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  1. Article ; Online: Realising the long-term promise of insulin therapy: the DCCT/EDIC study.

    Nathan, David M

    Diabetologia

    2021  Volume 64, Issue 5, Page(s) 1049–1058

    Abstract: The introduction of insulin in the treatment of juvenile-onset, now type 1, diabetes mellitus transformed a rapidly fatal disease into a chronic degenerative one. During the insulin-treatment era, long-term microvascular and cardiovascular complications ... ...

    Abstract The introduction of insulin in the treatment of juvenile-onset, now type 1, diabetes mellitus transformed a rapidly fatal disease into a chronic degenerative one. During the insulin-treatment era, long-term microvascular and cardiovascular complications proved to be the bane of existence for people with type 1 diabetes, leading to blindness, kidney failure, amputations, cardiovascular disease (CVD) and premature mortality. The nascent understanding of the link between non-physiologically regulated glucose levels and these complications led to the development of new treatment tools in the 1970s and 1980s that facilitated the delivery of insulin to achieve glucose levels closer to non-diabetic levels. These therapeutic advances set the stage for definitive testing of the glucose hypothesis. The Diabetes Control and Complications Trial (DCCT), supported by the National Institute of Diabetes Digestive and Kidney Diseases, National Institutes of Health (NIH), definitively established the benefits and risks of intensive therapy that substantially lowered mean blood glucose levels, measured by HbA
    MeSH term(s) Clinical Trials as Topic ; Diabetes Complications/pathology ; Diabetes Complications/therapy ; Diabetes Mellitus/drug therapy ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/history ; Follow-Up Studies ; History, 20th Century ; History, 21st Century ; Humans ; Insulin/history ; Insulin/therapeutic use ; National Institute of Diabetes and Digestive and Kidney Diseases (U.S.) ; National Institutes of Health (U.S.) ; United States
    Chemical Substances Insulin
    Language English
    Publishing date 2021-02-06
    Publishing country Germany
    Document type Historical Article ; Journal Article ; Review
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-021-05397-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 279: Show issues Location:
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  2. Article: Sodiated Oppolzer Enolates: Solution Structures, Mechanism of Alkylation, and Origin of Stereoselectivity.

    Lui, Nathan M / Collum, David B

    Organic chemistry frontiers : an international journal of organic chemistry

    2023  Volume 10, Issue 19, Page(s) 4750–4757

    Abstract: NMR spectroscopic studies reveal camphorsultam-derived sodium enolates known as Oppolzer enolates reside as monomers in neat THF and THF/HMPA solutions and as dimers in toluene when solvated ... ...

    Abstract NMR spectroscopic studies reveal camphorsultam-derived sodium enolates known as Oppolzer enolates reside as monomers in neat THF and THF/HMPA solutions and as dimers in toluene when solvated by
    Language English
    Publishing date 2023-08-17
    Publishing country England
    Document type Journal Article
    ISSN 2052-4110
    ISSN 2052-4110
    DOI 10.1039/d3qo01021j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Understanding Metabolic Memory: The Prolonged Influence of Glycemia During the Diabetes Control and Complications Trial (DCCT) on Future Risks of Complications During the Study of the Epidemiology of Diabetes Interventions and Complications (EDIC).

    Lachin, John M / Nathan, David M

    Diabetes care

    2021  

    Abstract: The Diabetes Control and Complications Trial (DCCT, 1983-1993) showed that intensive therapy (mean ... ...

    Abstract The Diabetes Control and Complications Trial (DCCT, 1983-1993) showed that intensive therapy (mean HbA
    Language English
    Publishing date 2021-09-21
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc20-3097
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Solvent-Assisted Control of Metal-Organic Nanotube Size and Morphology.

    Rosenmann, Nathan D / Barrett, Jacob A / Su, Shengyi / Gianneschi, Nathan C / Jenkins, David M

    Inorganic chemistry

    2024  

    Abstract: While intensive studies have focused on the synthesis and characterization of new metal-organic nanotube (MONT) structures, the lack of size and morphology control remains an obstacle in broadening applications for this class of materials. Herein, we ... ...

    Abstract While intensive studies have focused on the synthesis and characterization of new metal-organic nanotube (MONT) structures, the lack of size and morphology control remains an obstacle in broadening applications for this class of materials. Herein, we demonstrate control of MONT crystallite size and morphology by tuning polarity and the protic/aprotic nature of solvents, including dimethylformamide,
    Language English
    Publishing date 2024-05-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.4c00559
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  5. Article ; Online: Diagnosing diabetes mellitus - best practices still unclear.

    Nathan, David M

    Nature reviews. Endocrinology

    2018  Volume 14, Issue 10, Page(s) 572–573

    MeSH term(s) Blood Glucose ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Glycated Hemoglobin A/analysis ; Humans ; Prognosis ; Prospective Studies
    Chemical Substances Blood Glucose ; Glycated Hemoglobin A
    Language English
    Publishing date 2018-07-27
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 2489381-X
    ISSN 1759-5037 ; 1759-5029
    ISSN (online) 1759-5037
    ISSN 1759-5029
    DOI 10.1038/s41574-018-0072-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6336: Show issues Location:
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    Zs.MG 93: Show issues

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  6. Article: Myeloid neoplasms in inflammatory bowel disease: A case series and review of the literature.

    Mueller, David M / Nathan, Daniel I / Liu, Angela / Mascarenhas, John / Marcellino, Bridget K

    Leukemia research reports

    2024  Volume 21, Page(s) 100458

    Abstract: Patients with inflammatory bowel disease (IBD) are exposed to chronic systemic inflammation and are at risk for secondary malignancies. Here we review the literature on the risk of myeloid neoplasms (MN) in IBD and present the disease profiles of ... ...

    Abstract Patients with inflammatory bowel disease (IBD) are exposed to chronic systemic inflammation and are at risk for secondary malignancies. Here we review the literature on the risk of myeloid neoplasms (MN) in IBD and present the disease profiles of patients at a single institution with IBD who later developed MN, comparing them to those in the literature. No IBD characteristic was found to associate with MN disease severity, including the previously-identified association between MNs and thiopurine exposure. Of the somatic mutations identified in out cohort's MN, mutations in
    Language English
    Publishing date 2024-04-02
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2706248-X
    ISSN 2213-0489
    ISSN 2213-0489
    DOI 10.1016/j.lrr.2024.100458
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  7. Article ; Online: Adjunctive Treatments for Type 1 Diabetes.

    Nathan, David M

    The New England journal of medicine

    2017  

    Language English
    Publishing date 2017-09-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMe1711296
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Ua VI Zs.34: Show issues Location:
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  8. Article ; Online: Thoughts on the Surprising Effect of Priming on 22-Item Sino-Nasal Outcome Test (SNOT-22) Results.

    Yang, Nathan / Waytz, Adam / Soler, Zachary M / Overdevest, Jonathan B / Gudis, David A

    American journal of rhinology & allergy

    2024  , Page(s) 19458924241240846

    Language English
    Publishing date 2024-03-20
    Publishing country United States
    Document type Letter
    ZDB-ID 2482804-X
    ISSN 1945-8932 ; 1945-8924
    ISSN (online) 1945-8932
    ISSN 1945-8924
    DOI 10.1177/19458924241240846
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    Zs.A 2542: Show issues Location:
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  9. Article ; Online: Spatiotemporal variability in exposure to excessive heat at the sub-urban scale

    Shafran-Nathan, Rakefet / Broday, David M.

    Climatic Change. 2022 Sept., v. 174, no. 1-2 p.7-7

    2022  

    Abstract: Exposure to excessive heat can lead to adverse health outcomes in both healthy and vulnerable individuals. This study examines the spatiotemporal variability of exposure to severe heat at the sub-neighborhood scale using temperature and relative humidity ...

    Abstract Exposure to excessive heat can lead to adverse health outcomes in both healthy and vulnerable individuals. This study examines the spatiotemporal variability of exposure to severe heat at the sub-neighborhood scale using temperature and relative humidity measurements of a wireless distributed sensor network (WDSN). First, we demonstrate a multi-sensor calibration scheme for the temperature and the relative humidity sensors. Next, exposure to heat was calculated using the heat index (HI) scale, which enables linking exposure to HI and heat-related health risks. We noticed repeated exposures to excessive heat above the safe threshold for about 8 h per day throughout July–August, 2015, in Haifa, Israel. Persistent exposure to such conditions is unhealthy. The areas that experienced high HI were scattered across the study area, with the HI showing spatiotemporal variability. In general, in some microenvironments, the HI peaked earlier during the day than in other microenvironments. This was attributed to variability in urban physical drivers, which were found to be good predictors of the morning HI variability buildup but less so of the HI variability in the afternoon. Our results are consistent with summer HI occurrence in the study area in the past 20 years. Since exposure to excessive heat in the east Mediterranean is expected to increase in the future due to climate changes, it may result in a grave health toll.
    Keywords climate ; climate change ; heat ; relative humidity ; summer ; temperature ; Israel
    Language English
    Dates of publication 2022-09
    Size p. 7.
    Publishing place Springer Netherlands
    Document type Article ; Online
    ZDB-ID 751086-x
    ISSN 0165-0009
    ISSN 0165-0009
    DOI 10.1007/s10584-022-03425-9
    Database NAL-Catalogue (AGRICOLA)

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    Einzelsign.: Show issues
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  10. Article ; Online: Healthcare personnel opinions regarding the feasibility of a risk-tailored approach to contact precautions for methicillin-resistant

    O'Hara, Lyndsay M / Harris, Anthony D / Calfee, David P / Snyder, Graham M / Cottam, James / O'Hara, Nathan N / Martin, Elise M

    Infection control and hospital epidemiology

    2024  , Page(s) 1–3

    Abstract: All or none" approaches to the use of contact precautions for methicillin- ... ...

    Abstract "All or none" approaches to the use of contact precautions for methicillin-resistant
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639378-0
    ISSN 1559-6834 ; 0195-9417 ; 0899-823X
    ISSN (online) 1559-6834
    ISSN 0195-9417 ; 0899-823X
    DOI 10.1017/ice.2024.54
    Database MEDical Literature Analysis and Retrieval System OnLINE

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