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  1. Book: The neuromuscular junction

    Campagna, Jason A.

    (International anesthesiology clinics ; 44,2)

    2006  

    Author's details ed. by Jason A. Campagna
    Series title International anesthesiology clinics ; 44,2
    Collection
    Language English
    Size XIX, 183 S. : Ill., graph. Darst.
    Publisher Lippincott Williams & Wilkins
    Publishing place Philadelphia, Pa
    Publishing country United States
    Document type Book
    HBZ-ID HT014793007
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs B 243 -44,2- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Channel Expansion in the Ligand-Binding Domain of the Glucocorticoid Receptor Contributes to the Activity of Highly Potent Glucocorticoid Analogues.

    Seaton, Wesley B / Burke, Susan J / Fisch, Alexander R / Schilletter, William A / Beck, Mary Grace A / Cassagne, Gabrielle A / Harvey, Innocence / Fontenot, Molly S / Collier, J Jason / Campagna, Shawn R

    Molecules (Basel, Switzerland)

    2024  Volume 29, Issue 7

    Abstract: Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) and are commonly used as anti-inflammatory and immunosuppressant medications. Chronic GC use has been linked with unwanted complications such as steroid-induced diabetes mellitus (SIDM), ... ...

    Abstract Glucocorticoids (GCs) act through the glucocorticoid receptor (GR) and are commonly used as anti-inflammatory and immunosuppressant medications. Chronic GC use has been linked with unwanted complications such as steroid-induced diabetes mellitus (SIDM), although the mechanisms for these effects are not completely understood. Modification of six GC parent molecules with 2-mercaptobenzothiazole resulted in consistently less promoter activity in transcriptional activation assays using a 3xGRE reporter construct while constantly reducing inflammatory pathway activity. The most selective candidate,
    MeSH term(s) Glucocorticoids/pharmacology ; Receptors, Glucocorticoid ; Ligands ; Anti-Inflammatory Agents/pharmacology ; Dexamethasone/pharmacology
    Chemical Substances Glucocorticoids ; Receptors, Glucocorticoid ; Ligands ; Anti-Inflammatory Agents ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2024-03-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules29071546
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  3. Article ; Online: Clinical endpoints are necessary in the interim analysis of REGENERATE - Authors' reply.

    Ratziu, Vlad / Younossi, Zobair M / Campagna, Jason A / MacConell, Leigh / Sanyal, Arun J

    Lancet (London, England)

    2020  Volume 396, Issue 10252, Page(s) 663–664

    Language English
    Publishing date 2020-09-04
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(20)30807-2
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    Zs.MG 94: Show issues

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  4. Article ; Online: Pharmacological inhibition of lipolysis prevents adverse metabolic outcomes during glucocorticoid administration.

    Linden, Melissa A / Burke, Susan J / Pirzadah, Humza A / Huang, Tai-Yu / Batdorf, Heidi M / Mohammed, Walid K / Jones, Katarina A / Ghosh, Sujoy / Campagna, Shawn R / Collier, J Jason / Noland, Robert C

    Molecular metabolism

    2023  Volume 74, Page(s) 101751

    Abstract: Objective: Glucocorticoids are one of the most commonly prescribed classes of anti-inflammatory drugs; however, chronic treatment promotes iatrogenic (drug-induced) diabetes. As part of their physiological role, glucocorticoids stimulate lipolysis to ... ...

    Abstract Objective: Glucocorticoids are one of the most commonly prescribed classes of anti-inflammatory drugs; however, chronic treatment promotes iatrogenic (drug-induced) diabetes. As part of their physiological role, glucocorticoids stimulate lipolysis to spare glucose. We hypothesized that persistent stimulation of lipolysis during glucocorticoid therapy plays a causative role in the development of iatrogenic diabetes.
    Methods: Male C57BL/6J mice were given 100 μg/mL corticosterone (Cort) in the drinking water for two weeks and were fed either normal chow (TekLad 8640) or the same diet supplemented with an adipose triglyceride lipase inhibitor (Atglistatin - 2  g/kg diet) to inhibit the first step of lipolysis.
    Results: Herein, we report for the first time that glucocorticoid administration promotes a unique state of substrate excess and energetic overload in skeletal muscle that primarily results from the rampant mobilization of endogenous fuels. Inhibiting lipolysis protected mice from Cort-induced gains in fat mass, excess ectopic lipid accrual, hyperinsulinemia, and hyperglycemia. The role lipolysis plays in Cort-mediated pathology appears to differ between tissues. Within skeletal muscle, Cort-induced lipolysis facilitated diversion of glucose-derived carbons toward the pentose phosphate and hexosamine biosynthesis pathways but contributed to <3% of the Cort-induced genomic adaptations. In contrast, Cort stimulation of lipolysis accounted for ∼35% of the genomic changes in the liver but had minimal impact on hepatic metabolites reported.
    Conclusions: These data support the idea that activation of lipolysis plays a causal role in the progression toward iatrogenic diabetes during glucocorticoid therapy with differential impact on skeletal muscle and liver.
    MeSH term(s) Male ; Mice ; Animals ; Glucocorticoids/metabolism ; Lipolysis/genetics ; Insulin Resistance ; Mice, Inbred C57BL ; Corticosterone/pharmacology ; Glucose/metabolism ; Iatrogenic Disease
    Chemical Substances Glucocorticoids ; Corticosterone (W980KJ009P) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-06-07
    Publishing country Germany
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2708735-9
    ISSN 2212-8778 ; 2212-8778
    ISSN (online) 2212-8778
    ISSN 2212-8778
    DOI 10.1016/j.molmet.2023.101751
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Pharmacological inhibition of lipolysis prevents adverse metabolic outcomes during glucocorticoid administration

    Melissa A. Linden / Susan J. Burke / Humza A. Pirzadah / Tai-Yu Huang / Heidi M. Batdorf / Walid K. Mohammed / Katarina A. Jones / Sujoy Ghosh / Shawn R. Campagna / J. Jason Collier / Robert C. Noland

    Molecular Metabolism, Vol 74, Iss , Pp 101751- (2023)

    2023  

    Abstract: Objective: Glucocorticoids are one of the most commonly prescribed classes of anti-inflammatory drugs; however, chronic treatment promotes iatrogenic (drug-induced) diabetes. As part of their physiological role, glucocorticoids stimulate lipolysis to ... ...

    Abstract Objective: Glucocorticoids are one of the most commonly prescribed classes of anti-inflammatory drugs; however, chronic treatment promotes iatrogenic (drug-induced) diabetes. As part of their physiological role, glucocorticoids stimulate lipolysis to spare glucose. We hypothesized that persistent stimulation of lipolysis during glucocorticoid therapy plays a causative role in the development of iatrogenic diabetes. Methods: Male C57BL/6J mice were given 100 μg/mL corticosterone (Cort) in the drinking water for two weeks and were fed either normal chow (TekLad 8640) or the same diet supplemented with an adipose triglyceride lipase inhibitor (Atglistatin - 2 g/kg diet) to inhibit the first step of lipolysis. Results: Herein, we report for the first time that glucocorticoid administration promotes a unique state of substrate excess and energetic overload in skeletal muscle that primarily results from the rampant mobilization of endogenous fuels. Inhibiting lipolysis protected mice from Cort-induced gains in fat mass, excess ectopic lipid accrual, hyperinsulinemia, and hyperglycemia. The role lipolysis plays in Cort-mediated pathology appears to differ between tissues. Within skeletal muscle, Cort-induced lipolysis facilitated diversion of glucose-derived carbons toward the pentose phosphate and hexosamine biosynthesis pathways but contributed to <3% of the Cort-induced genomic adaptations. In contrast, Cort stimulation of lipolysis accounted for ∼35% of the genomic changes in the liver but had minimal impact on hepatic metabolites reported. Conclusions: These data support the idea that activation of lipolysis plays a causal role in the progression toward iatrogenic diabetes during glucocorticoid therapy with differential impact on skeletal muscle and liver.
    Keywords Glucocorticoid ; Substrate overload ; Lipolysis ; Adipose triglyceride lipase ; Iatrogenic diabetes ; Internal medicine ; RC31-1245
    Subject code 572
    Language English
    Publishing date 2023-08-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article: Development of the neuromuscular junction.

    Campagna, Jason A

    International anesthesiology clinics

    2006  Volume 44, Issue 2, Page(s) 1–20

    MeSH term(s) Animals ; Axons/physiology ; Cell Differentiation ; Humans ; Neuromuscular Junction/embryology ; Neuromuscular Junction/physiology ; Signal Transduction ; Synapses/physiology
    Language English
    Publishing date 2006-07-10
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 210757-0
    ISSN 1537-1913 ; 0020-5907
    ISSN (online) 1537-1913
    ISSN 0020-5907
    DOI 10.1097/00004311-200604420-00003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 243: Show issues Location:
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  7. Article: Academic anesthesia and M.D.-Ph.D.s.

    Campagna, Jason A

    Anesthesiology

    2006  Volume 105, Issue 3, Page(s) 627–8; author reply 628, 629–30

    MeSH term(s) Anesthesiology/education ; Anesthesiology/trends ; Biomedical Research ; Humans ; Internship and Residency ; Physicians ; United States
    Language English
    Publishing date 2006-08-21
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 269-0
    ISSN 0003-3022
    ISSN 0003-3022
    DOI 10.1097/00000542-200609000-00034
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 199: Show issues

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  8. Article: The end of religious fatalism: Boston as the venue for the demonstration of ether for the intentional relief of pain.

    Campagna, Jason A

    Surgery

    2005  Volume 138, Issue 1, Page(s) 46–55

    MeSH term(s) Anesthesia, Inhalation/history ; Anesthesiology/history ; Art ; Boston ; Ether/history ; History, 19th Century ; Humans ; Pain/history ; Pain/prevention & control ; Religion/history
    Chemical Substances Ether (0F5N573A2Y)
    Language English
    Publishing date 2005-07
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 202467-6
    ISSN 1532-7361 ; 0039-6060
    ISSN (online) 1532-7361
    ISSN 0039-6060
    DOI 10.1016/j.surg.2005.02.013
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uk I Zs.129: Show issues Location:
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  9. Article: Clevidipine resistance in a patient taking aripiprazole and methylphenidate.

    Jacklen, M Alysse / Campagna, Jason A / Tobias, Joseph D

    Journal of experimental pharmacology

    2014  Volume 6, Page(s) 11–14

    Abstract: Various factors may be responsible for blood pressure alterations during perioperative care. When these physiologic alterations require treatment, several therapeutic options are available. Clevidipine is an ultrashort-acting, intravenous L-type calcium ... ...

    Abstract Various factors may be responsible for blood pressure alterations during perioperative care. When these physiologic alterations require treatment, several therapeutic options are available. Clevidipine is an ultrashort-acting, intravenous L-type calcium channel antagonist of the dihydropyridine class. Anecdotal experience has demonstrated its efficacy in various clinical scenarios in the pediatric population. We report apparent resistance to the vasodilatory effects of clevidipine in a 13-year-old girl who presented for anesthetic care during posterior spinal fusion for neuromuscular scoliosis whose chronic medication regimen included aripiprazole and methylphenidate for the treatment of depression and attention-deficit/hyperactivity disorder. We discuss the potential interaction of aripiprazole and methylphenidate with the calcium channel antagonists and cellular mechanisms responsible for the resistance to the vasodilatory effects of clevidipine.
    Language English
    Publishing date 2014-10-17
    Publishing country New Zealand
    Document type Case Reports
    ZDB-ID 2587465-2
    ISSN 1179-1454
    ISSN 1179-1454
    DOI 10.2147/JEP.S71914
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Microbial survival mechanisms within serpentinizing Mariana forearc sediments.

    Mullis, Megan M / Selwyn, Jason D / Kevorkian, Richard / Tague, Eric D / Castro, Hector F / Campagna, Shawn R / Lloyd, Karen G / Reese, Brandi Kiel

    FEMS microbiology ecology

    2023  Volume 99, Issue 2

    Abstract: Marine deep subsurface sediment is often a microbial environment under energy-limited conditions. However, microbial life has been found to persist and even thrive in deep subsurface environments. The Mariana forearc represents an ideal location for ... ...

    Abstract Marine deep subsurface sediment is often a microbial environment under energy-limited conditions. However, microbial life has been found to persist and even thrive in deep subsurface environments. The Mariana forearc represents an ideal location for determining how microbial life can withstand extreme conditions including pH 10-12.5 and depleted nutrients. The International Ocean Discovery Program Expedition 366 to the Mariana Convergent Margin sampled three serpentinizing seamounts located along the Mariana forearc chain with elevated concentrations of methane, hydrogen, and sulfide. Across all three seamount summits, the most abundant transcripts were for cellular maintenance such as cell wall and membrane repair, and the most abundant metabolic pathways were the Entner-Doudoroff pathway and tricarboxylic acid cycle. At flank samples, sulfur cycling involving taurine assimilation dominated the metatranscriptomes. The in situ activity of these pathways was supported by the detection of their metabolic intermediates. All samples had transcripts from all three domains of Bacteria, Archaea, and Eukarya, dominated by Burkholderiales, Deinococcales, and Pseudomonales, as well as the fungal group Opisthokonta. All samples contained transcripts for aerobic methane oxidation (pmoABC) and denitrification (nirKS). The Mariana forearc microbial communities show activity not only consistent with basic survival mechanisms, but also coupled metabolic reactions.
    MeSH term(s) Seawater/microbiology ; Bacteria/genetics ; Bacteria/metabolism ; Archaea/genetics ; Archaea/metabolism ; Geologic Sediments/microbiology ; Methane/metabolism ; Phylogeny
    Chemical Substances Methane (OP0UW79H66)
    Language English
    Publishing date 2023-01-09
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 283722-5
    ISSN 1574-6941 ; 0168-6496
    ISSN (online) 1574-6941
    ISSN 0168-6496
    DOI 10.1093/femsec/fiad003
    Database MEDical Literature Analysis and Retrieval System OnLINE

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