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Article ; Online: Effects of dual therapy with betamethasone and tetracycline in a NC/Nga mouse model of atopic dermatitis.

Matsui, Katsuhiko / Kobayashi, Mahoka / Nagano, Mari / Matsuoka, Mio

Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques

2023 Volume 26, Page(s) 11182

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Mice ; Animals ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/pathology ; Betamethasone/pharmacology ; Betamethasone/therapeutic use ; Staphylococcus aureus ; Immunoglobulin E ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Skin ; Tetracycline/pharmacology ; Tetracycline/therapeutic use ; Disease Models, Animal
Chemical Substances	Betamethasone (9842X06Q6M) ; Immunoglobulin E (37341-29-0) ; Anti-Bacterial Agents ; Tetracycline (F8VB5M810T)
Language	English
Publishing date	2023-01-19
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1422972-9
ISSN	1482-1826 ; 1482-1826
ISSN (online)	1482-1826
ISSN	1482-1826
DOI	10.3389/jpps.2023.11182
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Article ; Online: Effects of β-glucan Rich Barley Flour on Glucose and Lipid Metabolism in the Ileum, Liver, and Adipose Tissues of High-Fat Diet Induced-Obesity Model Male Mice Analyzed by DNA Microarray.

Mio, Kento / Yamanaka, Chiemi / Matsuoka, Tsubasa / Kobayashi, Toshiki / Aoe, Seiichiro

Nutrients

2020 Volume 12, Issue 11

Abstract: We evaluated whether intake of β-glucan-rich barley flour affects expression levels of genes related to glucose and lipid metabolism in the ileum, liver, and adipose tissues of mice fed a high-fat diet. C57BL/6J male mice were fed a high-fat diet ... ...

Abstract	We evaluated whether intake of β-glucan-rich barley flour affects expression levels of genes related to glucose and lipid metabolism in the ileum, liver, and adipose tissues of mice fed a high-fat diet. C57BL/6J male mice were fed a high-fat diet supplemented with high β-glucan barley, for 92 days. We measured the expression levels of genes involved in glucose and lipid metabolism in the ileum, liver, and adipose tissues using DNA microarray and q-PCR. The concentration of short-chain fatty acids (SCFAs) in the cecum was analyzed by GC/MS. The metabolic syndrome indices were improved by barley flour intake. Microarray analysis showed that the expression of genes related to steroid synthesis was consistently decreased in the liver and adipose tissues. The expression of genes involved in glucose metabolism did not change in these organs. In liver, a negative correlation was showed between some SCFAs and the expression levels of mRNA related to lipid synthesis and degradation. Barley flour affects lipid metabolism at the gene expression levels in both liver and adipose tissues. We suggest that SCFAs are associated with changes in the expression levels of genes related to lipid metabolism in the liver and adipose tissues, which affect lipid accumulation.
MeSH term(s)	Adipose Tissue/metabolism ; Animals ; Diet, High-Fat ; Disease Models, Animal ; Flour ; Glucose/metabolism ; Hordeum ; Ileum/metabolism ; Lipid Metabolism/drug effects ; Liver/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Obesity/metabolism ; Oligonucleotide Array Sequence Analysis/methods ; beta-Glucans/pharmacology
Chemical Substances	beta-Glucans ; Glucose (IY9XDZ35W2)
Language	English
Publishing date	2020-11-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu12113546
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Article ; Online: Ectopically Localized Epithelial Cell Clumps in Ulcers Are Derived from Reserved Crypt Stem Cells in a Mouse Model of Ulcerative Colitis.

Kobayashi, Mio / Yamashita, Risako / Ichikawa, Ryo / Shibutani, Makoto / Yoshida, Toshinori

Digestive diseases and sciences

2022 Volume 67, Issue 10, Page(s) 4770–4779

Abstract: Background: We previously reported that clumps of a few epithelial cells were scattered in ulcer regions in a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis (UC).: Aims: To determine the ectopically localized epithelial clumps ...

Abstract	Background: We previously reported that clumps of a few epithelial cells were scattered in ulcer regions in a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis (UC). Aims: To determine the ectopically localized epithelial clumps might be derived from stem cells or their daughter progenitor cells. Methods: Female BALB/c mice were administered DSS in drinking water for 6 days, followed by withdrawal of DSS for 6 days. Histological and immunohistochemical examinations were conducted in the distal region and proximal region of the colorectum to determine expression of stem cell markers in the epithelial clumps. Results: Similar to the characteristics of UC, the ulcers were more severe in the distal region close to the anus than in the proximal region of the colorectum. Quantitative analyses revealed that the epithelial clumps appeared in relation to the severity of the ulcer, and they expressed the cell adhesion molecules E-cadherin and β-catenin. Among stem cell markers, the epithelial clumps primarily expressed +5 cell marker Dll1 as reserved intestinal stem cells, followed by +4 cell marker Bmi1 and crypt stem cell marker Lgr5 in that order. Nuclear expression of Sox9, but not nuclear β-catenin, was identified in the clumps. Conclusion: The present results suggest that most epithelial clumps comprised crypt-derived, reserved stem cells, which might have potential for mucosal healing.
MeSH term(s)	Animals ; Cadherins/metabolism ; Colitis/chemically induced ; Colitis, Ulcerative/pathology ; Dextran Sulfate/toxicity ; Disease Models, Animal ; Drinking Water/adverse effects ; Drinking Water/metabolism ; Epithelial Cells/metabolism ; Female ; Intestinal Mucosa/metabolism ; Mice ; Mice, Inbred BALB C ; Mice, Inbred C57BL ; Stem Cells/pathology ; Ulcer/chemically induced ; Ulcer/pathology ; beta Catenin/metabolism
Chemical Substances	Cadherins ; Drinking Water ; beta Catenin ; Dextran Sulfate (9042-14-2)
Language	English
Publishing date	2022-01-28
Publishing country	United States
Document type	Journal Article
ZDB-ID	304250-9
ISSN	1573-2568 ; 0163-2116
ISSN (online)	1573-2568
ISSN	0163-2116
DOI	10.1007/s10620-021-07340-4
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Article ; Online: Age-related changes and sex differences in ankle plantarflexion velocity.

Kanayama, Atsuki / Yamamoto, Saki / Ueba, Ryoga / Kobayashi, Mio / Ohmine, Toshimitsu / Iwata, Akira

Scientific reports

2023 Volume 13, Issue 1, Page(s) 22943

Abstract: Ankle plantar flexors play a vital role in the mobility of older adults. The strength and velocity of plantarflexion are critical factors in determining walking speed. Despite reports on how age and sex affect plantarflexion strength, basic information ... ...

Abstract	Ankle plantar flexors play a vital role in the mobility of older adults. The strength and velocity of plantarflexion are critical factors in determining walking speed. Despite reports on how age and sex affect plantarflexion strength, basic information regarding plantarflexion velocity is still lacking. This cross-sectional observational study investigated age-related changes and sex differences in plantarflexion velocity by comparing them with plantarflexion strength. A total of 550 healthy adults were classified into four age groups for each sex: Young (< 40 years old), Middle-aged (40-64 years old), Young-old (65-74 years old), and Older-old (≧ 75 years old). We measured plantarflexion velocity and strength in the long-sitting position using a gyroscope and a hand-held dynamometer, respectively. Two-way analysis of variance revealed no interaction between age and sex for either plantarflexion velocity or strength. Plantarflexion velocity exhibited a significant decline with aging, as did the plantarflexion strength. We found no significant sex differences in plantarflexion velocity in contrast to plantarflexion strength. The results indicated a significant decrease with age and no difference in plantarflexion velocity between males and females characteristic plantarflexion velocity. Understanding the characteristics of plantarflexion velocity could contribute to preventing a decline in mobility in older adults.
MeSH term(s)	Middle Aged ; Humans ; Male ; Female ; Aged ; Adult ; Ankle ; Cross-Sectional Studies ; Sex Characteristics ; Muscle, Skeletal ; Muscle Strength ; Ankle Joint
Language	English
Publishing date	2023-12-22
Publishing country	England
Document type	Observational Study ; Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-50275-1
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Article: Anti-Müllerian hormone beyond an ovarian reserve marker: the relationship with the physiology and pathology in the life-long follicle development.

Iwase, Akira / Hasegawa, Yuko / Tsukui, Yumiko / Kobayashi, Mio / Hiraishi, Hikaru / Nakazato, Tomoko / Kitahara, Yoshikazu

Frontiers in endocrinology

2023 Volume 14, Page(s) 1273966

Abstract: Anti-Müllerian hormone (AMH), an indirect indicator of the number of remaining follicles, is clinically used as a test for ovarian reserve. Typically, a decline suggests a decrease in the number of remaining follicles in relation to ovarian toxicity ... ...

Abstract	Anti-Müllerian hormone (AMH), an indirect indicator of the number of remaining follicles, is clinically used as a test for ovarian reserve. Typically, a decline suggests a decrease in the number of remaining follicles in relation to ovarian toxicity caused by interventions, which may implicate fertility. In contrast, serum AMH levels are elevated in patients with polycystic ovary syndrome. AMH is produced primarily in the granulosa cells of the preantral and small antral follicles. Thus it varies in association with folliculogenesis and the establishment and shrinking of the follicle cohort. Ovarian activity during the female half-life, from the embryonic period to menopause, is based on folliculogenesis and maintenance of the follicle cohort, which is influenced by developmental processes, life events, and interventions. AMH trends over a woman's lifetime are associated with
MeSH term(s)	Humans ; Female ; Anti-Mullerian Hormone ; Ovarian Reserve ; Ovarian Follicle/physiology ; Ovary ; Fertility/physiology ; Peptide Hormones
Chemical Substances	Anti-Mullerian Hormone (80497-65-0) ; Peptide Hormones
Language	English
Publishing date	2023-11-03
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1273966
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Article ; Online: Biodegradation of the methylenedioxyphenyl group in piperine and its derivatives: discovery of a novel methylenetransferase in an actinomycete.

Jian, Pu / Kumano, Takuto / Kimura, Mio / Kurisaki, Makoto / Hashimoto, Yoshiteru / Kobayashi, Michihiko

Applied and environmental microbiology

2023 Volume 89, Issue 11, Page(s) e0114523

Abstract: Importance: Pepper is a spice that has been used worldwide since the Age of Discovery. The substance that is responsible for the spiciness in pepper is piperine, a type of alkaloid. It has never been reported how piperine is degraded by microorganisms. ... ...

Abstract	Importance: Pepper is a spice that has been used worldwide since the Age of Discovery. The substance that is responsible for the spiciness in pepper is piperine, a type of alkaloid. It has never been reported how piperine is degraded by microorganisms. In this study, we discovered a bacterium in the soil that is capable of catabolizing piperine as its sole nitrogen source. Furthermore, we discovered the enzyme involved in piperine metabolism. This enzyme decomposed the methylenedioxyphenyl group, which is the common structure in various plant-derived bioactive compounds such as sesamin, piperonal, safrole, and berberin. By utilizing this enzyme, piperine can be converted into a useful antioxidant compound. The findings about previously unknown metabolic pathways in nature can lead to the discovery of new enzymes and provide methods for the enzymatic synthesis of useful compounds.
MeSH term(s)	Actinobacteria ; Alkaloids ; Polyunsaturated Alkamides/chemistry ; Piperidines/chemistry
Chemical Substances	piperine (U71XL721QK) ; Alkaloids ; Polyunsaturated Alkamides ; Piperidines
Language	English
Publishing date	2023-10-24
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	223011-2
ISSN	1098-5336 ; 0099-2240
ISSN (online)	1098-5336
ISSN	0099-2240
DOI	10.1128/aem.01145-23
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Article ; Online: Morphological identification in skull between spotted seal and harbor seal using geometric morphometrics.

Arai, Yuichi / Kanaiwa, Minoru / Kato, Mio / Kobayashi, Mari

Journal of morphology

2021 Volume 282, Issue 10, Page(s) 1455–1465

Abstract: The morphology of the skull contains considerable ecological information about a species, because the skull contains sensory organs that are used to look for food, compete for mates, or to migrate. Spotted seals (Phoca largha) and harbor seals (Phoca ... ...

Abstract	The morphology of the skull contains considerable ecological information about a species, because the skull contains sensory organs that are used to look for food, compete for mates, or to migrate. Spotted seals (Phoca largha) and harbor seals (Phoca vitulina) are similar in body size and pelage color but differ in habitat use and reproductive biology. The current study aims to clarify differences in the shapes of skulls in the spotted and harbor seals using geometric morphometrics and to discuss whether ecological differences can explain morphological differences in skulls. First, we discovered that the age at which the shape of skulls stopped changing was 7 years in both species, using the linear-threshold model. Using a total of 75 landmarks, 54 individuals (25 spotted seals, 29 harbor seals) that were older than the age at which skulls stopped changing were correctly identified at a rate of 100%. The total of 75 landmarks was narrowed down to eight key landmarks that resulted in an identification accuracy rate of 100% using random forests. Of the eight landmarks, seven were related to feeding apparatus, indicated that the harbor seal had a broader mouth and mandible than the spotted seal. Because of both species were dietary generalists and classified as pierce feeders, we suggested that the different features in the shapes of their skulls were caused not only by differences in their feeding behavior but also other differences related to reproductive behavior.
MeSH term(s)	Animals ; Caniformia ; Feeding Behavior ; Phoca ; Skull
Language	English
Publishing date	2021-07-31
Publishing country	United States
Document type	Journal Article
ZDB-ID	3084-3
ISSN	1097-4687 ; 0022-2887 ; 0362-2525
ISSN (online)	1097-4687
ISSN	0022-2887 ; 0362-2525
DOI	10.1002/jmor.21397
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Article ; Online: Effects of Strong Ground Motion with Identical Response Spectra and Different Duration on Pile Support Mechanism and Seismic Resistance of Spherical Gas Holders on Soft Ground

Mio Kobayashi / Toshihiro Noda / Kentaro Nakai / Toshihiro Takaine / Akira Asaoka

Applied Sciences, Vol 11, Iss 11152, p

2021 Volume 11152

Abstract: Safety measures are required for spherical gas holders to prevent them from malfunctioning even after a large earthquake. In this study, considering the strong nonlinearity of the ground and damage to the pile during an earthquake, a three-dimensional ... ...

Abstract	Safety measures are required for spherical gas holders to prevent them from malfunctioning even after a large earthquake. In this study, considering the strong nonlinearity of the ground and damage to the pile during an earthquake, a three-dimensional seismic response analysis of the holder–pile–ground interaction system was conducted for an actual gas holder on the soft ground consisting of alternating layers of sand and clay. In the analysis, the seismic response of the structure to strong ground motions of different durations with the same acceleration response spectrum was verified. The results show that the piles were relatively effective in controlling the settlement when the duration of the earthquake motion was long. This is because the axial force acting on the pile increased due to the redistribution of the holder load caused by the lowering of the effective confining pressure of the sand and clay layers during the earthquake, which increased the bearing capacity of the pile. In contrast, when the duration of the seismic motion was short, the piles had little effect on the reduction in the settlement because the maximum acceleration was higher than that in the former case, and the piles immediately lost their support function.
Keywords	seismic resistance ; earthquake duration ; response spectra ; soil–water coupled finite deformation analysis ; gas holder ; pile foundation ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	550
Language	English
Publishing date	2021-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Kinetic Analysis of the Motility of Giant Virus-Infected Amoebae Using Phase-Contrast Microscopic Images.

Fukaya, Sho / Aoki, Keita / Kobayashi, Mio / Takemura, Masaharu

Frontiers in microbiology

2020 Volume 10, Page(s) 3014

Abstract: Tracking cell motility is a useful tool for the study of cell physiology and microbiology. Although phase-contrast microscopy is commonly used, the existence of optical artifacts called "halo" and "shade-off" have inhibited image analysis of moving cells. ...

Abstract	Tracking cell motility is a useful tool for the study of cell physiology and microbiology. Although phase-contrast microscopy is commonly used, the existence of optical artifacts called "halo" and "shade-off" have inhibited image analysis of moving cells. Here we show kinetic image analysis of
Language	English
Publishing date	2020-01-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2019.03014
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Article ; Online: Anti-Müllerian hormone levels in the diagnosis of adolescent polycystic ovarian syndrome: a systematic review and meta-analysis.

Tsukui, Yumiko / Kitahara, Yoshikazu / Hasegawa, Yuko / Kobayashi, Mio / Osuka, Satoko / Iwase, Akira

Endocrine journal

2022 Volume 69, Issue 8, Page(s) 897–906

Abstract: Polycystic ovary syndrome (PCOS) is an endocrine disorder that causes menstrual cycle irregularities and infertility. PCOS is diagnosed based on hyperandrogenism, polycystic ovarian morphology (PCOM), and an-/oligo-ovulation. Upregulation of anti- ... ...

Abstract	Polycystic ovary syndrome (PCOS) is an endocrine disorder that causes menstrual cycle irregularities and infertility. PCOS is diagnosed based on hyperandrogenism, polycystic ovarian morphology (PCOM), and an-/oligo-ovulation. Upregulation of anti-Müllerian hormone (AMH) in the serum of women with PCOS may be another suitable alternative diagnostic criterion for PCOM. However, previous meta-analyses have reported conflicting results due to the age-dependent decline in serum AMH levels. Therefore, we performed a meta-analysis to evaluate the threshold of AMH for the diagnosis of PCOS in adolescents and women in their early twenties. Fifteen trials were included in this meta-analysis. PCOS is diagnosed with either Rotterdam criteria, NIH, or AE-PCOS. AMH levels were significantly higher in adolescents with PCOS (weighted mean difference, 3.05; 95% confidence interval: 2.09-4.01) than in the control group. The cutoff values of AMH for the diagnosis of adolescent PCOS were 6.1, 6.26, 7.03, 7.11, 7.2, and 7.25 ng/mL in the studies that reported the usefulness of AMH levels. The summary receiver operating characteristic analysis of the diagnostic accuracy demonstrated that the specificity and sensitivity were 81% and 66.3%, respectively. Our meta-analysis demonstrates that AMH may be a useful diagnostic test for adolescent PCOS and, based on the previous studies included in the meta-analysis, its cutoff value was estimated to be 6-7 ng/mL.
MeSH term(s)	Adolescent ; Anti-Mullerian Hormone ; Female ; Humans ; Hyperandrogenism ; Infertility ; Peptide Hormones ; Polycystic Ovary Syndrome ; ROC Curve
Chemical Substances	Peptide Hormones ; Anti-Mullerian Hormone (80497-65-0)
Language	English
Publishing date	2022-06-08
Publishing country	Japan
Document type	Journal Article ; Meta-Analysis ; Systematic Review
ZDB-ID	1151918-6
ISSN	1348-4540 ; 0918-8959
ISSN (online)	1348-4540
ISSN	0918-8959
DOI	10.1507/endocrj.EJ22-0081
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