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  1. Article ; Online: The role of macrophages in the innate immune response to Streptococcus pneumoniae and Staphylococcus aureus: mechanisms and contrasts.

    Cole, Joby / Aberdein, Jody / Jubrail, Jamil / Dockrell, David H

    Advances in microbial physiology

    2014  Volume 65, Page(s) 125–202

    Abstract: Macrophages are critical mediators of innate immune responses against bacteria. The Gram-positive bacteria Streptococcus pneumoniae and Staphylococcus aureus express a range of virulence factors, which challenge macrophages' immune competence. We review ... ...

    Abstract Macrophages are critical mediators of innate immune responses against bacteria. The Gram-positive bacteria Streptococcus pneumoniae and Staphylococcus aureus express a range of virulence factors, which challenge macrophages' immune competence. We review how macrophages respond to this challenge. Macrophages employ a range of strategies to phagocytose and kill each pathogen. When the macrophages capacity to clear bacteria is overwhelmed macrophages play important roles in orchestrating the inflammatory response through pattern recognition receptor-mediated responses. Macrophages also ensure the inflammatory response is tightly constrained, to avoid tissue damage, and play an important role in downregulating the inflammatory response once initial bacterial replication is controlled.
    MeSH term(s) Animals ; Humans ; Immunity, Innate ; Macrophage Activation ; Macrophages/cytology ; Macrophages/immunology ; Phagocytosis ; Pneumococcal Infections/immunology ; Staphylococcal Infections/immunology ; Staphylococcus aureus/genetics ; Staphylococcus aureus/immunology ; Streptococcus pneumoniae/genetics ; Streptococcus pneumoniae/immunology
    Language English
    Publishing date 2014
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 174-0
    ISSN 2162-5468 ; 0065-2911
    ISSN (online) 2162-5468
    ISSN 0065-2911
    DOI 10.1016/bs.ampbs.2014.08.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 366: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Clinical review: a systematic review of corticosteroid use in infections.

    Aberdein, Jody / Singer, Mervyn

    Critical care (London, England)

    2005  Volume 10, Issue 1, Page(s) 203

    Abstract: Traditional teaching suggests that corticosteroids should be avoided during acute infectious episodes for fear of compromising the immune response. However, the outcome benefit shown through steroid administration in early septic shock implies this ... ...

    Abstract Traditional teaching suggests that corticosteroids should be avoided during acute infectious episodes for fear of compromising the immune response. However, the outcome benefit shown through steroid administration in early septic shock implies this paranoia may be misplaced. We therefore performed a systematic review of the literature to identify the current strength of evidence for the use of corticosteroids in specified infections, and to make appropriate graded recommendations.
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Communicable Diseases/drug therapy ; Communicable Diseases/epidemiology ; Humans ; Practice Guidelines as Topic/standards ; Randomized Controlled Trials as Topic/methods ; Randomized Controlled Trials as Topic/standards
    Chemical Substances Adrenal Cortex Hormones
    Keywords covid19
    Language English
    Publishing date 2005-12-15
    Publishing country England
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2041406-7
    ISSN 1466-609X ; 1364-8535
    ISSN (online) 1466-609X
    ISSN 1364-8535
    DOI 10.1186/cc3904
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5517: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

    Order via subito

    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  3. Article ; Online: Hypoglycaemia associated with co-trimoxazole use in a 56-year-old Caucasian woman with renal impairment.

    Forde, Donall G / Aberdein, Jody / Tunbridge, Anne / Stone, Ben

    BMJ case reports

    2012  Volume 2012

    Abstract: Here we present a case of refractory hypoglycaemia associated with use of the antibiotic trimethoprim-sulfamethoxazole (TMP-SMX). This was used to treat Pneumocystis jirovecii pneumonia (PCP) infection. The patient had significant pre-existing renal ... ...

    Abstract Here we present a case of refractory hypoglycaemia associated with use of the antibiotic trimethoprim-sulfamethoxazole (TMP-SMX). This was used to treat Pneumocystis jirovecii pneumonia (PCP) infection. The patient had significant pre-existing renal impairment with a kidney transplant in situ. Refractory hypoglycaemia occurred 5 days after starting the antibiotic and persisted for 36 h after its cessation. SMX contains the same sulphanilamide structural group as the oral hypoglycaemic agents called sulphonureas. SMX could therefore act as an insulin secretagogue. The inappropriately raised insulin and c-peptide levels seen in our patient support this theory. The 5-day asymptomatic period would allow sufficient time for the drug to accumulate and the extended period seen after its cessation would be seen in a dose-dependent side effect. Following 3 days of observation and continuous glycaemic support on the High Dependency Unit she was discharged back to the ward, with no further occurrence of hypoglycaemia.
    MeSH term(s) Anti-Bacterial Agents/adverse effects ; Anti-Bacterial Agents/therapeutic use ; C-Peptide/metabolism ; European Continental Ancestry Group ; Female ; Humans ; Hypoglycemia/blood ; Hypoglycemia/etiology ; Insulin/blood ; Kidney Transplantation ; Middle Aged ; Pneumonia, Pneumocystis/drug therapy ; Renal Insufficiency/complications ; Trimethoprim, Sulfamethoxazole Drug Combination/adverse effects ; Trimethoprim, Sulfamethoxazole Drug Combination/therapeutic use
    Chemical Substances Anti-Bacterial Agents ; C-Peptide ; Insulin ; Trimethoprim, Sulfamethoxazole Drug Combination (8064-90-2)
    Language English
    Publishing date 2012-11-09
    Publishing country England
    Document type Case Reports ; Journal Article
    ISSN 1757-790X
    ISSN (online) 1757-790X
    DOI 10.1136/bcr-2012-007215
    Database MEDical Literature Analysis and Retrieval System OnLINE

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