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  1. Article: Presenilin 2 N141I Mutation Induces Hyperimmunity by Immune Cell-specific Suppression of REV-ERBα without Altering Central Circadian Rhythm.

    Nam, Hyeri / Kim, Boil / Lee, Younghwan / Choe, Han Kyoung / Yu, Seong-Woon

    Experimental neurobiology

    2023  Volume 32, Issue 4, Page(s) 259–270

    Abstract: Circadian rhythm is a 24-hour cycle of behavioral and physiological changes. Disrupted sleep-wake patterns and circadian dysfunction are common in patients of Alzheimer Disease (AD) and are closely related with neuroinflammation. However, it is not well ... ...

    Abstract Circadian rhythm is a 24-hour cycle of behavioral and physiological changes. Disrupted sleep-wake patterns and circadian dysfunction are common in patients of Alzheimer Disease (AD) and are closely related with neuroinflammation. However, it is not well known how circadian rhythm of immune cells is altered during the progress of AD. Previously, we found presenilin 2 (
    Language English
    Publishing date 2023-09-26
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2639017-6
    ISSN 2093-8144 ; 1226-2560
    ISSN (online) 2093-8144
    ISSN 1226-2560
    DOI 10.5607/en23012
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  2. Article: Asymptomatic hematuria in children: Korean Society of Pediatric Nephrology recommendations for diagnosis and management.

    Park, Eujin / Kim, Sang Woon / Kim, Su Jin / Baek, Minki / Ahn, Yo Han / Yang, Eun Mi / Cho, Myung Hyun / Lee, Hyun Kyung / Han, Kyoung Hee / Kim, Yae Lim / Choi, Miyoung / Kang, Hee Gyung / Suh, Jin-Soon

    Kidney research and clinical practice

    2024  

    Abstract: Hematuria is a relatively common condition among school-aged children. Because international guidelines for asymptomatic hematuria in children are unavailable, developing practical guidelines for the diagnosis and management of asymptomatic hematuria ... ...

    Abstract Hematuria is a relatively common condition among school-aged children. Because international guidelines for asymptomatic hematuria in children are unavailable, developing practical guidelines for the diagnosis and management of asymptomatic hematuria based on scientific evidence while considering real-world practice settings, values, and patient and physician preferences is essential. The Korean Society of Pediatric Nephrology developed clinical guidelines to address key questions regarding the diagnosis and management of asymptomatic hematuria in children.
    Language English
    Publishing date 2024-03-07
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2656420-8
    ISSN 2211-9132
    ISSN 2211-9132
    DOI 10.23876/j.krcp.23.231
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  3. Article: Impact of Wearing Face Masks on Patients with Severe Asthma During the COVID-19 Pandemic.

    Sohn, Kyoung-Hee / Lee, Myung-Nam / Sim, Da Woon / Kim, Sujeong / Cho, You Sook / Kwon, Hyouk-Soo / Kim, Sang-Heon

    Journal of asthma and allergy

    2022  Volume 15, Page(s) 1065–1068

    Language English
    Publishing date 2022-08-15
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494877-9
    ISSN 1178-6965
    ISSN 1178-6965
    DOI 10.2147/JAA.S356912
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  4. Article: No Difference in Allergenicity Among Small-Sized Dog Breeds Popular in Korea.

    Sim, Da Woon / Lee, Jong Sun / Park, Kyung Hee / Kim, Kyung Sik / Jeong, Kyoung Yong / Lee, Jae-Hyun / Park, Jung-Won

    Allergy, asthma & immunology research

    2022  Volume 14, Issue 1, Page(s) 143–145

    Language English
    Publishing date 2022-01-04
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2545725-1
    ISSN 2092-7363 ; 2092-7355
    ISSN (online) 2092-7363
    ISSN 2092-7355
    DOI 10.4168/aair.2022.14.1.143
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  5. Article: Cardiac Autonomic Dysfunction Is Associated with Severity of REM Sleep without Atonia in Isolated REM Sleep Behavior Disorder.

    You, Sooyeoun / Won, Kyoung Sook / Kim, Keun Tae / Lee, Hyang Woon / Cho, Yong Won

    Journal of clinical medicine

    2021  Volume 10, Issue 22

    Abstract: ... ...

    Abstract 123
    Language English
    Publishing date 2021-11-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm10225414
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  6. Article ; Online: Dasatinib, a selective tyrosine kinase inhibitor, prevents joint destruction in rheumatoid arthritis animal model.

    Min, Hong Ki / Kim, Se Hee / Won, Ji-Yeon / Kim, Kyoung-Woon / Lee, Ji-Yeon / Lee, Sang-Heon / Kim, Hae-Rim

    International journal of rheumatic diseases

    2023  Volume 26, Issue 4, Page(s) 718–726

    Abstract: Aim: We aimed to evaluate the preventive role of the tyrosine kinase inhibitor dasatinib in an animal model of rheumatoid arthritis (RA).: Methods: DBA/1J mice were injected with bovine type II collagen to induce arthritis (collagen-induced arthritis ...

    Abstract Aim: We aimed to evaluate the preventive role of the tyrosine kinase inhibitor dasatinib in an animal model of rheumatoid arthritis (RA).
    Methods: DBA/1J mice were injected with bovine type II collagen to induce arthritis (collagen-induced arthritis [CIA]). There were four experimental groups of mice, namely negative control (non-CIA), vehicle-treated CIA, dasatinib-pretreated CIA, and dasatinib-treated CIA. After collagen immunization, arthritis progression in the mice was clinically scored twice weekly for 5 weeks. Flow cytometry was used to evaluate in vitro CD4
    Results: We found that the clinical arthritis histological scores were lower in the dasatinib pretreatment group than in the vehicle and dasatinib post-treatment groups. Flow cytometry showed that FcεR1
    Conclusion: Dasatinib protected against arthritis in an animal model of RA by regulating the differentiation of regulatory T cells and IL-17
    MeSH term(s) Humans ; Animals ; Cattle ; Mice ; Interleukin-17/therapeutic use ; Dasatinib/pharmacology ; Dasatinib/therapeutic use ; Tyrosine Kinase Inhibitors ; Mice, Inbred DBA ; Arthritis, Rheumatoid/chemically induced ; Arthritis, Rheumatoid/drug therapy ; Arthritis, Rheumatoid/prevention & control ; Arthritis, Experimental/chemically induced ; Arthritis, Experimental/drug therapy ; Arthritis, Experimental/prevention & control ; Protein Kinase Inhibitors/pharmacology ; Protein Kinase Inhibitors/therapeutic use
    Chemical Substances Interleukin-17 ; Dasatinib (RBZ1571X5H) ; Tyrosine Kinase Inhibitors ; Protein Kinase Inhibitors
    Language English
    Publishing date 2023-02-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2426924-4
    ISSN 1756-185X ; 1756-1841
    ISSN (online) 1756-185X
    ISSN 1756-1841
    DOI 10.1111/1756-185X.14627
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6098: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
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  7. Article ; Online: T7 phage display reveals NOLC1 as a GM3 binding partner in human breast cancer MCF-7 cells.

    Choi, Hyunju / Kim, Hee-Do / Choi, Yeon-Woo / Lim, Hakseong / Kim, Kyung-Woon / Kim, Kyoung-Sook / Lee, Young-Choon / Kim, Cheorl-Ho

    Archives of biochemistry and biophysics

    2023  Volume 750, Page(s) 109810

    Abstract: ... vascular endothelial growth factor receptor and transforming growth factor-β receptor by the T7 phage display method (Chung et al., 2009; Kim ...

    Abstract Ganglioside GM3 is a simple monosialoganglioside (NeuAc-Gal-Glc-ceramide) that modulates cell adhesion, proliferation, and differentiation. Previously, we reported isolation of GM3-binding vascular endothelial growth factor receptor and transforming growth factor-β receptor by the T7 phage display method (Chung et al., 2009; Kim et al., 2013). To further identify novel proteins interacting with GM3, we extended the T7 phage display method in this study. After T7 phage display biopanning combined with immobilized biotin-labeled 3'-sialyllactose prepared on a streptavidin-coated microplate, we isolated 100 candidate sequences from the human lung cDNA library. The most frequently detected clones from the blast analysis were the human nucleolar and coiled-body phosphoprotein 1 (NOLC1) sequences. We initially identified NOLC1 as a molecule that possibly binds to GM3 and confirmed this binding ability using the glutathione S-transferase fusion protein. Herein, we report another GM3-interacting protein, NOLC1, that can be isolated by the T7 phage display method. These results are expected to be helpful for elucidating the functional roles of ganglioside GM3 with NOLC1. When human breast cancer MCF-7 cells were examined for subcellular localization of NOLC1, immunofluorescence of NOLC1 was observed in the intracellular region. In addition, NOLC1 expression was increased in the nucleolus after treatment with the anticancer drug doxorubicin. GM3 and NOLC1 levels in the doxorubicin-treated MCF-7 cells were correlated, indicating possible associations between GM3 and NOLC1. Therefore, direct interactions between carbohydrates and cellular proteins can pave the path for new signaling phenomena in biology.
    MeSH term(s) Humans ; Female ; Bacteriophage T7/genetics ; Vascular Endothelial Growth Factor A ; G(M3) Ganglioside ; MCF-7 Cells ; Breast Neoplasms/genetics ; Doxorubicin ; Nuclear Proteins/metabolism ; Phosphoproteins
    Chemical Substances Vascular Endothelial Growth Factor A ; G(M3) Ganglioside ; Doxorubicin (80168379AG) ; NOLC1 protein, human ; Nuclear Proteins ; Phosphoproteins
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 523-x
    ISSN 1096-0384 ; 0003-9861
    ISSN (online) 1096-0384
    ISSN 0003-9861
    DOI 10.1016/j.abb.2023.109810
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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.237: Show issues Location:
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  8. Article ; Online: Nephrotoxicity evaluation and proteomic analysis in kidneys of rats exposed to thioacetamide

    Ji-youn Lim / Woon-Won Jung / Woojin Kim / Kyoung-Sik Moon / Donggeun Sul

    Scientific Reports, Vol 12, Iss 1, Pp 1-

    2022  Volume 16

    Abstract: ... significantly in rats exposed to 30 mg/kg BW TAA. The expression levels of Kim-1 and NGAL were increased 4 to 5 ...

    Abstract Abstract Thioacetamide (TAA) was administered orally at 0, 10, and 30 mg/kg body weight (BW) daily to Sprague–Dawley rats aged 6–7 weeks for 28 consecutive days. Nephrotoxicity and proteomics were evaluated in the kidneys of rats exposed to TAA. The BW decreased, however, the relative kidneys weight increased. No significant histopathologic abnormalities were found in the kidneys. The numbers of monocytes and platelets were significantly increased. However, the mean corpuscular volume and hematocrit values were decreased significantly in rats exposed to 30 mg/kg BW TAA. The expression levels of Kim-1 and NGAL were increased 4 to 5-fold in the kidneys, resulting in significant nephrotoxicity. Proteomic analysis was conducted and a total of 5221 proteins spots were resolved. Of these, 3 and 21 protein spots were up- and downregulated, respectively. The validation of seven proteins was performed by Western blot analysis. The expression level of ASAP2 was significantly upregulated, whereas RGS14, MAP7Dl, IL-3Rα, Tmod1, NQO2, and MUP were reduced. Sixteen isoforms of MUP were found by the 2DE immunoblot assay and were significantly downregulated with increasing exposure to TAA. MUP isoforms were compared in the liver, kidneys, and urine of untreated rats and a total of 43 isoforms were found.
    Keywords Medicine ; R ; Science ; Q
    Subject code 630
    Language English
    Publishing date 2022-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: On-site detection of methicillin-resistant Staphylococcus aureus (MRSA) utilizing G-quadruplex based isothermal exponential amplification reaction (GQ-EXPAR).

    Seo, Seung Beom / Lee, Jina / Kim, Eunjung / Lim, Jaewoo / Jang, Soojin / Son, Seong Uk / Jeong, Yeonwoo / Kang, Taejeoon / Jung, Juyeon / Lee, Kyoung G / Lee, Sung-Woon / Kim, Kyujung / Lim, Eun-Kyung

    Talanta

    2024  Volume 275, Page(s) 126073

    Abstract: Methicillin-resistant Staphylococcus aureus (MRSA) has a high incidence in infectious hospitals and communities, highlighting the need for early on-site detection due to its resistance to methicillin antibiotics. The present study introduces a highly ... ...

    Abstract Methicillin-resistant Staphylococcus aureus (MRSA) has a high incidence in infectious hospitals and communities, highlighting the need for early on-site detection due to its resistance to methicillin antibiotics. The present study introduces a highly sensitive detection system for mecA, a crucial methicillin marker, utilizing an RCA-based isothermal exponential amplification reaction. The G-quadruplex-based isothermal exponential amplification reaction (GQ-EXPAR) method designs probes to establish G-quadruplex secondary structures incorporating thioflavin T for fluorescence. The system, unlike conventional genetic detection methods, works with portable isothermal PCR devices (isoQuark), facilitating on-site detection. A detection limit of 0.1 fmol was demonstrated using synthetic DNA, and effective detection was proven using thermal lysis. The study also validated the detection of targets swabbed from surfaces within bacterial 3D nanostructures using the GQ-EXPAR method. After applying complementary sequences to the padlock probe for the target, the GQ-EXPAR method can be used on various targets. The developed method could facilitate rapid and accurate diagnostics within MRSA strains.
    Language English
    Publishing date 2024-04-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500969-5
    ISSN 1873-3573 ; 0039-9140
    ISSN (online) 1873-3573
    ISSN 0039-9140
    DOI 10.1016/j.talanta.2024.126073
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  10. Article ; Online: Development of Plum Seed-Derived Carboxymethylcellulose Bioink for 3D Bioprinting.

    Lee, Juo / Lee, Sungmin / Lim, Jae Woon / Byun, Iksong / Jang, Kyoung-Je / Kim, Jin-Woo / Chung, Jong Hoon / Kim, Jungsil / Seonwoo, Hoon

    Polymers

    2023  Volume 15, Issue 23

    Abstract: Three-dimensional bioprinting represents an innovative platform for fabricating intricate, three-dimensional (3D) tissue structures that closely resemble natural tissues. The development of hybrid bioinks is an actionable strategy for integrating ... ...

    Abstract Three-dimensional bioprinting represents an innovative platform for fabricating intricate, three-dimensional (3D) tissue structures that closely resemble natural tissues. The development of hybrid bioinks is an actionable strategy for integrating desirable characteristics of components. In this study, cellulose recovered from plum seed was processed to synthesize carboxymethyl cellulose (CMC) for 3D bioprinting. The plum seeds were initially subjected to α-cellulose recovery, followed by the synthesis and characterization of plum seed-derived carboxymethyl cellulose (PCMC). Then, hybrid bioinks composed of PCMC and sodium alginate were fabricated, and their suitability for extrusion-based bioprinting was explored. The PCMC bioinks exhibit a remarkable shear-thinning property, enabling effortless extrusion through the nozzle and maintaining excellent initial shape fidelity. This bioink was then used to print muscle-mimetic 3D structures containing C2C12 cells. Subsequently, the cytotoxicity of PCMC was evaluated at different concentrations to determine the maximum acceptable concentration. As a result, cytotoxicity was not observed in hydrogels containing a suitable concentration of PCMC. Cell viability was also evaluated after printing PCMC-containing bioinks, and it was observed that the bioprinting process caused minimal damage to the cells. This suggests that PCMC/alginate hybrid bioink can be used as a very attractive material for bioprinting applications.
    Language English
    Publishing date 2023-11-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527146-5
    ISSN 2073-4360 ; 2073-4360
    ISSN (online) 2073-4360
    ISSN 2073-4360
    DOI 10.3390/polym15234473
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