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  1. Article: Topiramate: a viewpoint by Edward Faught.

    Faught, Edward

    CNS drugs

    2003  Volume 17, Issue 13, Page(s) 993–994

    MeSH term(s) Clinical Trials as Topic/methods ; Epilepsy/drug therapy ; Fructose/analogs & derivatives ; Fructose/therapeutic use ; Humans
    Chemical Substances topiramate (0H73WJJ391) ; Fructose (30237-26-4)
    Language English
    Publishing date 2003-06-19
    Publishing country New Zealand
    Document type Comment ; Journal Article
    ZDB-ID 1203800-3
    ISSN 1179-1934 ; 1172-7047
    ISSN (online) 1179-1934
    ISSN 1172-7047
    DOI 10.2165/00023210-200317130-00009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 4083: Show issues Location:
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  2. Article ; Online: Economic aspects of treating seizure clusters.

    Faught, Edward

    Epilepsia

    2022  Volume 63 Suppl 1, Page(s) S45–S54

    Abstract: Seizure clusters may initiate a chain of events that have economic as well as clinical consequences. The potential economic consequences of seizure clusters must be weighed against the cost of medication to attenuate them. This is true both for ... ...

    Abstract Seizure clusters may initiate a chain of events that have economic as well as clinical consequences. The potential economic consequences of seizure clusters must be weighed against the cost of medication to attenuate them. This is true both for individual patients and for society. Data needed for economic analyses include the chance that a cluster will progress to an adverse outcome, such as a need for emergency care, the costs of such an outcome, the cost of a rescue medication (RM), and the effectiveness of the RM. Indirect costs, such as lost employment for patients and caregivers, must also be considered. Several types of economic analyses can be used to determine costs and benefits of a medical intervention. There are studies comparing different RMs from an economic perspective, but there is little direct information on the costs of using an RM versus allowing clusters to run their course. However, the high expense of consequences of seizure clusters makes it likely that effective RMs will make economic as well as medical sense for many patients.
    MeSH term(s) Brain Damage, Chronic ; Cost-Benefit Analysis ; Drug Repositioning/economics ; Employment ; Epilepsy, Generalized ; Humans ; Seizures/drug therapy ; Seizures/economics
    Language English
    Publishing date 2022-08-23
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 216382-2
    ISSN 1528-1167 ; 0013-9580
    ISSN (online) 1528-1167
    ISSN 0013-9580
    DOI 10.1111/epi.17340
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    Zs.MO 475: Show issues

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  3. Article: Restoring EEG to its Rightful Place in Alzheimer Disease Care.

    Faught, Edward

    Epilepsy currents

    2021  Volume 21, Issue 3, Page(s) 175–176

    Language English
    Publishing date 2021-03-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/1535759721998656
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  4. Article: Reoperations for Epilepsy: How Many Times Should We Bat?

    Faught, Edward

    Epilepsy currents

    2020  Volume 20, Issue 6, Page(s) 367–368

    Language English
    Publishing date 2020-09-30
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/1535759720961059
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  5. Article: Measure for Measure: Measuring the Usefulness of Measuring Antiseizure Medication Levels.

    Faught, Edward

    Epilepsy currents

    2020  Volume 20, Issue 3, Page(s) 132–133

    Language English
    Publishing date 2020-04-09
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/1535759720915845
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  6. Article: The Winner by a Nose: Intranasal Midazolam.

    Faught, Edward

    Epilepsy currents

    2019  Volume 19, Issue 5, Page(s) 310–312

    Abstract: Box: see text]. ...

    Abstract [Box: see text].
    Language English
    Publishing date 2019-08-28
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/1535759719870508
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  7. Article: Predicting a Storm by Watching the Waves.

    Faught, Edward

    Epilepsy currents

    2018  Volume 18, Issue 2, Page(s) 99–100

    Language English
    Publishing date 2018-03-28
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.5698/1535-7597.18.2.99
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: The Cost of the Second Seizure: Rethinking the Treatment Decision.

    Faught, Edward

    Epilepsy currents

    2019  Volume 19, Issue 2, Page(s) 88–90

    Abstract: Antiepileptic Drug Treatment After an Unprovoked First Seizure: A Decision Analysis Bao EL, Chao LY, Ni P, et al. Neurology. 2018;91(15):e1429-e1439. doi:10.1212/WNL.0000000000006319 Objective: To compare the expected quality-adjusted life-years (QALYs) ... ...

    Abstract Antiepileptic Drug Treatment After an Unprovoked First Seizure: A Decision Analysis Bao EL, Chao LY, Ni P, et al. Neurology. 2018;91(15):e1429-e1439. doi:10.1212/WNL.0000000000006319 Objective: To compare the expected quality-adjusted life-years (QALYs) in adult patients undergoing immediate versus deferred antiepileptic drug (AED) treatment after a first unprovoked seizure.
    Methods: We constructed a simulated clinical trial (Markov decision model) to compare immediate versus deferred AED treatment after a first unprovoked seizure in adults. Three base cases were considered, representing patients with varying degrees of seizure recurrence risk and effect of seizures on quality of life (QOL). Cohort simulation was performed to determine which treatment strategy would maximize the patient's expected QALYs. Sensitivity analyses were guided by clinical data to define decision thresholds across plausible measurement ranges, including seizure recurrence rate, effect of seizure recurrence on QOL, and efficacy of AEDs.
    Results: For patients with a moderate risk of recurrent seizures (52.0% over 10 years after first seizure), immediate AED treatment maximized QALYs compared to deferred treatment. Sensitivity analyses showed that for the preferred choice to change to deferred AED treatment, key clinical measures needed to reach implausible values were 10-year seizure recurrence rate ≤38.0%, QOL reduction with recurrent seizures ≤0.06, and efficacy of AEDs on lowering seizure recurrence rate ≤16.3%.
    Conclusion: Our model determined that immediate AED treatment is preferable to deferred treatment in adult first-seizure patients over a wide and clinically relevant range of variables. Furthermore, our analysis suggests that the 10-year seizure recurrence rate that justifies AED treatment (38.0%) is substantially lower than the 60% threshold used in the current definition of epilepsy.
    Language English
    Publishing date 2019-06-18
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.1177/1535759719835367
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  9. Article ; Online: Balancing reality with hope in epilepsy therapy.

    Faught, Edward

    Neurology

    2018  Volume 91, Issue 22, Page(s) 989–990

    MeSH term(s) Epilepsy ; Hope ; Humans ; Seizures
    Language English
    Publishing date 2018-11-02
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 207147-2
    ISSN 1526-632X ; 0028-3878
    ISSN (online) 1526-632X
    ISSN 0028-3878
    DOI 10.1212/WNL.0000000000006561
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Defining a Place for Lacosamide in the Intensive Care Unit.

    Faught, R Edward

    Epilepsy currents

    2018  Volume 18, Issue 5, Page(s) 313–314

    Language English
    Publishing date 2018-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2270080-8
    ISSN 1535-7597
    ISSN 1535-7597
    DOI 10.5698/1535-7597.18.5.313
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