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Article ; Online: Elevated INR in a COVID-19 patient after concomitant administration of favipiravir and warfarin: A case report.

Sekimoto, Masao / Imai, Toru / Hidaka, Shinji / Chiba, Nobutaka / Sakurai, Atsushi / Hata, Mitsumasa / Kikuchi, Norikazu

Journal of clinical pharmacy and therapeutics

2021 Volume 47, Issue 3, Page(s) 407–410

Abstract: What is known and objective: Favipiravir is a promising treatment candidate for managing coronavirus disease 2019 (COVID-19). Warfarin has many drug interactions, but no interactions with favipiravir have been reported.: Case summary: Our patient was ...

Abstract	What is known and objective: Favipiravir is a promising treatment candidate for managing coronavirus disease 2019 (COVID-19). Warfarin has many drug interactions, but no interactions with favipiravir have been reported. Case summary: Our patient was taking warfarin for deep vein thrombosis. The international normalized ratio (INR) was stable (1.65 to 2.0); however, it increased to 4.63 after administering favipiravir. The patient had no other factors justifying this change. What is new and conclusion: Favipiravir and warfarin might have previously unidentified drug interactions that elevated the INR. Therefore, INR must be closely monitored when they are concomitantly administered in COVID-19 patients.
MeSH term(s)	Amides ; Anticoagulants/therapeutic use ; COVID-19/drug therapy ; Drug Interactions ; Humans ; International Normalized Ratio ; Pyrazines ; Warfarin/therapeutic use
Chemical Substances	Amides ; Anticoagulants ; Pyrazines ; Warfarin (5Q7ZVV76EI) ; favipiravir (EW5GL2X7E0)
Language	English
Publishing date	2021-08-02
Publishing country	England
Document type	Case Reports
ZDB-ID	639006-7
ISSN	1365-2710 ; 0269-4727
ISSN (online)	1365-2710
ISSN	0269-4727
DOI	10.1111/jcpt.13499
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Article ; Online: Suturing Fenestration of the Left Subclavian Artery Orifice in Frozen Elephant Trunk Procedure.

Hata, Mitsumasa / Wakui, Shinji / Ishii, Yusuke / Hinoura, Rei / Isaka, Susumu / Tanaka, Masashi

The Thoracic and cardiovascular surgeon

2020 Volume 69, Issue 4, Page(s) 362–365

Abstract: The frozen elephant trunk (FET) procedure enables easier replacement of the entire aortic arch because it does not require reaching the distal part of the left subclavian artery (LSCA). However, it requires additional management for reconstruction of the ...

Abstract	The frozen elephant trunk (FET) procedure enables easier replacement of the entire aortic arch because it does not require reaching the distal part of the left subclavian artery (LSCA). However, it requires additional management for reconstruction of the LSCA, which is associated with bleeding events. However, the fenestrated FET technique confers a risk of endoleakage from the fenestration site. We report our unique novel technique in which the proximal side of the hybrid stent graft is cut into V-shape around the subclavian artery and sutured continuously around the orifice of the subclavian artery during aortic stump fixation.
MeSH term(s)	Aged ; Aneurysm, Dissecting/diagnostic imaging ; Aneurysm, Dissecting/surgery ; Aorta, Thoracic/diagnostic imaging ; Aorta, Thoracic/surgery ; Aortic Aneurysm, Thoracic/diagnostic imaging ; Aortic Aneurysm, Thoracic/surgery ; Blood Vessel Prosthesis ; Blood Vessel Prosthesis Implantation/adverse effects ; Blood Vessel Prosthesis Implantation/instrumentation ; Endovascular Procedures/adverse effects ; Endovascular Procedures/instrumentation ; Female ; Humans ; Male ; Middle Aged ; Prosthesis Design ; Stents ; Subclavian Artery/diagnostic imaging ; Subclavian Artery/surgery ; Suture Techniques ; Treatment Outcome
Language	English
Publishing date	2020-09-08
Publishing country	Germany
Document type	Journal Article ; Video-Audio Media
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0040-1715434
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Article ; Online: Successful surgical treatment of cardiac metastasis from uterine leiomyosarcoma: A case report and literature review.

Maebayashi, Aki / Nagaishi, Masaji / Nakajima, Takahiro / Hata, Mitsumasa / Xiaoyan, Tang / Kawana, Kei

The journal of obstetrics and gynaecology research

2020 Volume 46, Issue 5, Page(s) 795–800

Abstract: Uterine leiomyosarcoma is a malignant soft tissue tumor resembling uterine fibroma clinically and is difficult to diagnose preoperatively. Since metastatic cardiac tumors are very rare and asymptomatic, most cardiac metastases are detected at autopsy ... ...

Abstract	Uterine leiomyosarcoma is a malignant soft tissue tumor resembling uterine fibroma clinically and is difficult to diagnose preoperatively. Since metastatic cardiac tumors are very rare and asymptomatic, most cardiac metastases are detected at autopsy after death due to other diseases. A 49-year-old woman presented with menorrhagia and anemia, and a uterine tumor. Total hysterectomy was performed for the uterine tumor. Histopathological examination revealed the tumor to be a leiomyosarcoma. Postoperative computed tomography showed multiple lung metastases and a metastatic cardiac tumor. The cardiac tumor, which was located within and almost entirely occluded the right ventricle, was 49 × 26 mm. To prevent sudden death, cardiac tumorectomy was performed semi-emergently. Chemotherapy was initiated in the early postoperative period, and the patient currently maintains a complete response. Cases with lung and cardiac metastases rarely undergo surgical resection of metastatic tumors. However, emergent surgical resection of cardiac metastatic tumors should be considered to prevent sudden death.
MeSH term(s)	Adult ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Deoxycytidine/administration & dosage ; Deoxycytidine/analogs & derivatives ; Docetaxel/administration & dosage ; Female ; Heart Neoplasms/diagnosis ; Heart Neoplasms/pathology ; Heart Neoplasms/secondary ; Heart Neoplasms/surgery ; Humans ; Hysterectomy ; Leiomyosarcoma/pathology ; Leiomyosarcoma/therapy ; Lung Neoplasms/pathology ; Lung Neoplasms/secondary ; Lung Neoplasms/therapy ; Middle Aged ; Uterine Neoplasms/diagnosis ; Uterine Neoplasms/therapy
Chemical Substances	Deoxycytidine (0W860991D6) ; Docetaxel (15H5577CQD) ; gemcitabine (B76N6SBZ8R)
Language	English
Publishing date	2020-03-12
Publishing country	Australia
Document type	Case Reports ; Journal Article ; Review
ZDB-ID	1327307-3
ISSN	1447-0756 ; 1341-8076
ISSN (online)	1447-0756
ISSN	1341-8076
DOI	10.1111/jog.14231
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Article ; Online: Safety of Intravenous Autologous Bone Marrow-Derived Mesenchymal Cell Transplantation in 5 Patients With Reduced Left Ventricular Ejection Fraction.

Sato, Yukihito / Kuragaichi, Takashi / Saga, Shunsuke / Nakayama, Hiroyuki / Obata, Tomoe / Watanabe, Mitsumasa / Fujikura, Kie / Watanabe, Masatoki / Hata, Ken-Ichiro / Ohgushi, Hajime

Circulation reports

2021 Volume 3, Issue 9, Page(s) 550–554

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-08-18
Publishing country	Japan
Document type	Journal Article
ISSN	2434-0790
ISSN (online)	2434-0790
DOI	10.1253/circrep.CR-21-0091
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Article: Limited Distal Arch Open Stenting for Type B Aortic Dissection with an Enlarged Ulcer-Like Projection, Complicated by Abdominal Aortic Occlusion.

Hata, Mitsumasa / Akiyama, Kenji / Orime, Yukihiko

The Thoracic and cardiovascular surgeon reports

2016 Volume 5, Issue 1, Page(s) 71–73

Abstract: A 79-year-old man underwent bifurcated graft replacement for abdominal aortic aneurysm, but the graft was totally occluded owing to an acute type B aortic dissection. We could not have access to the root for performing endovascular stenting for ... ...

Abstract	A 79-year-old man underwent bifurcated graft replacement for abdominal aortic aneurysm, but the graft was totally occluded owing to an acute type B aortic dissection. We could not have access to the root for performing endovascular stenting for dissecting aneurysm. Furthermore, it was difficult to remove the aneurysm via a left thoracotomy because it was impossible to perfuse the lower body with blood from the femoral artery and also a left axillary arterial cannulation was unusable. Herein, we report a patient who was successfully treated with open surgical aortic stenting for an enlarged ulcer-like projection complicated by a type B aortic dissection.
Language	English
Publishing date	2016-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2674018-7
ISSN	2194-7635
ISSN	2194-7635
DOI	10.1055/s-0035-1570377
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Article: Suturing Fenestration of the Left Subclavian Artery Orifice in Frozen Elephant Trunk Procedure

Hata, Mitsumasa / Wakui, Shinji / Ishii, Yusuke / Hinoura, Rei / Isaka, Susumu / Tanaka, Masashi

The Thoracic and Cardiovascular Surgeon

2020 Volume 69, Issue 04, Page(s) 362–365

Abstract	The frozen elephant trunk (FET) procedure enables easier replacement of the entire aortic arch because it does not require reaching the distal part of the left subclavian artery (LSCA). However, it requires additional management for reconstruction of the LSCA, which is associated with bleeding events. However, the fenestrated FET technique confers a risk of endoleakage from the fenestration site. We report our unique novel technique in which the proximal side of the hybrid stent graft is cut into V-shape around the subclavian artery and sutured continuously around the orifice of the subclavian artery during aortic stump fixation.
Keywords	aorta ; aortic ; aneurysm ; sutures
Language	English
Publishing date	2020-09-08
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	800050-5
ISSN	1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
ISSN (online)	1439-1902
ISSN	0171-6425 ; 0946-4778 ; 0172-6137
DOI	10.1055/s-0040-1715434
Database	Thieme publisher's database

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Article ; Online: Renin-Angiotensin System Control for Chronic Kidney Disease Patients Undergoing Coronary Surgery.

Yoshitake, Isamu / Sezai, Akira / Hata, Mitsumasa / Osaka, Shunji / Kimura, Haruka / Hata, Hiroaki / Shiono, Motomi

Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia

2016 Volume 22, Issue 5, Page(s) 291–297

Abstract: Purpose: We investigated the effectiveness of active renin-angiotensin-aldosterone system (RAAS) control with human atrial natriuretic peptide (hANP) and an angiotensin II receptor blocker (ARB) in patients with chronic kidney disease (CKD) undergoing ... ...

Abstract	Purpose: We investigated the effectiveness of active renin-angiotensin-aldosterone system (RAAS) control with human atrial natriuretic peptide (hANP) and an angiotensin II receptor blocker (ARB) in patients with chronic kidney disease (CKD) undergoing coronary artery bypass grafting (CABG). Methods: A total of 286 consecutive patients with CKD undergoing CABG were divided into three groups: Group C (n = 50) receiving placebo, the hANP group (n = 60) receiving hANP, and the active RAAS control therapy (ARC) group (n = 56) receiving hANP plus an ARB. Renal function, brain natriuretic peptide (BNP) and RAAS parameters were analyzed. Results: After 1 year, renal function parameters were better in the hANP and ARC groups compared with group C, and the dialysis rate was significantly lower (group C: 12%, hANP group: 1.7%, ARC group: 1.8%, p = 0.018) in the hANP and ARC groups. BNP levels were significantly lower in the hANP and ARC groups compared with group C (p = 0.001). There was also a significant difference of aldosterone among the groups (p = 0.023), as well as a significant difference between group C and the ARC group (p = 0.017). Conclusions: The present study showed that active RAAS control preserved renal function in patients with CKD undergoing CABG. The improved early postoperative outcome with RAAS control may lead to long-term inhibition of cardiovascular events.
MeSH term(s)	Aged ; Angiotensin II Type 1 Receptor Blockers/adverse effects ; Angiotensin II Type 1 Receptor Blockers/therapeutic use ; Atrial Natriuretic Factor/adverse effects ; Atrial Natriuretic Factor/therapeutic use ; Coronary Artery Bypass/adverse effects ; Coronary Artery Disease/complications ; Coronary Artery Disease/diagnosis ; Coronary Artery Disease/physiopathology ; Coronary Artery Disease/surgery ; Databases, Factual ; Female ; Humans ; Japan ; Kidney/drug effects ; Kidney/physiopathology ; Male ; Middle Aged ; Randomized Controlled Trials as Topic ; Renal Dialysis ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/drug therapy ; Renal Insufficiency, Chronic/physiopathology ; Renin-Angiotensin System/drug effects ; Time Factors ; Treatment Outcome
Chemical Substances	Angiotensin II Type 1 Receptor Blockers ; Atrial Natriuretic Factor (85637-73-6)
Language	English
Publishing date	2016-10-20
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2019756-1
ISSN	2186-1005 ; 1341-1098
ISSN (online)	2186-1005
ISSN	1341-1098
DOI	10.5761/atcs.oa.16-00105
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Article ; Online: Clinical characteristics of patients with bacterial pleuritis in the presence of Streptococcus anginosus group and obligate anaerobes detected by clone library analysis.

Hata, Ryosuke / Kawanami, Toshinori / Noguchi, Shingo / Fukuda, Kazumasa / Akata, Kentaro / Yamasaki, Kei / Saito, Mitsumasa / Yatera, Kazuhiro / Mukae, Hiroshi

The clinical respiratory journal

2019 Volume 14, Issue 3, Page(s) 267–276

Abstract: Introduction: Bacterial pleuritis is one of the most important pleural and respiratory infectious diseases, in addition, there have been no reports describing the clinical characteristics of patients with bacterial pleuritis according to molecular ... ...

Abstract	Introduction: Bacterial pleuritis is one of the most important pleural and respiratory infectious diseases, in addition, there have been no reports describing the clinical characteristics of patients with bacterial pleuritis according to molecular methods. An accurate understanding of the clinical characteristics and etiology of bacterial pleuritis is an issue that must be addressed. Objectives: The aim of this study was to clarify the clinical characteristics of the bacterial species in bacterial pleuritis. Methods: Pleural effusion samples were obtained from 29 patients with bacterial pleuritis. The microbiota of pleural effusion samples was analyzed by clone library analysis using the 16S ribosomal RNA gene. Results: The phylotypes of Fusobacterium spp. (24.1%) were most frequently the predominant phylotypes, followed by those of Streptococcus anginosus group (SAG) (20.7%) and S. aureus (17.2%). The predominant phylotypes of obligate anaerobes, including the Fusobacterium spp., were detected in 11 of 29 patients (37.9%). Patients in the SAG group were significantly older and presented lower serum albumin levels than those in the obligate anaerobe and other bacterial groups. Patients from the obligate anaerobe group took longer to present symptoms, and therefore the diagnosis of pleuritis was also delayed, in comparison to patients in the other bacterial groups. Conclusions: Our results demonstrated that there were characteristic differences between patients in SAG, obligate anaerobe and other bacterial groups. Physicians may need to consider treatment strategy options based on the clinical characteristics of patients with bacterial pleuritis.
MeSH term(s)	Aged ; Aged, 80 and over ; Bacteria, Anaerobic/genetics ; Bacterial Infections/complications ; Bacterial Infections/epidemiology ; Case-Control Studies ; Female ; Gene Library ; Genes, Bacterial/genetics ; Humans ; Japan/epidemiology ; Male ; Microbiota/genetics ; Middle Aged ; Pleurisy/microbiology ; RNA, Ribosomal, 16S/genetics ; Retrospective Studies ; Serum Albumin/analysis ; Staphylococcus aureus/genetics ; Staphylococcus aureus/isolation & purification ; Streptococcus anginosus/genetics ; Streptococcus anginosus/isolation & purification
Chemical Substances	RNA, Ribosomal, 16S ; Serum Albumin
Language	English
Publishing date	2019-12-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2442214-9
ISSN	1752-699X ; 1752-6981
ISSN (online)	1752-699X
ISSN	1752-6981
DOI	10.1111/crj.13127
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Article ; Online: Efficacy of modified less invasive quick replacement using mild hypothermic arrest and partial retrograde cerebral perfusion for type A acute aortic dissection.

Hata, Mitsumasa / Orime, Yukihiko / Wakui, Shinji / Umeda, Tomofumi / Akiyama, Kenji / Tanaka, Masashi

General thoracic and cardiovascular surgery

2017

Abstract: Objective: We previously reported a unique technique called "less invasive quick replacement (LIQR)" for treating type A acute aortic dissection with moderate hypothermic arrest (28 °C). This study examines the modified LIQR using mild hypothermic ... ...

Abstract	Objective: We previously reported a unique technique called "less invasive quick replacement (LIQR)" for treating type A acute aortic dissection with moderate hypothermic arrest (28 °C). This study examines the modified LIQR using mild hypothermic arrest (30 °C) with partial retrograde cerebral perfusion (RCP). Methods: 187 patients were divided into 2 groups: group L consisted of 130 patients underwent LIQR without any cerebral perfusion; group M consisted of 57 patients who were treated with modified LIQR. In modified LIQR, circulatory arrest was commenced under the 30 °C for open distal aortic stamp fixation. RCP was used during final half anastomosis of the prosthesis and then rapid re-warming was initiated. Results: The incidence of additional valve or coronary surgeries was significantly higher in group M (28.1%) than in group L (9.2%). The average rectal temperature was significantly higher in group M (29.5 °C) than in group L (27.4 °C). The durations of brain ischemia (M 7.7 min; L 18.6 min), cardiopulmonary bypass (M 82.0 min; L 93.3 min), and overall operation (M 145.2 min; L 154.2 min) were significantly shorter in group M. The incidence of postoperative brain damage was 6 patients (4.6%) in group L, but none in group M. The hospital mortality rate was 3 patients in group L (2.3%). All group M patients were discharged from the hospital without any complications. Conclusion: Modified LIQR is safe and effective. It makes the surgery much quicker and is a less invasive procedure. The surgical outcome was also favorable.
Language	English
Publishing date	2017-10-27
Publishing country	Japan
Document type	Journal Article
ZDB-ID	2376888-5
ISSN	1863-6713 ; 1863-6705
ISSN (online)	1863-6713
ISSN	1863-6705
DOI	10.1007/s11748-017-0844-3
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Article: Limited Distal Arch Open Stenting for Type B Aortic Dissection with an Enlarged Ulcer-Like Projection, Complicated by Abdominal Aortic Occlusion

Hata, Mitsumasa / Akiyama, Kenji / Orime, Yukihiko

The Thoracic and Cardiovascular Surgeon Reports

2016 Volume 05, Issue 01, Page(s) 71–73

Abstract	A 79-year-old man underwent bifurcated graft replacement for abdominal aortic aneurysm, but the graft was totally occluded owing to an acute type B aortic dissection. We could not have access to the root for performing endovascular stenting for dissecting aneurysm. Furthermore, it was difficult to remove the aneurysm via a left thoracotomy because it was impossible to perfuse the lower body with blood from the femoral artery and also a left axillary arterial cannulation was unusable. Herein, we report a patient who was successfully treated with open surgical aortic stenting for an enlarged ulcer-like projection complicated by a type B aortic dissection.
Keywords	aortic aneurysm ; cardiovascular surgery ; aortic stent
Language	English
Publishing date	2016-01-05
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	2674018-7
ISSN	2194-7643 ; 2194-7635
ISSN (online)	2194-7643
ISSN	2194-7635
DOI	10.1055/s-0035-1570377
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