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Article ; Online: Comparison of patterns of drug levels in head and body hair for medico-legal and workplace testing.

Tsanaclis, Lolita / Nutt, James / Bevan, Siân / Bagley, Kim / Wicks, John

2023 Volume 15, Issue 9, Page(s) 1027–1041

Abstract: This paper presents concentration ranges and positivity rates for the common drugs, alcohol markers, new psychoactive substances (NPS) and anabolic steroids tested in head hair (n = 138,352) and body hair (n = 9532) on samples of hair from medico-legal ( ... ...

Abstract	This paper presents concentration ranges and positivity rates for the common drugs, alcohol markers, new psychoactive substances (NPS) and anabolic steroids tested in head hair (n = 138,352) and body hair (n = 9532) on samples of hair from medico-legal (n = 112,033) and workplace (n = 35,851) sectors tested in our laboratory. Statistically significant higher levels were found more often in the various types of body hair when compared with head hair, but fewer cases exhibited lower levels. For example, statistically significant higher levels were detected in leg hair for cannabinol, THC, methadone and EtG and in beard hair for THC, THC-COOH and 6-acetylmorphine. In contrast, significantly lower levels were detected in axilla hair for cannabinol, THC and for EDDP, but median levels of mephedrone and DHEA were higher. Overall, higher medium levels were detected in head hair samples tested in the UK when compared with those previously published for samples tested in Germany, indicating geographical differences in drug consumption. Recommendations are, firstly, that hair testing laboratories use the results of their own compiled previous positive results for guidance when interpreting hair testing results and, secondly, that laboratories periodically share and combine their accumulated data with other testing laboratories. The latter could be used to establish reference ranges associated with specific technical procedures which would improve interlaboratory comparability and improve laboratory testing services when interpreting hair testing results.
MeSH term(s)	Cannabinol/analysis ; Gas Chromatography-Mass Spectrometry ; Methadone ; Hair/chemistry ; Workplace ; Substance Abuse Detection/methods
Chemical Substances	Cannabinol (7UYP6MC9GH) ; Methadone (UC6VBE7V1Z)
Language	English
Publishing date	2023-01-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2462336-2
ISSN	1942-7611 ; 1942-7603
ISSN (online)	1942-7611
ISSN	1942-7603
DOI	10.1002/dta.3434
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Zs.A 6792: Show issues

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Article: Pituitary incidentaloma.

Bevan, John S

Clinical medicine (London, England)

2013 Volume 13, Issue 3, Page(s) 296–298

MeSH term(s)	Adenoma/blood ; Adenoma/complications ; Adenoma/diagnosis ; Adenoma/epidemiology ; Adenoma/etiology ; Adenoma/therapy ; Biomarkers/blood ; Diagnosis, Differential ; Humans ; Incidence ; Incidental Findings ; Magnetic Resonance Imaging ; Pituitary Neoplasms/blood ; Pituitary Neoplasms/complications ; Pituitary Neoplasms/diagnosis ; Pituitary Neoplasms/epidemiology ; Pituitary Neoplasms/etiology ; Pituitary Neoplasms/therapy ; Predictive Value of Tests ; Prolactin/blood ; Sensitivity and Specificity ; Thyrotropin/blood ; Thyroxine/blood ; Treatment Outcome ; United Kingdom/epidemiology
Chemical Substances	Biomarkers ; Prolactin (9002-62-4) ; Thyrotropin (9002-71-5) ; Thyroxine (Q51BO43MG4)
Language	English
Publishing date	2013-06-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2048646-7
ISSN	1473-4893 ; 1470-2118
ISSN (online)	1473-4893
ISSN	1470-2118
DOI	10.7861/clinmedicine.13-3-296
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Zs.A 5439: Show issues

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Article ; Online: The Effect of Prolonged Storage Time on the Stability of Fatty Acid Ethyl Esters in Hair Samples.

Tsanaclis, Lolita / Bagley, Kim / Bevan, Sian / Wicks, John

Journal of analytical toxicology

2020 Volume 44, Issue 8, Page(s) 829–833

Abstract: The advantages of analysis of drugs in hair samples are recognized for the long window of detection, alongside easy sampling and long stability after sample collection. Alcohol markers, ethyl glucuronide (EtG) and total fatty acid ethyl esters (FAEEs) in ...

Abstract	The advantages of analysis of drugs in hair samples are recognized for the long window of detection, alongside easy sampling and long stability after sample collection. Alcohol markers, ethyl glucuronide (EtG) and total fatty acid ethyl esters (FAEEs) in hair, are widely used for monitoring alcohol consumption for clinical and forensic purposes. Although stability of drugs and EtG in hair samples is documented to a certain extent, stability of FAEEs in hair samples after collection has not been reported. This study covered hair samples that had been tested for FAEEs on the day of arrival at the laboratory and retested between 4 and 80 months later. The statistical analysis of the data set reveals significant lower FAEEs levels including ethyl palmitate (EtPa) ester levels when samples were retested for the second time after 6 days of storage under ideal conditions. Specifically, the results suggest that when measuring total FAEEs or solely EtPa in hair samples, the elapsed time between sample collection and analysis of the sample needs to be considered when interpreting the results. The recommendation is that whenever hair samples need to be tested for total FAEEs or EtPa, the analytical procedure needs to be performed within 1 week after collection in order to obtain meaningful results. The study results substantiate the case for the use of hair samples solely for the analysis of EtG, in conjunction with other measurements such as full blood count, carbohydrate-deficient transferrin test, liver function test or phosphatidylethanol alongside clinical assessment for a more effective evaluation of alcohol consumption.
MeSH term(s)	Alcohol Drinking ; Alcoholism ; Esters/analysis ; Fatty Acids/analysis ; Hair/chemistry ; Humans ; Substance Abuse Detection/methods
Chemical Substances	Esters ; Fatty Acids
Language	English
Publishing date	2020-03-24
Publishing country	England
Document type	Journal Article
ZDB-ID	752391-9
ISSN	1945-2403 ; 0146-4760
ISSN (online)	1945-2403
ISSN	0146-4760
DOI	10.1093/jat/bkaa026
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Zs.A 1333: Show issues

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Article ; Online: Type 1 drug hypersensitivity following first dose of pegvisomant.

Jacob, Jubbin J / Bevan, John S

Clinical endocrinology

2014 Volume 80, Issue 2, Page(s) 315

MeSH term(s)	Adult ; Drug Hypersensitivity/etiology ; Female ; Human Growth Hormone/adverse effects ; Human Growth Hormone/analogs & derivatives ; Humans ; Hypersensitivity, Immediate/chemically induced
Chemical Substances	Human Growth Hormone (12629-01-5) ; pegvisomant (N824AOU5XV)
Language	English
Publishing date	2014-02
Publishing country	England
Document type	Case Reports ; Letter
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.12230
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Zs.A 814: Show issues

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Article ; Online: Should all patients with acromegaly receive somatostatin analogue therapy before surgery and, if so, for how long?

Jacob, Jubbin J / Bevan, John S

Clinical endocrinology

2014 Volume 81, Issue 6, Page(s) 812–817

Abstract: Current guidelines do not recommend the routine use of somatostatin analogue pretreatment prior to surgery in patients with growth hormone-secreting pituitary tumours. In theory, presurgical use of somatostatin analogues should improve metabolic control ... ...

Abstract	Current guidelines do not recommend the routine use of somatostatin analogue pretreatment prior to surgery in patients with growth hormone-secreting pituitary tumours. In theory, presurgical use of somatostatin analogues should improve metabolic control and reduce soft tissue swelling, leading to improved anaesthetic outcomes. Shrinkage of tumours prior to surgery might also improve surgical remission rates. Hence, this article addresses the question: Should all patients with acromegaly receive a somatostatin analogue prior to surgery? Clinical trials published before December 2013 were reviewed, although literature in this area remains relatively deficient. We conclude: (i) On the basis of limited data available, somatostatin analogue pretreatment does not improve anaesthetic or immediate postoperative outcomes (i.e. hospital stay, rates of surgical complications and postoperative pituitary dysfunction). (ii) Somatostatin analogues should be considered in all patients with growth hormone-secreting macroadenomas, including invasive macroadenomas, when the overall surgical remission rate for macroadenomas at the treating centre is below 50%. Four recent RCTs have demonstrated increased rates of surgical remission using such an approach. (iii) When deemed appropriate, patients should be treated with somatostatin analogues for at least 3 months before surgery; there is currently no evidence that treatment beyond 6 months provides any additional benefit. Patients with minimally invasive macroadenomas are those most likely to benefit in terms of improved surgical remission.
MeSH term(s)	Adenoma/drug therapy ; Adenoma/surgery ; Antineoplastic Agents, Hormonal/therapeutic use ; Growth Hormone-Secreting Pituitary Adenoma/drug therapy ; Growth Hormone-Secreting Pituitary Adenoma/surgery ; Humans ; Intraoperative Complications/prevention & control ; Intubation, Intratracheal/adverse effects ; Neoadjuvant Therapy/methods ; Octreotide/therapeutic use ; Peptides, Cyclic/therapeutic use ; Preoperative Care ; Somatostatin/analogs & derivatives ; Somatostatin/therapeutic use ; Time Factors
Chemical Substances	Antineoplastic Agents, Hormonal ; Peptides, Cyclic ; lanreotide (0G3DE8943Y) ; Somatostatin (51110-01-1) ; Octreotide (RWM8CCW8GP)
Language	English
Publishing date	2014-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	121745-8
ISSN	1365-2265 ; 0300-0664
ISSN (online)	1365-2265
ISSN	0300-0664
DOI	10.1111/cen.12553
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Zs.A 814: Show issues

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Article ; Online: Maturity Has a Greater Association than Relative Age with Physical Performance in English Male Academy Soccer Players.

Radnor, John M / Staines, Jacob / Bevan, James / Cumming, Sean P / Kelly, Adam L / Lloyd, Rhodri S / Oliver, Jon L

Sports (Basel, Switzerland)

2021 Volume 9, Issue 12

Abstract: This study aimed to: (1) examine differences in physical performance across birth-quartiles and maturity-status, and (2) determine the relationships among relative age, maturation and physical performance in young male soccer players. The sample included ...

Abstract	This study aimed to: (1) examine differences in physical performance across birth-quartiles and maturity-status, and (2) determine the relationships among relative age, maturation and physical performance in young male soccer players. The sample included 199 males aged between 8.1 and 18.9 years, from two professional soccer academies in the English Football League. Data were collected for height, weight, self-reported biological parent heights, 30 m sprint time and countermovement jump (CMJ) height. Relative age was conveyed as a decimal, while maturity status was determined as the percentage of predicted adult height (PAH). There were no significant differences in any measure between birth quartiles, however early maturers outperformed on-time and later maturers in most performance measures. Pearson-product-moment correlations revealed that maturation was inversely associated with 30 m sprint time in U12 to U16 (
Language	English
Publishing date	2021-12-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2704239-X
ISSN	2075-4663 ; 2075-4663
ISSN (online)	2075-4663
ISSN	2075-4663
DOI	10.3390/sports9120171
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Article: Can dopamine agonists prevent postoperative remnant enlargement in nonfunctioning pituitary adenomas?

Bevan, John S

Nature clinical practice. Endocrinology & metabolism

2006 Volume 2, Issue 1, Page(s) 10–11

Language	English
Publishing date	2006-01
Publishing country	England
Document type	Journal Article
ZDB-ID	2228540-4
ISSN	1745-8366
ISSN	1745-8366
DOI	10.1038/ncpendmet0049
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Zs.A 6336: Show issues

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Article: The Impact of Probiotic Supplementation on Cognitive, Pathological and Metabolic Markers in a Transgenic Mouse Model of Alzheimer's Disease.

Webberley, Thomas S / Masetti, Giulia / Bevan, Ryan J / Kerry-Smith, Joshua / Jack, Alison A / Michael, Daryn R / Thomas, Sophie / Glymenaki, Maria / Li, Jia / McDonald, Julie A K / John, Daniel / Morgan, James E / Marchesi, Julian R / Good, Mark A / Plummer, Sue F / Hughes, Timothy R

Frontiers in neuroscience

2022 Volume 16, Page(s) 843105

Abstract: Brain degenerative disorders such as Alzheimer's disease (AD) can be exacerbated by aberrant metabolism. Supplementation with probiotic bacteria is emerging as a promising preventative strategy for both neurodegeneration and metabolic syndrome. In this ... ...

Abstract	Brain degenerative disorders such as Alzheimer's disease (AD) can be exacerbated by aberrant metabolism. Supplementation with probiotic bacteria is emerging as a promising preventative strategy for both neurodegeneration and metabolic syndrome. In this study, we assess the impact of the Lab4b probiotic consortium on (i) cognitive and pathological markers of AD progression and (ii) metabolic status in 3xTg-AD mice subjected to metabolic challenge with a high fat diet. The group receiving the probiotic performed better in the novel object recognition test and displayed higher hippocampal neuronal spine density than the control group at the end of the 12 weeks intervention period. These changes were accompanied by differences in localised (brain) and systemic anti-inflammatory responses that favoured the Probiotic group together with the prevention of diet induced weight gain and hypercholesterolaemia and the modulation of liver function. Compositional differences between the faecal microbiotas of the study groups included a lower Firmicutes:Bacteroidetes ratio and less numbers of viable yeast in the Probiotic group compared to the Control. The results illustrate the potential of the Lab4b probiotic as a neuroprotective agent and encourage further studies with human participants.
Language	English
Publishing date	2022-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2022.843105
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Article: Clinical review: The antitumoral effects of somatostatin analog therapy in acromegaly.

Bevan, John S

The Journal of clinical endocrinology and metabolism

2005 Volume 90, Issue 3, Page(s) 1856–1863

Abstract: Somatostatin analogs are the mainstay of medical therapy for acromegaly. Suppression of GH hypersecretion, lowering of IGF-I production, and control of symptoms are established benefits of therapy. In addition, clinically significant tumor shrinkage has ... ...

Abstract	Somatostatin analogs are the mainstay of medical therapy for acromegaly. Suppression of GH hypersecretion, lowering of IGF-I production, and control of symptoms are established benefits of therapy. In addition, clinically significant tumor shrinkage has been seen in a number of studies, particularly in patients undergoing primary medical therapy. This review summarizes current knowledge of the effects of somatostatin analogs on tumor size and cellular morphology and examines the available data on predictors of tumor shrinkage.
MeSH term(s)	Acromegaly/drug therapy ; Acromegaly/pathology ; Humans ; Pituitary Neoplasms/drug therapy ; Pituitary Neoplasms/pathology ; Somatostatin/analogs & derivatives
Chemical Substances	Somatostatin (51110-01-1)
Language	English
Publishing date	2005-03
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	3029-6
ISSN	1945-7197 ; 0021-972X
ISSN (online)	1945-7197
ISSN	0021-972X
DOI	10.1210/jc.2004-1093
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Article ; Online: The effectiveness of a primary care-based collaborative care model to improve quality of life in people with severe mental illness: PARTNERS2 cluster randomised controlled trial.

Byng, Richard / Creanor, Siobhan / Jones, Benjamin / Hosking, Joanne / Plappert, Humera / Bevan, Sheriden / Britten, Nicky / Clark, Michael / Davies, Linda / Frost, Julia / Gask, Linda / Gibbons, Bliss / Gibson, John / Hardy, Pollyanna / Hobson-Merrett, Charley / Huxley, Peter / Jeffery, Alison / Marwaha, Steven / Rawcliffe, Tim /

Reilly, Siobhan / Richards, Debra / Sayers, Ruth / Williams, Lynsey / Pinfold, Vanessa / Birchwood, Maximillian

The British journal of psychiatry : the journal of mental science

2023 Volume 222, Issue 6, Page(s) 246–256

Abstract: ... MANSA score did not differ between the groups (intervention: 0.25, s.d. 0.73; control: 0.21, s.d. 0.86 ...

Abstract	Background: Individuals living with severe mental illness can have significant emotional, physical and social challenges. Collaborative care combines clinical and organisational components. Aims: We tested whether a primary care-based collaborative care model (PARTNERS) would improve quality of life for people with diagnoses of schizophrenia, bipolar disorder or other psychoses, compared with usual care. Method: We conducted a general practice-based, cluster randomised controlled superiority trial. Practices were recruited from four English regions and allocated (1:1) to intervention or control. Individuals receiving limited input in secondary care or who were under primary care only were eligible. The 12-month PARTNERS intervention incorporated person-centred coaching support and liaison work. The primary outcome was quality of life as measured by the Manchester Short Assessment of Quality of Life (MANSA). Results: We allocated 39 general practices, with 198 participants, to the PARTNERS intervention (20 practices, 116 participants) or control (19 practices, 82 participants). Primary outcome data were available for 99 (85.3%) intervention and 71 (86.6%) control participants. Mean change in overall MANSA score did not differ between the groups (intervention: 0.25, s.d. 0.73; control: 0.21, s.d. 0.86; estimated fully adjusted between-group difference 0.03, 95% CI -0.25 to 0.31; Conclusions: There was no evidence of a difference in quality of life, as measured with the MANSA, between those receiving the PARTNERS intervention and usual care. Shifting care to primary care was not associated with increased adverse outcomes.
MeSH term(s)	Humans ; Quality of Life ; Mental Disorders/therapy ; Mental Disorders/complications ; Bipolar Disorder/psychology ; Psychotic Disorders/complications ; Schizophrenia/therapy ; Schizophrenia/complications ; Cost-Benefit Analysis
Language	English
Publishing date	2023-04-03
Publishing country	England
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	218103-4
ISSN	1472-1465 ; 0007-1250
ISSN (online)	1472-1465
ISSN	0007-1250
DOI	10.1192/bjp.2023.28
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