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  1. Article: Effect of Vitamin D

    Romero-Ibarguengoitia, Maria Elena / Gutiérrez-González, Dalia / Cantú-López, Carlos / Sanz-Sánchez, Miguel Ángel / González-Cantú, Arnulfo

    Microorganisms

    2023  Volume 11, Issue 2

    Abstract: ... ...

    Abstract Background
    Language English
    Publishing date 2023-01-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms11020282
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  2. Article ; Online: Presence but not number of secondary type mutations influences outcome in de novo AML without MDS-associated or recurring cytogenetic abnormalities.

    Weinberg, Olga K / Cantu, Miguel D / Gagan, Jeffrey / Madanat, Yazan F / Arber, Daniel A / Hasserjian, Robert P

    EJHaem

    2023  Volume 4, Issue 3, Page(s) 760–764

    Abstract: A group of gene mutations has been identified to be strongly associated with secondary acute myeloid leukemias (AML) arising from prior myeloid neoplasms. The International Consensus Classification (ICC) and proposed 5th edition of the World Health ... ...

    Abstract A group of gene mutations has been identified to be strongly associated with secondary acute myeloid leukemias (AML) arising from prior myeloid neoplasms. The International Consensus Classification (ICC) and proposed 5th edition of the World Health Organization (WHO) classification differ by inclusion of
    Language English
    Publishing date 2023-05-18
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.710
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  3. Article ; Online: Peripartum cardiomyopathy: An uncommon cause of ischemic stroke.

    Jiménez-Ruiz, Amado / García-Grimshaw, Miguel / Ortega-Márquez, Jorge / Moreno-Guillen, Alejandro / Flores-Silva, Fernando D / Cantú-Brito, Carlos

    Archivos de cardiologia de Mexico

    2020  Volume 91, Issue 2, Page(s) 249–251

    Title translation Miocardiopatía periparto: una causa infrecuente de enfermedad vascular cerebral isquémica
    Language Spanish
    Publishing date 2020-11-12
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 2059019-2
    ISSN 1665-1731 ; 1665-1731
    ISSN (online) 1665-1731
    ISSN 1665-1731
    DOI 10.24875/ACM.20000263
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: 2D Arrays of Organic Qubit Candidates Embedded into a Pillared-Paddlewheel Metal-Organic Framework.

    Jellen, Marcus J / Ayodele, Mayokun J / Cantu, Annabelle / Forbes, Malcolm D E / Garcia-Garibay, Miguel A

    Journal of the American Chemical Society

    2020  Volume 142, Issue 43, Page(s) 18513–18521

    Abstract: The creation of ordered arrays of qubits that can be interfaced from the macroscopic world is an essential challenge for the development of quantum information science (QIS) currently being explored by chemists and physicists. Recently, porous metal- ... ...

    Abstract The creation of ordered arrays of qubits that can be interfaced from the macroscopic world is an essential challenge for the development of quantum information science (QIS) currently being explored by chemists and physicists. Recently, porous metal-organic frameworks (MOFs) have arisen as a promising solution to this challenge as they allow for atomic-level spatial control of the molecular subunits that comprise their structures. To date, no organic qubit candidates have been installed in MOFs despite their structural variability and promise for creating systems with adjustable properties. With this in mind, we report the development of a pillared-paddlewheel-type MOF structure that contains 4,7-bis(2-(4-pyridyl)-ethynyl) isoindoline
    Language English
    Publishing date 2020-10-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.0c07251
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    In stock of ZB MED Bonn / Germany

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  5. Article ; Online: Comparison of Genetic Variants and Manifestations of OTUD6B-Related Disorder: The First Mexican Case.

    Romero-Ibarguengoitia, Maria Elena / Cantú-Reyna, Consuelo / Gutierrez-González, Dalia / Cruz-Camino, Héctor / González-Cantú, Arnulfo / Sanz Sánchez, Miguel Angel

    Journal of investigative medicine high impact case reports

    2020  Volume 8, Page(s) 2324709620957777

    Abstract: The intellectual disability syndrome characterized by seizures and dysmorphic features was initially described in 2017 and was associated with genetic variants in ... ...

    Abstract The intellectual disability syndrome characterized by seizures and dysmorphic features was initially described in 2017 and was associated with genetic variants in the
    MeSH term(s) Abnormalities, Multiple/genetics ; Child ; Endopeptidases/genetics ; Genetic Variation ; Homozygote ; Humans ; Intellectual Disability/genetics ; Male ; Mexico ; Seizures/genetics ; Whole Exome Sequencing
    Chemical Substances Endopeptidases (EC 3.4.-) ; OTUD6B protein, human (EC 3.4.-)
    Language English
    Publishing date 2020-09-12
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 2710326-2
    ISSN 2324-7096 ; 2324-7096
    ISSN (online) 2324-7096
    ISSN 2324-7096
    DOI 10.1177/2324709620957777
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  6. Article ; Online: Mutational Landscape of Bladder Cancer in Mexican Patients:

    Pérez-Montiel, María D / Cerrato-Izaguirre, Dennis / Sánchez-Pérez, Yesennia / Diaz-Chavez, Jose / Cortés-González, Carlo César / Rubio, Jairo A / Jiménez-Ríos, Miguel A / Herrera, Luis A / Scavuzzo, Anna / Meneses-García, Abelardo / Hernández-Martínez, Ricardo / Vaca-Paniagua, Felipe / Ramírez, Andrea / Orozco, Alicia / Cantú-de-León, David / Prada, Diddier

    International journal of molecular sciences

    2023  Volume 24, Issue 2

    Abstract: Bladder cancer (BC) is the most common neoplasm of the urinary tract, which originates in the epithelium that covers the inner surface of the bladder. The molecular BC profile has led to the development of different classifications of non-muscle invasive ...

    Abstract Bladder cancer (BC) is the most common neoplasm of the urinary tract, which originates in the epithelium that covers the inner surface of the bladder. The molecular BC profile has led to the development of different classifications of non-muscle invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). However, the genomic BC landscape profile of the Mexican population, including NMIBC and MIBC, is unknown. In this study, we aimed to identify somatic single nucleotide variants (SNVs) and copy number variations (CNVs) in Mexican patients with BC and their associations with clinical and pathological characteristics. We retrospectively evaluated 37 patients treated between 2012 and 2021 at the National Cancer Institute-Mexico (INCan). DNA samples were obtained from paraffin-embedded tumor tissues and exome sequenced. Strelka2 and Lancet packages were used to identify SNVs and insertions or deletions. FACETS was used to determine CNVs. We found a high frequency of mutations in
    MeSH term(s) Humans ; DNA Copy Number Variations ; Mexico ; Mutation ; Neoplasm Invasiveness ; Retrospective Studies ; Urinary Bladder Neoplasms/pathology ; DNA-Binding Proteins/genetics ; Neoplasm Proteins/genetics
    Chemical Substances KMT2D protein, human ; DNA-Binding Proteins ; Neoplasm Proteins
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24021092
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  7. Article: Combination of Metformin, Sodium Oxamate and Doxorubicin Induces Apoptosis and Autophagy in Colorectal Cancer Cells

    Coronel-Hernández, Jossimar / Salgado-García, Rebeca / Cantú-De León, David / Jacobo-Herrera, Nadia / Millan-Catalan, Oliver / Delgado-Waldo, Izamary / Campos-Parra, Alma D / Rodríguez-Morales, Miguel / Delgado-Buenrostro, Norma L / Pérez-Plasencia, Carlos

    Frontiers in oncology

    2021  Volume 11, Page(s) 594200

    Abstract: Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide in both sexes. Current therapies include surgery, chemotherapy, and targeted therapy; however, prolonged exposure to chemical agents induces toxicity in patients and ... ...

    Abstract Colorectal cancer (CRC) is the third leading cause of cancer-related death worldwide in both sexes. Current therapies include surgery, chemotherapy, and targeted therapy; however, prolonged exposure to chemical agents induces toxicity in patients and drug resistance. So, we implemented a therapeutic strategy based on the combination of doxorubicin, metformin, and sodium oxamate called triple therapy (Tt). We found that Tt significantly reduced proliferation by inhibiting the mTOR/AKT pathway and promoted apoptosis and autophagy in CRC derived cells compared with doxorubicin. Several autophagy genes were assessed by western blot; ULK1, ATG4, and LC3 II were overexpressed by Tt. Interestingly, ULK1 was the only one autophagy-related protein gradually overexpressed during Tt administration. Thus, we assumed that there was a post-transcriptional mechanism mediating by microRNAs that regulate UKL1 expression during autophagy activation. Through bioinformatics approaches, we ascertained that ULK1 could be targeted by mir-26a, which is overexpressed in advanced stages of CRC.
    Language English
    Publishing date 2021-05-26
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2021.594200
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  8. Article ; Online: Influence of luminal and basal subtype in prognosis of high-grade non muscle invasive urothelial carcinoma.

    Pérez-Montiel, Delia / Olivares-Mundo, Anny / Jiménez-Ríos, Miguel A / Morera, Carolina Silva / Scavuzzo, Anna / Orozco-Mora, Alicia / Prada, Diddier / Cantú-de León, David

    Annals of diagnostic pathology

    2023  Volume 63, Page(s) 152081

    Abstract: Background: Recent studies have shown that the classification of high-grade urothelial carcinoma non-muscle invasive (HGBCNMI) based on molecular subtypes might be a valuable strategy to identify patients with a worse clinical prognosis.: Objective: ... ...

    Abstract Background: Recent studies have shown that the classification of high-grade urothelial carcinoma non-muscle invasive (HGBCNMI) based on molecular subtypes might be a valuable strategy to identify patients with a worse clinical prognosis.
    Objective: Determine the effect of the luminal and basal molecular subtype determined by immunistochemical on prognosis in patients with HGBC in Mexican population.
    Methods: Phenotypes were evaluated by immunohistochemical staining of luminal (GATA3, FOXA1) and basal (CK5/6, CK14) markers in paraffin-embedded tissue samples from 45 patients with a diagnosis of HGBCNMI treated at Instituto Nacional de Cancerología-México (INCan) between 2009 and 2019. The association with prognosis was evaluated using Kaplan-Meier curves and multivariable-adjusted Cox models.
    Results: HGBCNMI patients showed mean age of 58.77 years (SD: ±12.08 years). We identified expression of the luminal molecular subtype in 35 cases (77.78 %), and 10 cases (22.22 %) with "combined" expression of the molecular subtype (basal and luminal expression). The combined phenotype was statistically more frequent in metastatic cases (p-value = 0.028). In Kaplan-Meier curves, combined expression of luminal and basal molecular markers was associated with disease progression (p-value = 0.002, log-rank test). Cox regression models confirmed this association, which was not influenced by age (p-value = 0.007) or gender (p-value = 0.007). No association of phenotypes with overall survival (p-value = 0.860) or relapse (p-value = 0.5) was observed.
    Conclusion: The combined expression of immunohistochemical markers of the luminal and basal subtype might be considered as predictor for disease progression in patients with HGBCNMI in Mexican population.
    MeSH term(s) Humans ; Urinary Bladder Neoplasms/pathology ; Carcinoma, Transitional Cell/pathology ; Biomarkers, Tumor/metabolism ; Neoplasm Recurrence, Local ; Prognosis ; Disease Progression
    Chemical Substances Biomarkers, Tumor
    Language English
    Publishing date 2023-01-17
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1440011-x
    ISSN 1532-8198 ; 1092-9134
    ISSN (online) 1532-8198
    ISSN 1092-9134
    DOI 10.1016/j.anndiagpath.2022.152081
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5463: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  9. Article: Detection of Pulmonary Shunts by Transcranial Doppler in Hospitalized Non-mechanically Ventilated Coronavirus Disease-19 Patients.

    Salazar-Orellana, Jaime L I / García-Grimshaw, Miguel / Valdés-Ferrer, Sergio I / Alday-Ramírez, Sergio M / Ríos-Argaiz, Eduardo / Vásquez-Ortiz, Zuilma Y / Rivero-Sigarroa, Eduardo / Jiménez-Ruiz, Amado / Chiquete, Erwin / Cantú-Brito, Carlos / Flores-Silva, Fernando D

    Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion

    2021  

    Abstract: In severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated disease coronavirus disease 2019 (COVID-19), hypoxemia mechanisms differ from those observed in acute respiratory distress syndrome. Hypoxemia and respiratory failure in COVID- 19 ...

    Abstract In severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated disease coronavirus disease 2019 (COVID-19), hypoxemia mechanisms differ from those observed in acute respiratory distress syndrome. Hypoxemia and respiratory failure in COVID- 19 are attributed to pulmonary angiopathy, increasing physiological pulmonary shunting1-3.
    Language English
    Publishing date 2021-01-11
    Publishing country Mexico
    Document type Journal Article
    ZDB-ID 138348-6
    ISSN 0034-8376
    ISSN 0034-8376
    DOI 10.24875/RIC.20000569
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 288: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  10. Article ; Online: Paradoxical manifestations during tuberculous meningitis treatment among HIV-negative patients: a retrospective descriptive study and literature review.

    Domínguez-Moreno, Rogelio / García-Grimshaw, Miguel / Medina-Julio, David / Cantú-Brito, Carlos / González-Duarte, Alejandra

    Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology

    2021  Volume 43, Issue 4, Page(s) 2699–2708

    Abstract: Background: Tuberculous meningitis (TBM) is the most frequent, severe, and disabling form of central nervous system (CNS) tuberculosis (TB). TBM paradoxical manifestations are characterized by clinical or paraclinical worsening after 1 month of ... ...

    Abstract Background: Tuberculous meningitis (TBM) is the most frequent, severe, and disabling form of central nervous system (CNS) tuberculosis (TB). TBM paradoxical manifestations are characterized by clinical or paraclinical worsening after 1 month of effective anti-TB treatment in patients who initially responded to treatment despite the use of adjunctive corticosteroids.
    Methods: Retrospective descriptive study of consecutive HIV-negative adult patients (≥ 18 years) with definitive TBM who developed a paradoxical manifestation following anti-TB in a tertiary-care hospital in Mexico from 2009 to 2019; we also conducted a literature review of published cases/series of paradoxical manifestations in HIV-negative patients from 1980 to 2020.
    Results: We detected 84 cases of definitive TBM; 55 (68.7%) HIV-negative patients and 29 (36.3%) HIV-infected patients. Among HIV-negative patients, four (7.3%), three female and one male (19-49 years old), developed a paradoxical manifestation within 4-14 weeks following treatment initiation despite receiving adequate corticosteroid doses; Mycobacterium bovis was isolated from the cerebrospinal fluid of three cases and Mycobacterium tuberculosis in one more. Two patients developed vasculopathy-related cerebral infarctions, one severe basilar meningitis, and hydrocephalus, one more a tuberculoma. Two were treated with intravenous cyclophosphamide, and two with steroids. One of the patients treated with steroids died; patients who received cyclophosphamide had a good clinical response.
    Conclusions: This case series illustrates the diverse clinical/radiologic paradoxical manifestations of TBM in HIV-negative patients. Cyclophosphamide may be safe and effective in treating TBM-associated paradoxical manifestations. Specific diagnostic and care protocols for these patients are needed.
    MeSH term(s) Adult ; Antitubercular Agents/therapeutic use ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; Humans ; Male ; Middle Aged ; Mycobacterium tuberculosis ; Retrospective Studies ; Tuberculosis, Meningeal/cerebrospinal fluid ; Tuberculosis, Meningeal/complications ; Tuberculosis, Meningeal/drug therapy ; Young Adult
    Chemical Substances Antitubercular Agents
    Language English
    Publishing date 2021-10-27
    Publishing country Italy
    Document type Journal Article ; Review
    ZDB-ID 2016546-8
    ISSN 1590-3478 ; 1590-1874
    ISSN (online) 1590-3478
    ISSN 1590-1874
    DOI 10.1007/s10072-021-05693-2
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1877: Show issues Location:
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