Article ; Online: Strong ions and charge-balance.
Scandinavian journal of clinical and laboratory investigation
2023 Volume 83, Issue 2, Page(s) 111–118
Abstract: It has been shown that the ability to predict the pH in any chemically characterized fluid, together with its buffer-capacity and acid content can be based on the requirement of electroneutrality, conservation of mass, and rules of dissociation as ... ...
| Abstract | It has been shown that the ability to predict the pH in any chemically characterized fluid, together with its buffer-capacity and acid content can be based on the requirement of electroneutrality, conservation of mass, and rules of dissociation as provided by physical chemistry. More is not required, and less is not enough. The charge in most biological fluids is dominated by the constant charge on the completely dissociated strong ions but, nonetheless, a persistent narrative in physiology has problematized the notion that these have any role at all in acid-base homeostasis. While skepticism is always to be welcomed, some common arguments against the importance of strong ions are examined and refuted here. We find that the rejection of the importance of strong ions comes with the prize that even very simple systems such as fluids containing nothing else, or solutions of sodium bicarbonate in equilibrium with known tensions of CO |
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| MeSH term(s) | Humans ; Acid-Base Equilibrium/physiology ; Hydrogen-Ion Concentration ; Ions ; Homeostasis |
| Chemical Substances | Ions |
| Language | English |
| Publishing date | 2023-02-22 |
| Publishing country | England |
| Document type | Journal Article |
| ZDB-ID | 3150-1 |
| ISSN | 1502-7686 ; 0036-5513 |
| ISSN (online) | 1502-7686 |
| ISSN | 0036-5513 |
| DOI | 10.1080/00365513.2023.2180658 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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