Article: Integrated chemical characterization, metabolite profiling, and pharmacokinetics analysis of Zhijun Tangshen Decoction by UPLC-Q/TOF-MS.
2024 Volume 15, Page(s) 1363678
Abstract: ... for the treatment of DN. In this study, the traditional Chinese medicine (TCM) formula, Zhijun Tangshen Decoction ...
Abstract | Diabetic nephropathy (DN) is the main cause of end-stage renal disease worldwide and a major public issue affecting the health of people. Therefore, it is essential to explore effective drugs for the treatment of DN. In this study, the traditional Chinese medicine (TCM) formula, Zhijun Tangshen Decoction (ZJTSD), a prescription modified from the classical formula Didang Decoction, has been used in the clinical treatment of DN. However, the chemical basis underlying the therapeutic effects of ZJTSD in treating DN remains unknown. In this study, compounds of ZJTSD and serum after oral administration in rats were identified and analyzed using ultra-high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC-Q/TOF-MS). Meanwhile, a semi-quantitative approach was used to analyze the dynamic changes in the compounds of ZJTSD |
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Language | English |
Publishing date | 2024-03-08 |
Publishing country | Switzerland |
Document type | Journal Article |
ZDB-ID | 2587355-6 |
ISSN | 1663-9812 |
ISSN | 1663-9812 |
DOI | 10.3389/fphar.2024.1363678 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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