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  1. Article ; Online: Reply.

    Takatsuki, Shinichi

    The Journal of pediatrics

    2017  Volume 184, Page(s) 240

    MeSH term(s) Child ; Humans ; Pulmonary Artery
    Language English
    Publishing date 2017-02-21
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 3102-1
    ISSN 1097-6833 ; 0022-3476
    ISSN (online) 1097-6833
    ISSN 0022-3476
    DOI 10.1016/j.jpeds.2017.01.032
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  2. Article ; Online: Clinical efficacy and safety of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension.

    Takatsuki, Shinichi / Nakayama, Tomotaka / Shimizu, Yurika / Kawai, Reiko / Matsuura, Hiroyuki

    Cardiology in the young

    2022  Volume 33, Issue 2, Page(s) 196–200

    Abstract: Objective: This study aimed to investigate the safety, tolerability, and efficacy of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension.: Methods: This retrospective cohort study included clinical ... ...

    Abstract Objective: This study aimed to investigate the safety, tolerability, and efficacy of selexipag in children and young adults with idiopathic and heritable pulmonary arterial hypertension.
    Methods: This retrospective cohort study included clinical data from five children and six young adults with pulmonary arterial hypertension receiving selexipag as add-on therapy or as a transition from beraprost sodium or epoprostenol infusion therapy. Clinical efficacy was evaluated by measuring improvement in clinical variables from baseline, including hemodynamic parameters.
    Results: Of the 11 patients, 6 were switched from beraprost sodium to selexipag and one paediatric patient transitioned from epoprostenol to selexipag. The median maintenance dose of selexipag in children was 80 μg/kg/day. In nine patients undergoing repeat catheterisation, statistically significant improvements were observed after the initiation of selexipag in terms of mean pulmonary arterial pressure (p < 0.01), pulmonary vascular resistance index (p < 0.05), and cardiac index (p < 0.01). None of the patients had clinical worsening after selexipag during follow-up, but one young adult patient discontinued treatment due to severe headache. The most common side effect profiles were headache, nausea, abdominal pain, jaw pain, myalgia, and diarrhoea.
    Conclusions: Selexipag may have a favourable safety profile and potential efficacy in children and young adults with pulmonary arterial hypertension.
    MeSH term(s) Humans ; Young Adult ; Child ; Epoprostenol/therapeutic use ; Pulmonary Arterial Hypertension/drug therapy ; Hypertension, Pulmonary/drug therapy ; Familial Primary Pulmonary Hypertension/drug therapy ; Antihypertensive Agents/adverse effects ; Retrospective Studies ; Treatment Outcome
    Chemical Substances Epoprostenol (DCR9Z582X0) ; selexipag (5EXC0E384L) ; Antihypertensive Agents
    Language English
    Publishing date 2022-04-06
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951122000415
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  3. Article ; Online: Clinical differences between children and adults with idiopathic and heritable pulmonary arterial hypertension.

    Takatsuki, Shinichi / Shimokawahara, Hiroto / Shimizu, Yurika / Kawai, Reiko / Matsuura, Hiroyuki / Matsubara, Hiromi

    Cardiology in the young

    2022  Volume 33, Issue 10, Page(s) 1909–1912

    Abstract: Background: Although previous studies have demonstrated that paediatric pulmonary arterial hypertension remains distinct from that in adults, there are limited studies evaluating a direct comparison between children and adults. The aim of this head-to- ... ...

    Abstract Background: Although previous studies have demonstrated that paediatric pulmonary arterial hypertension remains distinct from that in adults, there are limited studies evaluating a direct comparison between children and adults. The aim of this head-to-head comparison study was to compare the gender, haemodynamic parameters, and prognosis between paediatric and adult pulmonary arterial hypertension.
    Methods and results: We retrospectively assessed the clinical differences in 40 childhood-onset (under 20 years old) patients and 40 adult-onset patients with idiopathic and heritable pulmonary arterial hypertension who were followed up at two centres. There was no female predominance among patients with childhood-onset pulmonary arterial hypertension (child female: 42.5%, adult female: 80%). The percent of New York Heart Association functional class IV in adult-onset pulmonary arterial hypertension tended to be higher than those in childhood-onset pulmonary arterial hypertension (22.5 and 10%, respectively), although children had worse haemodynamic parameters at diagnosis (mean pulmonary artery pressure (children versus adults); median 65 mmHg versus 49 mmHg, p < 0.001). There was no significant difference in the event-free survival rate between the two groups (95% vs. 85%) during the follow-up period (median, 96 months; range, 1-120 months).
    Conclusions: Although paediatric pulmonary arterial hypertension patients had worse haemodynamic parameters at diagnosis than adults, children survived as long as adults with appropriate therapeutic strategies.
    MeSH term(s) Child ; Humans ; Adult ; Female ; Young Adult ; Male ; Familial Primary Pulmonary Hypertension/diagnosis ; Familial Primary Pulmonary Hypertension/genetics ; Pulmonary Arterial Hypertension ; Hypertension, Pulmonary/epidemiology ; Hypertension, Pulmonary/genetics ; Hypertension, Pulmonary/diagnosis ; Retrospective Studies ; Hemodynamics
    Language English
    Publishing date 2022-11-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1078466-4
    ISSN 1467-1107 ; 1047-9511
    ISSN (online) 1467-1107
    ISSN 1047-9511
    DOI 10.1017/S1047951122003432
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  4. Article ; Online: Correction to: Outcomes of idiopathic pulmonary arterial hypertension in Japanese children: a retrospective cohort study.

    Miyamoto, Kenji / Inai, Kei / Kobayashi, Tohru / Maeda, Jun / Takatsuki, Shinichi / Nakayama, Tomotaka / Furutani, Yoshiyuki / Yamagishi, Hiroyuki / Nakanishi, Toshio

    Heart and vessels

    2021  Volume 36, Issue 9, Page(s) 1400

    Language English
    Publishing date 2021-06-01
    Publishing country Japan
    Document type Published Erratum
    ZDB-ID 89678-0
    ISSN 1615-2573 ; 0910-8327 ; 0935-736X
    ISSN (online) 1615-2573
    ISSN 0910-8327 ; 0935-736X
    DOI 10.1007/s00380-021-01882-3
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  5. Article ; Online: Correction to: Clinical Effects of Syncope on Disease Severity and Adverse Outcomes in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension.

    Takatsuki, Shinichi / Yanai, Shun / Ikehara, Satoshi / Nakayama, Tomotaka / Matsuura, Hiroyuki

    Pediatric cardiology

    2018  Volume 40, Issue 1, Page(s) 215

    Abstract: The original version of this article unfortunately contained a mistake in the author name. The co-author name should be Hiroyuki Matsuura instead of Horoyuki Matsuura. The original article has been corrected. ...

    Abstract The original version of this article unfortunately contained a mistake in the author name. The co-author name should be Hiroyuki Matsuura instead of Horoyuki Matsuura. The original article has been corrected.
    Language English
    Publishing date 2018-07-30
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-018-2028-z
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  6. Article ; Online: Outcomes of idiopathic pulmonary arterial hypertension in Japanese children: a retrospective cohort study.

    Miyamoto, Kenji / Inai, Kei / Kobayashi, Tohru / Maeda, Jun / Takatsuki, Shinichi / Nakayama, Tomotaka / Furutani, Yoshiyuki / Yamagishi, Hiroyuki / Nakanishi, Toshio

    Heart and vessels

    2021  Volume 36, Issue 9, Page(s) 1392–1399

    Abstract: Recently, targeted therapy has been developed for idiopathic pulmonary arterial hypertension (IPAH). Studies evaluating the prognosis of IPAH have been conducted in adults. However, there is no nationwide survey of pediatric patients with IPAH regarding ... ...

    Abstract Recently, targeted therapy has been developed for idiopathic pulmonary arterial hypertension (IPAH). Studies evaluating the prognosis of IPAH have been conducted in adults. However, there is no nationwide survey of pediatric patients with IPAH regarding the long-term prognosis in Japan. Therefore, we investigated the clinical outcomes of Japanese pediatric patients with IPAH and risk factors for a poor prognosis. This multi-center, retrospective cohort study included pediatric patients with IPAH under the age of 15 years, who were gleaned from the nationwide network of Japanese Society of Pediatric Cardiology and Cardiac Surgery (JSPCCS). The questionnaire was sent to members of JSPCCS in 2015. Patients who were diagnosed with IPAH from 1994 to 2014 were included. The primary endpoint was death or lung transplantation. Ninety-five patients were finally enrolled. Both the mean age at diagnosis and the mean follow-up duration were 7 years. Ninety-five percent of patients had received targeted therapy for IPAH during follow-up. The overall 1, 3, 5, and 10-year event free rate, estimated using Kaplan-Meier survival estimate, was 96, 91, 83, and 74%, respectively. The prognosis was significantly poorer in patients with increased right ventricular systolic pressure (RVp), mean pulmonary artery pressure (mPAP) (≥ 52 mmHg), cardiothoracic ratio (≥ 55%), and levels of B-type natriuretic peptide (BNP) during follow-up (≥ 300 pg/mL) than in those without these parameters. In conclusion, in Japanese children with IPAH, the event-free rate for death or lung transplantation was found to be good. Greater RVp, mPAP, BNP levels during follow-up, and cardiothoracic ratio may be predictive indicators for a poor prognosis.
    MeSH term(s) Adolescent ; Child ; Familial Primary Pulmonary Hypertension ; Humans ; Japan/epidemiology ; Kaplan-Meier Estimate ; Prognosis ; Retrospective Studies
    Language English
    Publishing date 2021-03-18
    Publishing country Japan
    Document type Journal Article ; Multicenter Study
    ZDB-ID 89678-0
    ISSN 1615-2573 ; 0910-8327 ; 0935-736X
    ISSN (online) 1615-2573
    ISSN 0910-8327 ; 0935-736X
    DOI 10.1007/s00380-021-01806-1
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  7. Article ; Online: Clinical Effects of Syncope on Disease Severity and Adverse Outcomes in Children with Idiopathic and Heritable Pulmonary Arterial Hypertension.

    Takatsuki, Shinichi / Yanai, Shun / Ikehara, Satoshi / Nakayama, Tomotaka / Matsuura, Hiroyuki

    Pediatric cardiology

    2018  Volume 40, Issue 1, Page(s) 209–214

    Abstract: Syncope is more common in children with idiopathic pulmonary arterial hypertension (PAH) than in adults with PAH. Although syncope is associated with a poor prognosis in adult PAH, the clinical effects of syncopal events on disease severity and outcome ... ...

    Abstract Syncope is more common in children with idiopathic pulmonary arterial hypertension (PAH) than in adults with PAH. Although syncope is associated with a poor prognosis in adult PAH, the clinical effects of syncopal events on disease severity and outcome in children have not been carefully investigated. This study assessed the prevalence of syncope in pediatric PAH and examined its clinical, hemodynamic, and prognostic importance. This retrospective study assessed clinical data, including syncope status, from 78 children (37 girls) with idiopathic and heritable PAH (median age at diagnosis, 11 years). Patients were classified as syncopal or non-syncopal, and clinical data from the two groups were compared. The primary outcome was a composite of lung transplantation and cardiac mortality. Overall, 31 (38%) children had a history of syncope at presentation. Median age at diagnosis, sex ratio, brain natriuretic peptide level, and 6-min walk distance at diagnosis did not differ between groups. The hemodynamic parameters of initial right heart catheterization were similar between the syncope and non-syncope group (mean pulmonary artery pressure, 67 versus 71 mm Hg; cardiac index, 2.9 versus 2.9 l/min/m
    MeSH term(s) Adolescent ; Cardiac Catheterization/methods ; Case-Control Studies ; Child ; Child, Preschool ; Disease-Free Survival ; Familial Primary Pulmonary Hypertension/mortality ; Familial Primary Pulmonary Hypertension/physiopathology ; Familial Primary Pulmonary Hypertension/surgery ; Female ; Humans ; Male ; Proportional Hazards Models ; Retrospective Studies ; Severity of Illness Index ; Syncope/mortality ; Syncope/physiopathology ; Ventricular Function, Right ; Young Adult
    Language English
    Publishing date 2018-10-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 800857-7
    ISSN 1432-1971 ; 0172-0643
    ISSN (online) 1432-1971
    ISSN 0172-0643
    DOI 10.1007/s00246-018-1996-3
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  8. Article ; Online: Current challenges in pediatric pulmonary hypertension.

    Takatsuki, Shinichi / Ivy, David Dunbar

    Seminars in respiratory and critical care medicine

    2013  Volume 34, Issue 5, Page(s) 627–644

    Abstract: Pulmonary arterial hypertension (PAH) in the pediatric population is associated with a variety of underlying diseases and causes, significantly morbidity and mortality. In the majority of patients, PAH in children is idiopathic or associated with ... ...

    Abstract Pulmonary arterial hypertension (PAH) in the pediatric population is associated with a variety of underlying diseases and causes, significantly morbidity and mortality. In the majority of patients, PAH in children is idiopathic or associated with congenital heart disease (CHD), with pulmonary hypertension (PH) associated with connective tissue disease, a rare cause in children. Classification of pediatric PH has generally followed the WHO classification, but recognition of the importance of fetal origins of PH and developmental abnormalities have led to the formation of a new pediatric-specific classification. Incidence data from the Netherlands has revealed an annual incidence and point prevalence of 0.7 and 4.4 for idiopathic PAH and 2.2 and 15.6 for associated pulmonary arterial hypertension-CHD cases per million children. Although the treatment with new selective pulmonary vasodilators offers hemodynamic and functional improvement in pediatric populations, the treatments in children largely depend on results from evidence-based adult studies and experience of clinicians treating children. A recent randomized clinical trial of sildenafil and its long-term extension has led to disparate recommendations in the United States and Europe.
    MeSH term(s) Child ; Endothelin Receptor Antagonists ; Familial Primary Pulmonary Hypertension ; Heart Defects, Congenital/complications ; Humans ; Hypertension, Pulmonary/diagnosis ; Hypertension, Pulmonary/etiology ; Hypertension, Pulmonary/therapy ; Lung Transplantation ; Phosphodiesterase 5 Inhibitors/therapeutic use ; Prognosis ; Prostaglandins I/therapeutic use ; Vasodilator Agents/therapeutic use
    Chemical Substances Endothelin Receptor Antagonists ; Phosphodiesterase 5 Inhibitors ; Prostaglandins I ; Vasodilator Agents
    Language English
    Publishing date 2013-09-13
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1183617-9
    ISSN 1098-9048 ; 1069-3424
    ISSN (online) 1098-9048
    ISSN 1069-3424
    DOI 10.1055/s-0033-1356461
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  9. Article ; Online: JCS/JHRS 2022 Guideline on Diagnosis and Risk Assessment of Arrhythmia.

    Takase, Bonpei / Ikeda, Takanori / Shimizu, Wataru / Abe, Haruhiko / Aiba, Takeshi / Chinushi, Masaomi / Koba, Shinji / Kusano, Kengo / Niwano, Shinichi / Takahashi, Naohiko / Takatsuki, Seiji / Tanno, Kaoru / Watanabe, Eiichi / Yoshioka, Koichiro / Amino, Mari / Fujino, Tadashi / Iwasaki, Yu-Ki / Kohno, Ritsuko / Kinoshita, Toshio /
    Kurita, Yasuo / Masaki, Nobuyuki / Murata, Hiroshige / Shinohara, Tetsuji / Yada, Hirotaka / Yodogawa, Kenji / Kimura, Takeshi / Kurita, Takashi / Nogami, Akihiko / Sumitomo, Naokata

    Circulation journal : official journal of the Japanese Circulation Society

    2023  

    Language English
    Publishing date 2023-09-11
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2068090-9
    ISSN 1347-4820 ; 1346-9843
    ISSN (online) 1347-4820
    ISSN 1346-9843
    DOI 10.1253/circj.CJ-22-0827
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  10. Article ; Online: Headache in Patients with Cervical Spondylotic Myelopathy.

    Yabuki, Shoji / Takatsuki, Kozue / Otani, Koji / Nikaido, Takuya / Watanabe, Kazuyuki / Kato, Kinshi / Kobayashi, Hiroshi / Handa, Jun-Ichi / Konno, Shinichi

    Pain research & management

    2020  Volume 2020, Page(s) 8856088

    Abstract: Purpose: The anatomical mechanisms of cervicogenic headache caused by upper cervical lesions have been reported. However, the pathomechanisms of headache caused by lower cervical spine disorders remain unknown. The purpose of the current study was to ... ...

    Abstract Purpose: The anatomical mechanisms of cervicogenic headache caused by upper cervical lesions have been reported. However, the pathomechanisms of headache caused by lower cervical spine disorders remain unknown. The purpose of the current study was to clarify the prevalence and pathogenesis of headaches in patients with cervical spondylotic myelopathy (CSM).
    Methods: In this retrospective study, a questionnaire regarding preoperative and postoperative symptoms was sent to 147 patients with CSM who were surgically treated in our hospital during the previous 10 years. All of the surgical procedures were decompression surgeries between the C3 and C7 levels. Data from 74 patients (50.3%) were available for analysis. Subjects were divided into four groups according to the presence or absence of preoperative and postoperative headache. The severity of pain, severity of neuropathic pain symptoms, depression, severity of myelopathy, and quality of life (QOL) were also evaluated using questionnaires. The scores of these questionnaires were then compared between the four groups. Kruskal-Wallis tests with Dunn-Bonferroni
    Results: Of the patients with CSM, 31% had headaches preoperatively, and 43% of these headaches disappeared postoperatively. Type 4 (preoperative headache-positive/postoperative headache-positive) patients had more severe pain and neuropathic pain symptoms and lower QOL scores compared with type 1 (preoperative headache-negative/postoperative headache-negative) patients.
    Conclusions: Approximately one-third of all patients with CSM had headaches preoperatively. Headache in patients with CSM may be neuropathic pain. A proportion of headaches in patients with CSM can be treated by decompression surgery.
    MeSH term(s) Adult ; Aged ; Cervical Vertebrae/surgery ; Female ; Headache/diagnosis ; Headache/epidemiology ; Headache/surgery ; Humans ; Male ; Middle Aged ; Pain Measurement/methods ; Quality of Life/psychology ; Retrospective Studies ; Spinal Cord Diseases/diagnosis ; Spinal Cord Diseases/epidemiology ; Spinal Cord Diseases/surgery ; Spondylosis/diagnosis ; Spondylosis/epidemiology ; Spondylosis/surgery ; Surveys and Questionnaires ; Treatment Outcome
    Language English
    Publishing date 2020-09-28
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041085-2
    ISSN 1918-1523 ; 1203-6765
    ISSN (online) 1918-1523
    ISSN 1203-6765
    DOI 10.1155/2020/8856088
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