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  1. Book ; Thesis: Die Bedeutung der endogenen Zytokinexpression für die Regulation der induzierbaren Stickstoffmonoxidsynthase (iNOS) in Zellen der Blut-Hirn-Schranke

    Jüttler, Eric

    2002  

    Author's details vorgelegt von Thomas Eric Jüttler
    Language German
    Size XIII, 201 S., Ill., graph. Darst., 30 cm
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Heidelberg, Univ., Diss., 2002
    HBZ-ID HT013418567
    Database Catalogue ZB MED Medicine, Health

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  2. Article ; Online: Letter by Neugebauer and Jüttler Regarding Article, "Poor Collateral Circulation Assessed by Multiphase Computed Tomographic Angiography Predicts Malignant Middle Cerebral Artery Evolution After Reperfusion Therapies".

    Neugebauer, Hermann / Jüttler, Eric

    Stroke

    2016  Volume 47, Issue 2, Page(s) e33

    MeSH term(s) Cerebral Angiography ; Collateral Circulation ; Female ; Humans ; Infarction, Middle Cerebral Artery/diagnostic imaging ; Infarction, Middle Cerebral Artery/surgery ; Male ; Reperfusion/trends ; Tomography, X-Ray Computed
    Language English
    Publishing date 2016-02
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.115.011999
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Severe Dysphagia Predicts Poststroke Fever.

    Stösser, Sebastian / Gotthardt, Matthias / Lindner-Pfleghar, Beate / Jüttler, Eric / Kassubek, Rebecca / Neugebauer, Hermann

    Stroke

    2021  Volume 52, Issue 7, Page(s) 2284–2291

    Abstract: Background and purpose: Fever is a common observation after ischemic or hemorrhagic stroke and is associated with a worse clinical outcome. Infections, stroke severity, preexisting medical conditions, insertion of catheters, and dysphagia have been ... ...

    Abstract Background and purpose: Fever is a common observation after ischemic or hemorrhagic stroke and is associated with a worse clinical outcome. Infections, stroke severity, preexisting medical conditions, insertion of catheters, and dysphagia have been implicated in causing poststroke fever. Given that dysphagia has not been evaluated in detail yet, the aim of this study was to investigate if the severity of dysphagia assessed by a detailed swallowing assessment predicts poststroke fever.
    Methods: In this retrospective monocentric cohort study, all patients admitted for ischemic or hemorrhagic stroke within 12 months were included. Patients underwent a detailed standardized swallowing assessment including a clinical exam by a speech therapist and fiberoptic endoscopic evaluation in a subset of patients. Patients who developed fever within 5 days were compared with patients without fever regarding swallowing parameters and other clinical characteristics relevant for the prediction of poststroke fever.
    Results: Nine hundred twenty-three patients with acute ischemic or hemorrhagic stroke were included. One hundred twenty-seven (13.8%) patients developed fever. In multivariable analyses, fever was independently predicted by moderate-to-severe dysphagia in clinical assessments (odds ratio [95% CI], 3.05 [1.65–5.66]) and also by dysphagia with proven risk of aspiration as a combined end point of clinical and instrumental assessments (1.79 [1.07–3.00]). Other independent predictors were stroke severity (odds ratio, 1.06 per point on the National Institutes of Health Stroke Scale score [1.01–1.11]) and the presence of an urinary catheter (odds ratio, 2.03 [1.13–3.65]).
    Conclusions: Severe dysphagia evaluated by a detailed clinical assessment complemented by instrumental testing predicts the development of poststroke fever. Early identification of patients with severe dysphagia after stroke followed by consequent monitoring and treatment might be effective in reducing poststroke fever.
    MeSH term(s) Aged ; Aged, 80 and over ; Cohort Studies ; Deglutition Disorders/diagnosis ; Deglutition Disorders/epidemiology ; Female ; Fever/diagnosis ; Fever/epidemiology ; Germany/epidemiology ; Humans ; Male ; Predictive Value of Tests ; Retrospective Studies ; Severity of Illness Index ; Stroke/diagnosis ; Stroke/epidemiology
    Language English
    Publishing date 2021-04-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.120.033396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hemicraniectomy for malignant middle cerebral artery infarction: current status and future directions.

    Neugebauer, Hermann / Jüttler, Eric

    International journal of stroke : official journal of the International Stroke Society

    2014  Volume 9, Issue 4, Page(s) 460–467

    Abstract: Malignant middle cerebral artery infarction is a life-threatening sub-type of ischemic stroke that may only be survived at the expense of permanent disability. Decompressive hemicraniectomy is an effective surgical therapy to reduce mortality and improve ...

    Abstract Malignant middle cerebral artery infarction is a life-threatening sub-type of ischemic stroke that may only be survived at the expense of permanent disability. Decompressive hemicraniectomy is an effective surgical therapy to reduce mortality and improve functional outcome without promoting most severe disability. Evidence derives from three European randomized controlled trials in patients up to 60 years. The recently finished DEcompressive Surgery for the Treatment of malignant INfarction of the middle cerebral arterY - II trial gives now high-level evidence for the effectiveness of decompressive hemicraniectomy in patients older than 60 years. Nevertheless, pressing issues persist that need to be answered in future clinical trials, e.g. the acceptable degree of disability in survivors of malignant middle cerebral artery infarction, the importance of aphasia, and the best timing for decompressive hemicraniectomy. This review provides an overview of the current diagnosis and treatment of malignant middle cerebral artery infarction with a focus on decompressive hemicraniectomy and outlines future perspectives.
    MeSH term(s) Craniotomy/methods ; Craniotomy/trends ; Humans ; Infarction, Middle Cerebral Artery/surgery ; Treatment Outcome
    Language English
    Publishing date 2014-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2303728-3
    ISSN 1747-4949 ; 1747-4930
    ISSN (online) 1747-4949
    ISSN 1747-4930
    DOI 10.1111/ijs.12211
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Attitudes of Nurses Toward Disability and Treatment in Space-Occupying Middle Cerebral Artery Stroke.

    Neugebauer, Hermann / Malakou, Flora / Uttner, Ingo / Köpke, Melitta / Jüttler, Eric

    Neurocritical care

    2018  Volume 30, Issue 1, Page(s) 132–138

    Abstract: Background: Attitudes toward the degree of acceptable disability and the importance of aphasia are critical in deciding on decompressive hemicraniectomy (DHC) in space-occupying middle cerebral artery stroke (SOS). The attitudes of nurses deserve strong ...

    Abstract Background: Attitudes toward the degree of acceptable disability and the importance of aphasia are critical in deciding on decompressive hemicraniectomy (DHC) in space-occupying middle cerebral artery stroke (SOS). The attitudes of nurses deserve strong attention, because of their close interaction with patients during acute stroke treatment.
    Methods: This is a multicenter survey among 627 nurses from 132 hospitals in Germany. Questions address the acceptance of disability, importance of aphasia, and the preferred treatment in the hypothetical case of SOS.
    Results: Modified Rankin Scale (mRS) scores of 1 and 2 were considered acceptable by the majority of all respondents (89.7%). A mRS of 3, 4, and 5 was considered acceptable by 60.0, 15.5, and 1.6%, respectively. DHC was indicated as the treatment of choice in 31.4%. Every third participant considered the presence of aphasia important for treatment decision (33.3%). Older respondents more often refrained from DHC, irrespective of the presence of aphasia (dominant hemisphere p = 0.001, non-dominant hemisphere p = 0.004). Differences regarding acceptable disability and treatment decision were dependent on age, sex, and having relatives with stroke.
    Conclusion: Most German nurses indicate moderately severe disability after SOS not to be acceptable, without emphasizing the presence of aphasia. The results call for greater scientific efforts in order to find reliable predictors for outcome after SOS.
    MeSH term(s) Adult ; Age Factors ; Aphasia/etiology ; Aphasia/therapy ; Attitude of Health Personnel ; Clinical Decision-Making ; Decompressive Craniectomy ; Disabled Persons ; Female ; Germany ; Health Care Surveys ; Humans ; Infarction, Middle Cerebral Artery/complications ; Infarction, Middle Cerebral Artery/surgery ; Male ; Middle Aged ; Nursing Staff, Hospital ; Severity of Illness Index ; Young Adult
    Language English
    Publishing date 2018-08-02
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2381896-7
    ISSN 1556-0961 ; 1541-6933
    ISSN (online) 1556-0961
    ISSN 1541-6933
    DOI 10.1007/s12028-018-0586-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Cerebral Edema Associated With Large Hemispheric Infarction.

    Liebeskind, David S / Jüttler, Eric / Shapovalov, Yuriy / Yegin, Ashley / Landen, Jaren / Jauch, Edward C

    Stroke

    2019  Volume 50, Issue 9, Page(s) 2619–2625

    MeSH term(s) Aged ; Brain/diagnostic imaging ; Brain Edema/diagnosis ; Brain Edema/etiology ; Brain Edema/prevention & control ; Early Diagnosis ; Female ; Humans ; Infarction, Middle Cerebral Artery/complications ; Infarction, Middle Cerebral Artery/diagnosis ; Infarction, Middle Cerebral Artery/prevention & control ; Intracranial Hypertension/complications ; Intracranial Hypertension/diagnosis ; Intracranial Hypertension/prevention & control ; Male ; Middle Aged
    Language English
    Publishing date 2019-08-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.118.024766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Cannabinoide - Hemmer der Entzündungsreaktion beim Schlaganfall

    Jüttler, Eric

    MedReview

    2006  Volume 7, Issue 12, Page(s) 14

    Language German
    Document type Article
    ZDB-ID 2041837-1
    ISSN 1615-777X
    Database Current Contents Medicine

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  8. Article ; Online: Early decompressive hemicraniectomy in older patients with nondominant hemispheric infarction improves outcome.

    Jüttler, Eric / Hacke, Werner

    Stroke

    2011  Volume 42, Issue 3, Page(s) 843–844

    MeSH term(s) Age Factors ; Aged ; Cerebral Infarction/diagnosis ; Cerebral Infarction/surgery ; Decompressive Craniectomy/methods ; Female ; Humans ; Randomized Controlled Trials as Topic/methods ; Time Factors ; Treatment Outcome
    Language English
    Publishing date 2011-03
    Publishing country United States
    Document type Case Reports ; Journal Article ; Review
    ZDB-ID 80381-9
    ISSN 1524-4628 ; 0039-2499 ; 0749-7954
    ISSN (online) 1524-4628
    ISSN 0039-2499 ; 0749-7954
    DOI 10.1161/STROKEAHA.110.603597
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Acute Silent Brain Infarction in Monocular Visual Loss of Ischemic Origin.

    Lauda, Florian / Neugebauer, Hermann / Reiber, Lars / Jüttler, Eric

    Cerebrovascular diseases (Basel, Switzerland)

    2015  Volume 40, Issue 3-4, Page(s) 151–156

    Abstract: Background and purpose: Non-arteritic branch/central retinal artery occlusions (BRAO/CRAO) and amaurosis fugax (AF) are predominantly caused by embolism. Additionally, transported embolic material could cause ischemic stroke. The aim of the study was to ...

    Abstract Background and purpose: Non-arteritic branch/central retinal artery occlusions (BRAO/CRAO) and amaurosis fugax (AF) are predominantly caused by embolism. Additionally, transported embolic material could cause ischemic stroke. The aim of the study was to investigate the prevalence, pattern and underlying cause of concurrent acute brain infarctions in unselected patients with RAO and AF.
    Methods: A total of 213 consecutive patients with BRAO (20.7%), CRAO (47.4%), or AF (31.9%) were retrospectively studied from 2008 to 2013. Magnetic resonance imaging (MRI) was used to detect acute brain infarctions and a cardiovascular workup was performed to detect underlying etiologies according to the Trial of Org 10172 in Acute Stroke Management (TOAST).
    Results: MRI was obtained after 23.78 (±32.26) hours from the time of symptom onset. Acute brain infarctions were detected in 49 patients (23%); 44 of them (89.8%) did not experience any additional neurological symptoms. Older age (p < 0.001/p < 0.001), hypertension (p = 0.01/p = 0.03), atrial fibrillation (p = 0.006/p = 0.03) and type of RAO (p = 0.02/p = 0.016) were associated with total/silent stroke, respectively. In multivariate analysis, only age and type of occlusion remained positive predictors for silent stroke. Etiology of BRAO/CRAO and AF remained undetermined in 124 patients (58.2%). This rate was lower in patients with acute stroke (40.8 vs. 63.4%).
    Conclusions: Silent brain infarction is a frequent finding in unselected patients with BRAO/CRAO and AF. Etiology remains undetermined in approximately every second case. Because silent brain infarctions bear a high risk of future stroke, patients with BRAO/CRAO and AF should undergo prompt neuroimaging and cardiovascular checkup, preferably on a stroke unit.
    MeSH term(s) Aged ; Atrial Fibrillation/complications ; Blindness/complications ; Brain Infarction/complications ; Female ; Humans ; Hypertension/complications ; Male ; Middle Aged ; Retinal Artery Occlusion/complications ; Retinal Artery Occlusion/diagnosis ; Retrospective Studies ; Stroke/complications ; Visual Acuity/physiology
    Language English
    Publishing date 2015
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1069462-6
    ISSN 1421-9786 ; 1015-9770
    ISSN (online) 1421-9786
    ISSN 1015-9770
    DOI 10.1159/000437274
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Hemicraniectomy for middle-cerebral-artery stroke. Author reply.

    Jüttler, Eric / Unterberg, Andreas / Hacke, Werner

    The New England journal of medicine

    2014  Volume 370, Issue 24, Page(s) 2347–2348

    MeSH term(s) Craniotomy/methods ; Disabled Persons ; Female ; Humans ; Infarction, Middle Cerebral Artery/surgery ; Male
    Language English
    Publishing date 2014-06-12
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMc1404585
    Database MEDical Literature Analysis and Retrieval System OnLINE

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