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  1. Book: Multiple myeloma

    Heuck, Christoph / Weinhold, Niels

    methods and protocols

    (Methods in molecular biology ; 1792 ; Springer protocols)

    2018  

    Author's details edited by Christoph Heuck, Niels Weinhold
    Series title Methods in molecular biology ; 1792
    Springer protocols
    Collection
    Keywords Flowcytometry ; FISH ; signaling pathways ; PCR ; Microarray
    Subject code 610
    Language English
    Size x, 216 Seiten, Illustrationen,, 25.4 cm x 17.8 cm
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT019733443
    ISBN 978-1-4939-7864-9 ; 1-4939-7864-0 ; 9781493978656 ; 1493978659
    Database Catalogue ZB MED Medicine, Health

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    Shelf markLoan statusLocation
    Zs A 7042 -1792- verfügbar in Königswinter Königswinter

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  2. Article ; Online: The Immune Microenvironment in Multiple Myeloma Progression at a Single-cell Level.

    Schinke, Carolina / Weinhold, Niels

    HemaSphere

    2023  Volume 7, Issue 6, Page(s) e894

    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Editorial
    ISSN 2572-9241
    ISSN (online) 2572-9241
    DOI 10.1097/HS9.0000000000000894
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: When a solitary plasmacytoma is just the beginning….

    Rasche, Leo / Weinhold, Niels

    Blood

    2023  Volume 142, Issue 22, Page(s) 1849–1850

    MeSH term(s) Humans ; Plasmacytoma/diagnosis ; Chromosome Aberrations ; Disease Progression
    Language English
    Publishing date 2023-12-01
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood.2023021859
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Editorial: The role of the bone marrow microenvironment in multiple myeloma evolution and therapy.

    Schinke, Carolina / Weinhold, Niels / Delgado-Calle, Jesus

    Frontiers in oncology

    2023  Volume 13, Page(s) 1157555

    Language English
    Publishing date 2023-02-21
    Publishing country Switzerland
    Document type Editorial
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2023.1157555
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  5. Article ; Online: Impact of Clonal Heterogeneity in Multiple Myeloma.

    Schinke, Carolina / Rasche, Leo / Raab, Marc S / Weinhold, Niels

    Hematology/oncology clinics of North America

    2024  Volume 38, Issue 2, Page(s) 461–476

    Abstract: Multiple myeloma is characterized by a highly heterogeneous disease distribution within the bone marrow-containing skeletal system. In this review, we introduce the molecular mechanisms underlying clonal heterogeneity and the spatio-temporal evolution of ...

    Abstract Multiple myeloma is characterized by a highly heterogeneous disease distribution within the bone marrow-containing skeletal system. In this review, we introduce the molecular mechanisms underlying clonal heterogeneity and the spatio-temporal evolution of myeloma. We discuss the clinical impact of clonal heterogeneity, which is thought to be one of the biggest obstacles to overcome therapy resistance and to achieve cure.
    MeSH term(s) Humans ; Multiple Myeloma/genetics ; Multiple Myeloma/therapy ; Bone Marrow ; Clonal Evolution/genetics
    Language English
    Publishing date 2024-01-08
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2023.12.012
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: (Smoldering) multiple myeloma: mismatch between tumor load estimated from bone marrow biopsy at iliac crest and tumor load shown by MRI.

    Bauer, Fabian / Sauer, Sandra / Weinhold, Niels / Delorme, Stefan / Wennmann, Markus

    Skeletal radiology

    2023  Volume 52, Issue 12, Page(s) 2513–2518

    Abstract: In multiple myeloma and its precursor stages, precise quantification of tumor load is of high importance for diagnosis, risk assessment, and therapy response evaluation. Both whole-body MRI, which allows to investigate the complete bone marrow of a ... ...

    Abstract In multiple myeloma and its precursor stages, precise quantification of tumor load is of high importance for diagnosis, risk assessment, and therapy response evaluation. Both whole-body MRI, which allows to investigate the complete bone marrow of a patient, and bone marrow biopsy, which is commonly used to assess the histologic and genetic status, are relevant methods for tumor load assessment in multiple myeloma. We report on a series of striking mismatches between the plasma cell infiltration estimating the tumor load from unguided biopsies of the bone marrow at the posterior iliac crest and the tumor load assessment from whole-body MRI.
    MeSH term(s) Humans ; Bone Marrow/diagnostic imaging ; Bone Marrow/pathology ; Multiple Myeloma/diagnostic imaging ; Multiple Myeloma/pathology ; Ilium/diagnostic imaging ; Ilium/pathology ; Tumor Burden ; Magnetic Resonance Imaging/methods ; Biopsy
    Language English
    Publishing date 2023-06-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 527592-1
    ISSN 1432-2161 ; 0364-2348
    ISSN (online) 1432-2161
    ISSN 0364-2348
    DOI 10.1007/s00256-023-04383-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Correction to: A Rapid and Robust Protocol for Reduced Representation Bisulfite Sequencing in Multiple Myeloma.

    Heuck, Christoph / Weinhold, Niels

    Methods in molecular biology (Clifton, N.J.)

    2019  Volume 1792, Page(s) E3

    Abstract: The text highlighted in bold in the below line in Chapter 13 has been replaced as given below. "Chapter 13 Page no. 186. ...

    Abstract The text highlighted in bold in the below line in Chapter 13 has been replaced as given below. "Chapter 13 Page no. 186.
    Language English
    Publishing date 2019-02-06
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1940-6029
    ISSN (online) 1940-6029
    DOI 10.1007/978-1-4939-7865-6_17
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Sequence diversity of kappa light chains from patients with AL amyloidosis and multiple myeloma.

    Schreiner, Sarah / Berghaus, Natalie / Poos, Alexandra M / Raab, Marc S / Besemer, Britta / Fenk, Roland / Goldschmidt, Hartmut / Mai, Elias K / Müller-Tidow, Carsten / Weinhold, Niels / Hegenbart, Ute / Huhn, Stefanie / Schönland, Stefan O

    Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis

    2024  , Page(s) 1–9

    Abstract: Background: AL amyloidosis (AL) results from the misfolding of immunoglobulin light chains (IG LCs). Aim of this study was to comprehensively analyse kappa LC sequences from AL patients in comparison with multiple myeloma (MM).: Objective: We ... ...

    Abstract Background: AL amyloidosis (AL) results from the misfolding of immunoglobulin light chains (IG LCs). Aim of this study was to comprehensively analyse kappa LC sequences from AL patients in comparison with multiple myeloma (MM).
    Objective: We analysed
    Material and methods: cDNA and bulk RNA sequencing of the LCs of AL and MM patients.
    Results: We studied 41 AL and 83 MM patients showing that
    Conclusion: This study confirmed that germline usage has an influence on AL amyloidosis risk and organ involvement.
    Language English
    Publishing date 2024-01-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1205246-2
    ISSN 1744-2818 ; 1350-6129
    ISSN (online) 1744-2818
    ISSN 1350-6129
    DOI 10.1080/13506129.2023.2295221
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  9. Article ; Online: Cyclophosphamide etoposide dexamethasone as salvage and bridging therapy in relapsed refractory and extramedullary multiple myeloma.

    Kauer, Joseph / Sester, Lilli Sophie / Kriegsmann, Katharina / Weinhold, Niels / Ober, Michael / Müller-Tidow, Carsten / Goldschmidt, Hartmut / Raab, Marc-Steffen / Sauer, Sandra

    Hematological oncology

    2023  Volume 41, Issue 3, Page(s) 453–462

    Abstract: Patients with relapsed refractory multiple myeloma (RRMM) that are triple-exposed to immunomodulatory drugs, proteasome inhibitors, and anti-CD38 monoclonal antibodies have a poor prognosis. Standard treatment for these patients has not been established. ...

    Abstract Patients with relapsed refractory multiple myeloma (RRMM) that are triple-exposed to immunomodulatory drugs, proteasome inhibitors, and anti-CD38 monoclonal antibodies have a poor prognosis. Standard treatment for these patients has not been established. Patients with extramedullary disease or secondary plasma cell leukemia often display high tumor cell proliferation and might therefore be susceptible to chemotherapy. While current regimens are often platinum-based, we present single-center data on 70 patients with RRMM who were treated with cyclophosphamide, etoposide, and dexamethasone (CED) after a median of four lines of therapy. An overall response rate of 52% was achieved after 1-6 cycles, with 23% of patients having a very good partial response. Comparable response rates and survival were observed in patients with extramedullary disease and high-risk cytogenetics. Treatment resulted in non-hematological °III-IV adverse events in 31% of patients. No treatment-related deaths occurred. The median progression-free and overall survival were 6.2 and 10.9 months, respectively. 23% of patients were bridged to autologous stem cell transplantation (ASCT) or chimeric antigen receptor (CAR) T cell therapy. In summary, CED is an effective treatment regimen for RRMM cases with a tolerable safety profile and suitable as bridging therapy to CAR T cell treatment and ASCT.
    MeSH term(s) Humans ; Multiple Myeloma/drug therapy ; Cyclophosphamide ; Etoposide ; Hematopoietic Stem Cell Transplantation ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Transplantation, Autologous ; Dexamethasone ; Salvage Therapy
    Chemical Substances Cyclophosphamide (8N3DW7272P) ; Etoposide (6PLQ3CP4P3) ; Dexamethasone (7S5I7G3JQL)
    Language English
    Publishing date 2023-01-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 604884-5
    ISSN 1099-1069 ; 0278-0232
    ISSN (online) 1099-1069
    ISSN 0278-0232
    DOI 10.1002/hon.3123
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  10. Article ; Online: A patient survey indicates quality of life and progression-free survival as equally important outcome measures in multiple myeloma clinical trials.

    Fleischer, Anna / Zapf, Larissa / Allgaier, Johannes / Jordan, Karin / Gelbrich, Götz / Pryss, Rüdiger / Schobel, Johannes / Bittrich, Max / Einsele, Hermann / Kortüm, Martin / Maatouk, Imad / Weinhold, Niels / Rasche, Leo

    Journal of cancer research and clinical oncology

    2023  Volume 149, Issue 14, Page(s) 12897–12902

    Language English
    Publishing date 2023-07-19
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-023-05137-8
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