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Article: Detection of Lung Cancer via Blood Plasma and

Derveaux, Elien / Thomeer, Michiel / Mesotten, Liesbet / Reekmans, Gunter / Adriaensens, Peter

2021 Volume 11, Issue 8

Abstract: Metabolite profiling of blood plasma, by proton nuclear magnetic resonance ( ...

Abstract	Metabolite profiling of blood plasma, by proton nuclear magnetic resonance (
Language	English
Publishing date	2021-08-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo11080537
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Article: Changes in Metabolism as a Diagnostic Tool for Lung Cancer: Systematic Review.

Mariën, Hanne / Derveaux, Elien / Vanhove, Karolien / Adriaensens, Peter / Thomeer, Michiel / Mesotten, Liesbet

Metabolites

2022 Volume 12, Issue 6

Abstract: Lung cancer is the leading cause of cancer-related mortality worldwide, with five-year survival rates varying from 3-62%. Screening aims at early detection, but half of the patients are diagnosed in advanced stages, limiting therapeutic possibilities. ... ...

Abstract	Lung cancer is the leading cause of cancer-related mortality worldwide, with five-year survival rates varying from 3-62%. Screening aims at early detection, but half of the patients are diagnosed in advanced stages, limiting therapeutic possibilities. Positron emission tomography-computed tomography (PET-CT) is an essential technique in lung cancer detection and staging, with a sensitivity reaching 96%. However, since elevated 18F-fluorodeoxyglucose (
Language	English
Publishing date	2022-06-14
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2662251-8
ISSN	2218-1989
ISSN	2218-1989
DOI	10.3390/metabo12060545
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Article ; Online: Unraveling the Rewired Metabolism in Lung Cancer Using Quantitative NMR Metabolomics.

Vanhove, Karolien / Derveaux, Elien / Mesotten, Liesbet / Thomeer, Michiel / Criel, Maarten / Mariën, Hanne / Adriaensens, Peter

International journal of molecular sciences

2022 Volume 23, Issue 10

Abstract: Lung cancer cells are well documented to rewire their metabolism and energy production networks to enable proliferation and survival in a nutrient-poor and hypoxic environment. Although metabolite profiling of blood plasma and tissue is still emerging in ...

Abstract	Lung cancer cells are well documented to rewire their metabolism and energy production networks to enable proliferation and survival in a nutrient-poor and hypoxic environment. Although metabolite profiling of blood plasma and tissue is still emerging in omics approaches, several techniques have shown potential in cancer diagnosis. In this paper, the authors describe the alterations in the metabolic phenotype of lung cancer patients. In addition, we focus on the metabolic cooperation between tumor cells and healthy tissue. Furthermore, the authors discuss how metabolomics could improve the management of lung cancer patients.
MeSH term(s)	Humans ; Lung Neoplasms/metabolism ; Magnetic Resonance Imaging ; Magnetic Resonance Spectroscopy/methods ; Metabolomics/methods ; Phenotype
Language	English
Publishing date	2022-05-17
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms23105602
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Article ; Online: Sarcoidosis around the Globe.

Mateyo, Kondwelani / Thomeer, Michiel

Seminars in respiratory and critical care medicine

2017 Volume 38, Issue 4, Page(s) 393–403

MeSH term(s)	Genetic Predisposition to Disease ; Global Health/statistics & numerical data ; Humans ; Incidence ; Risk Factors ; Sarcoidosis/epidemiology ; Sarcoidosis/genetics ; Sarcoidosis/mortality
Language	English
Publishing date	2017-07-27
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1183617-9
ISSN	1098-9048 ; 1069-3424
ISSN (online)	1098-9048
ISSN	1069-3424
DOI	10.1055/s-0037-1602845
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Article ; Online: Remote patient monitoring in COVID-19: a critical appraisal.

Gruwez, Henri / Bakelants, Emma / Dreesen, Pauline / Broekmans, Jolien / Criel, Maarten / Thomeer, Michiel / Vandervoort, Pieter / Ruttens, David

The European respiratory journal

2022 Volume 59, Issue 2

MeSH term(s)	COVID-19 ; Humans ; Monitoring, Physiologic ; SARS-CoV-2 ; Telemedicine
Language	English
Publishing date	2022-02-03
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	639359-7
ISSN	1399-3003 ; 0903-1936
ISSN (online)	1399-3003
ISSN	0903-1936
DOI	10.1183/13993003.02697-2021
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Article ; Online: Physical status, symptoms and health-related quality of life during a severe exacerbation of COPD: Recovery and discriminative capacity for future events.

Quadflieg, Kirsten / Machado, Ana / de Lima, Fabiano Francisco / Dederen, Anand / Daenen, Marc / Ruttens, David / Thomeer, Michiel / Spruit, Martijn A / Burtin, Chris

Respiratory medicine

2023 Volume 220, Page(s) 107437

Abstract: Objective: Severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) can have a negative impact on functional capacity, symptoms and health-related quality of life (HRQOL). This study aimed to i) investigate the recovery of muscle ... ...

Abstract	Objective: Severe acute exacerbations of chronic obstructive pulmonary disease (AECOPD) can have a negative impact on functional capacity, symptoms and health-related quality of life (HRQOL). This study aimed to i) investigate the recovery of muscle strength, functional capacity, symptoms, and HRQOL in patients after a severe AECOPD; ii) compare with matched patients with stable COPD (SCOPD); and iii) assess whether these assessments at hospital discharge could discriminate patients' risk for future events. Methods: This observational study assessed patients with AECOPD during hospital discharge (T1) and one month after discharge (T2). Patients with SCOPD were assessed once. Quadriceps force, handgrip strength, short physical performance battery (SPPB), 6-min walk distance (6 MWD), COPD assessment test (CAT), London chest activity of daily living (LCADL), modified medical research council, checklist individual strength-fatigue, patient health questionnaire, and physical activity (Actigraph) were measured. Exacerbation-related readmission and mortality within six months and 1-year were collected. Results: Forty-four patients with AECOPD were matched with 44 patients with SCOPD. At T2, a significant improvement was found for the SPPB total score, 6 MWD, CAT score, and LCADL score. Compared to patients with SCOPD, a worse LCADL score was found at T2 in patients with AECOPD. Patients with AECOPD that were readmitted or died had a worse SPPB classification and five-repetition sit-to-stand test at T1. Conclusion: Patients after severe AECOPD improved in functional capacity and HRQOL one month after hospital discharge, but ADL performance was still worse compared to SCOPD. Patients who were readmitted or died had significantly worse scores on functional tests at hospital discharge.
MeSH term(s)	Humans ; Quality of Life ; Hand Strength ; Pulmonary Disease, Chronic Obstructive ; Asthma ; Disease Progression
Language	English
Publishing date	2023-11-02
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	1003348-8
ISSN	1532-3064 ; 0954-6111
ISSN (online)	1532-3064
ISSN	0954-6111
DOI	10.1016/j.rmed.2023.107437
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Article ; Online: Unraveling the Rewired Metabolism in Lung Cancer Using Quantitative NMR Metabolomics

Karolien Vanhove / Elien Derveaux / Liesbet Mesotten / Michiel Thomeer / Maarten Criel / Hanne Mariën / Peter Adriaensens

International Journal of Molecular Sciences, Vol 23, Iss 5602, p

2022 Volume 5602

Abstract	Lung cancer cells are well documented to rewire their metabolism and energy production networks to enable proliferation and survival in a nutrient-poor and hypoxic environment. Although metabolite profiling of blood plasma and tissue is still emerging in omics approaches, several techniques have shown potential in cancer diagnosis. In this paper, the authors describe the alterations in the metabolic phenotype of lung cancer patients. In addition, we focus on the metabolic cooperation between tumor cells and healthy tissue. Furthermore, the authors discuss how metabolomics could improve the management of lung cancer patients.
Keywords	lung cancer ; NMR (nuclear magnetic resonance) ; metabolism ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2022-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: HLA-I diversity and tumor mutational burden by comprehensive next-generation sequencing as predictive biomarkers for the treatment of non-small cell lung cancer with PD-(L)1 inhibitors.

Cuppens, Kristof / Baas, Paul / Geerdens, Ellen / Cruys, Bert / Froyen, Guy / Decoster, Lynn / Thomeer, Michiel / Maes, Brigitte

Lung cancer (Amsterdam, Netherlands)

2022 Volume 170, Page(s) 1–10

Abstract: Objectives: Immune checkpoint inhibitors (ICIs) improved outcomes in non-small cell lung cancer (NSCLC) patients. We report the predictive utility of human leukocyte antigen class I (HLA-I) diversity and tumor mutational burden (TMB) by comprehensive ... ...

Abstract	Objectives: Immune checkpoint inhibitors (ICIs) improved outcomes in non-small cell lung cancer (NSCLC) patients. We report the predictive utility of human leukocyte antigen class I (HLA-I) diversity and tumor mutational burden (TMB) by comprehensive next-generation sequencing. Methods: 126 patients were included. TMB high was defined as ≥ 10 nonsynonymous mutations/Mb. Patients exhibit high HLA-I diversity if at least one locus was in the upper 15th percentile for DNA alignment scores. Results: No difference in response rate (RR; 44.4% versus 30.9%; p = 0.1741) or 6-month survival rate (SR; 75.6% versus 77.8%; p = 0.7765) was noted between HLA-I high diversity and low diversity patients. HLA-I high diversity patients did significantly more often exhibit durable clinical benefit (DCB), defined as response or stable disease lasting minimally 6 months (64.4% [29/45] versus 43.2% [35/81]; p = 0.0223). TMB high patients exhibited higher RR (49.1% versus 25.4%; p = 0.0084) and SR 6 months after start ICI (85.5% versus 70.4%; p = 0.0468) than TMB low patients. The proportion of patients with DCB, did not differ significantly between TMB high and low subgroups (60.0% [33/55] versus 42.3% [30/71]; p = 0.0755). Patients with combined dual high TMB and HLA-I diversity had higher RR (63.2% versus 22.2%; p = 0.0033), but SR at 6 months did not differ significantly (84.2% versus 64,4%; p = 0.1536). A significantly higher rate of patients experienced DCB in dual high compared to the dual low group (73.7% [14/19] versus 35.6% [16/45]; p = 0.0052). Triple positive patients (high TMB and HLA-I diversity and PD-L1 positive) had higher RR (63.6% versus 0.0%; p = 0.0047) and SR at 6 months (100% versus 66.7%; p = 0.0378) compared to triple-negative patients. Conclusion: HLA-I diversity was able to predict durable clinical benefit in ICI treated NSCLC patients, but failed to confirm as a predictor of response or survival. TMB confirmed as a predictive biomarker.
MeSH term(s)	B7-H1 Antigen/genetics ; Biomarkers, Tumor/genetics ; Carcinoma, Non-Small-Cell Lung/drug therapy ; Carcinoma, Non-Small-Cell Lung/genetics ; Carcinoma, Non-Small-Cell Lung/pathology ; HLA Antigens ; High-Throughput Nucleotide Sequencing ; Humans ; Lung Neoplasms/drug therapy ; Lung Neoplasms/genetics ; Lung Neoplasms/pathology ; Mutation
Chemical Substances	B7-H1 Antigen ; Biomarkers, Tumor ; HLA Antigens
Language	English
Publishing date	2022-05-31
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	632771-0
ISSN	1872-8332 ; 0169-5002
ISSN (online)	1872-8332
ISSN	0169-5002
DOI	10.1016/j.lungcan.2022.05.019
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Article: NMR-Metabolomics Reveals a Metabolic Shift after Surgical Resection of Non-Small Cell Lung Cancer.

Derveaux, Elien / Geubbelmans, Melvin / Criel, Maarten / Demedts, Ingel / Himpe, Ulrike / Tournoy, Kurt / Vercauter, Piet / Johansson, Erik / Valkenborg, Dirk / Vanhove, Karolien / Mesotten, Liesbet / Adriaensens, Peter / Thomeer, Michiel

Cancers

2023 Volume 15, Issue 7

Abstract: Background: Lung cancer can be detected by measuring the patient's plasma metabolomic profile using nuclear magnetic resonance (NMR) spectroscopy. This NMR-based plasma metabolomic profile is patient-specific and represents a snapshot of the patient's ... ...

Abstract	Background: Lung cancer can be detected by measuring the patient's plasma metabolomic profile using nuclear magnetic resonance (NMR) spectroscopy. This NMR-based plasma metabolomic profile is patient-specific and represents a snapshot of the patient's metabolite concentrations. The onset of non-small cell lung cancer (NSCLC) causes a change in the metabolite profile. However, the level of metabolic changes after complete NSCLC removal is currently unknown. Patients and methods: Fasted pre- and postoperative plasma samples of 74 patients diagnosed with resectable stage I-IIIA NSCLC were analyzed using Results: A trained multivariate discriminant classification model shows a strong differentiation between the pre- and postoperative NSCLC profiles with a specificity of 96% (95% CI [86-100]) and a sensitivity of 92% (95% CI [81-98]). Validation of this model results in an excellent predictive accuracy of 90% (95% CI [77-97]) and an AUC value of 0.97 (95% CI [0.93-1]). The validation of a second trained model using an additional preoperative control sample dataset confirms the separation of the pre- and postoperative profiles with a predictive accuracy of 93% (95% CI [82-99]) and an AUC value of 0.97 (95% CI [0.93-1]). Metabolite analysis reveals significantly increased lactate, cysteine, asparagine and decreased acetate levels in the postoperative plasma metabolite profile. Conclusions: The results of this paper demonstrate that surgical removal of NSCLC generates a detectable metabolic shift in blood plasma. The observed metabolic shift indicates that the NSCLC metabolite profile is determined by the tumor's presence rather than donor-specific features. Furthermore, the ability to detect the metabolic difference before and after surgical tumor resection strongly supports the prospect that NMR-generated metabolite profiles via blood samples advance towards early detection of NSCLC recurrence.
Language	English
Publishing date	2023-04-03
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2527080-1
ISSN	2072-6694
ISSN	2072-6694
DOI	10.3390/cancers15072127
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Article ; Online: Physical Tests Are Poorly Related to Patient-Reported Outcome Measures during Severe Acute Exacerbations of COPD

Kirsten Quadflieg / Ana Machado / Sarah Haesevoets / Marc Daenen / Michiel Thomeer / David Ruttens / Martijn A. Spruit / Chris Burtin

Journal of Clinical Medicine, Vol 11, Iss 150, p

2022 Volume 150

Abstract: Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have a negative impact on patients’ health status, including physical function and patient-reported outcomes. We aimed to explore the associations between physical tests and patient- ... ...

Abstract	Acute exacerbations of chronic obstructive pulmonary disease (AECOPD) have a negative impact on patients’ health status, including physical function and patient-reported outcomes. We aimed to explore the associations between physical tests and patient-reported outcome measures (PROMs) in hospitalised patients for an AECOPD. Patients were assessed on the day of discharge. Quadriceps force, handgrip strength, short physical performance battery (SPPB), five-repetition sit-to-stand test (5STS), four-meter gait speed test (4MGS), balance test, six-minute walk test (6MWT), COPD Assessment Test (CAT), London Chest Activity of Daily Living scale (LCADL), modified Medical Research Council (mMRC) dyspnea scale, Checklist of Individual Strength (CIS)-fatigue subscale, and Patient Health Questionnaire (PHQ-9) were collected. Sixty-nine patients with an AECOPD were included (54% female; age 69 ± 9 years; FEV 1 39.2 (28.6–49.1%) predicted). Six-minute walk distance was strongly correlated with mMRC ( ρ : −0.64, p < 0.0001) and moderately correlated with LCADL total score, subscales self-care and household activities ( ρ ranging from −0.40 to −0.58, p < 0.01). Moreover, 4MGS was moderately correlated with mMRC ( ρ : −0.49, p < 0.0001). Other correlations were weak or non-significant. During a severe AECOPD, physical tests are generally poorly related to PROMs. Therefore, a comprehensive assessment combining both physical tests and PROMs needs to be conducted in these patients to understand their health status.
Keywords	chronic obstructive pulmonary disease ; acute exacerbations ; exercise capacity ; muscle function ; patient-reported outcome measures ; Medicine ; R
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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