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Article: Comparative Study of Ablation Zone of EMPRINT HP Microwave Device with Contemporary 2.4 GHz Microwave Devices in an Ex Vivo Porcine Liver Model.

Hui, Terrence C H / How, Guo Yuan / Chim, Michelle S M / Pua, Uei

2023 Volume 13, Issue 16

Abstract: 1) Background: Percutaneous microwave ablation (MWA) is an accepted treatment of non-operative liver cancer. This study compares the ablation zones of four commercially available 2.45 GHz MWA systems (Emprint, Eco, Neuwave, and Solero) in an ex vivo ... ...

Abstract	(1) Background: Percutaneous microwave ablation (MWA) is an accepted treatment of non-operative liver cancer. This study compares the ablation zones of four commercially available 2.45 GHz MWA systems (Emprint, Eco, Neuwave, and Solero) in an ex vivo porcine liver model. (2) Methods: Ex vivo porcine livers (
Language	English
Publishing date	2023-08-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662336-5
ISSN	2075-4418
ISSN	2075-4418
DOI	10.3390/diagnostics13162702
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Article ; Online: Arterial portography during transarterial chemoembolization: still a necessity in the age of contrast-enhanced cross-sectional imaging?

Hui, Terrence C H / Pua, Uei

Journal of vascular and interventional radiology : JVIR

2014 Volume 25, Issue 1, Page(s) 41–46

Abstract: Purpose: To evaluate the necessity of arterial portography (AP) if a patent portal vein is seen on imaging before transarterial chemoembolization.: Materials and methods: All patients who underwent transarterial chemoembolization between January 2004 ...

Abstract	Purpose: To evaluate the necessity of arterial portography (AP) if a patent portal vein is seen on imaging before transarterial chemoembolization. Materials and methods: All patients who underwent transarterial chemoembolization between January 2004 and July 2011 were retrospectively recruited. The study included 131 patients (100 men, 31 women) undergoing 243 transarterial chemoembolization procedures. AP was performed during 93 procedures. The mean time interval between imaging performed before transarterial chemoembolization and the transarterial chemoembolization procedure was 46.5 days (range, 0-161 d). Results: AP did not detect any new cases of portal vein thrombosis (PVT) when imaging performed transarterial chemoembolization showed a patent portal vein. Imaging performed after transarterial chemoembolization revealed one main PVT, one left PVT extending into the main portal vein, two left PVT, and one right PVT. When imaging performed before transarterial chemoembolization showed a patent portal vein and AP was omitted, imaging performed after transarterial chemoembolization showed one case of main PVT, two right PVT, and two left PVT. In both groups, there was no significant difference in mortality (P = .673) or morbidity (P = .581) related to transarterial chemoembolization. Conclusions: AP is unnecessary if transarterial chemoembolization is performed within a reasonable time frame following computed tomography or magnetic resonance imaging that showed a patent portal vein. Omitting AP potentially reduces contrast material and radiation burden to both the patient and the operator.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Carcinoma, Hepatocellular/diagnostic imaging ; Carcinoma, Hepatocellular/mortality ; Carcinoma, Hepatocellular/physiopathology ; Carcinoma, Hepatocellular/therapy ; Chemoembolization, Therapeutic/adverse effects ; Chemoembolization, Therapeutic/mortality ; Female ; Humans ; Liver Neoplasms/diagnostic imaging ; Liver Neoplasms/mortality ; Liver Neoplasms/physiopathology ; Liver Neoplasms/therapy ; Magnetic Resonance Imaging ; Male ; Middle Aged ; Multidetector Computed Tomography ; Portal Vein/diagnostic imaging ; Portal Vein/physiopathology ; Portography ; Predictive Value of Tests ; Radiation Dosage ; Radiography, Interventional ; Retrospective Studies ; Time Factors ; Time-to-Treatment ; Treatment Outcome ; Unnecessary Procedures ; Vascular Patency ; Venous Thrombosis/diagnostic imaging ; Venous Thrombosis/mortality ; Venous Thrombosis/physiopathology
Language	English
Publishing date	2014-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	1137756-2
ISSN	1535-7732 ; 1051-0443
ISSN (online)	1535-7732
ISSN	1051-0443
DOI	10.1016/j.jvir.2013.10.014
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Article: Clinical utility of chest radiography for severe COVID-19.

Hui, Terrence C H / Khoo, Hau Wei / Young, Barnaby E / Haja Mohideen, Salahudeen Mohamed / Lee, Yeong Shyan / Lim, Chien Joo / Leo, Yee Sin / Kaw, Gregory J L / Lye, David C / Tan, Cher Heng

Quantitative imaging in medicine and surgery

2020 Volume 10, Issue 7, Page(s) 1540–1550

Abstract: ... They also had higher C-reactive protein (CRP) (P<0.001), higher lactate dehydrogenase (LDH) (P<0.001), lower ...

Abstract	Background: Chest radiography (CXR) is performed more widely and readily than CT for the management of coronavirus disease (COVID-19), but there remains little data on its clinical utility. This study aims to assess the diagnostic performance of CXR, with emphasis on its predictive value, for severe COVID-19 disease. Methods: A retrospective cohort study was conducted, 358 chest radiographs were performed on 109 COVID-19 patients (median age 44.4 years, 58 males and 30 with comorbidities) admitted between 22 January 2020 and 15 March 2020. Each CXR was reviewed and scored by three radiologists in consensus using a 72-point COVID-19 Radiographic Score (CRS). Disease severity was determined by the need for supplemental oxygen and mechanical ventilation. Results: Patients who needed supplemental oxygen (n=19, 17.4%) were significantly older (P<0.001) and significantly more of them had co-morbidities (P=0.011). They also had higher C-reactive protein (CRP) (P<0.001), higher lactate dehydrogenase (LDH) (P<0.001), lower lymphocyte count (P<0.001) and lower hemoglobin (Hb) (P=0.001). Their initial (CRS Conclusions: Adjusting for key confounders of age and baseline Hb, CRS
Keywords	covid19
Language	English
Publishing date	2020-06-13
Publishing country	China
Document type	Journal Article
ZDB-ID	2653586-5
ISSN	2223-4306 ; 2223-4292
ISSN (online)	2223-4306
ISSN	2223-4292
DOI	10.21037/qims-20-642
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Article ; Online: The use of cone beam CT in achieving unipedicular spinal augmentation.

Hui, Terrence C H / Tan, Gideon Z L / Tan, Alvin K W / Pua, Uei

The British journal of radiology

2016 Volume 89, Issue 1065, Page(s) 20160030

Abstract: Objective: To assess the feasibility of cone beam CT (CBCT) in achieving unipedicular access during spinal cement augmentation.: Methods: A retrospective review of all patients who underwent CBCT-guided unipedicular spinal augmentation procedures ... ...

Abstract	Objective: To assess the feasibility of cone beam CT (CBCT) in achieving unipedicular access during spinal cement augmentation. Methods: A retrospective review of all patients who underwent CBCT-guided unipedicular spinal augmentation procedures between 1 January 2012 and 15 June 2015 was performed. 59 patients (43 females 16 males; mean-age, 74.0 years; range, 52-90 years) underwent unipedicular spinal augmentation in 78 vertebral levels (T5-T9, n = 14; T10-L2, n = 42; L3-L5, n = 22). Degree of cross-over in contralateral hemivertebral body, complications and 30-day mortality were recorded. Results: 97% (76/78) of procedures were technically successful. Two procedures failed owing to vertebral sclerosis. For vertebroplasty, all cases (6/6) demonstrated cross-over filling of cement and 50% (3/6) showed cement cross-over >50% of contralateral half of the vertebral body. For kyphoplasty, 13 out of 15 procedures demonstrated balloon and cement cross-over >50% of contralateral half of the vertebral body. Two kyphoplasty procedures required the second pedicle after midline cross-over of cement failed. Of the kyphoplasty procedures that were successfully performed with the unipedicular approach, 76.9% (10/13) showed cement cross-over >50% of contralateral half of the vertebral body. For stentoplasty, all cases (55/55) showed midline stent-cement complex cross-over and 78.2% (43/55) exhibited stent-cement complex cross-over >50% of contralateral half of the vertebral body. There was no major complication or mortality. Minor complications included asymptomatic cement extravasation (6.4%, n = 5) and self-limiting haematoma (1.3%, n = 1). Conclusion: Unipedicular access for spinal augmentation procedures is achieved at a high success rate with the use of CBCT. Advances in knowledge: This article describes the novel use of CBCT to achieve unipedicular spinal augmentation. Unipedicular spinal augmentation has the potential to reduce risk, duration, radiation and cost while achieving similar results.
MeSH term(s)	Aged ; Aged, 80 and over ; Bone Cements/therapeutic use ; Cone-Beam Computed Tomography/methods ; Feasibility Studies ; Female ; Fractures, Compression/surgery ; Humans ; Kyphoplasty/methods ; Male ; Middle Aged ; Radiography, Interventional ; Retrospective Studies ; Spinal Fractures/surgery ; Treatment Outcome
Chemical Substances	Bone Cements
Language	English
Publishing date	2016-09
Publishing country	England
Document type	Evaluation Studies ; Journal Article
ZDB-ID	2982-8
ISSN	1748-880X ; 0007-1285
ISSN (online)	1748-880X
ISSN	0007-1285
DOI	10.1259/bjr.20160030
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Article ; Online: Latent Porosity in Alkali-Metal M

Peryshkov, Dmitry V / Bukovsky, Eric V / Lacroix, Matthew R / Wu, Hui / Zhou, Wei / Jones, W Matthew / Lozinšek, Matic / Folsom, Travis C / Heyliger, D Luke / Udovic, Terrence J / Strauss, Steven H

Inorganic chemistry

2017 Volume 56, Issue 19, Page(s) 12023–12041

Abstract: Structures of the alkali-metal hydrates ... ...

Abstract	Structures of the alkali-metal hydrates Li
Language	English
Publishing date	2017-10-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.7b02081
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Article: Chest Radiography in Coronavirus Disease 2019 (COVID-19): Correlation with Clinical Course

Zhou, Joel C. / Hui, Terrence C. H. / Tan, Cher Heng / Khoo, Hau Wei / Young, Barnaby E. / Lye, David C. / Lee, Yeong Shyan / Kaw, Gregory J. L.

Annals Academy of Medicine Singapore

Abstract: Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 and was declared a global pandemic by the World Health Organization on 11 March 2020 A definitive diagnosis of COVID-19 is made after a positive result ... ...

Abstract	Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 and was declared a global pandemic by the World Health Organization on 11 March 2020 A definitive diagnosis of COVID-19 is made after a positive result is obtained on reverse transcription-polymerase chain reaction assay In Singapore, rigorous contact tracing was practised to contain the spread of the virus Nasal swabs and chest radiographs (CXR) were also taken from individuals who were suspected to be infected by COVID-19 upon their arrival at a centralised screening centre From our experience, about 40% of patients who tested positive for COVID-19 had initial CXR that appeared "normal" In this case series, we described the temporal evolution of COVID-19 in patients with an initial "normal" CXR Since CXR has limited sensitivity and specificity in COVID-19, it is not suitable as a first-line diagnostic tool However, when CXR changes become unequivocally abnormal, close monitoring is recommended to manage potentially severe COVID-19 pneumonia
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #777195
Database	COVID19

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Article ; Online: Highly pathogenic avian influenza A(H5N1) virus of clade 2.3.4.4b isolated from a human case in Chile causes fatal disease and transmits between co-housed ferrets.

Pulit-Penaloza, Joanna A / Brock, Nicole / Belser, Jessica A / Sun, Xiangjie / Pappas, Claudia / Kieran, Troy J / Thakur, Poulami Basu / Zeng, Hui / Cui, Dan / Frederick, Julia / Fasce, Rodrigo / Tumpey, Terrence M / Maines, Taronna R

Emerging microbes & infections

2024 , Page(s) 2332667

Abstract: Clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses have caused large outbreaks within avian populations on five continents, with concurrent spillover into a variety of mammalian species. Mutations associated with mammalian adaptation have ... ...

Abstract	Clade 2.3.4.4b highly pathogenic avian influenza A(H5N1) viruses have caused large outbreaks within avian populations on five continents, with concurrent spillover into a variety of mammalian species. Mutations associated with mammalian adaptation have been sporadically identified in avian isolates, and more frequently among mammalian isolates following infection. Reports of human infection with A(H5N1) viruses following contact with infected wildlife have been reported on multiple continents, highlighting the need for pandemic risk assessment of these viruses. In this study, the pathogenicity and transmissibility of A/Chile/25945/2023 HPAI A(H5N1) virus, a novel reassortment with four gene segments (PB1, PB2, NP, MP) from North America lineage, isolated from a severe human case in Chile, was evaluated in vitro and using the ferret model. This virus possessed a high capacity to cause fatal disease, characterized by high morbidity and extrapulmonary spread in virus-inoculated ferrets. The virus was capable of transmission to naïve contacts in a direct contact setting, with contact animals similarly exhibiting severe disease, but did not exhibit productive transmission in respiratory droplet or fomite transmission models. Our results indicate that the virus would need to acquire an airborne transmissible phenotype in mammals to potentially cause a pandemic. Nonetheless, this work warrants continuous monitoring of mammalian adaptations in avian viruses, especially in strains isolated from humans, to aid pandemic preparedness efforts.
Language	English
Publishing date	2024-03-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	2681359-2
ISSN	2222-1751 ; 2222-1751
ISSN (online)	2222-1751
ISSN	2222-1751
DOI	10.1080/22221751.2024.2332667
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Article ; Online: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters

Qiao, Wei / Lau, Hui En / Xie, Huizhi / Poon, Vincent K.M. / Chan, Chris C.S. / Chu, Hin / Yuan, Shuofeng / Yuen, Terrence T.T. / Chik, Kenn K.H. / Tsang, Jessica O.L. / Chan, Chris C.Y. / Cai, Jian-Piao / Luo, Cuiting / Yuen, Kwok-Yong / Cheung, Kenneth M.C. / Chan, Jasper F.W. / Yeung, Kelvin W.K.

bioRxiv

Abstract: Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though ...

Abstract	Extrapulmonary complications of different organ systems have been increasingly recognized in patients with severe or chronic Coronavirus Disease 2019 (COVID-19). However, limited information on the skeletal complications of COVID-19 is known, even though inflammatory diseases of the respiratory tract have been known to perturb bone metabolism and cause pathological bone loss. In this study, we characterized the effects of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection on bone metabolism in an established golden Syrian hamster model for COVID-19. SARS-CoV-2 causes significant multifocal loss of bone trabeculae in the long bones and lumbar vertebrae of all infected hamsters. The bone loss progressively worsens from the acute phase to the post-recovery phase. Mechanistically, the bone loss was associated with SARS-CoV-2-induced cytokine dysregulation which upregulates osteoclastic differentiation of monocyte-macrophage lineage. The pro-inflammatory cytokines further trigger a second wave of cytokine storm in the skeletal tissues to augment their pro-osteoclastogenesis effect. Our findings in this established hamster model suggest that pathological bone loss may be a neglected complication which warrants more extensive investigations during the long-term follow-up of COVID-19 patients. The benefits of potential prophylactic and therapeutic interventions against pathological bone loss should be further evaluated.
Keywords	covid19
Language	English
Publishing date	2021-10-09
Publisher	Cold Spring Harbor Laboratory
Document type	Article ; Online
DOI	10.1101/2021.10.08.463665
Database	COVID19

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Article ; Online: Receptor Usage of a Novel Bat Lineage C Betacoronavirus Reveals Evolution of Middle East Respiratory Syndrome-Related Coronavirus Spike Proteins for Human Dipeptidyl Peptidase 4 Binding.

The Journal of infectious diseases

2017 Volume 218, Issue 2, Page(s) 197–207

Abstract: Although bats are known to harbor Middle East Respiratory Syndrome coronavirus (MERS-CoV)-related viruses, the role of bats in the evolutionary origin and pathway remains obscure. We identified a novel MERS-CoV-related betacoronavirus, Hp-BatCoV HKU25, ... ...

Abstract	Although bats are known to harbor Middle East Respiratory Syndrome coronavirus (MERS-CoV)-related viruses, the role of bats in the evolutionary origin and pathway remains obscure. We identified a novel MERS-CoV-related betacoronavirus, Hp-BatCoV HKU25, from Chinese pipistrelle bats. Although it is closely related to MERS-CoV in most genome regions, its spike protein occupies a phylogenetic position between that of Ty-BatCoV HKU4 and Pi-BatCoV HKU5. Because Ty-BatCoV HKU4 but not Pi-BatCoV HKU5 can use the MERS-CoV receptor human dipeptidyl peptidase 4 (hDPP4) for cell entry, we tested the ability of Hp-BatCoV HKU25 to bind and use hDPP4. The HKU25-receptor binding domain (RBD) can bind to hDPP4 protein and hDPP4-expressing cells, but it does so with lower efficiency than that of MERS-RBD. Pseudovirus assays showed that HKU25-spike can use hDPP4 for entry to hDPP4-expressing cells, although with lower efficiency than that of MERS-spike and HKU4-spike. Our findings support a bat origin of MERS-CoV and suggest that bat CoV spike proteins may have evolved in a stepwise manner for binding to hDPP4.
MeSH term(s)	Animals ; Betacoronavirus/classification ; Betacoronavirus/genetics ; Betacoronavirus/isolation & purification ; Betacoronavirus/physiology ; Chiroptera ; Dipeptidyl Peptidase 4/metabolism ; Evolution, Molecular ; HEK293 Cells ; Humans ; Phylogeny ; Protein Binding ; Receptors, Virus/metabolism ; Sequence Analysis, DNA ; Spike Glycoprotein, Coronavirus/genetics ; Spike Glycoprotein, Coronavirus/metabolism ; Virus Internalization
Chemical Substances	Receptors, Virus ; Spike Glycoprotein, Coronavirus ; DPP4 protein, human (EC 3.4.14.5) ; Dipeptidyl Peptidase 4 (EC 3.4.14.5)
Keywords	covid19
Language	English
Publishing date	2017-12-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3019-3
ISSN	1537-6613 ; 0022-1899
ISSN (online)	1537-6613
ISSN	0022-1899
DOI	10.1093/infdis/jiy018
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Article ; Online: A naturally occurring HA-stabilizing amino acid (HA1-Y17) in an A(H9N2) low-pathogenic influenza virus contributes to airborne transmission.

Sun, Xiangjie / Belser, Jessica A / Pulit-Penaloza, Joanna A / Brock, Nicole / Kieran, Troy J / Zeng, Hui / Pappas, Claudia / Tumpey, Terrence M / Maines, Taronna R

mBio

2023 Volume 15, Issue 1, Page(s) e0295723

Abstract: Importance: Despite the accumulation of evidence showing that airborne transmissible influenza A virus (IAV) typically has a lower pH threshold for hemagglutinin (HA) fusion activation, the underlying mechanism for such a link remains unclear. In our ... ...

Abstract	Importance: Despite the accumulation of evidence showing that airborne transmissible influenza A virus (IAV) typically has a lower pH threshold for hemagglutinin (HA) fusion activation, the underlying mechanism for such a link remains unclear. In our study, by using a pair of isogenic recombinant A(H9N2) viruses with a phenotypical difference in virus airborne transmission in a ferret model due to an acid-destabilizing mutation (HA1-Y17H) in the HA, we demonstrate that an acid-stable A(H9N2) virus possesses a multitude of advantages over its less stable counterpart, including better fitness in the ferret respiratory tract, more effective aerosol emission from infected animals, and improved host susceptibility. Our study provides supporting evidence for the requirement of acid stability in efficient airborne transmission of IAV and sheds light on fundamental mechanisms for virus airborne transmission.
MeSH term(s)	Animals ; Ferrets ; Hemagglutinin Glycoproteins, Influenza Virus/genetics ; Hemagglutinin Glycoproteins, Influenza Virus/metabolism ; Influenza A Virus, H9N2 Subtype/genetics ; Influenza A Virus, H9N2 Subtype/metabolism ; Respiratory Aerosols and Droplets/virology ; Influenza, Human/transmission ; Humans ; Disease Models, Animal ; Amino Acid Substitution
Chemical Substances	Hemagglutinin Glycoproteins, Influenza Virus
Language	English
Publishing date	2023-12-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	2557172-2
ISSN	2150-7511 ; 2161-2129
ISSN (online)	2150-7511
ISSN	2161-2129
DOI	10.1128/mbio.02957-23
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