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  1. Article ; Online: Takotsubo syndrome: From a reversible to a chronic condition in search for the Ariadne's ball of string.

    Losi, Maria-Angela / Borrelli, Felice / Bossone, Eduardo / Esposito, Giovanni

    International journal of cardiology

    2023  Volume 393, Page(s) 131385

    Language English
    Publishing date 2023-09-22
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 779519-1
    ISSN 1874-1754 ; 0167-5273
    ISSN (online) 1874-1754
    ISSN 0167-5273
    DOI 10.1016/j.ijcard.2023.131385
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  2. Article ; Online: Determining the Relationship between Squat Jump Performance and Knee Angle in Female University Students.

    Di Domenico, Felice / Esposito, Giovanni / Aliberti, Sara / D'Elia, Francesca / D'Isanto, Tiziana

    Journal of functional morphology and kinesiology

    2024  Volume 9, Issue 1

    Abstract: The Squat Jump (SJ) test is widely recognized as a reliable test for assessing lower-limb explosive strength. However, uncertainty persists in the literature regarding the optimal starting positions for maximizing vertical jump performance. This ... ...

    Abstract The Squat Jump (SJ) test is widely recognized as a reliable test for assessing lower-limb explosive strength. However, uncertainty persists in the literature regarding the optimal starting positions for maximizing vertical jump performance. This uncertainty is exacerbated by a disproportionate focus on athletes in existing studies, with insufficient consideration being given to non-athletic women. To address this gap, this study investigated the influence of leg starting angle on explosive jump height in a homogeneous sample of non-athletic women. Thirty-two female students enrolled in a Sports Science master's degree program at the University of Salerno participated in the study. Descriptive statistics were employed to summarize data on various variables, and Pearson's correlations were calculated to assess the relationship between knee angle in the starting position and achieved jump height. The study revealed that different starting positions had a noteworthy impact on jump height among the participants. A strong negative correlation (-0.701) was identified between Squat Jump elevation and the knee angle in the starting position. Notably, 62.5% of the subjects opted for a starting knee position of approximately 70 degrees, with all of them consistently achieving a jump height associated with this specific angle. These findings provide valuable insights into the relationship between leg starting angle and explosive jump height in non-athletic women. The observed correlation underscores the significance of the starting position in Squat Jump performance. The prevalence of a specific knee angle choice among participants suggests potential implications for training and performance optimization in this sample.
    Language English
    Publishing date 2024-01-29
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2411-5142
    ISSN (online) 2411-5142
    DOI 10.3390/jfmk9010026
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  3. Article ; Online: Physical performance in masters' degree students in Exercise and Sport Sciences related to the motor learning approach.

    Felice Di Domenico / Giovanni Esposito / Tiziana D'Isanto / Sara Aliberti / Gaetano Raiola

    Motricidade, Vol 19, Iss

    2024  Volume 4

    Abstract: Physical activities (PA) can be characterized by a cognitive approach or an ecological-dynamic approach. Currently, no emphasis is given in master's degree in Sport Sciences to different effects of exercise in the two different forms of delivery: ... ...

    Abstract Physical activities (PA) can be characterized by a cognitive approach or an ecological-dynamic approach. Currently, no emphasis is given in master's degree in Sport Sciences to different effects of exercise in the two different forms of delivery: prescriptive teaching, heuristic learning. The objective was to measure levels of physical performance in students and test for associations between the effects of exercise and the type of learning approach. Thirty-eight sports science students were divided into two groups according to the teaching/learning methodology used in their training: cognitive (CG) and dynamic ecological (EDG). A battery of tests was administered: squat jump (SJ), countermovement jump (CMJ), countermovement jump free arms (CMJ-FA), and stiffness test (ST). A questionnaire on daily physical activity was administered. The data collected were statistically processed. Statistically significant associations emerged between outcomes and groups (P = < .05): 37% of CGs and 26% of EDGs used motorized vehicles at least once a week; only 5% of CGs and 26% of EDGs walked daily; 100% of CGs and 79% of EDGs practiced PA continuously; CGs performed better in CMJ-FA and ST. The two approaches differ in their impact on daily, structured physical activity and performance effects.
    Keywords Learning approach ; Physical activity ; Lifestyle promotion ; reproductive style ; Productive style ; Medicine ; R ; Sports medicine ; RC1200-1245
    Subject code 796
    Language English
    Publishing date 2024-01-01T00:00:00Z
    Publisher Desafio Singular
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Exploring the Influence of Cognitive and Ecological Dynamics Approaches on Countermovement Jumping Enhancement: A Comparative Training Study.

    Di Domenico, Felice / D'Isanto, Tiziana / Esposito, Giovanni / Aliberti, Sara / Raiola, Gaetano

    Journal of functional morphology and kinesiology

    2023  Volume 8, Issue 3

    Abstract: Countermovement jumping (CMJ) and free-arm countermovement jumping (CMJFA) express the explosive-elastic force of the lower limbs. Strategies to enhance performance in both types of jumping can be categorized into cognitive and ecological-dynamic ... ...

    Abstract Countermovement jumping (CMJ) and free-arm countermovement jumping (CMJFA) express the explosive-elastic force of the lower limbs. Strategies to enhance performance in both types of jumping can be categorized into cognitive and ecological-dynamic approaches. However, the effectiveness of these approaches in improving CMJ and CMJFA remains incompletely understood. This study aims to investigate the impact of training protocols based on the two approaches to improving CMJ. Thirty-six subjects with an average age of 26 years were selected and divided into two groups: the ecological-dynamic group (EDG) and the cognitive group (CG). For 12 weeks, both groups followed separate protocols of three weekly one-hour sessions. EDG group followed a protocol focused on circle time. The CG group followed an instructor-led training protocol. Incoming and outgoing flight heights were measured. Pre and post-intervention differences within and between groups were assessed using t-tests for dependent and independent samples, respectively (
    Language English
    Publishing date 2023-09-12
    Publishing country Switzerland
    Document type Journal Article
    ISSN 2411-5142
    ISSN (online) 2411-5142
    DOI 10.3390/jfmk8030133
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  5. Article ; Online: Fasting duration impacts ribosome protein 6 phosphorylation in zebrafish brain: New insights in aquatic organisms' welfare.

    Raggio, Maria / Giaquinto, Daniela / Attanasio, Chiara / Palladino, Antonio / Esposito, Vincenzo / Radaelli, Giuseppe / De Felice, Elena / de Girolamo, Paolo / D'Angelo, Livia

    Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft

    2024  Volume 254, Page(s) 152266

    Abstract: Background: Short- or mid-term fasting, full or partial, triggers metabolic response known to have in turn health effects in an organism. At central level, the metabolic stimulus triggered by fasting is known to be perceived firstly by hypothalamic ... ...

    Abstract Background: Short- or mid-term fasting, full or partial, triggers metabolic response known to have in turn health effects in an organism. At central level, the metabolic stimulus triggered by fasting is known to be perceived firstly by hypothalamic neurons. In the field of neuroscience, ribosomal protein S6 (S6) phosphorylation is commonly used as a readout of the mammalian target of rapamycin complex 1 signalling activation or as a marker for neuronal activity. The aim of this study is addressed to evaluate whether the phosphorylation of S6 occurs in the central neurons of zebrafish exposed to four (short-term) and seven (mid-term) days of complete fasting.
    Methods: Group-housed adult zebrafish were exposed to four and seven days of complete food withdrawal. At the end of the experimental period, Western blotting analyses were carried out to measure the expression levels of the phosphorylated S6 (pS6) by comparing the two experimental conditions versus the control group. The same antibody was then used to identify the distribution pattern of pS6 immunoreactive neurons in the whole brain and in the taste buds.
    Results: We did not observe increased pS6 levels expression in the brain of animals exposed to short-term fasting compared to the control, whereas the expression increased in brain homogenates of animals exposed to mid-term fasting. pS6 immunoreactivity was reported in some hypothalamic neurons, as well as in the dorsal area of telencephalon and preoptic area, a neurosecretory region homolog to the mammalian paraventricular nucleus. Remarkably, we observed pS6 immunostaining in the sensory cells of taste buds lining the oral epithelium.
    Conclusions: Taken together, our data show that in zebrafish, differently from other fish species, seven days of fasting triggers neuronal activity. Furthermore, the immunostaining on sensory cells of taste buds suggests that metabolic changes may modulate also peripheral sensory cells. This event may have valuable implications when using zebrafish to design metabolic studies involving fasting as well as practical consequences on the animal welfare, in particularly stressful conditions, such as transportation.
    Language English
    Publishing date 2024-04-18
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1106738-x
    ISSN 1618-0402 ; 0940-9602
    ISSN (online) 1618-0402
    ISSN 0940-9602
    DOI 10.1016/j.aanat.2024.152266
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  6. Article ; Online: Linear Scalp Incision in Brain Tumor Surgery: Intraoperative and Postoperative Considerations.

    Curcio, Antonello / Lorenzetti, Marco / Espahbodinea, Shervin / Angileri, Filippo Flavio / Esposito, Felice / D'Avella, Elena

    World neurosurgery

    2023  Volume 183, Page(s) e522–e529

    Abstract: Background: Although the linear scalp incision is commonly used in neurosurgical practice, a systematic study elucidating its pros and cons in a specific surgical setting is lacking. Herein, we analyzed our experience with linear scalp incision in brain ...

    Abstract Background: Although the linear scalp incision is commonly used in neurosurgical practice, a systematic study elucidating its pros and cons in a specific surgical setting is lacking. Herein, we analyzed our experience with linear scalp incision in brain tumor surgery and the impact on intraoperative variables and postoperative complications.
    Methods: Patients undergoing brain tumor surgery (January 2014-December 2021) at 2 neurosurgical departments were included and divided into 2 groups: linear or flap scalp incision. Patients' demographics characteristics, surgical variables, and wound-related complications were analyzed.
    Results: More than a total of 1036 craniotomies, linear incision (mean length 6cm) was adopted in 282 procedures (27.2%). Mean maximum diameter of the craniotomy was 5.25 cm, with no statistical difference between the 2 groups. In emergency surgery (36 cases), the linear and flap incisions were used indifferently. Linear incision was predominant in supratentorial and suboccipital lesions. Flap incision was significantly more frequent among meningiomas (P < 0.01). Neuronavigation, operative microscope, and subgaleal drain were more frequently used in the flap scalp incision group (P = 0.01). Overall complication rate was comparable to flap scalp opening (P = 0.40).
    Conclusions: The use of the linear incision was broadly applied for the removal of supratentorial and suboccipital tumors granting adequate surgical exposure with a low rate of postoperative complications. Tumors skull base localization resulted the only factor hindering the use of the linear incision. The choice of 1 incision over another didn't show to have any impact on intraoperative and postoperative variables, and it remains mainly based on surgeon expertise/preference.
    MeSH term(s) Humans ; Scalp/surgery ; Scalp/pathology ; Craniotomy/methods ; Surgical Wound/complications ; Postoperative Complications/etiology ; Brain Neoplasms/pathology
    Language English
    Publishing date 2023-12-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2023.12.135
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    Zs.A 1159: Show issues Location:
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  7. Article ; Online: Identification of an ultra-rare Alu insertion in the CFTR gene: Pitfalls and challenges in genetic test interpretation.

    Esposito, Speranza / Zollo, Immacolata / Villella, Valeria Rachela / Scialò, Filippo / Giordano, Sonia / Esposito, Maria Valeria / Salemme, Nunzia / Di Domenico, Carmela / Cernera, Gustavo / Zarrilli, Federica / Castaldo, Giuseppe / Amato, Felice

    Clinica chimica acta; international journal of clinical chemistry

    2024  Volume 558, Page(s) 118317

    Abstract: Cystic fibrosis (CF) is a life-limiting genetic disorder characterized by defective chloride ion transport due to mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Early detection through newborn screening programs ... ...

    Abstract Cystic fibrosis (CF) is a life-limiting genetic disorder characterized by defective chloride ion transport due to mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Early detection through newborn screening programs significantly improves outcomes for individuals with CF by enabling timely intervention. Here, we report the identification of an Alu element insertion within the exon 15 of CFTR gene, initially overlooked in standard next-generation sequencing analyses. However, using traditional molecular techniques, based on polymerase chain reaction and Sanger sequencing, allowed the identification of the Alu element and the reporting of a correct diagnosis. Our analysis, based on bioinformatics tools and molecular techniques, revealed that the Alu element insertion severely affects the gene expression, splicing patterns, and structure of CFTR protein. In conclusion, this study emphasizes the importance of how the integration of human expertise and modern technologies represents a pivotal step forward in genomic medicine, ensuring the delivery of precision healthcare to individuals affected by genetic diseases.
    MeSH term(s) Humans ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Alu Elements/genetics ; Cystic Fibrosis/genetics ; Cystic Fibrosis/diagnosis ; Genetic Testing/methods ; Infant, Newborn ; Male ; Female
    Chemical Substances Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6) ; CFTR protein, human
    Language English
    Publishing date 2024-04-04
    Publishing country Netherlands
    Document type Journal Article ; Case Reports
    ZDB-ID 80228-1
    ISSN 1873-3492 ; 0009-8981
    ISSN (online) 1873-3492
    ISSN 0009-8981
    DOI 10.1016/j.cca.2024.118317
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    Ud II Zs.173: Show issues Location:
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  8. Article ; Online: Practical Workflow from High-Throughput Genotyping to Genomic Estimated Breeding Values (GEBVs).

    Contaldi, Felice / Cappetta, Elisa / Esposito, Salvatore

    Methods in molecular biology (Clifton, N.J.)

    2020  Volume 2264, Page(s) 119–135

    Abstract: The global climate is changing, resulting in significant economic losses worldwide. It is thus necessary to speed up the plant selection process, especially for complex traits such as biotic and abiotic stresses. Nowadays, genomic selection (GS) is ... ...

    Abstract The global climate is changing, resulting in significant economic losses worldwide. It is thus necessary to speed up the plant selection process, especially for complex traits such as biotic and abiotic stresses. Nowadays, genomic selection (GS) is paving new ways to boost plant breeding, facilitating the rapid selection of superior genotypes based on the genomic estimated breeding value (GEBV). GEBVs consider all markers positioned throughout the genome, including those with minor effects. Indeed, although the effect of each marker may be very small, a large number of genome-wide markers retrieved by high-throughput genotyping (HTG) systems (mainly genotyping-by-sequencing, GBS) have the potential to explain all the genetic variance for a particular trait under selection. Although several workflows for GBS and GS data have been described, it is still hard for researchers without a bioinformatics background to carry out these analyses. This chapter has outlined some of the recently available bioinformatics resources that enable researchers to establish GBS applications for GS analysis in laboratories. Moreover, we provide useful scripts that could be used for this purpose and a description of key factors that need to be considered in these approaches.
    MeSH term(s) Chromosomes, Plant/genetics ; Computational Biology/methods ; DNA, Plant/analysis ; DNA, Plant/genetics ; Genetic Variation ; Genome, Plant ; Genotyping Techniques/methods ; High-Throughput Nucleotide Sequencing/methods ; Phenotype ; Plant Breeding/methods ; Plants/genetics ; Selection, Genetic
    Chemical Substances DNA, Plant
    Language English
    Publishing date 2020-12-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-0716-1201-9_9
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  9. Article ; Online: Impact of deep brain stimulation therapy on the vertebral sagittal balance in Parkinson's disease patients.

    Somma, Teresa / Fellico, Fabrizio / De Rosa, Andrea / Bocchino, Andrea / Corvino, Sergio / Milone, Antonio / Cappabianca, Paolo / Esposito, Felice

    Neurosurgical review

    2023  Volume 47, Issue 1, Page(s) 7

    Abstract: Parkinson's disease (PD) is characterized by cardinal motor signs: 4-6 Hz resting tremor, rigidity, and bradykinesia. In addition, 3-18% of PD patients have camptocormia, an abnormal forward flexion of the thoracolumbar spine, which may have a negative ... ...

    Abstract Parkinson's disease (PD) is characterized by cardinal motor signs: 4-6 Hz resting tremor, rigidity, and bradykinesia. In addition, 3-18% of PD patients have camptocormia, an abnormal forward flexion of the thoracolumbar spine, which may have a negative impact on patients' quality of life. Different possible treatments have been suggested for such a condition, but no one is resolutive. This study aims to define the possible impact of DBS, with selective targeting on the dorsal-lateral region of the STN, on the sagittal balance of patients affected by PD. Among all patients that have undergone DBS procedures in our institution, we selected eight subjects, four females and four males, with selective targeting on the dorsal-lateral region of the subthalamic nucleus (STN) because of camptocormia and other severe postural changes. Radiological assessments of spinal balance parameters before surgery and at 6 and 12 months postoperatively were carried out. Comparison of preoperative and postoperative spine X-ray data showed a statistically significant improvement in dorsal kyphosis angle (D-Cobb) 12 months after the operation. Deep brain stimulation with selective targeting of the dorsal lateral part of the STN may induce changes of the posture in patients with Parkinson's disease 12 months after the operation, which appears to improve in this small sample size, but larger observational and controlled trials would be required to confirm this observation.
    MeSH term(s) Male ; Female ; Humans ; Parkinson Disease/surgery ; Deep Brain Stimulation/methods ; Quality of Life ; Spinal Curvatures/surgery
    Language English
    Publishing date 2023-12-08
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 6907-3
    ISSN 1437-2320 ; 0344-5607
    ISSN (online) 1437-2320
    ISSN 0344-5607
    DOI 10.1007/s10143-023-02243-6
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  10. Article: Pitfalls and Tips in the Assessment of Aortic Stenosis by Transthoracic Echocardiography.

    Canciello, Grazia / Pate, Shabnam / Sannino, Anna / Borrelli, Felice / Todde, Gaetano / Grayburn, Paul / Losi, Maria-Angela / Esposito, Giovanni

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 14

    Abstract: Aortic stenosis (AS) is a valvular heart disease that significantly contributes to cardiovascular morbidity and mortality worldwide. The condition is characterized by calcification and thickening of the aortic valve leaflets, resulting in a narrowed ... ...

    Abstract Aortic stenosis (AS) is a valvular heart disease that significantly contributes to cardiovascular morbidity and mortality worldwide. The condition is characterized by calcification and thickening of the aortic valve leaflets, resulting in a narrowed orifice and increased pressure gradient across the valve. AS typically progresses from a subclinical phase known as aortic sclerosis, where valve calcification occurs without a transvalvular gradient, to a more advanced stage marked by a triad of symptoms: heart failure, syncope, and angina. Echocardiography plays a crucial role in the diagnosis and evaluation of AS, serving as the primary non-invasive imaging modality. However, to minimize misdiagnoses, it is crucial to adhere to a standardized protocol for acquiring echocardiographic images. This is because, despite continuous advances in echocardiographic technology, diagnostic errors still occur during the evaluation of AS, particularly in classifying its severity and hemodynamic characteristics. This review focuses on providing guidance for the imager during the echocardiographic assessment of AS. Firstly, the review will report on how the echo machine should be set to improve image quality and reduce noise and artifacts. Thereafter, the review will report specific emphasis on accurate measurements of left ventricular outflow tract diameter, aortic valve morphology and movement, as well as aortic and left ventricular outflow tract velocities. By considering these key factors, clinicians can ensure consistency and accuracy in the evaluation of AS using echocardiography.
    Language English
    Publishing date 2023-07-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13142414
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