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  1. Article ; Online: Genetic structure of indigenous and migratory populations in the area of Tuzla region considering some static and dynamic-morphological properties

    Ahmić Adisa / Tursunović Aldijana / Bašić Alma / Hamidović Hajrija / Hadžihalilović Jasminka / Pojskić Naris / Hadžiselimović Rifat

    Glasnik Antropološkog Društva Srbije, Vol 2012, Iss 47, Pp 173-

    2012  Volume 180

    Abstract: Genetic structure of two human populations, indigenous and migratory population in the area of the Tuzla region, was analyzed with respect to some static and dynamic-morphological properties. The analyzed genetic data were collected by direct observation ...

    Abstract Genetic structure of two human populations, indigenous and migratory population in the area of the Tuzla region, was analyzed with respect to some static and dynamic-morphological properties. The analyzed genetic data were collected by direct observation and survey of 472 pupils of school age. The investigated parameters of genetic heterogeneity were estimated by: analysis of the frequency of recessive phenotypes for every observed property, t-test analysis, and assessment of intragroup variation by analysis of Wahlund variance. Based on the obtained results it was observed that the frequency of the recessive homozygote for most of the analyzed properties was slightly higher in migratory populations. All values obtained by Wahlund variance analysis indicated a small genetic differentiation.
    Keywords genetic structure ; genetic differentiation ; Anthropology ; GN1-890
    Subject code 580
    Language English
    Publishing date 2012-01-01T00:00:00Z
    Publisher Antropološko društvo Srbije i Univerzitet u Nišu, Prirodno-matematički fakultet
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  2. Article ; Online: Clinical significance of ABCB1 genotyping in oncology.

    Hamidovic, Alma / Hahn, Kristine / Kolesar, Jill

    Journal of oncology pharmacy practice : official publication of the International Society of Oncology Pharmacy Practitioners

    2009  Volume 16, Issue 1, Page(s) 39–44

    Abstract: Background: P-glycoprotein (Pgp) is a drug efflux pump that transports natural products, including taxanes and other chemotherapeutic agents, from cells. Several frequent polymorphisms in ATP binding cassette gene B1 (ABCB1) may influence Pgp levels and ...

    Abstract Background: P-glycoprotein (Pgp) is a drug efflux pump that transports natural products, including taxanes and other chemotherapeutic agents, from cells. Several frequent polymorphisms in ATP binding cassette gene B1 (ABCB1) may influence Pgp levels and drug efflux. The purpose of this review was to assess the clinical significance of ABCB1 polymorphisms in oncology.
    Methods: Peer-reviewed studies were identified through a search of PubMed/MEDLINE (1990-2008) and the ASCO abstracts (2003-2008) database. Included studies described clinical trials where ABCB1 genotyping was performed in patients with cancer. Search terms included ABCB1, Pgp, docetaxel, paclitaxel, irinotecan, imatinib, and anticancer agent. Studies were excluded if the manuscript was not available in English.
    Results: The influence of polymorphisms in ABCB1 2677G>T/A, 3435C>T, and 1236C>T and progression-free and overall survival in 309 patients from the Australian Ovarian Cancer Study treated with paclitaxel/carboplatin demonstrated that compared to homozygote GG carriers at 2677, women with the minor T/A alleles were significantly less likely to relapse following treatment. Other trials of ABCB1 genotyping in breast and prostate cancer patients receiving taxanes have shown inconsistent results. Pharmacokinetic studies where ABCB1 was genotyped and patients received irinotecan or imatinib have also shown inconsistent results.
    Conclusion: A number of commercially available drugs are substrates for Pgp, and the ABCB1-variant genotypes are frequent and functionally significant, which may have future implications for drug dosing.
    MeSH term(s) ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily B, Member 1/genetics ; ATP Binding Cassette Transporter, Subfamily B, Member 1/physiology ; Antineoplastic Agents/pharmacokinetics ; Antineoplastic Agents/therapeutic use ; Drug Resistance, Neoplasm/genetics ; Female ; Genotype ; Humans ; Male ; Neoplasms/drug therapy ; Neoplasms/mortality ; Pharmacogenetics/methods ; Polymorphism, Genetic ; Sequence Analysis, DNA/methods ; Treatment Outcome
    Chemical Substances ABCB1 protein, human ; ATP Binding Cassette Transporter, Subfamily B ; ATP Binding Cassette Transporter, Subfamily B, Member 1 ; Antineoplastic Agents
    Language English
    Publishing date 2009-04-28
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1330764-2
    ISSN 1477-092X ; 1078-1552
    ISSN (online) 1477-092X
    ISSN 1078-1552
    DOI 10.1177/1078155209104380
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Frequency of inherited congenital anomalies of arms and feet in sample of newborns in Tuzla Canton (Bosnia and Herzegovina)

    Tursunović Aldijana / Terzić Rifet / Ahmić Adisa / Širanović Suad / Hamidović Hajrija / Hadžiavdić Vesna / Fazlović Alma / Fatušić Zlatan

    Glasnik Antropološkog Društva Srbije, Vol 2013, Iss 48, Pp 7-

    2013  Volume 17

    Abstract: Genetic burden size estimation of the world population and its individual components has a great theoretical and practical (medical) significance, and genetic determinators of congenital defects represent one of its most interesting components. ... ...

    Abstract Genetic burden size estimation of the world population and its individual components has a great theoretical and practical (medical) significance, and genetic determinators of congenital defects represent one of its most interesting components. Congenital anomaly of fists and feet may occur in different forms. In this paper we studied the incidence of syndactyly (syndactylia), clinodactyly (clynodactylia) and polydactyly (polydactylia) in a sample of newborns of Tuzla Canton. Data were collected at the Department of Gynecology and Obstetrics of University Clinical Center in Tuzla. The main source of needed information was disease history of mothers and newborns. The observed anomalies were registered by first pediatric examination of newborns. The study included 8419 infants (4335 males and 4084 females) of which 7793 passed and 626 undelivered newborns, born during the time period 2007 - 2008 year. The total incidence of anomalies in the analyzed sample was 0,23%, of which the relative frequency of polydactyly is 0,05%, syndactyly 0,07% and clinodactyly 0,11%. The highest frequency of the studied anomalies was observed in the subsample of undelivered newborns (0,80%), and in the subsample of delivered newborns was 0,18%. Comparison of our data with literature data showed that the frequency of observed anomalies falls in the range of variation of parameters investigated in other populations.
    Keywords newborn ; syndactyly ; polydactyly ; clynodactyly ; Tuzla Canton ; Anthropology ; GN1-890
    Language English
    Publishing date 2013-01-01T00:00:00Z
    Publisher Antropološko društvo Srbije i Univerzitet u Nišu, Prirodno-matematički fakultet
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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