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Article ; Online: Chemical profiling and quantification of multiple components in Jin-Gu-Lian capsule using a multivariate data processing approach based on UHPLC-Orbitrap Exploris 240 MS and UHPLC-MS/MS.

Zhou, Zu-Ying / Huang, Yong / Xiao, Jin-Chao / Liu, Hui / Wang, Yong-Lin / Gong, Zi-Peng / Li, Yue-Ting / Wang, Ai-Min / Li, Yong-Jun / Zheng, Lin

Journal of separation science

2022 Volume 45, Issue 6, Page(s) 1282–1291

Abstract: The Jin-Gu-Lian capsule, a Chinese Miao herbal compound, is widely used to treat rheumatoid ... developed to analyze the chemical composition of Jin-Gu-Lian capsules. A total of 88 compounds were ... simultaneously determined in the Jin-Gu-Lian capsules. The established method was successfully validated and ...

Abstract	The Jin-Gu-Lian capsule, a Chinese Miao herbal compound, is widely used to treat rheumatoid arthritis. In this study, a rapid, selective, and sensitive UHPLC-Orbitrap Exploris 240 MS method was developed to analyze the chemical composition of Jin-Gu-Lian capsules. A total of 88 compounds were identified, including 23 flavonoids, 23 organic acids, 14 phenylpropanoids, 12 phenols, eight alkaloids, four terpenes, three quinones, and one ketone. Among these, 21 compounds were clearly detected based on a comparison with reference standards and selected as quality control markers. Thereafter, these compounds were simultaneously determined in the Jin-Gu-Lian capsules. The established method was successfully validated and applied for the simultaneous determination of 21 biologically active compounds in Jin-Gu-Lian capsules of 27 sample batches. Quantitative data of the analytes were analyzed using multivariate statistical analysis to determine the quality of the Jin-Gu-Lian capsules. Four compounds (JGLC6 [salidroside], JGLC8 [chlorogenic acid], JGLC12 [liriodendrin], JGLC19 [quercetin]) were identified as chemical markers for quality control of Jin-Gu-Lian capsules. Altogether, the established method was validated as a novel and efficient tool, that can be used for rapid analysis of Jin-Gu-Lian capsules. Accordingly, this study serves as a reference for scientific research on traditional Chinese and ethnic medicine.
MeSH term(s)	Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/analysis ; Flavonoids/analysis ; Quality Control ; Tandem Mass Spectrometry/methods
Chemical Substances	Drugs, Chinese Herbal ; Flavonoids
Language	English
Publishing date	2022-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202100762
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Network Pharmacology and Experimental Validation to Explore the Mechanism of Qing-Jin-Hua-Tan-Decoction Against Acute Lung Injury.

Xiao, Shunli / Liu, Lu / Sun, Zhengxiao / Liu, Xiaoqian / Xu, Jing / Guo, Zhongyuan / Yin, Xiaojie / Liao, Fulong / Xu, Jun / You, Yun / Zhang, Tiejun

Frontiers in pharmacology

2022 Volume 13, Page(s) 891889

Abstract: Qing-Jin-Hua-Tan-Decoction (QJHTD), a classic famous Chinese ancient prescription, has been used ...

Abstract	Qing-Jin-Hua-Tan-Decoction (QJHTD), a classic famous Chinese ancient prescription, has been used for treatment of pulmonary diseases since Ming Dynasty. A total of 22 prototype compounds of QJHTD absorbed into rat blood were chosen as candidates for the pharmacological network analysis and molecular docking. The targets from the intersection of compound target and ALI disease targets were used for GO and KEGG enrichment analyses. Molecular docking was adopted to further verify the interactions between 22 components and the top 20 targets with higher degree values in the component-target-pathway network.
Language	English
Publishing date	2022-07-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2022.891889
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Article ; Online: Deborah S. Jin (1968-2016).

Regal, Cindy / Ye, Jun

Science (New York, N.Y.)

2016 Volume 354, Issue 6313, Page(s) 709

Language	English
Publishing date	2016-11-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	128410-1
ISSN	1095-9203 ; 0036-8075
ISSN (online)	1095-9203
ISSN	0036-8075
DOI	10.1126/science.aal2545
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Zs.A 27: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article: Chemical profiling and quantification of multiple components in Jin‐Gu‐Lian capsule using a multivariate data processing approach based on UHPLC‐Orbitrap Exploris 240 MS and UHPLC‐MS/MS

Zhou, Zu‐Ying / Huang, Yong / Xiao, Jin‐Chao / Liu, Hui / Wang, Yong‐Lin / Gong, Zi‐Peng / Li, Yue‐Ting / Wang, Ai‐Min / Li, Yong‐Jun / Zheng, Lin

Journal of separation science. 2022 Mar., v. 45, no. 6

2022

Abstract: The Jin‐Gu‐Lian capsule, a Chinese Miao herbal compound, is widely used to treat rheumatoid ... developed to analyze the chemical composition of Jin‐Gu‐Lian capsules. A total of 88 compounds were ... simultaneously determined in the Jin‐Gu‐Lian capsules. The established method was successfully validated and ...

Abstract	The Jin‐Gu‐Lian capsule, a Chinese Miao herbal compound, is widely used to treat rheumatoid arthritis. In this study, a rapid, selective, and sensitive UHPLC‐Orbitrap Exploris 240 MS method was developed to analyze the chemical composition of Jin‐Gu‐Lian capsules. A total of 88 compounds were identified, including 23 flavonoids, 23 organic acids, 14 phenylpropanoids, 12 phenols, eight alkaloids, four terpenes, three quinones, and one ketone. Among these, 21 compounds were clearly detected based on a comparison with reference standards and selected as quality control markers. Thereafter, these compounds were simultaneously determined in the Jin‐Gu‐Lian capsules. The established method was successfully validated and applied for the simultaneous determination of 21 biologically active compounds in Jin‐Gu‐Lian capsules of 27 sample batches. Quantitative data of the analytes were analyzed using multivariate statistical analysis to determine the quality of the Jin‐Gu‐Lian capsules. Four compounds (JGLC6 [salidroside], JGLC8 [chlorogenic acid], JGLC12 [liriodendrin], JGLC19 [quercetin]) were identified as chemical markers for quality control of Jin‐Gu‐Lian capsules. Altogether, the established method was validated as a novel and efficient tool, that can be used for rapid analysis of Jin‐Gu‐Lian capsules. Accordingly, this study serves as a reference for scientific research on traditional Chinese and ethnic medicine.
Keywords	chemical species ; chlorogenic acid ; medicine ; multivariate analysis ; quality control ; quercetin ; quinones ; rapid methods ; rheumatoid arthritis ; salidroside ; separation ; terpenoids
Language	English
Dates of publication	2022-03
Size	p. 1282-1291.
Publishing place	John Wiley & Sons, Ltd
Document type	Article
Note	JOURNAL ARTICLE
ZDB-ID	2047990-6
ISSN	1615-9314 ; 1615-9306
ISSN (online)	1615-9314
ISSN	1615-9306
DOI	10.1002/jssc.202100762
Database	NAL-Catalogue (AGRICOLA)

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Article: Theaflavoids A-C, new flavan-3-ols with potent α-glucosidase inhibitory activity from Yunnan black tea 'Jin-Ya'

Li, Na / Chen, Min / Zhu, Hong-Tao / Zhang, Man / Wang, Dong / Yang, Chong-Ren / Zhang, Ying-Jun

Lebensmittel-Wissenschaft + Technologie. 2022 Oct. 01, v. 168

2022

Abstract: ... The extensive investigation on the chemical constituents of Yunnan black tea 'Jin-Ya', produced from the leaf ... only moderate activities. The results indicated that Yunnan black tea 'Jin-Ya' is an ideal drink ...

Abstract	Black tea, rich in various and complex polyphenols, is one of the most popular beverages in the world due to its pleasant aroma and health benefits, such as alleviate hyperglycemia and antioxidant. The extensive investigation on the chemical constituents of Yunnan black tea 'Jin-Ya', produced from the leaf buds of Camellia sinensis var. assamica, led to the isolation and identification of 16 flavonoids including three new flavan-3-ols, namely theaflavoids A-C (1–3). Most of the isolates displayed obvious inhibitory activity on α-glucosidase with IC₅₀ values ranging from 1.11 to 24.7 μM. Notably, the new theaflavoids 1–3 showed much stronger inhibitory activity (IC₅₀ = 1.34, 1.11, and 4.57 μM, respectively) than those of the positive controls (acarbose and quercetin, IC₅₀ = 228 and 9.38 μM, respectively). In addition, the isolated flavonol glycosides 5–16 were evaluated for their antioxidant activities by DPPH and ABTS ⁺ radical scavenging assays. Those with galloyl group in molecular exhibited comparable free radical scavenging activities to the positive controls (ascorbic acid and Trolox), while most of the flavonol glycosides showed only moderate activities. The results indicated that Yunnan black tea 'Jin-Ya' is an ideal drink with hypoglycemic and antioxidant property, and is worthy of regular consumption.
Keywords	Camellia sinensis var. assamica ; acarbose ; antioxidant activity ; antioxidants ; ascorbic acid ; black tea ; flavanols ; free radicals ; glycosides ; hyperglycemia ; leaves ; odors ; polyphenols ; quercetin ; China
Language	English
Dates of publication	2022-1001
Publishing place	Elsevier Ltd
Document type	Article
ZDB-ID	241369-3
ISSN	0460-1173 ; 0023-6438
ISSN	0460-1173 ; 0023-6438
DOI	10.1016/j.lwt.2022.113918
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: New Flavoalkaloids with Potent α-Glucosidase and Acetylcholinesterase Inhibitory Activities from Yunnan Black Tea 'Jin-Ya'.

Li, Na / Zhu, Hong-Tao / Wang, Dong / Zhang, Man / Yang, Chong-Ren / Zhang, Ying-Jun

Journal of agricultural and food chemistry

2020 Volume 68, Issue 30, Page(s) 7955–7963

Abstract: As a subgroup of flavoalkaloids, ...

Abstract	As a subgroup of flavoalkaloids,
MeSH term(s)	Acetylcholinesterase/chemistry ; Alkaloids/chemistry ; Camellia sinensis/chemistry ; China ; Enzyme Inhibitors/chemistry ; Glycosides/chemistry ; Humans ; Kinetics ; Molecular Structure ; Plant Extracts/chemistry ; Plant Leaves/chemistry ; alpha-Glucosidases/chemistry
Chemical Substances	Alkaloids ; Enzyme Inhibitors ; Glycosides ; Plant Extracts ; Acetylcholinesterase (EC 3.1.1.7) ; alpha-Glucosidases (EC 3.2.1.20)
Language	English
Publishing date	2020-07-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	241619-0
ISSN	1520-5118 ; 0021-8561
ISSN (online)	1520-5118
ISSN	0021-8561
DOI	10.1021/acs.jafc.0c02401
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Zs.A 1172: Show issues

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Article ; Online: Erratum: KE JIANG, JIN-LONG REN, JUN-FENG GUO, ZENG WANG, LI DING1 amp; JIA-TANG LI (2020) A new species of the genus Dendrelaphis (Squamata: Colubridae) from Yunnan Province, China, with discussion of the occurrence of D. cyanochloris (Wall, 1921) in China. Zootaxa, 4743: 001-020.

Jiang, K E / Ren, Jin-Long / Guo, Jun-Feng / Wang, Zeng / Ding, L I / Li, Jia-Tang

Zootaxa

2020 Volume 4759, Issue 4, Page(s) zootaxa.4759.4.13

Language	English
Publishing date	2020-04-06
Publishing country	New Zealand
Document type	Journal Article ; Published Erratum
ISSN	1175-5334
ISSN (online)	1175-5334
DOI	10.11646/zootaxa.4759.4.13
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Article ; Online: Metabolomic analysis reveals a protective effect of Fu-Fang-Jin-Qian-Chao herbal granules on oxalate-induced kidney injury.

Chen, Wei / Liu, Wen-Rui / Hou, Jie-Bin / Ding, Jia-Rong / Peng, Zhong-Jiang / Gao, Song-Yan / Dong, Xin / Ma, Jun-Hua / Lin, Qi-Shan / Lu, Jian-Rao / Guo, Zhi-Yong

Bioscience reports

2019 Volume 39, Issue 2

Abstract: ... of persistent renal dysfunction. Fu-Fang-Jin-Qian-Chao granules (FFJQC), a traditional Chinese herb formula, is ...

Abstract	Nephrolithiasis is one of the world's major public health burdens with a high incidence and a risk of persistent renal dysfunction. Fu-Fang-Jin-Qian-Chao granules (FFJQC), a traditional Chinese herb formula, is commonly used in treatment of nephrolithiasis. However, the therapeutic mechanism of FFJQC on kidney stone has still been a mystery. The objective of the present study is to explore the therapeutic mechanism of FFJQC on kidney injury and identify unique metabolomics patterns using a mouse model of kidney stone induced by a calcium oxalate (CaOx) deposition. Von Kossa staining and immuno-histopathological staining of osteopontin (OPN), cluster of differentiation 44 (CD44) and calbindin-D28k were conducted on renal sections. Biochemical analysis was performed on serum, urine, and kidney tissues. A metabolomics approach based on ultra-HPLC coupled with quadrupole-TOF-MS (UHPLC-Q-TOF/MS) was used for serum metabolic profiling. The immunohistopathological and biochemical analysis showed the therapeutic benefits of FFJQC. The expression levels of OPN and CD44 were decreased while calbindin-D28k increased after the CaOx injured mice were treated with FFJQC. In addition, total of 81 serum metabolites were identified to be associated with protective effects of FFJQC on CaOx crystal injured mice. Most of these metabolites were involved in purine, amino acid, membrane lipid and energy metabolism. Potential metabolite biomarkers were found for CaOx crystal-induced renal damage. Potential metabolite biomarkers of CaOx crystal-induced renal damage were found. FFJQC shows therapeutic benefits on CaOx crystal injured mice via regulation of multiple metabolic pathways including amino acids, purine, pyrimidine, glycerolipid, arachidonic acid (AA), sphingolipid, glycerophospholipid, and fatty acid.
MeSH term(s)	Animals ; Calcium Oxalate/adverse effects ; Disease Models, Animal ; Drugs, Chinese Herbal/therapeutic use ; Kidney/drug effects ; Kidney/metabolism ; Kidney/pathology ; Kidney Calculi/drug therapy ; Kidney Calculi/etiology ; Kidney Calculi/metabolism ; Kidney Calculi/pathology ; Male ; Metabolome/drug effects ; Metabolomics ; Mice, Inbred C57BL ; Protective Agents/therapeutic use
Chemical Substances	Drugs, Chinese Herbal ; Protective Agents ; Calcium Oxalate (2612HC57YE)
Language	English
Publishing date	2019-02-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	764946-0
ISSN	1573-4935 ; 0144-8463
ISSN (online)	1573-4935
ISSN	0144-8463
DOI	10.1042/BSR20181833
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 1676: Show issues

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Article: A Metabolic Insight Into the Neuroprotective Effect of Jin-Mai-Tong (JMT) Decoction on Diabetic Rats With Peripheral Neuropathy Using Untargeted Metabolomics Strategy.

Zhang, Qian / Song, Wei / Liang, Xiaochun / Xie, Jun / Shi, Yue / Shi, Xiaohu / Qiu, Bintao / Chen, Xiuting

Frontiers in pharmacology

2020 Volume 11, Page(s) 221

Abstract: Jin-Mai-Tong (JMT) decoction is a traditional Chinese compound prescription for treating diabetic ...

Abstract	Jin-Mai-Tong (JMT) decoction is a traditional Chinese compound prescription for treating diabetic peripheral neuropathy (DPN). The aim of this study is to investigate the neuroprotective effect of JMT decoction on diabetic rats with peripheral neuropathy and to elucidate the potential mechanism based on a metabolomics approach. Sprague-Dawley (SD) rats were randomly divided into four groups: control group, Streptozotocin (STZ) induced model group, JMT low dose (JMT-L) treated group and JMT high dose (JMT-H) treated group. After 12 weeks of treatment, behavioral changes, small fiber loss, and histopathological damages of sciatic nerves were estimated. Serum samples were collected for untargeted metabolomics analysis based on UPLC/QTOF-MS and multivariate statistics. As a result, JMT treatment at two dosages (13.9 and 27.8 g/kg⋅d) evidently improved the mechanical pain threshold (
Language	English
Publishing date	2020-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587355-6
ISSN	1663-9812
ISSN	1663-9812
DOI	10.3389/fphar.2020.00221
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Article ; Online: The characteristics of abnormal wintertime pollution events in the Jing-Jin-Ji region and its relationships with meteorological factors.

Zhu, Wenhui / Xu, Xiangde / Zheng, Jun / Yan, Peng / Wang, Yinjun / Cai, Wenyue

The Science of the total environment

2018 Volume 626, Page(s) 887–898

Abstract: ... events were still encountered in the Beijing-Tianjin-Hebei (Jing-Jin-Ji) region during the winter 2016 ... dynamical and thermal structures, and PBL height over the Jing-Jin-Ji region in history and recent years ...

Abstract	Despite the implementation of strict air pollution control measures in recent years, severe haze events were still encountered in the Beijing-Tianjin-Hebei (Jing-Jin-Ji) region during the winter 2016. In this work, seasonal differences in correlations between air pollution and geographic terrain, atmospheric dynamical and thermal structures, and PBL height over the Jing-Jin-Ji region in history and recent years were investigated and a comprehensive model of atmospheric factors affecting winter air pollution formation was proposed. We found that the distribution of PM
MeSH term(s)	Air Pollutants/analysis ; Air Pollution/statistics & numerical data ; Beijing ; Environmental Monitoring ; Meteorological Concepts ; Particulate Matter/analysis ; Seasons
Chemical Substances	Air Pollutants ; Particulate Matter
Language	English
Publishing date	2018-02-19
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	121506-1
ISSN	1879-1026 ; 0048-9697
ISSN (online)	1879-1026
ISSN	0048-9697
DOI	10.1016/j.scitotenv.2018.01.083
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