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Article ; Online: Reply to 'Slowly progressive insulin dependent diabetes mellitus in type 1 diabetes endotype 2'.

Redondo, Maria J / Morgan, Noel G

2024 Volume 20, Issue 5, Page(s) 313

MeSH term(s)	Humans ; Diabetes Mellitus, Type 1 ; Diabetes Mellitus, Type 2 ; Insulin/therapeutic use
Chemical Substances	Insulin
Language	English
Publishing date	2024-03-21
Publishing country	England
Document type	Letter
ZDB-ID	2489381-X
ISSN	1759-5037 ; 1759-5029
ISSN (online)	1759-5037
ISSN	1759-5029
DOI	10.1038/s41574-024-00977-x
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Zs.A 6336: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
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Article: Inflammation et cancer : une relation complexe à double sens.

Scheen, A J / Noël, A / Delvenne, Ph / Jérusalem, G

Revue medicale de Liege

2022 Volume 77, Issue 5-6, Page(s) 354–360

Abstract: The relationships between inflammation and cancer are known since the original work by Virchow in the 19th century and have been largely confirmed after-wards. An interesting question is what might be the primum movens. Numerous clinical observations ... ...

Title translation	Inflammation and cancer : a complex two-way relationship.
Abstract	The relationships between inflammation and cancer are known since the original work by Virchow in the 19th century and have been largely confirmed after-wards. An interesting question is what might be the primum movens. Numerous clinical observations have shown that a chronic inflammatory state, as that observed with some infections, toxic agents or dysimmune diseases, may be associated with the development of cancer later on. Besides, cancer is generally accompanied by an inflammatory microenvironment, with numerous cellular and humoral components, which promotes both tumorigenesis and the invasivity of the tumour. This article aims at defining the pathophysiology of this association, with a description of underlying mechanisms and mediators, and at determining possible therapeutic implications.
MeSH term(s)	Humans ; Inflammation/complications ; Inflammation/drug therapy ; Neoplasms/drug therapy ; Tumor Microenvironment
Language	French
Publishing date	2022-06-03
Publishing country	Belgium
Document type	Journal Article
ZDB-ID	414001-1
ISSN	0370-629X ; 0035-3663
ISSN	0370-629X ; 0035-3663
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Zs.A 597: Show issues

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Article ; Online: Repurposing of rituximab biosimilars to treat B cell mediated autoimmune diseases.

Mostkowska, Agata / Rousseau, Guy / Raynal, Noël J-M

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

2024 Volume 38, Issue 5, Page(s) e23536

Abstract: Rituximab, the first monoclonal antibody approved for the treatment of lymphoma, eventually became one of the most popular and versatile drugs ever in terms of clinical application and revenue. Since its patent expiration, and consequently, the loss of ... ...

Abstract	Rituximab, the first monoclonal antibody approved for the treatment of lymphoma, eventually became one of the most popular and versatile drugs ever in terms of clinical application and revenue. Since its patent expiration, and consequently, the loss of exclusivity of the original biologic, its repurposing as an off-label drug has increased dramatically, propelled by the development and commercialization of its many biosimilars. Currently, rituximab is prescribed worldwide to treat a vast range of autoimmune diseases mediated by B cells. Here, we present a comprehensive overview of rituximab repurposing in 115 autoimmune diseases across 17 medical specialties, sourced from over 1530 publications. Our work highlights the extent of its off-label use and clinical benefits, underlining the success of rituximab repurposing for both common and orphan immune-related diseases. We discuss the scientific mechanism associated with its clinical efficacy and provide additional indications for which rituximab could be investigated. Our study presents rituximab as a flagship example of drug repurposing owing to its central role in targeting cluster of differentiate 20 positive (CD20) B cells in 115 autoimmune diseases.
MeSH term(s)	Humans ; Rituximab/therapeutic use ; Biosimilar Pharmaceuticals/therapeutic use ; Drug Repositioning ; Off-Label Use ; Autoimmune Diseases/drug therapy ; Rare Diseases
Chemical Substances	Rituximab (4F4X42SYQ6) ; Biosimilar Pharmaceuticals
Language	English
Publishing date	2024-03-12
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	639186-2
ISSN	1530-6860 ; 0892-6638
ISSN (online)	1530-6860
ISSN	0892-6638
DOI	10.1096/fj.202302259RR
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Zs.A 2266: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Ni-Catalyzed Electro-Reductive Cross-Electrophile Couplings of Alkyl Amine-Derived Radical Precursors with Aryl Iodides.

Wesenberg, Lars J / Sivo, Alessandra / Vilé, Gianvito / Noël, Timothy

The Journal of organic chemistry

2023

Abstract: In recent years, the "Escape-from-Flatland" trend has prompted the synthetic community to develop a set of cross-coupling strategies to introduce ... ...

Abstract	In recent years, the "Escape-from-Flatland" trend has prompted the synthetic community to develop a set of cross-coupling strategies to introduce sp
Language	English
Publishing date	2023-05-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.3c00859
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Zs.A 4473: Show issues

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Article ; Online: Impact of adjuvant radiotherapy and chemotherapy on thymoma.

Dumont, J / Bou-Gharios, J / Keller, A / Chambrelant, I / Pamart, G / Mascaux, C / Falcoz, P-E / Antoni, D / Olland, A / Pietta, G A / Noël, G

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2024 Volume 28, Issue 2, Page(s) 174–181

Abstract: Purpose: Thymoma is a rare tumour. The most common treatment for thymoma is surgical resection, while the use of radiotherapy and chemotherapy remains controversial.: Patients and methods: We conducted a monocentric observational study of 31 patients ...

Abstract	Purpose: Thymoma is a rare tumour. The most common treatment for thymoma is surgical resection, while the use of radiotherapy and chemotherapy remains controversial. Patients and methods: We conducted a monocentric observational study of 31 patients diagnosed with thymoma from June 2004 to July 2020 at cancer centre in Strasbourg, France. We analysed the outcomes of the patients. Results: The 2- and 5- year locoregional relapse-free survival rates were 96.3% (95% confidence interval [CI]: 76.5-99.5%) and 68.0% (95% CI: 43.8-83.5%), respectively. Radiotherapy and chemotherapy significantly improved local tumour control (P=0.0008 and 0.04, respectively), while a larger initial tumour size significantly worsened local control rates (P=0.04). The 5- and 10-year overall survival rates were 87.1% (95% CI: 69.2-95%) and 81.7% (95% CI: 60.3-92.2%), respectively. The median overall survival was not reached, and no favourable factor was retrieved. For relapsed patients, the median overall survival after relapse was 115 months. Conclusion: Despite the inherent limitations of retrospective studies with a limited patient sample size, we demonstrated that chemotherapy and radiotherapy in addition to surgery were effective in achieving local control and contributed to improving patient outcomes in thymoma. Notably, an aggressive treatment strategy at the time of relapse resulted in favourable outcomes for retreated patients.
MeSH term(s)	Humans ; Thymoma/radiotherapy ; Radiotherapy, Adjuvant ; Retrospective Studies ; Neoplasm Recurrence, Local/pathology ; Thymus Neoplasms/therapy ; Thymus Neoplasms/pathology ; Recurrence ; Chemotherapy, Adjuvant ; Neoplasm Staging ; Disease-Free Survival
Language	English
Publishing date	2024-01-04
Publishing country	France
Document type	Observational Study ; Journal Article
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2023.08.009
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Zs.A 4832: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Heterogeneity and endotypes in type 1 diabetes mellitus.

Redondo, Maria J / Morgan, Noel G

Nature reviews. Endocrinology

2023 Volume 19, Issue 9, Page(s) 542–554

Abstract: Despite major advances over the past decade, prevention and treatment of type 1 diabetes mellitus (T1DM) remain suboptimal, with large and unexplained variations in individual responses to interventions. The current classification schema for diabetes ... ...

Abstract	Despite major advances over the past decade, prevention and treatment of type 1 diabetes mellitus (T1DM) remain suboptimal, with large and unexplained variations in individual responses to interventions. The current classification schema for diabetes mellitus does not capture the complexity of this disease or guide clinical management effectively. One of the approaches to achieve the goal of applying precision medicine in diabetes mellitus is to identify endotypes (that is, well-defined subtypes) of the disease each of which has a distinct aetiopathogenesis that might be amenable to specific interventions. Here, we describe epidemiological, clinical, genetic, immunological, histological and metabolic differences within T1DM that, together, suggest heterogeneity in its aetiology and pathogenesis. We then present the emerging endotypes and their impact on T1DM prediction, prevention and treatment.
MeSH term(s)	Humans ; Diabetes Mellitus, Type 1/genetics ; Diabetes Mellitus, Type 1/therapy
Language	English
Publishing date	2023-06-19
Publishing country	England
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2489381-X
ISSN	1759-5037 ; 1759-5029
ISSN (online)	1759-5037
ISSN	1759-5029
DOI	10.1038/s41574-023-00853-0
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Article ; Online: 10 tips on working with human body donors in medical training and research.

Balta, Joy Y / Venne, Gabriel / Noël, Geoffroy P J C

Anatomical science international

2022 Volume 97, Issue 3, Page(s) 307–312

Abstract: Human body donors selflessly decided to make the ultimate gift to donate their bodies to education. Being on the receiving end, the health sciences education community owes it to the donors to ensure that they are being treated with utmost respect by ... ...

Abstract	Human body donors selflessly decided to make the ultimate gift to donate their bodies to education. Being on the receiving end, the health sciences education community owes it to the donors to ensure that they are being treated with utmost respect by promoting and developing high ethical standards and maximizing the benefits from this gift. Working with human body donors for research purposes has increased over the years, while regulations associated with these processes did not change. This article draws upon current literature and author's experiences to offer practical tips for health educators and everyone working with body donors to achieve these goals. We offer 10 practical tips that help in starting the conversation about the best ways to work with body donors to maximize their contribution to health sciences education.
MeSH term(s)	Human Body ; Humans ; Tissue Donors
Language	English
Publishing date	2022-02-10
Publishing country	Japan
Document type	Journal Article ; Review
ZDB-ID	2079994-9
ISSN	1447-073X ; 1447-6959 ; 0022-7722
ISSN (online)	1447-073X
ISSN	1447-6959 ; 0022-7722
DOI	10.1007/s12565-022-00651-0
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Article ; Online: Harnessing Children's Picture Books to Socialize Children About Pain and Injury: A Qualitative Study.

Wallwork, Sarah B / Nichols, Sue / Jordan, Abbie / Noel, Melanie / Madden, Victoria J / Lorimer Moseley, G

The journal of pain

2024 , Page(s) 104520

Abstract: Pain experiences are common during childhood (eg, "everyday" pain, vaccine injections) and are powerful opportunities for children to learn about pain and injury. These experiences likely inform fundamental and life-long beliefs about pain. There is ... ...

Abstract	Pain experiences are common during childhood (eg, "everyday" pain, vaccine injections) and are powerful opportunities for children to learn about pain and injury. These experiences likely inform fundamental and life-long beliefs about pain. There is scant research investigating the sociocultural contexts in which children learn about pain and injury. One unexplored context is the shared reading of picture books (eg, between parents/caregivers and children). In this study, we investigated whether shared reading of picture books that included depictions of pain and/or injury prompted parent/caregiver-child interactions. If interactions were observed, we explored what those interactions entailed. Twenty parents/caregivers (8 men, 12 women) and their children (n = 27; 10 boys, 17 girls) were recruited from libraries in South Australia. Parent/caregiver-child families chose from 8 books (7 fiction, 1 nonfiction) with varying amounts of pain/injury-related content. Shared reading interactions were video recorded, transcribed, and analyzed alongside analysis of the picture books using reflexive thematic analysis. Pain/injury-related interactions were observed between parents/caregivers and children during shared reading of picture books. Qualitative analyses generated 1 main theme and 3 subthemes. Findings identified that shared reading presented an opportunity for children's understanding of pain and injury to be socialized through discussion of characters' experiences. This included teaching children about pain and injury, as well as promoting empathy and emotional attunement toward characters who were depicted as being in pain. Finally, parents/caregivers often responded with observable/expressed amusement if pain/injury was depicted in a light-hearted or unrealistic way. Overall, shared reading of picture books presents an untapped opportunity to socialize children about pain and injury. PERSPECTIVE: Shared reading of picture books that have depictions of pain and/or injury can prompt parent/caregiver-child interactions about pain and injury. These interactions present critical opportunities that can be harnessed to promote children's learning of adaptive pain-related concepts and behaviors during a critical developmental period.
Language	English
Publishing date	2024-04-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2018789-0
ISSN	1528-8447 ; 1526-5900
ISSN (online)	1528-8447
ISSN	1526-5900
DOI	10.1016/j.jpain.2024.03.016
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Article ; Online: Incertitudes inhérentes au concept actuel de volume cible prévisionnel en radiothérapie.

Noël, G / Thariat, J / Antoni, D

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2020 Volume 24, Issue 6-7, Page(s) 667–675

Abstract: The planning target volume is an essential notion in radiotherapy, that requires a new conceptualization. Indeed, the variability and diversity of the uncertainties involved or improved with the development of the new modern technologies and devices in ... ...

Title translation	Uncertainties in the current concept of radiotherapy planning target volume.
Abstract	The planning target volume is an essential notion in radiotherapy, that requires a new conceptualization. Indeed, the variability and diversity of the uncertainties involved or improved with the development of the new modern technologies and devices in radiotherapy suggest that random and systematic errors cannot be currently generalized. This article attempts to discuss these various uncertainties and tries to demonstrate that a redefinition of the concept of planning target volume toward its personalization for each patient and the robustness notion are likely an improvement basis to take into account the radiotherapy uncertainties.
MeSH term(s)	Humans ; Neoplasms/pathology ; Neoplasms/radiotherapy ; Patient Care Planning ; Radiotherapy/methods ; Radiotherapy Dosage ; Tumor Burden/radiation effects ; Uncertainty
Language	French
Publishing date	2020-08-20
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2020.06.004
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Zs.A 4832: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Increased cardiac uptake of (

Eber, J / Leroy-Freschini, B / Antoni, D / Noël, G / Pflumio, C

Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique

2022 Volume 26, Issue 5, Page(s) 724–729

Abstract: Radiation-induced heart disease is a complication that occurs years after thoracic irradiation. Recent studies suggest that radiation-induced heart disease could be an earlier complication and that subclinical cardiac injury can be detected. The present ... ...

Abstract	Radiation-induced heart disease is a complication that occurs years after thoracic irradiation. Recent studies suggest that radiation-induced heart disease could be an earlier complication and that subclinical cardiac injury can be detected. The present case described an increased uptake of (
MeSH term(s)	Fluorodeoxyglucose F18 ; Heart/diagnostic imaging ; Heart Diseases ; Humans ; Positron-Emission Tomography/methods ; Radiation Injuries ; Tomography, Emission-Computed, Single-Photon ; Tomography, X-Ray Computed
Chemical Substances	Fluorodeoxyglucose F18 (0Z5B2CJX4D)
Language	English
Publishing date	2022-02-12
Publishing country	France
Document type	Case Reports
ZDB-ID	1397169-4
ISSN	1769-6658 ; 1278-3218
ISSN (online)	1769-6658
ISSN	1278-3218
DOI	10.1016/j.canrad.2021.10.010
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