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  1. Article ; Online: Exploring IL-1 inhibition in chronic refractory idiopathic myocarditis: emerging insights and perspectives.

    Wu, Maddalena Alessandra / Bizzi, Emanuele / Brucato, Antonio

    Internal and emergency medicine

    2024  Volume 19, Issue 2, Page(s) 273–274

    MeSH term(s) Humans ; Myocarditis/drug therapy ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Interleukin 1 Receptor Antagonist Protein/pharmacology ; Chronic Disease ; Interleukin-1
    Chemical Substances Interleukin 1 Receptor Antagonist Protein ; Interleukin-1
    Language English
    Publishing date 2024-02-26
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-024-03552-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Inflammatory puzzle: Unveiling the role of D-Dimer in acute pericarditis and thromboinflammation.

    Wu, Maddalena Alessandra / Bizzi, Emanuele / Brucato, Antonio

    European journal of internal medicine

    2023  Volume 116, Page(s) 41–42

    MeSH term(s) Humans ; Thrombosis ; Thromboinflammation ; Inflammation ; Fibrin Fibrinogen Degradation Products ; Pericarditis/diagnosis
    Chemical Substances fibrin fragment D ; Fibrin Fibrinogen Degradation Products
    Language English
    Publishing date 2023-07-27
    Publishing country Netherlands
    Document type Journal Article ; Comment
    ZDB-ID 1038679-8
    ISSN 1879-0828 ; 0953-6205
    ISSN (online) 1879-0828
    ISSN 0953-6205
    DOI 10.1016/j.ejim.2023.07.028
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  3. Article: Autonomic Function and Baroreflex Control in COVID-19 Patients Admitted to the Intensive Care Unit.

    Gelpi, Francesca / Wu, Maddalena Alessandra / Bari, Vlasta / Cairo, Beatrice / De Maria, Beatrice / Fossali, Tommaso / Colombo, Riccardo / Porta, Alberto

    Journal of clinical medicine

    2024  Volume 13, Issue 8

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2024-04-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13082228
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  4. Article ; Online: Lanadelumab for the treatment of hereditary angioedema.

    Wu, Maddalena Alessandra

    Expert opinion on biological therapy

    2019  Volume 19, Issue 12, Page(s) 1233–1245

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Angioedemas, Hereditary/drug therapy ; Antibodies, Monoclonal, Humanized/immunology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Humans ; Immunoglobulin G/immunology ; Immunoglobulin G/therapeutic use ; Plasma Kallikrein/antagonists & inhibitors ; Plasma Kallikrein/immunology ; Quality of Life
    Chemical Substances Antibodies, Monoclonal, Humanized ; Immunoglobulin G ; lanadelumab (2372V1TKXK) ; Plasma Kallikrein (EC 3.4.21.34)
    Language English
    Publishing date 2019-11-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2052501-1
    ISSN 1744-7682 ; 1471-2598
    ISSN (online) 1744-7682
    ISSN 1471-2598
    DOI 10.1080/14712598.2019.1685490
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  5. Article: Angioödeme ohne Urtikaria: Anamnese und Befunde.

    Badini, Matteo / Georgitsogiannakos, Nikolaos / Angelella, Jennifer / Wu, Maddalena Alessandra

    Praxis

    2023  Volume 112, Issue 4, Page(s) 223–225

    Abstract: Angioedema without Urticaria: Medical History and ... ...

    Title translation Angioedema without Urticaria: Medical History and Findings.
    Abstract Angioedema without Urticaria: Medical History and Findings
    MeSH term(s) Female ; Humans ; Angioedema/diagnosis ; Angioedema/drug therapy ; Angioedema/etiology ; Urticaria/diagnosis ; Urticaria/drug therapy ; Urticaria/etiology ; Bradykinin/therapeutic use
    Chemical Substances Bradykinin (S8TIM42R2W)
    Language German
    Publishing date 2023-03-08
    Publishing country Switzerland
    Document type Case Reports ; English Abstract ; Journal Article
    ZDB-ID 209026-0
    ISSN 1661-8165 ; 1661-8157 ; 0369-8394
    ISSN (online) 1661-8165
    ISSN 1661-8157 ; 0369-8394
    DOI 10.1024/1661-8157/a003995
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  6. Article ; Online: A rare presentation of heart failure with preserved ejection fraction.

    Donadoni, Mattia / Petullà, Marina / Del Medico, Marta / Barosi, Alberto / Wu, Maddalena Alessandra

    Internal and emergency medicine

    2023  Volume 18, Issue 8, Page(s) 2339–2345

    MeSH term(s) Humans ; Stroke Volume ; Heart Failure/diagnosis ; Hospitalization
    Language English
    Publishing date 2023-05-06
    Publishing country Italy
    Document type Case Reports ; Interview
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-023-03296-7
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  7. Article: Venous Thromboembolism Management throughout the COVID-19 Era: Addressing Acute and Long-Term Challenges.

    Wu, Maddalena Alessandra / Taino, Alba / Facchinetti, Pietro / Rossi, Valentina / Ruggiero, Diego / Berra, Silvia / Blanda, Giulia / Flor, Nicola / Cogliati, Chiara / Colombo, Riccardo

    Journal of clinical medicine

    2024  Volume 13, Issue 6

    Abstract: Background: ...

    Abstract Background:
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm13061825
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  8. Article ; Online: Unlocking endothelial barrier restoration: FX06 in systemic capillary leak syndrome and beyond.

    Wu, Maddalena Alessandra / Locatelli, Laura / Cogliati, Chiara / Colombo, Riccardo / Maier, Jeanette A

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

    2024  Volume 171, Page(s) 116147

    Abstract: Increased vascular permeability is a prevalent feature in a wide spectrum of clinical conditions, but no effective treatments to restore the endothelial barrier are available. Idiopathic systemic capillary leak syndrome (ISCLS) is a life-threatening ... ...

    Abstract Increased vascular permeability is a prevalent feature in a wide spectrum of clinical conditions, but no effective treatments to restore the endothelial barrier are available. Idiopathic systemic capillary leak syndrome (ISCLS) is a life-threatening Paroxysmal Permeability Disorder characterized by abrupt, massive plasma extravasation. This condition serves as a robust model for investigating therapeutic approaches targeting interendothelial junctions. We conducted a single-center, interventional in vitro study at the Referral Center for ISCLS in Italy, involving four diagnosed ISCLS patients, aiming at investigating the effects of FX06, a Bβ15-42 fibrin-derived peptide binding to VE-Cadherin, on endothelial barrier exposed to intercritical and acute ISCLS sera. The Transwell Permeability Assay was used to assess the permeability of human umbilical vein endothelial cells (HUVECs) exposed to ISCLS sera with or without FX06 (50 µg/ml). Acute ISCLS serum was also tested in a three-dimensional microfluidic device. Nitric oxide (NO), VE-Cadherin localization, and cytoskeletal organization were also assessed. In two and three-dimensional systems, ISCLS sera increased endothelial permeability, with a more pronounced effect for acute sera. Furthermore, acute sera altered VE-Cadherin localization and cytoskeletal organization. NO levels remained unchanged. FX06 restored the endothelial barrier function by influencing cellular localization rather than VE-Cadherin levels. In conclusion, FX06 prevents and reverts the hyperpermeability induced by ISCLS sera. These preliminary yet promising results provide initial evidence of the in vitro efficacy of a drug targeting the underlying pathophysiological mechanisms of ISCLS. Moreover, this approach may hold potential for addressing hyperpermeability in a spectrum of clinical conditions beyond ISCLS.
    MeSH term(s) Humans ; Capillary Leak Syndrome/metabolism ; Endothelial Cells ; Capillary Permeability ; Endothelium, Vascular ; Cadherins/metabolism ; Italy
    Chemical Substances Cadherins
    Language English
    Publishing date 2024-01-18
    Publishing country France
    Document type Journal Article
    ZDB-ID 392415-4
    ISSN 1950-6007 ; 0753-3322 ; 0300-0893
    ISSN (online) 1950-6007
    ISSN 0753-3322 ; 0300-0893
    DOI 10.1016/j.biopha.2024.116147
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    Ud II Zs.198: Show issues Location:
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  9. Article ; Online: Appropriateness of care: from medication reconciliation to deprescribing.

    Wu, Maddalena Alessandra / Carnovale, Carla / Gabiati, Claudia / Montori, Daniela / Brucato, Antonio

    Internal and emergency medicine

    2021  Volume 16, Issue 8, Page(s) 2047–2050

    MeSH term(s) Deprescriptions ; Humans ; Medication Reconciliation ; Polypharmacy
    Language English
    Publishing date 2021-09-28
    Publishing country Italy
    Document type Journal Article ; Comment
    ZDB-ID 2454173-4
    ISSN 1970-9366 ; 1828-0447
    ISSN (online) 1970-9366
    ISSN 1828-0447
    DOI 10.1007/s11739-021-02846-1
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  10. Article ; Online: Systemic leak capillary syndrome with myocardial involvement and cardiogenic shock: a case report.

    Garatti, Laura / Wu, Maddalena Alessandra / Ammirati, Enrico / Sacco, Alice

    European heart journal. Case reports

    2022  Volume 6, Issue 7, Page(s) ytac262

    Abstract: Background: Systemic capillary leak syndrome (SCLS) is a potentially fatal disorder characterized by relapses of hypovolemic shock episodes.: Case summary: We present a case of a 58-year-old man who presented to the Emergency Department with a ... ...

    Abstract Background: Systemic capillary leak syndrome (SCLS) is a potentially fatal disorder characterized by relapses of hypovolemic shock episodes.
    Case summary: We present a case of a 58-year-old man who presented to the Emergency Department with a history of recurrent episodes of syncope in the last hours. A few days before medical contact the patient complained of sore throat, fever, and flu-like symptoms. He was initially admitted with a diagnosis of suspected myopericarditis. Forty-eight hours later, the haemodynamic status suddenly deteriorated to a mixed cardiogenic and shock; an endomyocardial biopsy showed localized inflammatory infiltrates and areas of necrosis of cardiomyocytes with positive viral search for parvovirus B19 (PVB19), therefore the patient was treated with methylprednisolone pulses. Based on the concurrent presence of the typical triad of hypotension, hypoalbuminaemia, and haemoconcentration we suspected systemic leak capillary syndrome potentially triggered by the PVB19 infection with acute myocarditis. The clinical conditions further deteriorated with rhabdomyolysis and acute kidney injury: we started continuous veno-venous haemofiltration adding a cytokines adsorber. In the following hours, we observed a significant clinical improvement. The patient was discharged 1 month later and 5 months after discharge he experienced a new attack of SCLS, this time without myocardial involvement and with prompt symptoms resolution.
    Conclusion: Systemic capillary leak syndrome is a potentially fatal disorder: early recognition of this entity and prompt initiation of supportive therapy are warranted, therefore, it is paramount that an emergency physician thinks of SCLS in patients with signs of cardiogenic shock and the classical triad of hypotension, hypoalbuminia, and haemoconcentration.
    Language English
    Publishing date 2022-06-28
    Publishing country England
    Document type Case Reports
    ISSN 2514-2119
    ISSN (online) 2514-2119
    DOI 10.1093/ehjcr/ytac262
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