

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