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  1. Book: The genetics of Type 2 diabetes and related traits

    Florez, Jose C.

    biology, physiology and translation

    2016  

    Keywords complex disease ; human genetic variation ; quantitave traits ; genome-wide association studies ; epigenetics
    Language English
    Size XI, 576 S. : Ill., graph. Darst., 235 mm x 155 mm
    Publisher Springer
    Publishing place Cham
    Publishing country Germany
    Document type Book
    HBZ-ID HT018954382
    ISBN 978-3-319-01573-6 ; 3-319-01573-7 ; 978-3-319-01574-3 ; 3-319-01574-5
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2016 A 1027 available for loan (reading room) Lesesaal EG

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  2. Article ; Online: Advancing precision medicine in type 2 diabetes.

    Florez, Jose C

    The lancet. Diabetes & endocrinology

    2023  Volume 12, Issue 2, Page(s) 87–88

    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/therapy ; Precision Medicine
    Language English
    Publishing date 2023-12-21
    Publishing country England
    Document type Journal Article
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(23)00384-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Genomic discoveries unveil mechanistic insights in diabetes.

    Florez, Jose C

    Cell genomics

    2022  Volume 2, Issue 12, Page(s) 100230

    Abstract: Two diabetes-related papers are featured in this issue ... ...

    Abstract Two diabetes-related papers are featured in this issue of
    Language English
    Publishing date 2022-12-14
    Publishing country United States
    Document type News
    ISSN 2666-979X
    ISSN (online) 2666-979X
    DOI 10.1016/j.xgen.2022.100230
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Precision medicine of obesity as an integral part of type 2 diabetes management - past, present, and future.

    Szczerbinski, Lukasz / Florez, Jose C

    The lancet. Diabetes & endocrinology

    2023  Volume 11, Issue 11, Page(s) 861–878

    Abstract: Obesity is a complex and heterogeneous condition that leads to various metabolic complications, including type 2 diabetes. Unfortunately, for some, treatment options to date for obesity are insufficient, with many people not reaching sustained weight ... ...

    Abstract Obesity is a complex and heterogeneous condition that leads to various metabolic complications, including type 2 diabetes. Unfortunately, for some, treatment options to date for obesity are insufficient, with many people not reaching sustained weight loss or having improvements in metabolic health. In this Review, we discuss advances in the genetics of obesity from the past decade-with emphasis on developments from the past 5 years-with a focus on metabolic consequences, and their potential implications for precision management of the disease. We also provide an overview of the potential role of genetics in guiding weight loss strategies. Finally, we propose a vision for the future of precision obesity management that includes developing an obesity-centred multidisease management algorithm that targets both obesity and its comorbidities. However, further collaborative efforts and research are necessary to fully realise its potential and improve metabolic health outcomes.
    MeSH term(s) Humans ; Diabetes Mellitus, Type 2/complications ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/therapy ; Precision Medicine ; Obesity/complications ; Obesity/genetics ; Obesity/therapy ; Anti-Obesity Agents ; Weight Loss
    Chemical Substances Anti-Obesity Agents
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article ; Review ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(23)00232-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Extending precision medicine tools to populations at high risk of type 2 diabetes.

    Misra, Shivani / Florez, Jose C

    PLoS medicine

    2022  Volume 19, Issue 5, Page(s) e1003989

    Abstract: In this Perspective, Shivani Misra and Jose C Florez discuss the application of precision medicine ...

    Abstract In this Perspective, Shivani Misra and Jose C Florez discuss the application of precision medicine tools in under-represented populations.
    MeSH term(s) Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/genetics ; Humans ; Precision Medicine
    Language English
    Publishing date 2022-05-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2185925-5
    ISSN 1549-1676 ; 1549-1277
    ISSN (online) 1549-1676
    ISSN 1549-1277
    DOI 10.1371/journal.pmed.1003989
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6042: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: On the Verge of Precision Medicine in Diabetes.

    Li, Josephine H / Florez, Jose C

    Drugs

    2022  Volume 82, Issue 13, Page(s) 1389–1401

    Abstract: The epidemic of type 2 diabetes (T2D) is a significant global public health challenge and a major cause of morbidity and mortality. Despite the recent proliferation of pharmacological agents for the treatment of T2D, current therapies simply treat the ... ...

    Abstract The epidemic of type 2 diabetes (T2D) is a significant global public health challenge and a major cause of morbidity and mortality. Despite the recent proliferation of pharmacological agents for the treatment of T2D, current therapies simply treat the symptom, i.e. hyperglycemia, and do not directly address the underlying disease process or modify the disease course. This article summarizes how genomic discovery has contributed to unraveling the heterogeneity in T2D, reviews relevant discoveries in the pharmacogenetics of five commonly prescribed glucose-lowering agents, presents evidence supporting how pharmacogenetics can be leveraged to advance precision medicine, and calls attention to important research gaps to its implementation to guide treatment choices.
    MeSH term(s) Diabetes Mellitus, Type 2/diagnosis ; Diabetes Mellitus, Type 2/drug therapy ; Glucose/therapeutic use ; Humans ; Hypoglycemic Agents/therapeutic use ; Precision Medicine
    Chemical Substances Hypoglycemic Agents ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-09-19
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 120316-2
    ISSN 1179-1950 ; 0012-6667
    ISSN (online) 1179-1950
    ISSN 0012-6667
    DOI 10.1007/s40265-022-01774-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 762: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: A roadmap to achieve pharmacological precision medicine in diabetes.

    Florez, Jose C / Pearson, Ewan R

    Diabetologia

    2022  Volume 65, Issue 11, Page(s) 1830–1838

    Abstract: Current pharmacological treatment of diabetes is largely algorithmic. Other than for cardiovascular disease or renal disease, where sodium-glucose cotransporter 2 inhibitors and/or glucagon-like peptide-1 receptor agonists are indicated, the choice of ... ...

    Abstract Current pharmacological treatment of diabetes is largely algorithmic. Other than for cardiovascular disease or renal disease, where sodium-glucose cotransporter 2 inhibitors and/or glucagon-like peptide-1 receptor agonists are indicated, the choice of treatment is based upon overall risks of harm or side effect and cost, and not on probable benefit. Here we argue that a more precise approach to treatment choice is necessary to maximise benefit and minimise harm from existing diabetes therapies. We propose a roadmap to achieve precision medicine as standard of care, to discuss current progress in relation to monogenic diabetes and type 2 diabetes, and to determine what additional work is required. The first step is to identify robust and reliable genetic predictors of response, recognising that genotype is static over time and provides the skeleton upon which modifiers such as clinical phenotype and metabolic biomarkers can be overlaid. The second step is to identify these metabolic biomarkers (e.g. beta cell function, insulin sensitivity, BMI, liver fat, metabolite profile), which capture the metabolic state at the point of prescribing and may have a large impact on drug response. Third, we need to show that predictions that utilise these genetic and metabolic biomarkers improve therapeutic outcomes for patients, and fourth, that this is cost-effective. Finally, these biomarkers and prediction models need to be embedded in clinical care systems to enable effective and equitable clinical implementation. Whilst this roadmap is largely complete for monogenic diabetes, we still have considerable work to do to implement this for type 2 diabetes. Increasing collaborations, including with industry, and access to clinical trial data should enable progress to implementation of precision treatment in type 2 diabetes in the near future.
    MeSH term(s) Biomarkers ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/genetics ; Diabetes Mellitus, Type 2/metabolism ; Glucagon-Like Peptide-1 Receptor/genetics ; Glucose ; Humans ; Hypoglycemic Agents/therapeutic use ; Precision Medicine ; Sodium
    Chemical Substances Biomarkers ; Glucagon-Like Peptide-1 Receptor ; Hypoglycemic Agents ; Sodium (9NEZ333N27) ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-06-24
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 1694-9
    ISSN 1432-0428 ; 0012-186X
    ISSN (online) 1432-0428
    ISSN 0012-186X
    DOI 10.1007/s00125-022-05732-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 279: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Extending precision medicine tools to populations at high risk of type 2 diabetes.

    Shivani Misra / Jose C Florez

    PLoS Medicine, Vol 19, Iss 5, p e

    2022  Volume 1003989

    Abstract: In this Perspective, Shivani Misra and Jose C Florez discuss the application of precision medicine ...

    Abstract In this Perspective, Shivani Misra and Jose C Florez discuss the application of precision medicine tools in under-represented populations.
    Keywords Medicine ; R
    Language English
    Publishing date 2022-05-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  9. Article ; Online: Genetics and biobanks converge to resolve a vexing knowledge gap in diabetes.

    Florez, Jose C

    The lancet. Diabetes & endocrinology

    2018  Volume 6, Issue 2, Page(s) 87–89

    MeSH term(s) Biological Specimen Banks ; Diabetes Mellitus ; Humans
    Language English
    Publishing date 2018
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2213-8595
    ISSN (online) 2213-8595
    DOI 10.1016/S2213-8587(17)30399-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Genetics of Diabetic Kidney Disease.

    Florez, Jose C

    Seminars in nephrology

    2016  Volume 36, Issue 6, Page(s) 474–480

    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 604652-6
    ISSN 1558-4488 ; 0270-9295
    ISSN (online) 1558-4488
    ISSN 0270-9295
    DOI 10.1016/j.semnephrol.2016.09.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Se 784: Show issues Location:
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