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  1. Article ; Online: Ten Things to Know About Primary Mediastinal B Cell Lymphoma.

    Avivi, Irit

    Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation

    2018  Volume 24, Issue 10, Page(s) 1959–1960

    MeSH term(s) B-Lymphocytes ; Humans ; Lymphoma ; Lymphoma, B-Cell ; Lymphoma, Non-Hodgkin ; Mediastinal Neoplasms
    Language English
    Publishing date 2018-09-19
    Publishing country United States
    Document type Journal Article ; Comment
    ZDB-ID 1474865-4
    ISSN 1523-6536 ; 1083-8791
    ISSN (online) 1523-6536
    ISSN 1083-8791
    DOI 10.1016/j.bbmt.2018.09.010
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5082: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 462: Show issues

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  2. Article ; Online: Senescent Secretome of Blind Mole Rat

    Odeh, Amani / Eddini, Hossam / Shawasha, Lujain / Chaban, Anastasia / Avivi, Aaron / Shams, Imad / Manov, Irena

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Subterranean blind mole rat, ...

    Abstract Subterranean blind mole rat,
    MeSH term(s) Animals ; Humans ; Female ; Spalax ; Mole Rats ; Breast Neoplasms/drug therapy ; Secretome ; Cellular Senescence ; Tumor Microenvironment
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065132
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Current treatment of lymphoma in pregnancy.

    Gurevich-Shapiro, Anna / Avivi, Irit

    Expert review of hematology

    2019  Volume 12, Issue 6, Page(s) 449–459

    Abstract: ... ...

    Abstract Introduction
    MeSH term(s) Antineoplastic Combined Chemotherapy Protocols/pharmacology ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use ; Female ; Hodgkin Disease/drug therapy ; Humans ; Lymphoma, Non-Hodgkin/drug therapy ; Pregnancy
    Language English
    Publishing date 2019-05-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2516804-6
    ISSN 1747-4094 ; 1747-4086
    ISSN (online) 1747-4094
    ISSN 1747-4086
    DOI 10.1080/17474086.2019.1615878
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 6943: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Treatment with low-dose, single-agent belantamab mafodotin is safe and provides long-term responses in heavily pretreated multiple myeloma patients.

    Avivi, Irit / Shragai, Tamir / Luttwak, Efrat / Trestman, Svetlana / Cohen, Yael C

    European journal of haematology

    2023  Volume 112, Issue 3, Page(s) 367–370

    Abstract: Objectives: To evaluate whether low-dose belantamab mafodotin (B-MAF) dosing results in lower toxicity and better overall outcome.: Methods: We retrospectively evaluated nine consecutive patients treated with low-dose (1.9 mg/kg) B-MAF.: Results: ... ...

    Abstract Objectives: To evaluate whether low-dose belantamab mafodotin (B-MAF) dosing results in lower toxicity and better overall outcome.
    Methods: We retrospectively evaluated nine consecutive patients treated with low-dose (1.9 mg/kg) B-MAF.
    Results: The median age was 70 years. Most patients were penta-refractory. Ocular toxicity was observed in 77.7%. Adverse events resulting in treatment delays were recorded in 9 out of 124 cycles being given. Overall response rate was 66% (6/9), and all responding patients achieved very good partial response or better. Within a median follow-up of 12 (range 0.5-13.8) months, median progression-free survival and overall survival were 14 (CI95% 6-22) and 20 (95%CI 0-41) months, respectively.
    Conclusion: Low-dose B-MAF regimen showed high-efficacy and low-toxicity profile.
    MeSH term(s) Humans ; Aged ; Multiple Myeloma/diagnosis ; Multiple Myeloma/drug therapy ; Retrospective Studies ; Dexamethasone ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Antibodies, Monoclonal, Humanized
    Chemical Substances belantamab mafodotin (DB1041CXDG) ; Dexamethasone (7S5I7G3JQL) ; Antibodies, Monoclonal, Humanized
    Language English
    Publishing date 2023-10-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 392482-8
    ISSN 1600-0609 ; 0902-4441
    ISSN (online) 1600-0609
    ISSN 0902-4441
    DOI 10.1111/ejh.14120
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 323: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article ; Online: Remote Digital Microscopy Improves Hematology Laboratory Workflow by Reducing Peripheral Blood Smear Analysis Turnaround Time.

    Katz, Ben-Zion / Benisty, Dan / Sayegh, Yael / Lamm, Inna / Avivi, Irit

    Applied clinical informatics

    2022  Volume 13, Issue 5, Page(s) 1108–1115

    Abstract: Background: The demand for morphological diagnosis by peripheral blood smear (PBS) analysis with clearly defined turnaround times (TAT), coupled with a shortage of morphologists and increasing cost containment, is driving digitalization to the forefront ...

    Abstract Background: The demand for morphological diagnosis by peripheral blood smear (PBS) analysis with clearly defined turnaround times (TAT), coupled with a shortage of morphologists and increasing cost containment, is driving digitalization to the forefront of laboratory workflow. Labor-intensive manual PBS review affects weekend workflow with limited staff availability. The impact of remote analysis of PBS on the performance of hematology laboratories has not yet been assessed.
    Objectives: Following implementation of fully remote digital microscopy within our laboratory, we measured its impact on morphology workflow efficiency, TAT, and hours saved per month.
    Methods: A retrospective study of the effects of remote PBS analysis on the morphology workflow in a tertiary medical center using the Scopio Labs X100 Full-Field PBS system was conducted. 10,704 PBS samples were analyzed pre-and post -implementation, over a 5-month period. Overall PBS workload, and average TAT of PBS samples over weekends and the first two weekdays were collected and evaluated.
    Results: Remote weekend viewing resulted in a 15.8% reduction in the overall morphology TAT of the laboratory (
    Conclusion: The Scopio Labs Full-Field X100 PBS system with remote analysis capacity significantly reduced PBS TAT and improved the morphology workflow of the hematology laboratory. PBSs with significant clinical findings are now available for remote viewing by on-call clinicians located outside the medical center perimeter. Remote PBS viewing, coupled with the overall monthly cost savings, merit consideration for the implementation of full digitalization for remote PBS review.
    MeSH term(s) Humans ; Laboratories ; Workflow ; Microscopy ; Retrospective Studies ; Hematology
    Language English
    Publishing date 2022-10-08
    Publishing country Germany
    Document type Journal Article
    ISSN 1869-0327
    ISSN (online) 1869-0327
    DOI 10.1055/a-1957-6219
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Image-Based Deep Learning Detection of High-Grade B-Cell Lymphomas Directly from Hematoxylin and Eosin Images.

    Perry, Chava / Greenberg, Orli / Haberman, Shira / Herskovitz, Neta / Gazy, Inbal / Avinoam, Assaf / Paz-Yaacov, Nurit / Hershkovitz, Dov / Avivi, Irit

    Cancers

    2023  Volume 15, Issue 21

    Abstract: Deep learning applications are emerging as promising new tools that can support the diagnosis and classification of different cancer types. While such solutions hold great potential for hematological malignancies, there have been limited studies ... ...

    Abstract Deep learning applications are emerging as promising new tools that can support the diagnosis and classification of different cancer types. While such solutions hold great potential for hematological malignancies, there have been limited studies describing the use of such applications in this field. The rapid diagnosis of double/triple-hit lymphomas (DHLs/THLs) involving
    Language English
    Publishing date 2023-10-29
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15215205
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  7. Article ; Online: Predictors of Early and Late Mortality for Patients with Hematologic Malignancy and Invasive Mold Disease.

    Yashphe, Eva L / Ram, Ron / Avivi, Irit / Ben-Ami, Ronen

    Journal of fungi (Basel, Switzerland)

    2021  Volume 7, Issue 9

    Abstract: Background: Invasive mold infections (IMI) are leading infectious causes of mortality among patients with hematological malignancies.: Objectives: To determine the relative contribution of host, disease, and treatment-related factors to patient ... ...

    Abstract Background: Invasive mold infections (IMI) are leading infectious causes of mortality among patients with hematological malignancies.
    Objectives: To determine the relative contribution of host, disease, and treatment-related factors to patient survival.
    Methods: An observational, retrospective cohort study reviewing the medical records of patients with hematological malignancy and IMI (2006-2016). Causes of death were classified up to 90 days after diagnosis. Kaplan-Meier and Cox regression analyses were used to determine risk factors for early, late, and overall mortality.
    Results: Eighty-six patients with IMI were included; 29 (34%) and 41 (47%) died within 6 and 12 weeks of diagnosis, respectively. Death was attributed to IMI in 22 (53.6%) patients, all of whom died within 45 days of diagnosis. Risk factors for early mortality were elevated serum galactomannan, treatment with amphotericin B, IMI progression 3 weeks after diagnosis, and lymphoma undergoing HCT. Late mortality was associated with relapsed/refractory malignancy and elevated serum galactomannan.
    Conclusions: In this single-center study of patients with IMI, infections were the most frequent causes of death, and time-dependent risk factors for death were identified. These results may help direct risk-assessment and monitoring of patients undergoing treatment of IMI.
    Language English
    Publishing date 2021-08-27
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2784229-0
    ISSN 2309-608X ; 2309-608X
    ISSN (online) 2309-608X
    ISSN 2309-608X
    DOI 10.3390/jof7090697
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  8. Article ; Online: REGEN-COV antibody combination in patients with lymphoproliferative malignancies and SARS-CoV-2 infection.

    Bronstein, Yotam / Avivi, Irit / Cohen, Yael C / Feigin, Eugene / Perry, Chava / Herishanu, Yair

    EJHaem

    2022  Volume 3, Issue 2, Page(s) 471–474

    Abstract: Patients with lymphoproliferative diseases are at high risk for SARS-CoV-2-related complications and mortality. The role of casirivimab and imdevimab (REGEN-COV), a neutralizing antibody cocktail, to treat immunocompromised hemato-oncological patients ... ...

    Abstract Patients with lymphoproliferative diseases are at high risk for SARS-CoV-2-related complications and mortality. The role of casirivimab and imdevimab (REGEN-COV), a neutralizing antibody cocktail, to treat immunocompromised hemato-oncological patients with SARS-CoV-2 disease 2019 (Covid-19) remains unknown. Here, we present our clinical experience on the outcome of 15 hematological patients treated with REGEN-COV for SARS-CoV-2 infection. Most patients failed to respond or achieved low antibody titer after 2-3 doses of BNT162b2 mRNA vaccine. All patients experienced clinical improvement with no mortality within a median follow-up of 70 days. In conclusion, early administration of REGEN-COV to high-risk hematological patients may prevent clinical deterioration and mortality from SARS-CoV-2 infection. The effectiveness of neutralizing antibodies may vary depending on the virus variants and in particular with the omicron variant (B.1.1.529).
    Language English
    Publishing date 2022-02-23
    Publishing country United States
    Document type Journal Article
    ISSN 2688-6146
    ISSN (online) 2688-6146
    DOI 10.1002/jha2.403
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Vagal Nerve Activity Predicts Prognosis in Diffused Large B-Cell Lymphoma and Multiple Myeloma.

    Atar, Or / Ram, Ron / Avivi, Irit / Amit, Odelia / Vitkon, Roy / Luttwak, Efrat / Bar-On, Yael / Gidron, Yori

    Journal of clinical medicine

    2023  Volume 12, Issue 3

    Abstract: This study examined the prognostic role of vagal nerve activity in patients with relapsed/refractory diffused large B-cell lymphoma (R/R-DLBCL) treated with chimeric antigen receptor cell therapy (CAR-T) and in patients with multiple myeloma (MM) ... ...

    Abstract This study examined the prognostic role of vagal nerve activity in patients with relapsed/refractory diffused large B-cell lymphoma (R/R-DLBCL) treated with chimeric antigen receptor cell therapy (CAR-T) and in patients with multiple myeloma (MM) undergoing an autologous hematopoietic cell transplantation (AutoHCT). Participants included 29 patients with R/R-DLBCL and 37 patients with MM. Inclusion criteria were: (1) age over 18; (2) diagnosed with DLBCL or MM; (3) being treated with CAR-T or AutoHCT; and (4) having an ECG prior to cell transfusion. The predictor was vagal nerve activity indexed by heart rate variability (HRV) and obtained retroactively from 10 s ECGs. The main endpoint for R/R-DLBCL was overall survival (OS), and for MM the endpoint was progression-free survival (PFS). Data of 122 patients were obtained, 66 of whom were included in the study. In DLBCL, HRV significantly predicted OS independently of confounders (e.g., performance status, disease status at cell therapy), hazard ratio (HR), and 95% confidence interval (HR = 0.20; 95%CI: 0.06-0.69). The prognostic role of disease severity was moderated by HRV: among severely disease patients, 100% died with low HRV, while only 37.5% died with high HRV. In MM, HRV significantly predicted PFS (HR = 0.19; 95%CI: 0.04-0.90) independently of confounders. Vagal nerve activity independently predicts prognosis in patients with R/R-DLBCL and with MM undergoing cell therapy. High vagal activity overrides the prognostic role of disease severity. Testing the effects of vagal nerve activation on prognosis in blood cancers is recommended.
    Language English
    Publishing date 2023-01-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12030908
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  10. Article: Characterization of extracellular vesicles in COVID-19 infection during pregnancy.

    Dangot, Ayelet / Zavaro, Mor / Bar-Lev, Tali Hana / Bannon, Lian / Zilberman, Ayala / Pickholz, Eliana / Avivi, Irit / Aharon, Anat

    Frontiers in cell and developmental biology

    2023  Volume 11, Page(s) 1135821

    Abstract: Introduction: ...

    Abstract Introduction:
    Language English
    Publishing date 2023-07-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1135821
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