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  1. Article: Radio Immune Assay (RIA) Enabled Total Triiodothyronine (TT3) and Total Thyroxine (TT4) in Canine Trypanosomiasis: First Case Report from Maharashtra (India).

    Salutgi, Pragati / Galdhar, Chandrakant / Sonigra, Riddhi / Natu, Kaustubh / Mumbarkar, Neha / Mathkar, Saloni / Dalvie, Arundhati / Gaikwad, Rajiv

    Iranian journal of parasitology

    2022  Volume 18, Issue 1, Page(s) 107–112

    Abstract: Radio Immune Assay (RIA) is an extremely sensitive in vitro assay technique to measure concentrations of antigen viz. hormones in biological fluids using antibodies. The present study reports the status of total triiodothyronine ( ... ...

    Abstract Radio Immune Assay (RIA) is an extremely sensitive in vitro assay technique to measure concentrations of antigen viz. hormones in biological fluids using antibodies. The present study reports the status of total triiodothyronine (TT
    Language English
    Publishing date 2022-11-30
    Publishing country Iran
    Document type Case Reports
    ZDB-ID 2388453-8
    ISSN 2008-238X ; 1735-7020
    ISSN (online) 2008-238X
    ISSN 1735-7020
    DOI 10.18502/ijpa.v18i1.12387
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Clinico-biochemical and therapeutic studies on notoedric mange in pet rabbits

    Galdhar, C. N / Khangal, P. S / Pawar, M. L / Rasal, T. D / Digraskar, S. U

    Journal of parasitic diseases. 2015 Mar., v. 39, no. 1

    2015  

    Abstract: Two male and two female pet rabbits of about 1 year of age, naturally infested with Notoedres cuniculi were studied in the present investigation. Clinical examination revealed presence of crustaceous lesions on the head, ear pinnae, both the limbs and ... ...

    Abstract Two male and two female pet rabbits of about 1 year of age, naturally infested with Notoedres cuniculi were studied in the present investigation. Clinical examination revealed presence of crustaceous lesions on the head, ear pinnae, both the limbs and external genitalia. Microscopic examination of skin scrapings confirmed presence of Notoedres mange infestation. Biochemical parameters revealed altered values of total serum protein, albumin, globulin, and activities of aspartate amino transferase, alanine amino transferase and alkaline phosphatase respectively. The affected rabbits were treated with two injections of Ivermectin (400 μg/kg, subcutaneously, at interval of 15 days) along with supportive therapy. This treatment showed appreciable improvement in clinical signs and restoration in biochemical parameters.
    Keywords Notoedres ; alanine transaminase ; albumins ; alkaline phosphatase ; aspartate transaminase ; blood proteins ; clinical examination ; ears ; genitalia ; head ; ivermectin ; mange ; microscopy ; rabbits ; therapeutics
    Language English
    Dates of publication 2015-03
    Size p. 113-116.
    Publishing place Springer-Verlag
    Document type Article
    ZDB-ID 2548456-4
    ISSN 0975-0703 ; 0971-7196
    ISSN (online) 0975-0703
    ISSN 0971-7196
    DOI 10.1007/s12639-013-0277-6
    Database NAL-Catalogue (AGRICOLA)

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  3. Article: Clinico-biochemical and therapeutic studies on notoedric mange in pet rabbits.

    Galdhar, C N / Khangal, P S / Pawar, M L / Rasal, T D / Digraskar, S U

    Journal of parasitic diseases : official organ of the Indian Society for Parasitology

    2013  Volume 39, Issue 1, Page(s) 113–116

    Abstract: Two male and two female pet rabbits of about 1 year of age, naturally infested with Notoedres cuniculi were studied in the present investigation. Clinical examination revealed presence of crustaceous lesions on the head, ear pinnae, both the limbs and ... ...

    Abstract Two male and two female pet rabbits of about 1 year of age, naturally infested with Notoedres cuniculi were studied in the present investigation. Clinical examination revealed presence of crustaceous lesions on the head, ear pinnae, both the limbs and external genitalia. Microscopic examination of skin scrapings confirmed presence of Notoedres mange infestation. Biochemical parameters revealed altered values of total serum protein, albumin, globulin, and activities of aspartate amino transferase, alanine amino transferase and alkaline phosphatase respectively. The affected rabbits were treated with two injections of Ivermectin (400 μg/kg, subcutaneously, at interval of 15 days) along with supportive therapy. This treatment showed appreciable improvement in clinical signs and restoration in biochemical parameters.
    Language English
    Publishing date 2013-03-12
    Publishing country India
    Document type Journal Article
    ZDB-ID 2548456-4
    ISSN 0975-0703 ; 0971-7196
    ISSN (online) 0975-0703
    ISSN 0971-7196
    DOI 10.1007/s12639-013-0277-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparative in silico-in vivo evaluation of ASGP-R ligands for hepatic targeting of curcumin Gantrez nanoparticles.

    D'Souza, Anisha A / Jain, Puneet / Galdhar, C N / Samad, Abdul / Degani, Mariam S / Devarajan, Padma V

    The AAPS journal

    2013  Volume 15, Issue 3, Page(s) 696–706

    Abstract: The present study aims to design hepatic targeted curcumin (CUR) nanoparticles using Gantrez (GZ) as a polymer. Three carbohydrate-based hepatocyte asialoglycoprotein receptor (ASGP-R) ligands were selected for the study, namely kappa carrageenan (KC), ... ...

    Abstract The present study aims to design hepatic targeted curcumin (CUR) nanoparticles using Gantrez (GZ) as a polymer. Three carbohydrate-based hepatocyte asialoglycoprotein receptor (ASGP-R) ligands were selected for the study, namely kappa carrageenan (KC), arabinogalactan (AG), and pullulan (P). AG and KC are galactose based while P is a glucose-based polymer. CUR-GZ nanoparticles were prepared by nanoprecipitation and anchored with the ligands by nonspecific adsorption onto preformed nanoparticles. The change in zeta potential values confirmed adsorption of the ligands. Docking simulation was evaluated as a tool to predict ligand ASGP-R interactions, using grid-based ligand docking with energies (Glide). Monomers and dimers were used as representative units of polymer for docking analysis. The binding of ASGP-R was validated using D-galactose as monomer. The interaction of the ligands with the receptor was evaluated based on Glide scores and E model values, both for monomers and dimers. The data of the docking study based on Glide scores and E model values suggested higher affinity of AG and P to the ASGP-R, compared to KC. At 1 h, following intravenous administration of the nanoparticles to rats, the in vivo hepatic accumulation in the order CUR-GZAG > CUR-GZKC > CUR-GZP correlated with the docking data based on Glide scores. However, at the end of 6 h, pullulan exhibited maximum hepatic accumulation and arabinogalactan minimum accumulation (p < 0.05). Nevertheless, as predicted by docking analysis, arabinogalactan and pullulan revealed maximum hepatic accumulation. Docking analysis using dimers as representative stereochemical units of polymers provides a good indication of ligand receptor affinity. Docking analysis provides a useful tool for the preliminary screening of ligands for hepatic targeting.
    MeSH term(s) Animals ; Asialoglycoprotein Receptor/chemistry ; Asialoglycoprotein Receptor/metabolism ; Binding Sites/physiology ; Computer Simulation ; Curcumin/chemistry ; Curcumin/metabolism ; Drug Delivery Systems/methods ; Drug Evaluation, Preclinical/methods ; Female ; Hepatocytes/metabolism ; Ligands ; Maleates/chemistry ; Maleates/metabolism ; Nanoparticles/chemistry ; Polyvinyls/chemistry ; Polyvinyls/metabolism ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Asialoglycoprotein Receptor ; Ligands ; Maleates ; Polyvinyls ; polyvinylmethoxyethylene-maleic anhydride copolymer ; Curcumin (IT942ZTH98)
    Language English
    Publishing date 2013-04-12
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Validation Study
    ISSN 1550-7416
    ISSN (online) 1550-7416
    DOI 10.1208/s12248-013-9474-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: Hepatic drug metabolism and lipid peroxidation in thiamine deficient rats.

    Galdhar, N R / Pawar, S S

    International journal for vitamin and nutrition research. Internationale Zeitschrift fur Vitamin- und Ernahrungsforschung. Journal international de vitaminologie et de nutrition

    1976  Volume 46, Issue 1, Page(s) 14–23

    Abstract: In vitro metabolism of aminopyrene, ethylmorphine (Type I substrates), N-methylaniline and ... of thiamine deficiency. However, a significant increase in the in vitro oxidation of aminopyrene, ethylmorphine, N ... lipid peroxidation was also increased during thiamine deficiency. The levels of NADPH cytochrome c ...

    Abstract In vitro metabolism of aminopyrene, ethylmorphine (Type I substrates), N-methylaniline and acetanilide (Type II substrates) in liver microsomal fraction from thiamine deficient male and female rats was studied. No significant change in microsomal protein content was noticed during the period of thiamine deficiency. However, a significant increase in the in vitro oxidation of aminopyrene, ethylmorphine, N-methylaniline and hydroxylation of acetanilide was observed. The NADPH linked and ascorbate induced lipid peroxidation was also increased during thiamine deficiency. The levels of NADPH cytochrome c-reductase, cytochrome b5 and heme were noticeably increased in thiamine deficient animals as compared to normal rats. Phenobarbital treatment induced the activities of all drug enzymes and inhibited the lipid peroxidation in either sex during the period of thiamine deficiency. It appears that thiamine intake is an important determination in drug metabolism and lipid peroxidation.
    MeSH term(s) Acetanilides/metabolism ; Aminopyrine/metabolism ; Aniline Compounds/metabolism ; Animals ; Biotransformation ; Body Weight/drug effects ; Cytochromes/metabolism ; Electron Transport/drug effects ; Female ; Heme/metabolism ; Inactivation, Metabolic ; Lipid Metabolism ; Liver/drug effects ; Male ; Microsomes, Liver/enzymology ; Microsomes, Liver/metabolism ; Morphine Derivatives/metabolism ; NADPH-Ferrihemoprotein Reductase/metabolism ; Organ Size/drug effects ; Oxidation-Reduction ; Phenobarbital/pharmacology ; Rats ; Thiamine Deficiency/metabolism
    Chemical Substances Acetanilides ; Aniline Compounds ; Cytochromes ; Morphine Derivatives ; Aminopyrine (01704YP3MO) ; Heme (42VZT0U6YR) ; NADPH-Ferrihemoprotein Reductase (EC 1.6.2.4) ; Phenobarbital (YQE403BP4D)
    Language English
    Publishing date 1976
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 120692-8
    ISSN 0300-9831
    ISSN 0300-9831
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Uc I Zs.210: Show issues Location:
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    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  6. Article: Effect of inhibitors and phenobarbital pretreatment upon hepatic lipid peroxidation during protein and riboflavin dietary stress in male rats.

    Patel, J M / Galdhar, N R / Javalgekar, S Y / Pawar, S S

    Lipids

    1975  Volume 10, Issue 4, Page(s) 220–226

    Abstract: ... control groups. Cytochrome C inhibited peroxide formation, but the inhibition was greater in rats from the low ...

    Abstract Male young albino rats divided into three groups were maintained on the following diets. The normal group was maintained on 13% casein, 45% corn starch, 31% sucrose, 6% salt mixture, 4% peanut oil, and 1% vitamin mixture. The low protein group animals recieved only 5% casein, and the riboflavin-deficient group was fed normal diet, except that the riboflavin was absent from the vitamin mixture and ordinary casein was replaced by 13% vitamin-free casein. The effects of various inhibitors upon triphosphopyridine nucleotide, reduced form-linked lipid peroxide formation by the supernatant fraction of liver at 9000 × g from rats fed a normal diet, a low protein diet, or a riboflavin-deficient diet for 2,4, and 7 weeks were investigated. A significant decrease in triphosphoryridine nucleotide, reduced form-linked and ascorbate-induced lipid peroxidation was noticed in rats fed on low protein and riboflavin-deficient diet. Glutathione inhibited the triphosphopyridine nucleotide, reduced form-linked lipid peroxidation in rats from all three groups. However, the observed response was variable due to the nature of the diet. The magnitude of inhibition was greater in low protein-fed animals than in animals from the riboflavin-deficient and control groups. Cytochrome C inhibited peroxide formation, but the inhibition was greater in rats from the low protein and riboflavin-deficient groups than in animals from the normal group. Tocopherol exhibited the antioxidant property in all three groups of rats. Deoxycholate inhibited lipid peroxide formation in all the three groups.
    Language English
    Publishing date 1975-04
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 241539-2
    ISSN 1558-9307 ; 0024-4201
    ISSN (online) 1558-9307
    ISSN 0024-4201
    DOI 10.1007/BF02532484
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 645: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (1.OG)
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  7. Article: Clinico-biochemical and therapeutic studies on notoedric mange in pet rabbits

    Galdhar, C. N. / Khangal, P. S. / Pawar, M. L. / Rasal, T. D. / Digraskar, S. U.

    Journal of parasitic diseases

    Volume v. 39,, Issue no. 1

    Abstract: Two male and two female pet rabbits of about 1 year of age, naturally infested with Notoedres cuniculi were studied in the present investigation. Clinical examination revealed presence of crustaceous lesions on the head, ear pinnae, both the limbs and ... ...

    Abstract Two male and two female pet rabbits of about 1 year of age, naturally infested with Notoedres cuniculi were studied in the present investigation. Clinical examination revealed presence of crustaceous lesions on the head, ear pinnae, both the limbs and external genitalia. Microscopic examination of skin scrapings confirmed presence of Notoedres mange infestation. Biochemical parameters revealed altered values of total serum protein, albumin, globulin, and activities of aspartate amino transferase, alanine amino transferase and alkaline phosphatase respectively. The affected rabbits were treated with two injections of Ivermectin (400 μg/kg, subcutaneously, at interval of 15 days) along with supportive therapy. This treatment showed appreciable improvement in clinical signs and restoration in biochemical parameters.
    Keywords therapeutics ; genitalia ; rabbits ; Notoedres ; alkaline phosphatase ; clinical examination ; ivermectin ; aspartate transaminase ; blood proteins ; albumins ; mange ; microscopy ; ears ; head ; alanine transaminase
    Language English
    Document type Article
    ISSN 0971-7196
    Database AGRIS - International Information System for the Agricultural Sciences and Technology

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