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Article ; Online: Management of Retropharyngeal Node Metastases from Thyroid Carcinoma: Reply.

Hartl, Dana M

2016 Volume 40, Issue 2, Page(s) 489

MeSH term(s)	Carcinoma/secondary ; Carcinoma/therapy ; Female ; Humans ; Male ; Thyroid Neoplasms/pathology ; Thyroid Neoplasms/therapy
Language	English
Publishing date	2016-02
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	224043-9
ISSN	1432-2323 ; 0364-2313
ISSN (online)	1432-2323
ISSN	0364-2313
DOI	10.1007/s00268-015-3253-8
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Article ; Online: Reply to letter: "Optimization of staging of the neck with prophylactic central and lateral neck dissection for papillary thyroid carcinoma".

Hartl, Dana M

Annals of surgery

2015 Volume 261, Issue 1, Page(s) e30

MeSH term(s)	Female ; Humans ; Male ; Neck Dissection ; Thyroid Neoplasms/pathology
Language	English
Publishing date	2015-01
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	340-2
ISSN	1528-1140 ; 0003-4932
ISSN (online)	1528-1140
ISSN	0003-4932
DOI	10.1097/SLA.0000000000000511
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Article ; Online: Autofluorescence of Parathyroid Glands: A Review of Methods of Parathyroid Gland Identification and Parathyroid Vascular Assessment.

Karcioglu, Amanda Silver / Hartl, Dana / Shonka, David C / Slough, Cristian M / Stack, Brendan C / Tolley, Neil / Abdelhamid Ahmed, Amr H / Randolph, Gregory W

Otolaryngologic clinics of North America

2023 Volume 57, Issue 1, Page(s) 139–154

Abstract: Postoperative hypoparathyroidism may cause significant patient morbidity and even mortality. Emerging technologies centered on autofluorescent properties of parathyroid glands when exposed to near-infrared light hold promise to improve surgical ... ...

Abstract	Postoperative hypoparathyroidism may cause significant patient morbidity and even mortality. Emerging technologies centered on autofluorescent properties of parathyroid glands when exposed to near-infrared light hold promise to improve surgical parathyroid gland identification and preservation. Two systems (probe-based and camera-based) are commercially available currently; however, neither system alone provides indication of vascular viability or postoperative parathyroid gland function. The administration of indocyanine green, when combined with near-infrared fluorescence imaging, enables subjective assessment of parathyroid gland perfusion. Additional technologies to assess parathyroid gland perfusion are being developed. The impact of these nascent technologies on relevant clinical outcomes is an area of active investigation.
MeSH term(s)	Humans ; Parathyroid Glands/diagnostic imaging ; Parathyroid Glands/surgery ; Thyroidectomy/adverse effects ; Hypoparathyroidism/diagnosis ; Hypoparathyroidism/etiology ; Hypoparathyroidism/surgery ; Indocyanine Green ; Optical Imaging/adverse effects ; Optical Imaging/methods
Chemical Substances	Indocyanine Green (IX6J1063HV)
Language	English
Publishing date	2023-08-25
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	417489-6
ISSN	1557-8259 ; 0030-6665
ISSN (online)	1557-8259
ISSN	0030-6665
DOI	10.1016/j.otc.2023.07.011
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Article: Intraoperative Parathyroid Gland Identification Using Autofluorescence Imaging in Thyroid Cancer Surgery with Central Neck Dissection: Impact on Post-Operative Hypocalcemia.

Guerlain, Joanne / Breuskin, Ingrid / Abbaci, Muriel / Lamartina, Livia / Hadoux, Julien / Baudin, Eric / Al Ghuzlan, Abir / Moog, Sophie / Marhic, Alix / Villard, Adrien / Obongo, Rais / Hartl, Dana M

Cancers

2023 Volume 16, Issue 1

Abstract: Hypoparathyroidism is the most frequent complication in thyroid surgery. The aim of this study was to evaluate the impact of intraoperative parathyroid gland identification, using autofluorescence imaging, on the rate of post-operative (PO) ... ...

Abstract	Hypoparathyroidism is the most frequent complication in thyroid surgery. The aim of this study was to evaluate the impact of intraoperative parathyroid gland identification, using autofluorescence imaging, on the rate of post-operative (PO) hypoparathyroidism in thyroid cancer surgery. Patients undergoing total thyroidectomy with central neck dissection from 2018 to 2022 were included. A prospective cohort of 77 patients operated on using near-infrared autofluorescence (NIRAF+) with the Fluobeam
Language	English
Publishing date	2023-12-29
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers16010182
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Article: Recurrent Laryngeal Nerve Intraoperative Neuromonitoring Indications in Non-Thyroid and Non-Parathyroid Surgery.

Brunet, Aina / Rovira, Aleix / Quer, Miquel / Sanabria, Alvaro / Guntinas-Lichius, Orlando / Zafereo, Mark / Hartl, Dana M / Coca-Pelaz, Andrés / Shaha, Ashok R / Marie, Jean-Paul / Vander Poorten, Vincent / Piazza, Cesare / Kowalski, Luiz P / Randolph, Gregory W / Shah, Jatin P / Rinaldo, Alessandra / Simo, Ricard

Journal of clinical medicine

2024 Volume 13, Issue 8

Abstract: Introperative nerve monitoring (IONM) of the recurrent laryngeal nerve (RLN) is a well-established technique to aid in thyroid/parathyroid surgery. However, there is little evidence to support its use in non-thyroid or non-parathyroid surgery. The aim of ...

Abstract	Introperative nerve monitoring (IONM) of the recurrent laryngeal nerve (RLN) is a well-established technique to aid in thyroid/parathyroid surgery. However, there is little evidence to support its use in non-thyroid or non-parathyroid surgery. The aim of this paper was to review the current evidence regarding the use of IONM in non-thyroid/non-parathyroid surgery in the head and neck and thorax. A literature search was performed from their inception up to January 2024, including the term "recurrent laryngeal nerve monitoring". IONM in non-thyroid/non-parathyroid surgery has mainly been previously described in oesophageal surgery and in tracheal resections. However, there is little published evidence on the role of IONM with other resections in the vicinity of the RLN. Current evidence is low-level for the use of RLN IONM in non-thyroid/non-parathyroid surgery. However, clinicians should consider its use in surgery for pathologies where the RLN is exposed and could be injured.
Language	English
Publishing date	2024-04-11
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm13082221
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Article ; Online: Evidence-based practice: management of glottic cancer.

Hartl, Dana M

Otolaryngologic clinics of North America

2012 Volume 45, Issue 5, Page(s) 1143–1161

Abstract: The main issue in the management of glottic squamous cell carcinoma, as for all cancers, is adequate disease control while optimizing functional outcomes and minimizing morbidity. This is true for early-stage disease as for advanced tumors. This article ... ...

Abstract	The main issue in the management of glottic squamous cell carcinoma, as for all cancers, is adequate disease control while optimizing functional outcomes and minimizing morbidity. This is true for early-stage disease as for advanced tumors. This article evaluates the current evidence for the diagnostic and pretherapeutic workup for glottic squamous cell carcinoma and the evidence concerning different treatment options for glottic carcinoma, from early-stage to advanced-stage disease.
MeSH term(s)	Carcinoma, Squamous Cell/epidemiology ; Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/therapy ; Chemotherapy, Adjuvant/methods ; Chemotherapy, Adjuvant/statistics & numerical data ; Combined Modality Therapy ; Disease Management ; Disease-Free Survival ; Evidence-Based Practice ; Glottis/pathology ; Glottis/surgery ; Humans ; Laryngeal Neoplasms/epidemiology ; Laryngeal Neoplasms/pathology ; Laryngeal Neoplasms/therapy ; Neck Dissection/adverse effects ; Neck Dissection/methods ; Neck Dissection/statistics & numerical data ; Neoplasm Grading ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Otorhinolaryngologic Surgical Procedures/adverse effects ; Otorhinolaryngologic Surgical Procedures/methods ; Otorhinolaryngologic Surgical Procedures/statistics & numerical data ; Prognosis ; Radiotherapy, Adjuvant/methods ; Radiotherapy, Adjuvant/statistics & numerical data ; Randomized Controlled Trials as Topic ; Treatment Outcome
Language	English
Publishing date	2012-10
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	417489-6
ISSN	1557-8259 ; 0030-6665
ISSN (online)	1557-8259
ISSN	0030-6665
DOI	10.1016/j.otc.2012.06.014
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Article: Intraoperative Autofluorescence Imaging for Parathyroid Gland Identification during Total Laryngectomy with Thyroidectomy.

Obongo Anga, Raïs / Abbaci, Muriel / Guerlain, Joanne / Breuskin, Ingrid / Casiraghi, Odile / Marhic, Alix / Benmoussa-Rebibo, Nadia / de Kermadec, Héloïse / Moya-Plana, Antoine / Temam, Stéphane / Gorphe, Philippe / Hartl, Dana M

Cancers

2023 Volume 15, Issue 3

Abstract: Objective: Hypoparathyroidism is a known complication of total laryngectomy, although parathyroid preservation and/or reimplantation are not routine. Autofluorescence is a new technique for identifying parathyroid glands intraoperatively. The aim of ... ...

Abstract	Objective: Hypoparathyroidism is a known complication of total laryngectomy, although parathyroid preservation and/or reimplantation are not routine. Autofluorescence is a new technique for identifying parathyroid glands intraoperatively. The aim of this study was to evaluate the feasibility of autofluorescence in this context. Materials and methods: A retrospective study of patients undergoing total laryngectomy/pharyngectomy with concomitant thyroidectomy using the Fluobeam Results: Eighteen patients (16 males, median age 67) underwent total laryngectomy/pharyngectomy with total thyroidectomy (n = 12) or hemithyroidectomy (n = 6). A median of 2 parathyroid glands were identified per patient. Ninety-two percent were identified by autofluorescence before visualisation. All parathyroids were reimplanted due to devascularization. Temporary hypoparathyroidism occurred in nine patients, and was permanent in one patient. After 34 months of median follow-up (range 1-49), no tumor recurrence was observed in the reimplantation sites. Conclusions: To our knowledge, this is the largest study to evaluate autofluorescence during total laryngectomy with thyroidectomy. No tumor recurrence occurred in the sites of parathyroid reimplantation.
Language	English
Publishing date	2023-01-31
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15030875
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Article ; Online: Risk staging with prophylactic unilateral central neck dissection in low-risk papillary thyroid carcinoma.

Hartl, Dana M / Al Ghuzlan, Abir / Bidault, Sophie / Breuskin, Ingrid / Guerlain, Joanne / Girard, Elizabeth / Baudin, Eric / Lamartina, Livia / Hadoux, Julien

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology

2022 Volume 49, Issue 3, Page(s) 568–574

Abstract: Objective: Current guidelines favor thyroid lobectomy for intrathyroidal cT1bT2cN0 papillary thyroid carcinoma. Prophylactic neck dissection (PND) is not recommended for these low-risk tumors due to the lack of high-level evidence on improvement in ... ...

Abstract	Objective: Current guidelines favor thyroid lobectomy for intrathyroidal cT1bT2cN0 papillary thyroid carcinoma. Prophylactic neck dissection (PND) is not recommended for these low-risk tumors due to the lack of high-level evidence on improvement in outcomes, but the information from PND may be used for staging. The aim of this study was to evaluate the rate of upstaging with ipsilateral PND. Materials and methods: Retrospective study of patients with intrathyroidal unifocal cT1bT2cN0 papillary thyroid carcinoma from 2008 to 2021. All patients underwent total thyroidectomy and PND. Tumors were classified as low or intermediate risk based on the information from pathological analysis of the primary tumor and then from adding the analysis of the lymph nodes. The difference between the tumor-only and the PND-added risk staging was evaluated. Results: Three hundred three patients (241 women, median age 45, median tumor size 17 mm) were included. Microscopic extrathyroidal extension was found in 23.4%, aggressive histology in 6.6%, vascular invasion in 29.3%, and lymph node metastases in 37.3%. One hundred ten patients (36.3%) were intermediate-risk based on the primary tumor. An additional 26 (8.6%) were upstaged to intermediate-risk based on the ipsilateral PND and 2% based on the contralateral PND. Kaplan-Meier 10-year event-free survival in tumors upstaged with ipsilateral PND was not statistically different from intermediate-risk tumors based on the primary tumor characteristics (92% versus 90.9%, Log Rank p = 0.943). Conclusions: Ipsilateral PND upstaged low-risk cT1bT2cN0 patients to intermediate risk in only 8.6% of cases, and contralateral PND in an additional 2%. Routinely performing PND may not be warranted.
MeSH term(s)	Humans ; Female ; Middle Aged ; Thyroid Cancer, Papillary/pathology ; Neck Dissection ; Retrospective Studies ; Thyroid Neoplasms/pathology ; Carcinoma, Papillary/pathology ; Lymph Nodes/pathology ; Thyroidectomy ; Neoplasm Recurrence, Local/pathology
Language	English
Publishing date	2022-11-08
Publishing country	England
Document type	Journal Article
ZDB-ID	632519-1
ISSN	1532-2157 ; 0748-7983
ISSN (online)	1532-2157
ISSN	0748-7983
DOI	10.1016/j.ejso.2022.11.007
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Zs.A 1149: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Impact of lymphovascular invasion on otherwise low-risk papillary thyroid carcinomas: a retrospective and observational study.

Puga, Francisca Marques / Al Ghuzlan, Abir / Hartl, Dana M / Bani, Mohamed-Amine / Moog, Sophie / Pani, Fabiana / Breuskin, Ingrid / Guerlain, Joanne / Faron, Matthieu / Denadreis, Desirée / Baudin, Eric / Hadoux, Julien / Lamartina, Livia

Endocrine

2023 Volume 83, Issue 1, Page(s) 150–159

Abstract: Purpose: Presence of venous vascular invasion is a criterion of intermediate risk of recurrence in papillary thyroid carcinoma (PTC). However, the presence and type of vascular invasion (lymphatic or venous) is often underreported and its impact on PTCs ...

Abstract	Purpose: Presence of venous vascular invasion is a criterion of intermediate risk of recurrence in papillary thyroid carcinoma (PTC). However, the presence and type of vascular invasion (lymphatic or venous) is often underreported and its impact on PTCs without other risk features remains unknown. The aim of this study was to evaluate the impact of both lymphatic and venous invasion on the risk of recurrence/persistence on otherwise low-risk PTCs. Methods: Retrospective study including patients with otherwise low-risk PTCs but with vascular invasion, diagnosed between 2013 and 2019. The persistence/recurrence during the follow-up was evaluated. Pathology was reviewed to confirm the presence of lymphovascular invasion and determine the type of invasion. Results: A total of 141 patients were included. Lymphovascular invasion was confirmed in 20.6%. After surgery, 48.9% (N = 69) of the patients received radioactive iodine (RAI). The median follow-up time was 4 [3-6] years. Overall, 6 (4.2%) patients experienced persistent/recurrent disease in the neck, including 3 with lymphovascular invasion, confirmed as "only lymphatic". Overall, patients with tumors harboring lymphovascular invasion had sensibly more persistent/recurrence disease compared with those without lymphovascular invasion (10.3% vs 2.7%, p = 0.1), especially in the subgroup of patients not treated with RAI (20% vs 1.6%, p = 0.049) [OR 15.25, 95% CI 1.24-187.85, p = 0.033]. Conclusion: Lymphovascular invasion, including lymphatic invasion only, is associated with a sensibly higher risk of persistent/recurrent disease in otherwise low-risk PTCs, namely in patients not treated with RAI. Lymphatic invasion could have a role in risk-stratification systems for decision making.
MeSH term(s)	Humans ; Thyroid Cancer, Papillary/pathology ; Retrospective Studies ; Thyroid Neoplasms/pathology ; Iodine Radioisotopes ; Neck ; Thyroidectomy ; Neoplasm Recurrence, Local/pathology
Chemical Substances	Iodine Radioisotopes
Language	English
Publishing date	2023-08-28
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	1194484-5
ISSN	1559-0100 ; 1355-008X ; 0969-711X
ISSN (online)	1559-0100
ISSN	1355-008X ; 0969-711X
DOI	10.1007/s12020-023-03475-8
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Article ; Online: Contemporary Surgical Management of Early Glottic Cancer.

Hartl, Dana M / Brasnu, Daniel F

Otolaryngologic clinics of North America

2015 Volume 48, Issue 4, Page(s) 611–625

Abstract: For early-stage T1-T2 glottic squamous cell carcinoma, transoral laser microsurgery (TLM) is the main surgical modality, with rates of local control and laryngeal preservation ranging from 85% to 100% and low morbidity. For extensive lesions, open ... ...

Abstract	For early-stage T1-T2 glottic squamous cell carcinoma, transoral laser microsurgery (TLM) is the main surgical modality, with rates of local control and laryngeal preservation ranging from 85% to 100% and low morbidity. For extensive lesions, open conservation laryngeal surgery may enable wider resections than TLM but at costs of longer hospital stay and higher postoperative morbidity. Surgery provides results that are comparable to nonsurgical treatment options while reserving radiation therapy for recurrences or second primary cancers, particularly in younger patients. In the future, transoral robot-assisted surgery may enable more extensive transoral resections than laser alone, decreasing further the indications for open surgery.
MeSH term(s)	Carcinoma, Squamous Cell/pathology ; Carcinoma, Squamous Cell/surgery ; Glottis/pathology ; Humans ; Laryngeal Neoplasms/surgery ; Laryngectomy/methods ; Laser Therapy/methods ; Male ; Microsurgery/methods ; Middle Aged ; Neoplasm Recurrence, Local/surgery ; Neoplasm Staging
Language	English
Publishing date	2015-08
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	417489-6
ISSN	1557-8259 ; 0030-6665
ISSN (online)	1557-8259
ISSN	0030-6665
DOI	10.1016/j.otc.2015.04.007
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