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  1. Article ; Online: Impact of Preinjury Anticoagulation with Warfarin on Outcomes of Adult Trauma Patients: Experience of a Level 1 Trauma Center.

    Hossri, Sami / Ghanem, Sassine / Saouma, Samer / Atanassov, Krassimir

    The American surgeon

    2017  Volume 83, Issue 6, Page(s) e202–204

    MeSH term(s) Aged ; Anticoagulants/administration & dosage ; Blood Coagulation Tests ; Case-Control Studies ; Female ; Glasgow Coma Scale ; Hemorrhage/etiology ; Humans ; Injury Severity Score ; Intensive Care Units/statistics & numerical data ; Length of Stay/statistics & numerical data ; Male ; Risk Factors ; Trauma Centers ; Treatment Outcome ; United States ; Warfarin/administration & dosage ; Wounds and Injuries/mortality ; Wounds and Injuries/surgery
    Chemical Substances Anticoagulants ; Warfarin (5Q7ZVV76EI)
    Language English
    Publishing date 2017-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 202465-2
    ISSN 1555-9823 ; 0003-1348
    ISSN (online) 1555-9823
    ISSN 0003-1348
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Patient-nephrologist prognostic awareness and discordance in end stage renal disease on renal replacement therapy.

    Ghanem, Sassine / Hossri, Sami / Fuca, Nicholas / Granina, Evgenia / Saouma, Samer / Forte, Frank

    International urology and nephrology

    2020  Volume 52, Issue 4, Page(s) 765–773

    Abstract: Purpose: The 1-year mortality rate of patients with end-stage renal disease (ESRD) on renal replacement therapy (RRT) is 20-25% comparable to many cancers. Studies have shown that cancer patients commonly overestimate their likelihood of survival ... ...

    Abstract Purpose: The 1-year mortality rate of patients with end-stage renal disease (ESRD) on renal replacement therapy (RRT) is 20-25% comparable to many cancers. Studies have shown that cancer patients commonly overestimate their likelihood of survival relative to their physicians. It is unclear if this translates into other terminal illnesses.
    Methods: Adult and elderly patients with ESRD on RRT without cognitive defect were interviewed to evaluate their prognostic estimates at 1 and 5 years. Past medical history and demographic data was abstracted from their medical charts. Each patient's proper nephrologist was then interviewed regarding his proper prognostic estimate for this patient. Both the patient and the nephrologist's estimates were compared and a difference of greater than 20% was defined as the threshold for prognostic concordance.
    Results: 77% of patients were found to be in prognostic discordance with their nephrologists. This group was older, had more comorbidities, a lower albumin level and a poorer prognosis. The majority of patients were in disagreement with their nephrologists regarding whether a discussion about prognosis had taken place. The choice of end of life care for 55% of patients was focused on relieving pain and discomfort.
    Conclusion: Communication of prognosis and discussions related to life expectancy and end of life care are lacking in the routine care of ESRD patients. ESRD patients therefore tend to overestimate their prognosis which might lead to overutilization of invasive procedures with increased acute healthcare costs as well as a delay in instigation of palliative or hospice measures.
    MeSH term(s) Adult ; Age Factors ; Aged ; Aged, 80 and over ; Communication ; Comorbidity ; Female ; Health Knowledge, Attitudes, Practice ; Humans ; Kidney Failure, Chronic/psychology ; Kidney Failure, Chronic/therapy ; Life Expectancy ; Male ; Middle Aged ; Nephrologists ; Prognosis ; Renal Replacement Therapy ; Surveys and Questionnaires ; Terminal Care ; Young Adult
    Language English
    Publishing date 2020-03-03
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 204048-7
    ISSN 1573-2584 ; 0301-1623 ; 0042-1162
    ISSN (online) 1573-2584
    ISSN 0301-1623 ; 0042-1162
    DOI 10.1007/s11255-020-02420-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Clinically significant anticardiolipin antibodies associated with COVID-19.

    Hossri, Sami / Shadi, Mahmoud / Hamarsha, Zaid / Schneider, Rick / El-Sayegh, Dany

    Journal of critical care

    2020  Volume 59, Page(s) 32–34

    Abstract: The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well ...

    Abstract The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well documented. We discuss two cases selected from patients requiring critical care in April 2020 in New York City with a unique clinical course. Both cases reveal significant thrombotic events noted on imaging during their hospital course. Obtaining serial inflammatory markers in conjunction with anti-phospholipid antibody testing revealed clinically significant Antiphospholipid syndrome (APS). This case series reviews the details preceding APS observed in SARS-CoV-2 and aims to report findings that could potentially further our understanding of the disease.
    MeSH term(s) Adult ; Antibodies, Anticardiolipin/immunology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Anticoagulants/therapeutic use ; Antiphospholipid Syndrome/blood ; Antiphospholipid Syndrome/complications ; Antiphospholipid Syndrome/immunology ; Antiviral Agents/therapeutic use ; Arterial Occlusive Diseases/etiology ; Betacoronavirus ; COVID-19 ; Cerebral Infarction/etiology ; Computed Tomography Angiography ; Coronavirus Infections/blood ; Coronavirus Infections/complications ; Coronavirus Infections/drug therapy ; Coronavirus Infections/immunology ; Critical Illness ; Female ; Heparin/therapeutic use ; Humans ; Hydroxychloroquine/therapeutic use ; Interleukin 1 Receptor Antagonist Protein/therapeutic use ; Male ; Middle Aged ; New York City ; Pandemics ; Pneumonia, Viral/blood ; Pneumonia, Viral/complications ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/immunology ; SARS-CoV-2 ; Splenic Infarction/etiology ; Thrombosis/blood ; Thrombosis/drug therapy ; Thrombosis/etiology ; Tibial Arteries
    Chemical Substances Antibodies, Anticardiolipin ; Antibodies, Monoclonal, Humanized ; Anticoagulants ; Antiviral Agents ; Interleukin 1 Receptor Antagonist Protein ; Hydroxychloroquine (4QWG6N8QKH) ; Heparin (9005-49-6) ; tocilizumab (I031V2H011)
    Keywords covid19
    Language English
    Publishing date 2020-05-29
    Publishing country United States
    Document type Case Reports
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2020.05.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Primary Pulmonary Hodgkin's Lymphoma: A Rare Etiology of a Cavitary Lung Mass.

    El Hage, Halim / Hossri, Sami / Samra, Bachar / El-Sayegh, Dany

    Cureus

    2017  Volume 9, Issue 8, Page(s) e1620

    Abstract: Primary pulmonary Hodgkin's lymphoma (PPHL) is an uncommon disease. This entity is different from Hodgkin's lymphoma with parenchymal or nodal lung involvement. In this report, we highlight the case of a young female presenting with a six-month history ... ...

    Abstract Primary pulmonary Hodgkin's lymphoma (PPHL) is an uncommon disease. This entity is different from Hodgkin's lymphoma with parenchymal or nodal lung involvement. In this report, we highlight the case of a young female presenting with a six-month history of a productive cough and constitutional B symptoms. Imaging showed cavitary lesions in the right-upper and right-middle lobes. The initial comprehensive infectious workup was negative. Histopathology and immunochemistry confirmed the diagnosis of PPHL. PPHL is an uncommon etiology of cavitary lung lesions. Despite its diagnostic difficulties, awareness of such a disease is crucial, given its high rate of response to treatment, especially in the young population.
    Language English
    Publishing date 2017-08-28
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.1620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Clinically significant anticardiolipin antibodies associated with COVID-19

    Hossri, Sami / Shadi, Mahmoud / Hamarsha, Zaid / Schneider, Rick / El-Sayegh, Dany

    Journal of Critical Care

    2020  Volume 59, Page(s) 32–34

    Keywords Critical Care and Intensive Care Medicine ; covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ZDB-ID 632818-0
    ISSN 1557-8615 ; 0883-9441
    ISSN (online) 1557-8615
    ISSN 0883-9441
    DOI 10.1016/j.jcrc.2020.05.017
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Investigational PD-1 inhibitors for advanced non-small lung cancer: new players in a shifting paradigm.

    Ghanem, Sassine / Valecha, Gautam Krichore / Hossri, Sami / Ibrahim, Uroosa / Atallah, Jean Paul

    Expert opinion on investigational drugs

    2017  Volume 26, Issue 12, Page(s) 1317–1319

    Language English
    Publishing date 2017-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 1182884-5
    ISSN 1744-7658 ; 0967-8298 ; 1354-3784
    ISSN (online) 1744-7658
    ISSN 0967-8298 ; 1354-3784
    DOI 10.1080/13543784.2017.1395019
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Clinically significant anticardiolipin antibodies associated with COVID-19

    Hossri, Sami / Shadi, Mahmoud / Hamarsha, Zaid / Schneider, Rick / El-Sayegh, Dany

    J Crit Care

    Abstract: The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well ...

    Abstract The novel coronavirus strain known as SARS-CoV-2 has rapidly spread around the world creating distinct challenges to the healthcare workforce. Coagulopathy contributing to significant morbidity in critically ill patients with SARS-CoV-2 has now been well documented. We discuss two cases selected from patients requiring critical care in April 2020 in New York City with a unique clinical course. Both cases reveal significant thrombotic events noted on imaging during their hospital course. Obtaining serial inflammatory markers in conjunction with anti-phospholipid antibody testing revealed clinically significant Antiphospholipid syndrome (APS). This case series reviews the details preceding APS observed in SARS-CoV-2 and aims to report findings that could potentially further our understanding of the disease.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #436896
    Database COVID19

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  8. Article: Vanishing Lung Syndrome: Compound Effect of Tobacco and Marijuana Use on the Development of Bullous Lung Disease - A Joint Effort.

    Wiesel, Shimshon / Siddiqui, Faraz / Khan, Tahir / Hossri, Sami / El-Sayegh, Dany

    Cureus

    2017  Volume 9, Issue 7, Page(s) e1530

    Abstract: Marijuana use has been increasing across the United States due to its legalization as both a medicinal and recreational product. A small number of case reports have described a pathological entity called vanishing lung syndrome (VLS), which is a rare ... ...

    Abstract Marijuana use has been increasing across the United States due to its legalization as both a medicinal and recreational product. A small number of case reports have described a pathological entity called vanishing lung syndrome (VLS), which is a rare bullous lung disease usually caused by tobacco smoking. Recent case reports have implicated marijuana in the development of VLS. We present a case of a 47-year-old man, who presented to our hospital with shortness of breath, fevers and a productive cough. On physical exam, he was tachypneic with audible stridor and absent right sided breath sounds. Laryngoscopy showed a retropharyngeal abscess, and chest radiography showed a possible right pneumothorax. Chest computed tomography (CT) showed bilateral bullous emphysematous lung disease with a giant bulla occupying most of his right lung field. He was placed on mechanical ventilation and treated with broad spectrum antibiotics in the intensive care unit, where he developed acute respiratory distress syndrome (ARDS). He continued to decline, and developed disseminated intravascular coagulation, after which he succumbed to his disease.
    Language English
    Publishing date 2017-07-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.1530
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: What we know about surgical therapy in early-stage non-small-cell lung cancer: a guide for the medical oncologist.

    Ghanem, Sassine / El Bitar, Sandy / Hossri, Sami / Weerasinghe, Chanudi / Atallah, Jean Paul

    Cancer management and research

    2017  Volume 9, Page(s) 267–278

    Abstract: Lung cancer remains the leading cause of death in cancer patients. The gold standard for the treatment of early-stage non-small-cell lung cancer is lobectomy with mediastinal lymph-node dissection or systematic lymph-node sampling. The evidence behind ... ...

    Abstract Lung cancer remains the leading cause of death in cancer patients. The gold standard for the treatment of early-stage non-small-cell lung cancer is lobectomy with mediastinal lymph-node dissection or systematic lymph-node sampling. The evidence behind this recommendation is based on the sole randomized controlled trial conducted to date, done by the Lung Cancer Study Group and published in 1995, which found a superiority for lobectomy over sublobar resection with regard to local recurrence rate and improved survival. The population studied at that time were medically fit patients at low risk for surgery with a stage IA non-small-cell lung carcinoma, ie, a solitary tumor less than 3 cm in size. In practice, however, thoracic surgeons have continued to push the limit of a more conservative surgical resection in this patient population. Since then, several retrospective studies have attempted to identify the ideal population to benefit from sublobar resection without it affecting survival or local recurrence. Several variables have been studied, including tumor size, patient age, surgical approach, histological and radiological properties, and optimal surgical resection margin, as well as promising prognostic biomarkers. In this review, we summarize the data available in the literature regarding the surgical approach to patients with stage IA non-small-cell lung cancer studying all the aforementioned variables.
    Language English
    Publishing date 2017-07-06
    Publishing country New Zealand
    Document type Journal Article ; Review
    ZDB-ID 2508013-1
    ISSN 1179-1322
    ISSN 1179-1322
    DOI 10.2147/CMAR.S139253
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Dual carpometacarpal dislocation.

    Jones, Erika / Hossri, Sami / Pilat, Elzbieta / Ljuljic, Tauta / O'Connor, Jamie / Hahn, Barry

    The Journal of emergency medicine

    2015  Volume 48, Issue 4, Page(s) e109–10

    MeSH term(s) Adult ; Humans ; Joint Dislocations/diagnostic imaging ; Male ; Metacarpus/injuries ; Radiography ; Wrist Injuries/diagnostic imaging
    Language English
    Publishing date 2015-04
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 605559-x
    ISSN 0736-4679
    ISSN 0736-4679
    DOI 10.1016/j.jemermed.2014.11.007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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