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Article ; Online: PET tracers based on (86)Y.

Huang, Jinming / Cui, Liyang / Wang, Fan / Liu, Zhaofei

Current radiopharmaceuticals

2011 Volume 4, Issue 2, Page(s) 122–130

Abstract: Positron emission tomography (PET) has become a powerful tool for probing biochemical processes ... in living subjects. PET imaging depends largely on the development of novel PET tracers labeled ... with positron-emitting radionuclides. Since the four traditional PET isotopes (18F, 11C, 13N, and 15O) are ...

Abstract	Positron emission tomography (PET) has become a powerful tool for probing biochemical processes in living subjects. PET imaging depends largely on the development of novel PET tracers labeled with positron-emitting radionuclides. Since the four traditional PET isotopes (18F, 11C, 13N, and 15O) are produced in a cyclotron and are short-lived, their use for long-term observation of biological processes in vivo is limited. In the last decades, extensive research in the development of other unconventional radionuclides (such as 64Cu, 68Ga, 89Zr, 86Y, and 124I) labeled tracers with half-lives complementary to the biological properties of their targeting agents has been conducted. Among these tracers, 86Y-based PET tracers have gained increasing attention since they are ideal surrogates for in vivo determination of biodistribution and dosimetry of therapeutic 90Y (pure β - emitter) pharmaceuticals. In this review article, we will brief introduce the physical characteristics, production, and radiochemistry of 86Y, and will summarize the current 86Y-based PET tracers used for molecular imaging and cancer detection in animal studies and in clinical trials.
MeSH term(s)	Animals ; Humans ; Neoplasms/diagnostic imaging ; Positron-Emission Tomography/methods ; Radiopharmaceuticals ; Yttrium Radioisotopes/chemistry
Chemical Substances	Radiopharmaceuticals ; Yttrium Radioisotopes
Language	English
Publishing date	2011-12-20
Publishing country	United Arab Emirates
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1874-4729
ISSN (online)	1874-4729
DOI	10.2174/1874471011104020122
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Article ; Online: Calibration setting numbers for dose calibrators for the PET isotopes (52)Mn, (64)Cu, (76)Br, (86)Y, (89)Zr, (124)I.

Wooten, A Lake / Lewis, Benjamin C / Szatkowski, Daniel J / Sultan, Deborah H / Abdin, Kinda I / Voller, Thomas F / Liu, Yongjian / Lapi, Suzanne E

Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

2016 Volume 113, Page(s) 89–95

Abstract: For PET radionuclides, the radioactivity of a sample can be conveniently measured by a dose ... of several PET radionuclides. Our results reiterate the notion that in-house, experimental calibrations are ...

Abstract	For PET radionuclides, the radioactivity of a sample can be conveniently measured by a dose calibrator. These devices depend on a "calibration setting number", but many recommended settings from manuals were interpolated based on standard sources of other radionuclide(s). We conducted HPGe gamma-ray spectroscopy, resulting in a reference for determining settings in two types of vessels containing one of several PET radionuclides. Our results reiterate the notion that in-house, experimental calibrations are recommended for different radionuclides and vessels.
MeSH term(s)	Bromine Radioisotopes/analysis ; Calibration ; Copper Radioisotopes/analysis ; Humans ; Iodine Radioisotopes/analysis ; Manganese/analysis ; Positron-Emission Tomography/standards ; Positron-Emission Tomography/statistics & numerical data ; Radioisotopes/analysis ; Radiometry/standards ; Radiometry/statistics & numerical data ; Yttrium Radioisotopes/analysis ; Zirconium/analysis
Chemical Substances	Bromine Radioisotopes ; Bromine-76 ; Copper Radioisotopes ; Copper-64 ; Iodine Radioisotopes ; Iodine-124 ; Manganese-52 ; Radioisotopes ; Yttrium Radioisotopes ; Yttrium-86 ; Manganese (42Z2K6ZL8P) ; Zirconium (C6V6S92N3C) ; Zirconium-89 (NTM296JU95)
Language	English
Publishing date	2016-04-26
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1142596-9
ISSN	1872-9800 ; 0883-2889 ; 0969-8043
ISSN (online)	1872-9800
ISSN	0883-2889 ; 0969-8043
DOI	10.1016/j.apradiso.2016.04.025
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Article: HIGH-RESOLUTION L(Y)SO DETECTORS USING PMT-QUADRANT-SHARING FOR HUMAN & ANIMAL PET CAMERAS.

Ramirez, Rocio A / Liu, Shitao / Liu, Jiguo / Zhang, Yuxuan / Kim, Soonseok / Baghaei, Hossain / Li, Hongdi / Wang, Yu / Wong, Wai-Hoi

IEEE transactions on nuclear science

2009 Volume 55, Issue 3, Page(s) 862–869

Abstract: We developed high resolution L(Y)SO detectors for human and animal PET applications using ... resolution of the PET cameras with these blocks, we used GATE (Geant4 Application for Tomographic Emission ... simulation package. GATE is a GEANT4 based software toolkit for realistic simulation of PET and SPECT systems ...

Abstract	We developed high resolution L(Y)SO detectors for human and animal PET applications using Photomultiplier-quadrant-sharing (PQS) technology. The crystal sizes were 1.27 × 1.27 × 10 mm(3) for the animal PQS-blocks and 3.25 × 3.25 × 20 mm(3) for human ones. Polymer mirror film patterns (PMR) were placed between crystals as reflector. The blocks were assembled together using optical grease and wrapped by Teflon tape. The blocks were coupled to regular round PMT's of 19/51 mm in PQS configuration. List-mode data of Ga-68 source (511 KeV) were acquired with our high yield pileup-event recovery (HYPER) electronics and data acquisition software. The high voltage bias was 1100V. Crystal decoding maps and individual crystal energy resolutions were extracted from the data. To investigate the potential imaging resolution of the PET cameras with these blocks, we used GATE (Geant4 Application for Tomographic Emission) simulation package. GATE is a GEANT4 based software toolkit for realistic simulation of PET and SPECT systems. The packing fractions of these blocks were found to be 95.6% and 98.2%. From the decoding maps, all 196 and 225 crystals were clearly identified. The average energy resolutions were 14.0% and 15.6%. For small animal PET systems, the detector ring diameter was 16.5 cm with an axial field of view (AFOV) of 11.8 cm. The simulation data suggests that a reconstructed radial (tangential) spatial resolution of 1.24 (1.25) mm near the center is potentially achievable. For the wholebody human PET systems, the detector ring diameter was 86 cm. The simulation data suggests that a reconstructed radial (tangential) spatial resolution of 3.09(3.38) mm near the center is potentially achievable. From this study we can conclude that PQS design could achieve high spatial resolutions and excellent energy resolutions on human and animal PET systems with substantially lower production costs and inexpensive readout devices.
Language	English
Publishing date	2009-11-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	218510-6
ISSN	0018-9499
ISSN	0018-9499
DOI	10.1109/TNS.2008.922832
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Article ; Online: The biochemical confirmation of adult male hypogonadism: Global perspectives from the International Society of Andrology.

Corona, Giovani / Goulis, Dimitrios G / Liu, Peter Y

Clinical endocrinology

2023 Volume 99, Issue 4, Page(s) 398–400

MeSH term(s)	Humans ; Male ; Adult ; Andrology ; Testosterone ; Hypogonadism/diagnosis
Chemical Substances	Testosterone (3XMK78S47O)
Language	English
Publishing date	2023-06-09
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.14941
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Article ; Online: Correction: The Effect of Fat Grafting on Scars Hyperpigmentation: A Systematic Review and Meta-Analysis.

Bonetti, Mario Alessandri / Arellano, Jose Antonio / Scarabosio, Anna / Liu, Hilary Y / Giorgino, Riccardo / Ejaz, Asim / Rubin, J Peter / Egro, Francesco M

Aesthetic plastic surgery

2024 Volume 48, Issue 7, Page(s) 1508

Language	English
Publishing date	2024-02-26
Publishing country	United States
Document type	Published Erratum
ZDB-ID	532791-x
ISSN	1432-5241 ; 0364-216X
ISSN (online)	1432-5241
ISSN	0364-216X
DOI	10.1007/s00266-024-03916-3
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Article ; Online: Sleep, testosterone and cortisol balance, and ageing men.

Liu, Peter Y / Reddy, Radha T

Reviews in endocrine & metabolic disorders

2022 Volume 23, Issue 6, Page(s) 1323–1339

Abstract: Sleep serves important biological functions, and influences health and longevity through endocrine and metabolic related systems. Sleep debt, circadian misalignment and sleep disruption from obstructive sleep apnea is widespread in modern society and ... ...

Abstract	Sleep serves important biological functions, and influences health and longevity through endocrine and metabolic related systems. Sleep debt, circadian misalignment and sleep disruption from obstructive sleep apnea is widespread in modern society and accumulates with life because recovery sleep is not completely restorative. Accumulated disordered sleep throughout life impacts the ageing process and the development of age-related diseases. When epidemiological and interventional studies are considered collectively, sleep loss and lower sleep duration are associated with lower morning, afternoon and 24-h testosterone; as well as higher afternoon, but not morning or 24-h cortisol. These reciprocal changes imbalances anabolic-catabolic signaling because testosterone and cortisol are respectively the main anabolic and catabolic signals in man. Fixing testosterone-cortisol balance by means of a novel dual-hormone clamp mitigates the induction of insulin resistance by sleep restriction and provided the first proof-of-concept that the metabolic harm from sleep loss can be ameliorated by approaches that do not require sleeping more. Obstructive sleep apnea is associated with lower testosterone, even after controlling for age and obesity whereas the conclusion that continuous positive airway pressure therapy has no effect on testosterone is premature because available studies are underpowered and better-quality studies suggest otherwise. High dose testosterone therapy induces OSA, but more physiological dosing may not; and this effect may be transient or may dissipate with longer term therapy. Studies investigating the origin of the diurnal testosterone rhythm, the effect of circadian misalignment on testosterone-cortisol balance, and methods to mitigate metabolic harm, are required.
MeSH term(s)	Male ; Humans ; Testosterone/metabolism ; Hydrocortisone/metabolism ; Sleep/physiology ; Sleep Apnea, Obstructive/etiology ; Sleep Apnea, Obstructive/therapy ; Aging
Chemical Substances	Testosterone (3XMK78S47O) ; Hydrocortisone (WI4X0X7BPJ)
Language	English
Publishing date	2022-09-24
Publishing country	Germany
Document type	Journal Article ; Review ; Research Support, N.I.H., Extramural
ZDB-ID	2185718-0
ISSN	1573-2606 ; 1389-9155
ISSN (online)	1573-2606
ISSN	1389-9155
DOI	10.1007/s11154-022-09755-4
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Article ; Online: A Clinical Perspective of Sleep and Andrological Health: Assessment, Treatment Considerations, and Future Research.

Liu, Peter Y

The Journal of clinical endocrinology and metabolism

2019 Volume 104, Issue 10, Page(s) 4398–4417

Abstract: Context: Sleep that is insufficient, misaligned, or disrupted causes hypersomnolence and neuropsychological deficits, adversely affects cardiometabolic health, and is increasingly recognized to impair other biological processes that lead to conditions ... ...

Abstract	Context: Sleep that is insufficient, misaligned, or disrupted causes hypersomnolence and neuropsychological deficits, adversely affects cardiometabolic health, and is increasingly recognized to impair other biological processes that lead to conditions important to men, such as hypogonadism, erectile dysfunction, and infertility. Evidence acquisition: Literature review from 1970 to December 2018. Evidence synthesis: High-quality and complementary epidemiological and interventional studies establish that abnormal sleep is associated with increased mortality, hypertension, and other cardiometabolic disorders (insufficient, disrupted, and misaligned sleep), as well as reduced fecundity and total sperm count (insufficient sleep), erectile dysfunction (disrupted sleep), and low testosterone (both). Circadian misalignment shifts the peak of testosterone's diurnal rhythm to occur soon after waking up, irrespective of the biological clock time, but it does not change the mean concentration. Preliminary studies show that extending sleep in individuals who are chronically sleep deprived may become a strategy to reduce insulin resistance and hypertension. Continuous positive airway pressure therapy can improve erectile function, and possibly systemic testosterone exposure, but only when used adherently by men with obstructive sleep apnea. Both high-dose and replacement-dose testosterone therapies modestly worsen sleep-disordered breathing, but they also improve cardiometabolic function and sexual desire. Persistence of either the adverse or beneficial outcomes over the longer term requires further investigation. Conclusions: Sleep is increasingly recognized to be essential for healthy living. Establishing the effect of abnormal sleep, and of improving sleep, on andrological issues of prime interest to men will promote prioritization of sleep, and may thereby improve overall long-term health outcomes.
MeSH term(s)	Age Factors ; Androgens/metabolism ; Continuous Positive Airway Pressure/methods ; Erectile Dysfunction/diagnosis ; Erectile Dysfunction/epidemiology ; Hormone Replacement Therapy/methods ; Humans ; Hypertension/diagnosis ; Hypertension/epidemiology ; Hypogonadism/diagnosis ; Hypogonadism/epidemiology ; Male ; Prevalence ; Prognosis ; Quality of Life ; Risk Assessment ; Sleep/physiology ; Sleep Apnea, Obstructive/diagnosis ; Sleep Apnea, Obstructive/epidemiology ; Sleep Apnea, Obstructive/therapy ; Sleep Wake Disorders/diagnosis ; Sleep Wake Disorders/epidemiology ; Sleep Wake Disorders/therapy
Chemical Substances	Androgens
Language	English
Publishing date	2019-05-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Review
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2019-00683
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Article ; Online: Dietary crude protein reductions in wheat-based diets with two energy densities compromised performance of broiler chickens from 15 to 36 days post-hatch.

Macelline, Shemil P / Chrystal, Peter V / Toghyani, Mehdi / Selle, Peter H / Liu, Sonia Y

Poultry science

2023 Volume 102, Issue 10, Page(s) 102932

Abstract: This study was designed to investigate the impacts of 2 energy densities (13.0 and 12.5 MJ/kg ME) in wheat-based diets with 3 tiers of CP concentrations (210, 190, and 170 g/kg) on the performance of broiler chickens. The parameters assessed included ... ...

Abstract	This study was designed to investigate the impacts of 2 energy densities (13.0 and 12.5 MJ/kg ME) in wheat-based diets with 3 tiers of CP concentrations (210, 190, and 170 g/kg) on the performance of broiler chickens. The parameters assessed included growth performance (15-36 d posthatch), carcass traits, nutrient utilization, starch-protein digestive dynamics, apparent ileal amino acid digestibility coefficients, and the free amino acid and ammonia (NH
MeSH term(s)	Animals ; Chickens ; Triticum/metabolism ; Ammonia/metabolism ; Dietary Proteins/metabolism ; Diet/veterinary ; Weight Gain ; Digestion ; Amino Acids/metabolism ; Glycine max/metabolism ; Brassica napus ; Animal Feed/analysis ; Animal Nutritional Physiological Phenomena ; Energy Metabolism
Chemical Substances	Ammonia (7664-41-7) ; Dietary Proteins ; Amino Acids
Language	English
Publishing date	2023-07-16
Publishing country	England
Document type	Journal Article
ZDB-ID	242586-5
ISSN	1525-3171 ; 0032-5791
ISSN (online)	1525-3171
ISSN	0032-5791
DOI	10.1016/j.psj.2023.102932
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Article ; Online: Protein sources and starch-protein digestive dynamics manipulate growth performance in broiler chickens defined by an equilateral-triangle response surface design.

Macelline, Shemil P / Chrystal, Peter V / Selle, Peter H / Liu, Sonia Y

Animal nutrition (Zhongguo xu mu shou yi xue hui)

2022 Volume 9, Page(s) 204–213

Abstract: A total of 360 male, off-sex Ross 308 chicks were offered 10 dietary treatments from 14 to 35 d post-hatch in an equilateral-triangle response surface design feeding study in order to confirm the importance of protein and amino acid digestive dynamics in ...

Abstract	A total of 360 male, off-sex Ross 308 chicks were offered 10 dietary treatments from 14 to 35 d post-hatch in an equilateral-triangle response surface design feeding study in order to confirm the importance of protein and amino acid digestive dynamics in broiler chickens. The 3 apical diets were nutritionally-equivalent containing either soybean meal, non-bound amino acids or whey protein concentrate as the major source of dietary protein and amino acids. Appropriate blends of the 3 apical diets comprised the balance of 7 diets and each dietary treatment was offered to 6 replicate cages with 6 birds per cage. Growth performance, nutrient utilisation, apparent protein and starch digestibility coefficients were determined in 4 small intestinal segments. The optimal weight gain (2,085 g/bird) and feed conversion ratios (FCR, 1.397) were generated by Diet 50S50W which included a 50:50 blend of apical diets rich in whey protein concentrate and soybean meal. Broiler chickens offered Diet 50S50W also had the highest experimental and predicted jejunal digestibility (0.685 in proximal jejunum and 0.823 in distal jejunum). FCR was not correlated with apparent distal ileal digestibility coefficient (
Language	English
Publishing date	2022-02-03
Publishing country	China
Document type	Journal Article
ISSN	2405-6383
ISSN (online)	2405-6383
DOI	10.1016/j.aninu.2022.01.003
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Article ; Online: Assessing new peptides that may be involved in the physiological regulation of the gonadal axis in humans: gonadotrophin inhibitory hormone.

Liu, Peter Y

Clinical endocrinology

2017 Volume 86, Issue 5, Page(s) 658–659

MeSH term(s)	Gonadotropins ; Humans ; Luteinizing Hormone
Chemical Substances	Gonadotropins ; Luteinizing Hormone (9002-67-9)
Language	English
Publishing date	2017-06-03
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.13328
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