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  1. Article: Iliacus Myositis and Bacteremia Caused by Non-typhoidal Salmonella in a Healthy Adult: A Case Report.

    Miyazaki, Yu / Adachi, Takuya

    Cureus

    2024  Volume 16, Issue 1, Page(s) e52182

    Abstract: Typically, non- ... ...

    Abstract Typically, non-typhoidal
    Language English
    Publishing date 2024-01-12
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.52182
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Human mpox presenting with penile edema and ulcer: A case report.

    Miyazaki, Yu / Adachi, Takuya

    Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy

    2024  

    Abstract: Human mpox, which has spread worldwide since May 2022, is characterized by symptoms involving the genital area; however, its treatment methods and clinical course are not completely understood. Furthermore, penile swelling in human mpox can be difficult ... ...

    Abstract Human mpox, which has spread worldwide since May 2022, is characterized by symptoms involving the genital area; however, its treatment methods and clinical course are not completely understood. Furthermore, penile swelling in human mpox can be difficult to differentiate from cellulitis and antibiotic use has been reported in such cases. Herein, we report a case of human mpox in Japan with prominent penile swelling and persistent penile ulcers that improved without specific treatment. The patient was a Japanese man in his 20s with a history of having sexual intercourse with men frequently. He visited Tokyo Metropolitan Toshima Hospital because of a fever and rash in the genital area. Physical examination revealed vesicles on the limbs, penile pigmentation, and significant penile swelling and redness. There were no signs of cellulitis and symptomatic treatment was initiated with outpatient follow-up. After 7 days, an improving trend in penile swelling, redness, and pain was observed. However, a partially black skin ulcer with exudate was observed at the left coronal sulcus of the penis. Therefore, the symptomatic treatment was continued. On illness day 28, the penile swelling completely improved; however, the penile ulcer and pain persisted, and the exudate was observed again. By illness day 63, the pain in his anogenital area had disappeared, and the penile skin ulcer had healed. The following observations were noted in this case: (i) human mpox can improve without specific treatment such as tecovirimat administration and (ii) skin lesions in the genital area may change over time.
    Language English
    Publishing date 2024-01-11
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 1355399-9
    ISSN 1437-7780 ; 1341-321X
    ISSN (online) 1437-7780
    ISSN 1341-321X
    DOI 10.1016/j.jiac.2024.01.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5236: Show issues Location:
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  3. Article: Dual immuno-oncology agents as neoadjuvant therapy for patients with resectable non-small cell lung cancer.

    Adachi, Hiroyuki / Ito, Hiroyuki / Nagashima, Takuya / Isaka, Tetsuya / Saito, Aya

    Translational lung cancer research

    2024  Volume 13, Issue 2, Page(s) 229–235

    Language English
    Publishing date 2024-02-20
    Publishing country China
    Document type Editorial ; Comment
    ZDB-ID 2754335-3
    ISSN 2226-4477 ; 2218-6751
    ISSN (online) 2226-4477
    ISSN 2218-6751
    DOI 10.21037/tlcr-23-738
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Alternatives to water oxidation in the photocatalytic water splitting reaction for solar hydrogen production.

    Wu, Yaqiang / Sakurai, Takuya / Adachi, Takumi / Wang, Qian

    Nanoscale

    2023  Volume 15, Issue 14, Page(s) 6521–6535

    Abstract: The photocatalytic water splitting process to produce ... ...

    Abstract The photocatalytic water splitting process to produce H
    Language English
    Publishing date 2023-04-06
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/d3nr00260h
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: [Thoracoscopic Segmentectomy Using Three-dimensional Image Simulation of the Pulmonary Artery Perfusion Area and Indocyanine Green( ICG) Intravenous Injection Method].

    Nagashima, Takuya / Ito, Hiroyuki / Adachi, Hiroyuki

    Kyobu geka. The Japanese journal of thoracic surgery

    2023  Volume 76, Issue 1, Page(s) 54–58

    Abstract: Purpose: When performing segmentectomy, we aim to keep adequate distance from the tumor using three-dimensional( 3D) images of the pulmonary artery perfusion area and the indocyanine green( ICG) injection method. The effectiveness and improvement of ... ...

    Abstract Purpose: When performing segmentectomy, we aim to keep adequate distance from the tumor using three-dimensional( 3D) images of the pulmonary artery perfusion area and the indocyanine green( ICG) injection method. The effectiveness and improvement of this method were examined.
    Patients and method: We retrospectively investigated 50 consecutive patients who underwent segmentectomy with this method. In simulation, we measured the predicted margin distance( PMD) on a 3D image. Then, we measured the actual margin distance (AMD) on resected specimens fixed in formalin. We compared these two distances and evaluated factors influencing shorter AMD.
    Results: The median AMD was 1.7 cm, and there was no positive margin case. The median ratio of AMD/PMD was 0.73. In multivariate analysis, shorter PMD and no resection of subsegment bronchi next to the tumor were significant factors associated with shorter AMD( p<0.001, p=0.014).
    Conclusions: Our method was effective for segmentectomy. For adequate AMD, a longer PMD in simulation and subsegmental bronchi resection next to the tumor should be considered.
    MeSH term(s) Humans ; Indocyanine Green ; Lung Neoplasms/diagnostic imaging ; Lung Neoplasms/surgery ; Lung Neoplasms/pathology ; Pneumonectomy/methods ; Injections, Intravenous ; Imaging, Three-Dimensional ; Retrospective Studies ; Pulmonary Artery/diagnostic imaging ; Pulmonary Artery/surgery
    Chemical Substances Indocyanine Green (IX6J1063HV)
    Language Japanese
    Publishing date 2023-01-31
    Publishing country Japan
    Document type English Abstract ; Journal Article
    ZDB-ID 603899-2
    ISSN 0021-5252
    ISSN 0021-5252
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Delineating the Ultra-Low Misorientation between the Dislocation Cellular Structures in Additively Manufactured 316L Stainless Steel.

    Sun, Fei / Adachi, Yoshitaka / Sato, Kazuhisa / Ishimoto, Takuya / Nakano, Takayoshi / Koizumi, Yuichiro

    Materials (Basel, Switzerland)

    2024  Volume 17, Issue 8

    Abstract: Sub-micro dislocation cellular structures formed during rapid solidification break the strength-ductility trade-off in laser powder bed fusion (LPBF)-processed 316L stainless steel through high-density dislocations and segregated elements or precipitates ...

    Abstract Sub-micro dislocation cellular structures formed during rapid solidification break the strength-ductility trade-off in laser powder bed fusion (LPBF)-processed 316L stainless steel through high-density dislocations and segregated elements or precipitates at the cellular boundaries. The high-density dislocation entangled at the cellular boundary accommodates solidification strains among the cellular structures and cooling stresses through elastoplastic deformation. Columnar grains with cellular structures typically form along the direction of thermal flux. However, the ultra-low misorientations between the adjacent cellular structures and their interactions with the cellular boundary formation remain unclear. In this study, we revealed the ultra-low misorientations between the cellular structures in LPBF-processed 316L stainless steel using conventional electron backscatter diffraction (EBSD), transmission Kikuchi diffraction (TKD), and transmission electron microscopy (TEM). The conventional EBSD and TKD analysis results could provide misorientation angles smaller than 2°, while the resolution mainly depends on the specimen quality and scanning step size, and so on. A TEM technique with higher spatial resolution provides accurate information between adjacent dislocation cells with misorientation angles smaller than 1°. This study presents evidence that the TEM method is the better and more precise analytical method for the misorientation measurement of the cellular structures and provides insights into measuring the small misorientation angles between adjacent dislocation cells and nanograins in nanostructured metals and alloys with ultrafine-grained microstructures.
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2487261-1
    ISSN 1996-1944
    ISSN 1996-1944
    DOI 10.3390/ma17081851
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Non-biomedical factors in the Ebola virus disease outbreak in West Africa.

    Adachi, Takuya

    Uirusu

    2015  Volume 65, Issue 1, Page(s) 83–88

    Abstract: The outbreak of Ebola virus disease, reported in West Africa in 2014, has become the largest ever one in the history. Tremendous efforts by all the parties concerned are now bringing this epidemic closer to the end, while observing a large number of ... ...

    Abstract The outbreak of Ebola virus disease, reported in West Africa in 2014, has become the largest ever one in the history. Tremendous efforts by all the parties concerned are now bringing this epidemic closer to the end, while observing a large number of cases and deaths, including health care workers.This paper features five questions:1. Why did it emerge in West Africa?2. Why has it spread so wide and intensely?3. Why were so many health care workers infected?4. Why is it being brought under control?5. Would it emerge and spread in Japan in the same way?Ebola virus transmits through human acts such as caregiving of the sick and attending a funeral, therefore an epidemic is not likely to subside naturally, but intentional interventions are needed to terminate its transmission. Who the outbreak response is meant for, either patients, the general public in the affected countries, or international communities, also determines its success or failure.
    MeSH term(s) Africa, Western/epidemiology ; Animals ; Disease Outbreaks ; Family ; Hemorrhagic Fever, Ebola/epidemiology ; Hemorrhagic Fever, Ebola/mortality ; Hemorrhagic Fever, Ebola/transmission ; Humans ; Infectious Disease Transmission, Patient-to-Professional/prevention & control ; Infectious Disease Transmission, Patient-to-Professional/statistics & numerical data ; Patient Care Team
    Language Japanese
    Publishing date 2015
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 603272-2
    ISSN 0042-6857
    ISSN 0042-6857
    DOI 10.2222/jsv.65.83
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 266: Show issues Location:
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  8. Article: A new type of simulated partial gravity apparatus for rats based on a pully-spring system.

    Zhang, Shenke / Adachi, Takuya / Zhang, Shengli / Yoshida, Yukari / Takahashi, Akihisa

    Frontiers in cell and developmental biology

    2022  Volume 10, Page(s) 965656

    Abstract: The return to the Moon and the landing on Mars has emphasized the need for greater attention to the effects of partial gravity on human health. Here, we sought to devise a new type of simulated partial gravity apparatus that could more efficiently and ... ...

    Abstract The return to the Moon and the landing on Mars has emphasized the need for greater attention to the effects of partial gravity on human health. Here, we sought to devise a new type of simulated partial gravity apparatus that could more efficiently and accurately provide a partial gravity environment for rat hindlimbs. The new apparatus uses a pulley system and tail suspension to create the simulated partial gravity of the rat's hind limbs by varying the weight in a balance container attached to the pulley system. An experiment was designed to verify the reliability and stability of the new apparatus. In this experiment, 25 seven-week-old male Wistar Hannover rats were randomly divided into five groups (
    Language English
    Publishing date 2022-08-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2022.965656
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  9. Article ; Online: Chloroquine decreases cardiac fibrosis and improves cardiac function in a mouse model of Duchenne muscular dystrophy.

    Hirata, Takuya / Baba, Shiro / Akagi, Kentaro / Matsuda, Koichi / Umeda, Katsutsugu / Adachi, Souichi / Heike, Toshio / Takita, Junko

    PloS one

    2024  Volume 19, Issue 1, Page(s) e0297083

    Abstract: Background: Duchenne muscular dystrophy (DMD), a severe degenerative skeletal and cardiac muscle disease, has a poor prognosis, and no curative treatments are available. Because decreased autophagy has been reported to contribute to skeletal muscle ... ...

    Abstract Background: Duchenne muscular dystrophy (DMD), a severe degenerative skeletal and cardiac muscle disease, has a poor prognosis, and no curative treatments are available. Because decreased autophagy has been reported to contribute to skeletal muscle degeneration, therapies targeting autophagy are expected to improve skeletal muscle hypofunction. However, the role of this regulatory mechanism has not been evaluated clearly in DMD cardiomyocytes.
    Methods: In this present study, we evaluated myocardial fibrosis and its mechanism in mdx mice, a model of DMD, and also evaluated changes in cardiac function.
    Results: As assessed by LC3 immunohistochemistry, a small number of autophagosomes were detected in cardiomyocytes of both mdx mice and control wild-type (WT) mice. The number of autophagosomes was significantly enhanced by 4 weeks of isoproterenol-induced cardiac stress in cardiomyocytes of mdx but not WT mice. Simultaneously, isoproterenol increased cardiomyocyte fibrosis in mdx but not WT mice. Administration of chloroquine significantly decreased cardiomyocyte fibrosis in mdx mice, even after isoproterenol treatment. Left ventricle size and function were evaluated by echocardiography. Left ventricular contraction was decreased in mdx mice after isoproterenol treatment compared with control mice, which was alleviated by chloroquine administration.
    Conclusions: Heart failure in DMD patients is possibly treated with chloroquine, and the mechanism probably involves chloroquine's anti-inflammatory effects.
    MeSH term(s) Humans ; Mice ; Animals ; Muscular Dystrophy, Duchenne/pathology ; Mice, Inbred mdx ; Isoproterenol/pharmacology ; Cardiomyopathies ; Muscle, Skeletal ; Myocytes, Cardiac/pathology ; Fibrosis ; Disease Models, Animal ; Dystrophin
    Chemical Substances Isoproterenol (L628TT009W) ; Dystrophin
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0297083
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Deep learning model to predict Ki-67 expression of breast cancer using digital breast tomosynthesis.

    Oba, Ken / Adachi, Maki / Kobayashi, Tomoya / Takaya, Eichi / Shimokawa, Daiki / Fukuda, Toshinori / Takahashi, Kengo / Yagishita, Kazuyo / Ueda, Takuya / Tsunoda, Hiroko

    Breast cancer (Tokyo, Japan)

    2024  

    Abstract: Background: Developing a deep learning (DL) model for digital breast tomosynthesis (DBT) images to predict Ki-67 expression.: Methods: The institutional review board approved this retrospective study and waived the requirement for informed consent ... ...

    Abstract Background: Developing a deep learning (DL) model for digital breast tomosynthesis (DBT) images to predict Ki-67 expression.
    Methods: The institutional review board approved this retrospective study and waived the requirement for informed consent from the patients. Initially, 499 patients (mean age: 50.5 years, range: 29-90 years) referred to our hospital for breast cancer were participated, 126 patients with pathologically confirmed breast cancer were selected and their Ki-67 expression measured. The Xception architecture was used in the DL model to predict Ki-67 expression levels. The high Ki-67 vs low Ki-67 expression diagnostic performance of our DL model was assessed by accuracy, sensitivity, specificity, areas under the receiver operating characteristic curve (AUC), and by using sub-datasets divided by the radiological characteristics of breast cancer.
    Results: The average accuracy, sensitivity, specificity, and AUC were 0.912, 0.629, 0.985, and 0.883, respectively. The AUC of the four subgroups separated by radiological findings for the mass, calcification, distortion, and focal asymmetric density sub-datasets were 0.890, 0.750, 0.870, and 0.660, respectively.
    Conclusions: Our results suggest the potential application of our DL model to predict the expression of Ki-67 using DBT, which may be useful for preoperatively determining the treatment strategy for breast cancer.
    Language English
    Publishing date 2024-03-07
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2052429-8
    ISSN 1880-4233 ; 1340-6868
    ISSN (online) 1880-4233
    ISSN 1340-6868
    DOI 10.1007/s12282-024-01549-7
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    Zs.A 5536: Show issues Location:
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