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Article ; Online: Occurrence, multiphase partition and risk assessment of organic amine pesticides in drinking water source of Xiang River, China.

Jiao, Cao / Wu, Linjunyue / Zhao, Wenyu / Cai, Minghong / Liu, Yanju / Xie, Sha

2024 Volume 46, Issue 3, Page(s) 105

Abstract: ... on the Xiang River (XR), a representative drinking water source, as the research area to investigate ...

Abstract	The extensive use of organic amine pesticides (OAPs) in agricultural practices has resulted in the contamination of water environments, posing threats to ecosystems and human health. This study focused on the Xiang River (XR), a representative drinking water source, as the research area to investigate the occurrence characteristics of 34 OAPs. Diphenylamine emerged as the most prevalent OAP in surface water due to industrial and agricultural activities, while cycloate dominated in sediments due to cumulative effects. Generally, the concentration of OAPs in a mixed tap water sample was lower than those in surface water samples, indicating OAPs can be removed by water plants to a certain extent. The water-sediment distribution coefficients (k
MeSH term(s)	Humans ; Drinking Water ; Pesticides ; Amines ; Ecosystem ; Rivers ; China ; Risk Assessment
Chemical Substances	Drinking Water ; Pesticides ; Amines
Language	English
Publishing date	2024-03-05
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	52039-1
ISSN	1573-2983 ; 0142-7245 ; 0269-4042
ISSN (online)	1573-2983
ISSN	0142-7245 ; 0269-4042
DOI	10.1007/s10653-024-01900-z
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 4723: Show issues

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Article ; Online: Rapid characterization of non-volatile phenolic compounds reveals the reliable chemical markers for authentication of traditional Chinese medicine Xiang-ru among confusing Elsholtzia species.

Zeng, Zhen / Zhang, Chen / Hu, Jiadong / Wang, Feiyan / Wu, Ziding / Wang, Jing / Zhang, Jun / Yang, Shuda / Chen, Junfeng / Li, Mingming / Tong, Qi / Qiu, Shi / Chen, Wansheng

Chinese journal of natural medicines

2024 Volume 22, Issue 4, Page(s) 375–384

Abstract: ... utilized in traditional Chinese medicine (TCM), known collectively as Xiang-ru. However, due to clinical ... as reliable chemical markers for distinguishing Xiang-ru from closely related Elsholtzia species ...

Abstract	The aerial parts of Mosla chinensis Maxim. and Mosla chinensis cv. 'Jiangxiangru' (MCJ) are widely utilized in traditional Chinese medicine (TCM), known collectively as Xiang-ru. However, due to clinical effectiveness concerns and frequent misidentification, the original plants have increasingly been substituted by various species within the genera Elsholtzia and Mosla. The challenge in distinguishing between these genera arises from their similar morphological and metabolic profiles. To address this issue, our study introduced a rapid method for metabolic characterization, employing high-resolution mass spectrometry-based metabolomics. Through detailed biosynthetic and chemometric analyses, we pinpointed five phenolic compounds-salviaflaside, cynaroside, scutellarein-7-O-D-glucoside, rutin, and vicenin-2-among 203 identified compounds, as reliable chemical markers for distinguishing Xiang-ru from closely related Elsholtzia species. This methodology holds promise for broad application in the analysis of plant aerial parts, especially in verifying the authenticity of aromatic traditional medicinal plants. Our findings underscore the importance of non-volatile compounds as dependable chemical markers in the authentication process of aromatic traditional medicinal plants.
MeSH term(s)	Phenols/analysis ; Phenols/chemistry ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/analysis ; Lamiaceae/chemistry ; Lamiaceae/classification ; Medicine, Chinese Traditional ; Metabolomics/methods ; Mass Spectrometry/methods ; Plant Components, Aerial/chemistry
Chemical Substances	Phenols ; Drugs, Chinese Herbal
Language	English
Publishing date	2024-01-11
Publishing country	China
Document type	Journal Article ; Evaluation Study
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(24)60614-X
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Article ; Online: Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia.

Li, Qiang / Liu, Peng / Wu, Chen / Bai, Lijie / Zhang, Zhongyun / Bao, Zilu / Zou, Min / Ren, Zhaoxiang / Yuan, Lin / Liao, Maochuan / Lan, Zhou / Yin, Shijin / Chen, Lvyi

Journal of ethnopharmacology

2022 Volume 298, Page(s) 115679

Abstract: Ethnopharmacological relevance: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal ...

Abstract	Ethnopharmacological relevance: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). However, its exact pharmacological mechanism remains unclear. Aims of the study: To preliminarily elucidate the regulatory effects and possible mechanisms of SWR on hyperuricemia using network pharmacology and experimental validation. Materials and methods: A mouse model of hyperuricemia was used to evaluate the alleviating effect of SWR on hyperuricemia. The major components of SWR were acquired by UPLC-Q/TOF-MS. The potential molecular targets and associated signaling pathways were predicted through network pharmacology. The mechanism of action of SWR in ameliorating hyperuricemia was further investigated by pharmacological evaluation. Results: Mice with hyperuricemia and renal dysfunction were ameliorated by SWR. The 36 components of SWR included phenolic acids, terpenoids, alkaloids and flavonoids were identified. Network pharmacological analysis showed the involvement of the above compounds, and 115 targets were involved to treat hyperuricemia, involving multiple biological processes and different signaling pathways. Pharmacological experiments validated that SWR ameliorated hyperuricemic nephropathy in mice by modulating the mitogen-activated protein kinase (MAPK) signaling pathway, nuclear factor kappaB (NF-κB) signaling pathway and NOD-like receptor signaling pathway. Conclusion: MAPK signaling pathway, NF-κB signaling pathway and NOD-like receptor signaling pathway play important roles in the therapeutic effects of SWR on hyperuricemia.
MeSH term(s)	Animals ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Hyperuricemia/drug therapy ; Hyperuricemia/metabolism ; Medicine, Tibetan Traditional ; Mice ; NF-kappa B ; NLR Proteins ; Network Pharmacology ; Powders/therapeutic use
Chemical Substances	Drugs, Chinese Herbal ; NF-kappa B ; NLR Proteins ; Powders
Language	English
Publishing date	2022-09-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115679
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1494: Show issues

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Article: Pd/Xiang-Phos-catalyzed enantioselective intermolecular carboheterofunctionalization under mild conditions.

Tao, Mengna / Tu, Youshao / Liu, Yu / Wu, Haihong / Liu, Lu / Zhang, Junliang

Chemical science

2020 Volume 11, Issue 24, Page(s) 6283–6288

Abstract: A mild and practical Pd/ ...

Abstract	A mild and practical Pd/
Language	English
Publishing date	2020-05-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d0sc01391a
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Article ; Online: Integration of non-targeted multicomponent profiling, targeted characteristic chromatograms and quantitative to accomplish systematic quality evaluation strategy of Huo-Xiang-Zheng-Qi oral liquid.

Li, Xuejuan / Wu, Mengfan / Ding, Hui / Li, Wei / Yin, Jiaxin / Lin, Ruimei / Wu, Xinlong / Han, Lifeng / Yang, Wenzhi / Bie, Songtao / Li, Fangyi / Song, Xinbo / Yu, Heshui / Dong, Ziliang / Li, Zheng

Journal of pharmaceutical and biomedical analysis

2023 Volume 236, Page(s) 115715

Abstract: Huo-Xiang-Zheng-Qi oral liquid (HXZQOL) is a well-known traditional Chinese medicine formula ...

Abstract	Huo-Xiang-Zheng-Qi oral liquid (HXZQOL) is a well-known traditional Chinese medicine formula for the treatment of gastrointestinal diseases, with the pharmacologic effects of antiinflammatory, immune protection and gastrointestinal motility regulation. More significantly, HXZQOL is recommended for the treatment of COVID-19 patients with gastrointestinal symptoms, and it has been clinically proven to reduce the inflammatory response in patients with COVID-19. However, the effective and overall quality control of HXZQOL is currently limited due to its complex composition, especially the large amount of volatile and non-volatile active components involved. In this study, aimed to fully develop a comprehensive strategy based on non-targeted multicomponent identification, targeted authentication and quantitative analysis for quality evaluation of HXZQOL from different batches. Firstly, the non-targeted high-definition MS
MeSH term(s)	Humans ; Qi ; Chromatography, High Pressure Liquid/methods ; COVID-19 ; Medicine, Chinese Traditional ; Mass Spectrometry ; Drugs, Chinese Herbal/analysis
Chemical Substances	Drugs, Chinese Herbal
Language	English
Publishing date	2023-09-11
Publishing country	England
Document type	Journal Article
ZDB-ID	604917-5
ISSN	1873-264X ; 0731-7085
ISSN (online)	1873-264X
ISSN	0731-7085
DOI	10.1016/j.jpba.2023.115715
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Zs.A 1850: Show issues

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Article: Integrating network pharmacology and pharmacological validation to explore the effect of Shi Wei Ru Xiang powder on suppressing hyperuricemia

Li, Qiang / Liu, Peng / Wu, Chen / Bai, Lijie / Zhang, Zhongyun / Bao, Zilu / Zou, Min / Ren, Zhaoxiang / Yuan, Lin / Liao, Maochuan / Lan, Zhou / Yin, Shijin / Chen, Lvyi

Journal of ethnopharmacology. 2022 Nov. 15, v. 298

2022

Abstract: Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect ...

Abstract	Shi Wei Ru Xiang powder (SWR) is a traditional Tibetan medicinal formula with the effect of dispelling dampness and dispersing cold. In clinical practice, SWR is generally used for the treatment of hyperuricemia (HUA). However, its exact pharmacological mechanism remains unclear. To preliminarily elucidate the regulatory effects and possible mechanisms of SWR on hyperuricemia using network pharmacology and experimental validation. A mouse model of hyperuricemia was used to evaluate the alleviating effect of SWR on hyperuricemia. The major components of SWR were acquired by UPLC-Q/TOF-MS. The potential molecular targets and associated signaling pathways were predicted through network pharmacology. The mechanism of action of SWR in ameliorating hyperuricemia was further investigated by pharmacological evaluation. Mice with hyperuricemia and renal dysfunction were ameliorated by SWR. The 36 components of SWR included phenolic acids, terpenoids, alkaloids and flavonoids were identified. Network pharmacological analysis showed the involvement of the above compounds, and 115 targets were involved to treat hyperuricemia, involving multiple biological processes and different signaling pathways. Pharmacological experiments validated that SWR ameliorated hyperuricemic nephropathy in mice by modulating the mitogen-activated protein kinase (MAPK) signaling pathway, nuclear factor kappaB (NF-κB) signaling pathway and NOD-like receptor signaling pathway. MAPK signaling pathway, NF-κB signaling pathway and NOD-like receptor signaling pathway play important roles in the therapeutic effects of SWR on hyperuricemia.
Keywords	cold ; flavonoids ; hyperuricemia ; kidney diseases ; mechanism of action ; mice ; mitogen-activated protein kinase ; models ; pharmacology ; terpenoids ; therapeutics ; traditional medicine ; transcription factor NF-kappa B
Language	English
Dates of publication	2022-1115
Publishing place	Elsevier B.V.
Document type	Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2022.115679
Database	NAL-Catalogue (AGRICOLA)

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Article: Integrated Network Pharmacology and GC-MS-Based Metabolomics to Investigate the Effect of Xiang-Su Volatile Oil Against Menopausal Depression.

Li, Yao / Yang, Xinyi / Chen, Shanshan / Wu, Lei / Zhou, Jinyong / Jia, Keke / Ju, Wenzheng

Frontiers in pharmacology

2021 Volume 12, Page(s) 765638

Abstract: Menopausal depression perplexes a great number of women in later life. Xiangfu-Zisu (Xiang-Su ...

Abstract	Menopausal depression perplexes a great number of women in later life. Xiangfu-Zisu (Xiang-Su), a traditional Chinese herbal pair composed of rhizomes of
Language	English
Publishing date	2021-12-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2021.765638
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Article ; Online: NIR Rapid Assessments of Blumea balsamifera (Ai-na-xiang) in China.

Yu, Fu-Lai / Zhao, Na / Wu, Zhi-Sheng / Huang, Mei / Wang, Dan / Zhang, Ying-Bo / Hu, Xuan / Chen, Xiao-Lu / Huang, Lu-Qi / Pang, Yu-Xin

Molecules (Basel, Switzerland)

2017 Volume 22, Issue 10

Abstract: ... Blumea ... ...

Abstract	Blumea balsamifera
MeSH term(s)	Algorithms ; Asteraceae/chemistry ; Discriminant Analysis ; Flavones/chemistry ; Green Chemistry Technology/methods ; Least-Squares Analysis ; Spectroscopy, Near-Infrared/methods
Chemical Substances	Flavones ; flavone (S2V45N7G3B)
Language	English
Publishing date	2017-10-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	1413402-0
ISSN	1420-3049 ; 1431-5165 ; 1420-3049
ISSN (online)	1420-3049
ISSN	1431-5165 ; 1420-3049
DOI	10.3390/molecules22101730
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Article ; Online: Pharmacokinetic Herb-Drug Interactions of Xiang-Sha-Liu-Jun-Zi-Tang and Paclitaxel in Male Sprague Dawley Rats and Its Influence on Enzyme Kinetics in Human Liver Microsomes

Alinafe Magret Kapelemera / Yow-Shieng Uang / Li-Hsuan Wang / Tien-Yuan Wu / Fang-Yu Lee / Li Tai / Ching-Chiung Wang / Chia-Jung Lee

Frontiers in Pharmacology, Vol

2022 Volume 13

Abstract: ... before, during, and after chemotherapy. Xiang-Sha-Liu-Jun-Zi Tang (XSLJZT) is a herbal formula commonly used ...

Abstract	Paclitaxel is a prescribed anticancer drug used to treat various cancers. It is a substrate of cytochrome P-450 (CYP-450) enzymes. Despite its efficacy, paclitaxel has severe side effects. Herbal medicines are commonly used to treat the side effects of chemotherapy. They can be administered before, during, and after chemotherapy. Xiang-Sha-Liu-Jun-Zi Tang (XSLJZT) is a herbal formula commonly used in breast cancer patients. The main purpose of this study was to assess the pharmacokinetic (PK) influence of XSLJZT on paclitaxel PK parameters, determine its effect on CYP-450 enzyme expression, and evaluate its effect on enzyme activity. Sprague Dawley rats were classified into pretreatment and co-treatment groups, where XSLJZT was pre-administered for 3, 5, and 7 days and co-administered 2 h before paclitaxel administration. The rat liver tissues and Hep-G2 cells were used to determine the effects of XSLJZT on CYP3A1/2 and CYP3A4 enzymes respectively. Western blot analysis was used to detect changes in the CYP3A1/2 and CYP3A4 enzymes expression. The influence of XSLJZT on enzyme activity was evaluated using human liver microsomes, and a liquid chromatography-tandem mass spectrometric system was developed to monitor paclitaxel levels in rat plasma. Results demonstrated that XSLJZT increased the area under the concentration versus time curve (AUC) for paclitaxel in pretreatment groups by 2-, 3-, and 4-fold after 3, 5, and 7 days, respectively. In contrast, no significant change in the AUC was observed in the co-treatment group. However, the half-life was prolonged in all groups from 17.11 min to a maximum of 37.56 min. XSLJZT inhibited CYP3A1/2 expression in the rat liver tissues and CYP3A4 enzymes in Hep-G2 cells in a time-dependent manner, with the highest inhibition observed after 7 days of pretreatment in rat liver tissues. In the enzyme kinetics study, XSLJZT inhibited enzyme activity in a competitive dose-dependent manner. In conclusion, there is a potential interaction between XSLJZT and paclitaxel at ...
Keywords	traditional Chinese medicine formula ; Xiang-Sha-Liu-Jun-Zi tang ; paclitaxel ; pharmacokinetics ; enzyme kinetics ; Therapeutics. Pharmacology ; RM1-950
Subject code	610
Language	English
Publishing date	2022-04-01T00:00:00Z
Publisher	Frontiers Media S.A.
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: NIR Rapid Assessments of Blumea balsamifera (Ai-na-xiang) in China

Fu-Lai Yu / Na Zhao / Zhi-Sheng Wu / Mei Huang / Dan Wang / Ying-Bo Zhang / Xuan Hu / Xiao-Lu Chen / Lu-Qi Huang / Yu-Xin Pang

Molecules, Vol 22, Iss 10, p

2017 Volume 1730

Abstract: Blumea balsamifera (Ai-na-xiang) is used as an important plant source of natural borneol, which is ...

Abstract	Blumea balsamifera (Ai-na-xiang) is used as an important plant source of natural borneol, which is widely used in the pharmaceutical industry. The aim of this study was to establish the methods based on near infrared (NIR) spectroscopy for determining the geographical origin of B. balsamifera, as well as developing a method for the quantitative rapid analysis of the active pharmaceutical ingredients (APIs). A total of 109 samples were collected from China in 2013 and arbitrarily divided into calibration and prediction sets using the Kennard–Stone algorithm. The l-borneol and total flavone contents of the samples were measured by gas chromatography and ultraviolet-visible spectroscopy, respectively. The NIR spectra were acquired using an integrating sphere and a partial least squares (PLS) model was built using the optimum wavelength regions, which were selected using a synergy interval partial least-squares (SiPLS) algorithm. The root mean square errors of prediction of the l-borneol and total flavone models were 0.0779 and 2.2694 mg/g, with R2 of 0.9069 and 0.8013, respectively. A discriminant model to determine the geographical origin of B. balsamifera (Guizhou and Hainan) was also established using a partial least squares discriminant analysis method with an optimum pretreatment method. The prediction accuracy rate of the model was 100%. NIR spectroscopy can be used as a reliable and environmentally friendly method to determine the API and the origin of different B. balsamifera samples.
Keywords	Blumea balsamifera ; NIR ; l-borneol ; total flavone ; rapid assessments ; green chemistry ; Organic chemistry ; QD241-441
Subject code	540
Language	English
Publishing date	2017-10-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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