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  1. Article: Population-wide persistent hemostatic changes after vaccination with ChAdOx1-S.

    de Laat, Bas / Stragier, Hendrik / de Laat-Kremers, Romy / Ninivaggi, Marisa / Mesotten, Dieter / Thiessen, Steven / Van Pelt, Kristien / Roest, Mark / Penders, Joris / Vanelderen, Pascal / Huskens, Dana / De Jongh, Raf / Laenen, Margot Vander / Fivez, Tom / Ten Cate, Hugo / Heylen, Rene / Heylen, Line / Steensels, Deborah

    Frontiers in cardiovascular medicine

    2022  Volume 9, Page(s) 966028

    Abstract: ... vaccines, including ChAdOx1-S, could be associated with an increased risk of thrombosis. We investigated ... the hemostatic changes after ChAdOx1-S vaccination in 631 health care workers. Blood samples were collected 32 ... days on average after the second ChAdOx1-S vaccination, to evaluate hemostatic markers such as D-dimer ...

    Abstract Various vaccines were developed to reduce the spread of the Severe Acute Respiratory Syndrome Cov-2 (SARS-CoV-2) virus. Quickly after the start of vaccination, reports emerged that anti-SARS-CoV-2 vaccines, including ChAdOx1-S, could be associated with an increased risk of thrombosis. We investigated the hemostatic changes after ChAdOx1-S vaccination in 631 health care workers. Blood samples were collected 32 days on average after the second ChAdOx1-S vaccination, to evaluate hemostatic markers such as D-dimer, fibrinogen, α2-macroglobulin, FVIII and thrombin generation. Endothelial function was assessed by measuring Von Willebrand Factor (VWF) and active VWF. IL-6 and IL-10 were measured to study the activation of the immune system. Additionally, SARS-CoV-2 anti-nucleoside and anti-spike protein antibody titers were determined. Prothrombin and fibrinogen levels were significantly reduced after vaccination (-7.5% and -16.9%,
    Language English
    Publishing date 2022-07-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2022.966028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Critical Analysis of Thrombocytopenia Associated With Glycoprotein IIb/IIIa Inhibitors and Potential Role of Zalunfiban, a Novel Small Molecule Glycoprotein Inhibitor, in Understanding the Mechanism(s).

    Rikken, Sem A O F / van 't Hof, Arnoud W J / Ten Berg, Jurriën M / Kereiakes, Dean J / Coller, Barry S

    Journal of the American Heart Association

    2023  Volume 12, Issue 24, Page(s) e031855

    Abstract: Thrombocytopenia is a rare but serious complication of the intravenous glycoprotein IIb/IIIa (GPIIb/IIIa; integrin αIIbβ3) receptor inhibitors (GPIs), abciximab, eptifibatide, and tirofiban. The thrombocytopenia ranges from mild (50 000-100 000 platelets/ ...

    Abstract Thrombocytopenia is a rare but serious complication of the intravenous glycoprotein IIb/IIIa (GPIIb/IIIa; integrin αIIbβ3) receptor inhibitors (GPIs), abciximab, eptifibatide, and tirofiban. The thrombocytopenia ranges from mild (50 000-100 000 platelets/μL), to severe (20 000 to <50 000/μL), to profound (<20 000/μL). Profound thrombocytopenia appears to occur in <1% of patients receiving their first course of therapy. Thrombocytopenia can be either acute (<24 hours) or delayed (up to ~14 days). Both hemorrhagic and thrombotic complications have been reported in association with thrombocytopenia. Diagnosis requires exclusion of pseudothrombocytopenia and heparin-induced thrombocytopenia. Therapy based on the severity of thrombocytopenia and symptoms may include drug withdrawals and treatment with steroids, intravenous IgG, and platelet transfusions. Abciximab-associated thrombocytopenia is most common and due to either preformed antibodies or antibodies induced in response to abciximab (delayed). Readministration of abciximab is associated with increased risk of thrombocytopenia. Evidence also supports an immune basis for thrombocytopenia associated with the 2 small molecule GPIs. The latter bind αIIbβ3 like the natural ligands and thus induce the receptor to undergo major conformational changes that potentially create neoepitopes. Thrombocytopenia associated with these drugs is also immune-mediated, with antibodies recognizing the αIIbβ3 receptor only in the presence of the drug. It is unclear whether the antibody binding depends on the conformational change and whether the drug contributes directly to the epitope. Zalunfiban, a second-generation subcutaneous small molecule GPI, does not induce the conformational changes; therefore, data from studies of zalunfiban will provide information on the contribution of the conformational changes to the development of GPI-associated thrombocytopenia.
    MeSH term(s) Humans ; Abciximab/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Platelet Glycoprotein GPIIb-IIIa Complex ; Antibodies, Monoclonal/therapeutic use ; Immunoglobulin Fab Fragments/adverse effects ; Tyrosine ; Thrombocytopenia/chemically induced
    Chemical Substances Abciximab (X85G7936GV) ; Platelet Aggregation Inhibitors ; Platelet Glycoprotein GPIIb-IIIa Complex ; Antibodies, Monoclonal ; Immunoglobulin Fab Fragments ; Tyrosine (42HK56048U)
    Language English
    Publishing date 2023-12-08
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.031855
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  3. Article ; Online: Transforming growth factor-β challenge alters the N-, O-, and glycosphingolipid glycomes in PaTu-S pancreatic adenocarcinoma cells.

    Zhang, Jing / Zhang, Zejian / Holst, Stephanie / Blöchl, Constantin / Madunic, Katarina / Wuhrer, Manfred / Ten Dijke, Peter / Zhang, Tao

    The Journal of biological chemistry

    2022  Volume 298, Issue 3, Page(s) 101717

    Abstract: ... Here, we investigated the TGF-β-mediated response and glycosylation changes in the PaTu-8955S (PaTu-S ... signaling. PaTu-S cells responded to TGF-β by upregulating SMAD2 phosphorylation and target gene expression ... glycosphingolipid-linked glycans in PaTu-S cells upon TGF-β stimulation. TGF-β treatment primarily induced N-glycome ...

    Abstract Pancreatic ductal adenocarcinoma (PDAC) is characterized by poor prognosis and high mortality. Transforming growth factor-β (TGF-β) plays a key role in PDAC tumor progression, which is often associated with aberrant glycosylation. However, how PDAC cells respond to TGF-β and the role of glycosylation therein is not well known. Here, we investigated the TGF-β-mediated response and glycosylation changes in the PaTu-8955S (PaTu-S) cell line deficient in SMA-related and MAD-related protein 4 (SMAD4), a signal transducer of the TGF-β signaling. PaTu-S cells responded to TGF-β by upregulating SMAD2 phosphorylation and target gene expression. We found that TGF-β induced expression of the mesenchymal marker N-cadherin but did not significantly affect epithelial marker E-cadherin expression. We also examined differences in N-glycans, O-glycans, and glycosphingolipid-linked glycans in PaTu-S cells upon TGF-β stimulation. TGF-β treatment primarily induced N-glycome aberrations involving elevated levels of branching, core fucosylation, and sialylation in PaTu-S cells, in agreement with TGF-β-induced changes in the expression of glycosylation-associated genes. In addition, we observed differences in O glycosylation and glycosphingolipid glycosylation profiles after TGF-β treatment, including lower levels of sialylated Tn antigen and neoexpression of globosides. Furthermore, the expression of transcription factor sex-determining region Y-related high-mobility group box 4 was upregulated upon TGF-β stimulation, and its depletion blocked TGF-β-induced N-glycomic changes. Thus, TGF-β-induced N-glycosylation changes can occur in a sex-determining region Y-related high-mobility group box 4-dependent and SMAD4-independent manner in the pancreatic PaTu-S cancer cell line. Our results open up avenues to study the relevance of glycosylation in TGF-β signaling in SMAD4-inactivated PDAC.
    MeSH term(s) Carcinoma, Pancreatic Ductal/metabolism ; Cell Line, Tumor ; Glycosphingolipids/metabolism ; Humans ; Pancreatic Neoplasms/metabolism ; Polysaccharides ; Transforming Growth Factor beta/metabolism
    Chemical Substances Glycosphingolipids ; Polysaccharides ; Transforming Growth Factor beta
    Language English
    Publishing date 2022-02-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2997-x
    ISSN 1083-351X ; 0021-9258
    ISSN (online) 1083-351X
    ISSN 0021-9258
    DOI 10.1016/j.jbc.2022.101717
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  4. Article ; Online: The State of the World’s Midwifery 2021 report

    Andrea Nove / Petra ten Hoope-Bender / Martin Boyce / Sarah Bar-Zeev / Luc de Bernis / Geeta Lal / Zoë Matthews / Million Mekuria / Caroline S. E. Homer

    Human Resources for Health, Vol 19, Iss 1, Pp 1-

    findings to drive global policy and practice

    2021  Volume 7

    Abstract: Abstract The third global State of the World’s Midwifery report (SoWMy 2021) provides an updated ...

    Abstract Abstract The third global State of the World’s Midwifery report (SoWMy 2021) provides an updated evidence base on the sexual, reproductive, maternal, newborn and adolescent health (SRMNAH) workforce. For the first time, SoWMy includes high-income countries (HICs) as well as low- and middle-income countries. This paper describes the similarities and differences between regions and income groups, and discusses the policy implications of these variations. SoWMy 2021 estimates a global shortage of 900,000 midwives, which is particularly acute in low-income countries (LICs) and in Africa. The shortage is projected to improve only slightly by 2030 unless additional investments are made. The evidence suggests that these investments would yield important returns, including: more positive birth experiences, improved health outcomes, and inclusive and equitable economic growth. Most HICs have sufficient SRMNAH workers to meet the need for essential interventions, and their education and regulatory environments tend to be strong. Upper-middle-income countries also tend to have strong policy environments. LICs and lower-middle-income countries tend to have a broader scope of practice for midwives, and many also have midwives in leadership positions within national government. Key regional variations include: major midwife shortages in Africa and South-East Asia but more promising signs of growth in South-East Asia than in Africa; a strong focus in Africa on professional midwives (rather than associate professionals: the norm in many South-East Asian countries); heavy reliance on medical doctors rather than midwives in the Americas and Eastern Mediterranean regions and parts of the Western Pacific; and a strong educational and regulatory environment in Europe but a lack of midwife leaders at national level. SoWMy 2021 provides stakeholders with the latest data and information to inform their efforts to build back better and fairer after COVID-19. This paper provides a number of policy responses to SoWMy 2021 that are ...
    Keywords Midwives ; Midwifery ; Human resources for health ; Health workforce ; Sexual ; reproductive ; maternal ; newborn and adolescent health ; Medicine (General) ; R5-920 ; Public aspects of medicine ; RA1-1270
    Subject code 306 ; 360
    Language English
    Publishing date 2021-11-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Robustness of Bergmann’s and Rapoport’s rules to different geographical range estimates in New World pit vipers

    Ten Caten, Cleber / Lima‐Ribeiro, Matheus Souza / Yañez‐Arenas, Carlos / Villalobos, Fabricio / Díaz‐Gamboa, Luis / Terribile, Levi Carina

    Journal of Biogeography. 2023 Feb., v. 50, no. 2 p.365-379

    2023  

    Abstract: AIM: Bergmann's and Rapoport's rules are two ecogeographical patterns that predict an increase in species body size and range size, respectively, with increasing latitudes. Here, we evaluated whether using different geographical range estimates affects ... ...

    Abstract AIM: Bergmann's and Rapoport's rules are two ecogeographical patterns that predict an increase in species body size and range size, respectively, with increasing latitudes. Here, we evaluated whether using different geographical range estimates affects the assessment of Bergmann's and Rapoport's rules at the cross‐species and assemblage levels in New World pit vipers. LOCATION: New World. TAXON: New World pit vipers (Crotalinae). METHODS: We estimated geographical ranges for 135 (i.e. ≈93%) Crotalinae species using ecological niche modelling (ENM) and expert maps and assessed alternative hypotheses that could account for Bergmann's and Rapoport's rules. We evaluated both rules using ‘cross‐species’ (i.e. species as units of observation) and ‘assemblage’ (i.e. sites/grid cells as units of observation) approaches. We used phylogenetic generalized least squares (PGLS) analyses and generalized least squares (GLS) analyses to account for phylogenetic and spatial autocorrelation that could affect the evaluation of these rules at the cross‐species and assemblage levels, respectively. RESULTS: Expert maps differed significantly from ENM ranges. The cross‐species approach was robust to these different range estimates when Bergmann's and Rapoport's rules were evaluated. The assemblage analyses were more vulnerable to different range estimates, where contrasting results were observed in the assessment of Bergmann's rule but not in the evaluation of Rapoport's rule. MAIN CONCLUSIONS: Different geographical range estimates affected mainly the assessment of ecogeographical rules at the assemblage level, whereas the cross‐species analyses were more robust. However, this increased susceptibility of the assemblage approach to different range estimates was only observed when evaluating Bergmann's rule. Thus, our findings suggest that ecogeographical rules can have different levels of sensitivity to different range estimates, which can especially affect the assemblage‐level assessment of these ecogeographical patterns.
    Keywords autocorrelation ; biogeography ; body size ; niches ; phylogeny
    Language English
    Dates of publication 2023-02
    Size p. 365-379.
    Publishing place John Wiley & Sons, Ltd
    Document type Article ; Online
    Note JOURNAL ARTICLE
    ZDB-ID 188963-1
    ISSN 0305-0270
    ISSN 0305-0270
    DOI 10.1111/jbi.14538
    Database NAL-Catalogue (AGRICOLA)

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    In stock of ZB MED Bonn / Germany

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  6. Article ; Online: Longitudinal Flow Decorrelations in Xe+Xe Collisions at sqrt[s_{NN}]=5.44  TeV with the ATLAS Detector.

    Aad, G / Abbott, B / Abbott, D C / Abed Abud, A / Abeling, K / Abhayasinghe, D K / Abidi, S H / AbouZeid, O S / Abraham, N L / Abramowicz, H / Abreu, H / Abulaiti, Y / Acharya, B S / Achkar, B / Adachi, S / Adam, L / Adam Bourdarios, C / Adamczyk, L / Adamek, L /
    Adelman, J / Adersberger, M / Adiguzel, A / Adorni, S / Adye, T / Affolder, A A / Afik, Y / Agapopoulou, C / Agaras, M N / Aggarwal, A / Agheorghiesei, C / Aguilar-Saavedra, J A / Ahmadov, F / Ahmed, W S / Ai, X / Aielli, G / Akatsuka, S / Åkesson, T P A / Akilli, E / Akimov, A V / Al Khoury, K / Alberghi, G L / Albert, J / Alconada Verzini, M J / Alderweireldt, S / Aleksa, M / Aleksandrov, I N / Alexa, C / Alexopoulos, T / Alfonsi, A / Alfonsi, F / Alhroob, M / Ali, B / Aliev, M / Alimonti, G / Allaire, C / Allbrooke, B M M / Allen, B W / Allport, P P / Aloisio, A / Alonso, F / Alpigiani, C / Alshehri, A A / Alunno Camelia, E / Alvarez Estevez, M / Alviggi, M G / Amaral Coutinho, Y / Ambler, A / Ambroz, L / Amelung, C / Amidei, D / Amor Dos Santos, S P / Amoroso, S / Amrouche, C S / An, F / Anastopoulos, C / Andari, N / Andeen, T / Anders, C F / Anders, J K / Andrean, S Y / Andreazza, A / Andrei, V / Anelli, C R / Angelidakis, S / Angerami, A / Anisenkov, A V / Annovi, A / Antel, C / Anthony, M T / Antipov, E / Antonelli, M / Antrim, D J A / Anulli, F / Aoki, M / Aparisi Pozo, J A / Aparo, M A / Aperio Bella, L / Araque, J P / Araujo Ferraz, V / Araujo Pereira, R / Arcangeletti, C / Arce, A T H / Arduh, F A / Arguin, J-F / Argyropoulos, S / Arling, J-H / Armbruster, A J / Armstrong, A / Arnaez, O / Arnold, H / Arrubarrena Tame, Z P / Artoni, G / Artz, S / Asai, S / Asawatavonvanich, T / Asbah, N / Asimakopoulou, E M / Asquith, L / Assahsah, J / Assamagan, K / Astalos, R / Atkin, R J / Atkinson, M / Atlay, N B / Atmani, H / Augsten, K / Avolio, G / Ayoub, M K / Azuelos, G / Bachacou, H / Bachas, K / Backes, M / Backman, F / Bagnaia, P / Bahmani, M / Bahrasemani, H / Bailey, A J / Bailey, V R / Baines, J T / Bakalis, C / Baker, O K / Bakker, P J / Bakshi Gupta, D / Balaji, S / Baldin, E M / Balek, P / Balli, F / Balunas, W K / Balz, J / Banas, E / Bandieramonte, M / Bandyopadhyay, A / Banerjee, Sw / Barak, L / Barbe, W M / Barberio, E L / Barberis, D / Barbero, M / Barbour, G / Barillari, T / Barisits, M-S / Barkeloo, J / Barklow, T / Barnea, R / Barnett, B M / Barnett, R M / Barnovska-Blenessy, Z / Baroncelli, A / Barone, G / Barr, A J / Barranco Navarro, L / Barreiro, F / Barreiro Guimarães da Costa, J / Barsov, S / Bartels, F / Bartoldus, R / Bartolini, G / Barton, A E / Bartos, P / Basalaev, A / Basan, A / Bassalat, A / Basso, M J / Bates, R L / Batlamous, S / Batley, J R / Batool, B / Battaglia, M / Bauce, M / Bauer, F / Bauer, K T / Bawa, H S / Beacham, J B / Beau, T / Beauchemin, P H / Becherer, F / Bechtle, P / Beck, H C / Beck, H P / Becker, K / Becot, C / Beddall, A / Beddall, A J / Bednyakov, V A / Bedognetti, M / Bee, C P / Beermann, T A / Begalli, M / Begel, M / Behera, A / Behr, J K / Beisiegel, F / Bell, A S / Bella, G / Bellagamba, L / Bellerive, A / Bellos, P / Beloborodov, K / Belotskiy, K / Belyaev, N L / Benchekroun, D / Benekos, N / Benhammou, Y / Benjamin, D P / Benoit, M / Bensinger, J R / Bentvelsen, S / Beresford, L / Beretta, M / Berge, D / Bergeaas Kuutmann, E / Berger, N / Bergmann, B / Bergsten, L J / Beringer, J / Berlendis, S / Bernardi, G / Bernius, C / Bernlochner, F U / Berry, T / Berta, P / Bertella, C / Bertram, I A / Bessidskaia Bylund, O / Besson, N / Bethani, A / Bethke, S / Betti, A / Bevan, A J / Beyer, J / Bhattacharya, D S / Bhattarai, P / Bi, R / Bianchi, R M / Biebel, O / Biedermann, D / Bielski, R / Bierwagen, K / Biesuz, N V / Biglietti, M / Billoud, T R V / Bindi, M / Bingul, A / Bini, C / Biondi, S / Birman, M / Bisanz, T / Biswal, J P / Biswas, D / Bitadze, A / Bittrich, C / Bjørke, K / Blazek, T / Bloch, I / Blocker, C / Blue, A / Blumenschein, U / Bobbink, G J / Bobrovnikov, V S / Bocchetta, S S / Bocci, A / Bogavac, D / Bogdanchikov, A G / Bohm, C / Boisvert, V / Bokan, P / Bold, T / Bolz, A E / Bomben, M / Bona, M / Bonilla, J S / Boonekamp, M / Booth, C D / Borecka-Bielska, H M / Borgna, L S / Borisov, A / Borissov, G / Bortfeldt, J / Bortoletto, D / Boscherini, D / Bosman, M / Bossio Sola, J D / Bouaouda, K / Boudreau, J / Bouhova-Thacker, E V / Boumediene, D / Boutle, S K / Boveia, A / Boyd, J / Boye, D / Boyko, I R / Bozson, A J / Bracinik, J / Brahimi, N / Brandt, G / Brandt, O / Braren, F / Brau, B / Brau, J E / Breaden Madden, W D / Brendlinger, K / Brenner, L / Brenner, R / Bressler, S / Brickwedde, B / Briglin, D L / Britton, D / Britzger, D / Brock, I / Brock, R / Brooijmans, G / Brooks, W K / Brost, E / Broughton, J H / Bruckman de Renstrom, P A / Bruncko, D / Bruni, A / Bruni, G / Bruni, L S / Bruno, S / Bruschi, M / Bruscino, N / Bryngemark, L / Buanes, T / Buat, Q / Buchholz, P / Buckley, A G / Budagov, I A / Bugge, M K / Bührer, F / Bulekov, O / Burch, T J / Burdin, S / Burgard, C D / Burger, A M / Burghgrave, B / Burr, J T P / Burton, C D / Burzynski, J C / Büscher, V / Buschmann, E / Bussey, P J / Butler, J M / Buttar, C M / Butterworth, J M / Butti, P / Buttinger, W / Buxo Vazquez, C J / Buzatu, A / Buzykaev, A R / Cabras, G / Cabrera Urbán, S / Caforio, D / Cai, H / Cairo, V M M / Cakir, O / Calace, N / Calafiura, P / Calderini, G / Calfayan, P / Callea, G / Caloba, L P / Caltabiano, A / Calvente Lopez, S / Calvet, D / Calvet, S / Calvet, T P / Calvetti, M / Camacho Toro, R / Camarda, S / Camarero Munoz, D / Camarri, P / Cameron, D / Camincher, C / Campana, S / Campanelli, M / Camplani, A / Campoverde, A / Canale, V / Canesse, A / Cano Bret, M / Cantero, J / Cao, T / Cao, Y / Capeans Garrido, M D M / Capua, M / Cardarelli, R / Cardillo, F / Carducci, G / Carli, I / Carli, T / Carlino, G / Carlson, B T / Carlson, E M / Carminati, L / Carney, R M D / Caron, S / Carquin, E / Carrá, S / Carter, J W S / Casado, M P / Casha, A F / Castillo, F L / Castillo Garcia, L / Castillo Gimenez, V / Castro, N F / Catinaccio, A / Catmore, J R / Cattai, A / Cavaliere, V / Cavallaro, E / Cavalli-Sforza, M / Cavasinni, V / Celebi, E / Cerda Alberich, L / Cerny, K / Cerqueira, A S / Cerri, A / Cerrito, L / Cerutti, F / Cervelli, A / Cetin, S A / Chadi, Z / Chakraborty, D / Chan, J / Chan, W S / Chan, W Y / Chapman, J D / Chargeishvili, B / Charlton, D G / Charman, T P / Chau, C C / Che, S / Chekanov, S / Chekulaev, S V / Chelkov, G A / Chen, B / Chen, C / Chen, C H / Chen, H / Chen, J / Chen, S / Chen, S J / Chen, X / Chen, Y-H / Cheng, H C / Cheng, H J / Cheplakov, A / Cheremushkina, E / Cherkaoui El Moursli, R / Cheu, E / Cheung, K / Chevalérias, T J A / Chevalier, L / Chiarella, V / Chiarelli, G / Chiodini, G / Chisholm, A S / Chitan, A / Chiu, I / Chiu, Y H / Chizhov, M V / Choi, K / Chomont, A R / Chouridou, S / Chow, Y S / Chu, M C / Chu, X / Chudoba, J / Chwastowski, J J / Chytka, L / Cieri, D / Ciesla, K M / Cinca, D / Cindro, V / Cioară, I A / Ciocio, A / Cirotto, F / Citron, Z H / Citterio, M / Ciubotaru, D A / Ciungu, B M / Clark, A / Clark, M R / Clark, P J / Clement, C / Coadou, Y / Cobal, M / Coccaro, A / Cochran, J / Coelho Lopes De Sa, R / Cohen, H / Coimbra, A E C / Cole, B / Colijn, A P / Collot, J / Conde Muiño, P / Connell, S H / Connelly, I A / Constantinescu, S / Conventi, F / Cooper-Sarkar, A M / Cormier, F / Cormier, K J R / Corpe, L D / Corradi, M / Corrigan, E E / Corriveau, F / Costa, M J / Costanza, F / Costanzo, D / Cowan, G / Cowley, J W / Crane, J / Cranmer, K / Crawley, S J / Creager, R A / Crépé-Renaudin, S / Crescioli, F / Cristinziani, M / Croft, V / Crosetti, G / Cueto, A / Cuhadar Donszelmann, T / Cukierman, A R / Cunningham, W R / Czekierda, S / Czodrowski, P / Czurylo, M M / Da Cunha Sargedas De Sousa, M J / Da Fonseca Pinto, J V / Da Via, C / Dabrowski, W / Dachs, F / Dado, T / Dahbi, S / Dai, T / Dallapiccola, C / Dam, M / D'amen, G / D'Amico, V / Damp, J / Dandoy, J R / Daneri, M F / Dann, N S / Danninger, M / Dao, V / Darbo, G / Dartsi, O / Dattagupta, A / Daubney, T / D'Auria, S / David, C / Davidek, T / Davis, D R / Dawson, I / De, K / De Asmundis, R / De Beurs, M / De Castro, S / De Cecco, S / De Groot, N / de Jong, P / De la Torre, H / De 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    Physical review letters

    2021  Volume 126, Issue 12, Page(s) 122301

    Abstract: ... in Xe+Xe collisions at sqrt[s_{NN}]=5.44  TeV is obtained using 3  μb^{-1} of data with the ATLAS detector ... centrality and p_{T} dependence is seen. When compared with the results from Pb+Pb collisions at sqrt[s_{NN ...

    Abstract The first measurement of longitudinal decorrelations of harmonic flow amplitudes v_{n} for n=2-4 in Xe+Xe collisions at sqrt[s_{NN}]=5.44  TeV is obtained using 3  μb^{-1} of data with the ATLAS detector at the LHC. The decorrelation signal for v_{3} and v_{4} is found to be nearly independent of collision centrality and transverse momentum (p_{T}) requirements on final-state particles, but for v_{2} a strong centrality and p_{T} dependence is seen. When compared with the results from Pb+Pb collisions at sqrt[s_{NN}]=5.02  TeV, the longitudinal decorrelation signal in midcentral Xe+Xe collisions is found to be larger for v_{2}, but smaller for v_{3}. Current hydrodynamic models reproduce the ratios of the v_{n} measured in Xe+Xe collisions to those in Pb+Pb collisions but fail to describe the magnitudes and trends of the ratios of longitudinal flow decorrelations between Xe+Xe and Pb+Pb. The results on the system-size dependence provide new insights and an important lever arm to separate effects of the longitudinal structure of the initial state from other early and late time effects in heavy-ion collisions.
    Language English
    Publishing date 2021-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.126.122301
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Search for Displaced Leptons in sqrt[s]=13  TeV pp Collisions with the ATLAS Detector.

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Stugu, B / Stupak, J / Styles, N A / Su, D / Su, W / Su, X / Suarez, N B / Sulin, V V / Sullivan, M J / Sultan, D M S / Sultansoy, S / Sumida, T / Sun, S / Sun, X / Suster, C J E / Sutton, M R / Svatos, M / Swiatlowski, M / Swift, S P / Swirski, T / Sydorenko, A / Sykora, I / Sykora, M / Sykora, T / Ta, D / Tackmann, K / Taenzer, J / Taffard, A / Tafirout, R / Tagiev, E / Taibah, R H M / Takashima, R / Takeda, K / Takeshita, T / Takeva, E P / Takubo, Y / Talby, M / Talyshev, A A / Tam, K C / Tamir, N M / Tanaka, J / Tanaka, R / Tapia Araya, S / Tapprogge, S / Tarek Abouelfadl Mohamed, A / Tarem, S / Tariq, K / Tarna, G / Tartarelli, G F / Tas, P / Tasevsky, M / Tassi, E / Tateno, G / Tayalati, Y / Taylor, G N / Taylor, W / Teagle, H / Tee, A S / Teixeira De Lima, R / Teixeira-Dias, P / Ten Kate, H / Teoh, J J / Terashi, K / Terron, J / Terzo, S / Testa, M / Teuscher, R J / Themistokleous, N / Theveneaux-Pelzer, T / Thomas, D W / Thomas, J P / Thompson, E A / Thompson, P D / Thomson, E / Thorpe, E J / Tikhomirov, V O / Tikhonov, Yu A / Timoshenko, S / Tipton, P / Tisserant, S / Todome, K / Todorova-Nova, S / Todt, S / Tojo, J / Tokár, S / Tokushuku, K / Tolley, E / Tombs, R / Tomoto, M / Tompkins, L / Tornambe, P / Torrence, E / Torres, H / Torró Pastor, E / Toscani, M / Tosciri, C / Toth, J / Tovey, D R / Traeet, A / Treado, C J / Trefzger, T / Tresoldi, F / Tricoli, A / Trigger, I M / Trincaz-Duvoid, S / Trischuk, D A / Trischuk, W / Trocmé, B / Trofymov, A / Troncon, C / Trovato, F / Truong, L / Trzebinski, M / Trzupek, A / Tsai, F / Tsiareshka, P V / Tsirigotis, A / Tsiskaridze, V / Tskhadadze, E G / Tsopoulou, M / Tsukerman, I I / Tsulaia, V / Tsuno, S / Tsybychev, D / Tu, Y / Tudorache, A / Tudorache, V / Tuna, A N / Turchikhin, S / Turgeman, D / Turk Cakir, I / Turner, R J / Turra, R / Tuts, P M / Tzamarias, S / Tzovara, E / Uchida, K / Ukegawa, F / Unal, G / Unal, M / Undrus, A / Unel, G / Ungaro, F C / Uno, K / Urban, J / Urquijo, P / Usai, G / Uysal, Z / 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    Physical review letters

    2021  Volume 127, Issue 5, Page(s) 51802

    Abstract: A search for charged leptons with large impact parameters using 139  fb^{-1} of sqrt[s]=13  TeV pp ...

    Abstract A search for charged leptons with large impact parameters using 139  fb^{-1} of sqrt[s]=13  TeV pp collision data from the ATLAS detector at the LHC is presented, addressing a long-standing gap in coverage of possible new physics signatures. Results are consistent with the background prediction. This search provides unique sensitivity to long-lived scalar supersymmetric lepton partners (sleptons). For lifetimes of 0.1 ns, selectron, smuon, and stau masses up to 720, 680, and 340  GeV, respectively, are excluded at 95% confidence level, drastically improving on the previous best limits from LEP.
    Language English
    Publishing date 2021-07-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 208853-8
    ISSN 1079-7114 ; 0031-9007
    ISSN (online) 1079-7114
    ISSN 0031-9007
    DOI 10.1103/PhysRevLett.127.051802
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  8. Article ; Online: S-World

    Stoorvogel, J.J. / Bakkenes, Michel / Temme, A.J.A.M. / Batjes, N.H. / Ten Brink, Ben

    Land Degradation and Development

    a Global Soil Map for Environmental Modelling

    2017  Volume 28, Issue 1

    Abstract: ... the distribution of soil properties. The methodology, denominated S-World (Soils of the world) resulted in readily ...

    Abstract The research community increasingly analyses global environmental problems like climate change and desertification with models. These global environmental modelling studies require global, high resolution, spatially exhaustive, and quantitative data describing the soil profile. This study aimed to develop a pedological approach that takes stock of available legacy and auxiliary data to create a global, 30 arc second soil property database for modelling. The methodology uses the Harmonized World Soil Database and the ISRIC-WISE 3.1 soil profile database. Auxiliary information at 30 arc second resolution for various landscape properties is used to describe the variation in landscape properties (temperature and precipitation, topography, elevation, land use, and land cover). Complex mapping units of the HWSD were first disaggregated using a digital elevation model and toposequences to generate delineated areas described by a single soil type. Secondly, ranges of soil properties per soil type were determined using the soil profile data. Then a meta-analysis on a broad literature survey was used to develop a simple model that, based on landscape properties at a particular location, determines the position within these ranges and thus provides an estimation of the local soil properties. Finally, the model was implemented at the global level to determine the distribution of soil properties. The methodology, denominated S-World (Soils of the world) resulted in readily available, high resolution, global soil property maps that are now available for environmental modelling.
    Keywords GlobalSoilMap Digital soil mapping ; Rwanda ; Soil property maps
    Subject code 910
    Language English
    Publishing country nl
    Document type Article ; Online
    ZDB-ID 1319202-4
    ISSN 1085-3278
    ISSN 1085-3278
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Multy-Culture and Diversity Management in Today’s Organizations

    Yu. P. Ten / I. L. Smirnova / S. P. Ivanova

    Вестник Российского экономического университета имени Г. В. Плеханова, Vol 17, Iss 4, Pp 158-

    2020  Volume 166

    Abstract: In today’s organizations the concept of diversity management has won a steady position for the last ... subjects of diversity management, which is acute and needed for today’s business-practice. They analyzed G ... from different layers of society could contribute to attainment of organization’s goals and realize his/her own ...

    Abstract In today’s organizations the concept of diversity management has won a steady position for the last 30 years and is becoming more and more important due to inevitable extension of human society diversity. The article provides certain aspects of multi-culturalism ideology, some approaches to managing cultural diversification within the frames of the current context of management. The authors studies subjects of diversity management, which is acute and needed for today’s business-practice. They analyzed G. Hofsted cultural typology, ranged key types of world cultures according to R. D. Lewis and their principle characteristics. The research aims at two basic positions: on the one hand, diversity management can help organizations that are afraid of the phenomenon because of its assumed adverse consequences; on the other hand, it can help companies, which realize this concept now and use its advantages. In conclusion the authors write that efficient diversity management implies changes in consciousness, attitude, behavior, organizational practice, structure and culture, as well as in totality of rules, procedures and ethic of business, where every person from different layers of society could contribute to attainment of organization’s goals and realize his/her own potential.
    Keywords мультикультурность ; управление многообразием ; культурная диверсификация в организации ; глобализация ; Economics as a science ; HB71-74
    Subject code 650
    Language Russian
    Publishing date 2020-07-01T00:00:00Z
    Publisher Plekhanov Russian University of Economics
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Isolated neuro-Behçet’s disease in a child, from headache to diagnosis

    Rojan İpek / Barıs Ten / Mustafa Kömür / Cetin Okuyaz

    Dicle Medical Journal, Vol 49, Iss 2, Pp 381-

    A case report

    2022  Volume 384

    Abstract: Behçet's disease (BD) is an immuno-inflammatory multi-systemic disease characterized by ophthalmological and skin involvement, also oral and genital ulcers. Its etiology and pathogenesis are not clearly known. Neuro-Behçet's disease can occur as an ... ...

    Abstract Behçet's disease (BD) is an immuno-inflammatory multi-systemic disease characterized by ophthalmological and skin involvement, also oral and genital ulcers. Its etiology and pathogenesis are not clearly known. Neuro-Behçet's disease can occur as an isolated form or a rare complication of BD. Besides, diagnosis of neuro-Behçet's disease is difficult. Since Neuro-Behçet can result in morbidity and mortality, early diagnosis and treatment are important. The most important genetic factor in the pathogenesis of BD is Human Leucocyte Antigen (HLA-B 51) allele positivity. A 9-year-old girl was brought to our outpatient clinic for 6 months with a migraine-like headache. The headache of the patient has a partial response to analgesics and rarely awakes from sleep at night accompanied by vomiting. The patient was diagnosed with an isolated neuro-Behçet's disease by HLA-B 51 allele positivity and brain magnetic resonance imaging (MRI) findings. In the current study, the roles of HLA-B 51 allele positivity and brain MRI findings were discussed in the diagnosis of neuro-Behçet's disease.
    Keywords hla-b51 positivity ; isolated neuro-behçet's disease ; migrain like headache ; mri ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 610
    Language English
    Publishing date 2022-06-01T00:00:00Z
    Publisher Dicle University Medical School
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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