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  1. Article: Complete Genome Sequence of a

    Lassen, Simon B / Lomholt, Hans B / Brüggemann, Holger

    Genome announcements

    2017  Volume 5, Issue 10

    Abstract: Staphylococcus ... ...

    Abstract Staphylococcus epidermidis
    Language English
    Publishing date 2017-03-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.00004-17
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  2. Article ; Online: Fusidic acid resistant Staphylococcus aureus and skin disease.

    Lomholt, Hans B

    Acta dermato-venereologica

    2010  Volume 90, Issue 1, Page(s) 4

    MeSH term(s) Administration, Topical ; Anti-Bacterial Agents/administration & dosage ; Blister/drug therapy ; Blister/microbiology ; Dermatitis, Atopic/drug therapy ; Dermatitis, Atopic/microbiology ; Drug Resistance, Bacterial ; Fusidic Acid/administration & dosage ; Humans ; Impetigo/drug therapy ; Impetigo/microbiology ; Patient Selection ; Staphylococcus aureus/drug effects ; Staphylococcus aureus/isolation & purification
    Chemical Substances Anti-Bacterial Agents ; Fusidic Acid (59XE10C19C)
    Language English
    Publishing date 2010
    Publishing country Sweden
    Document type Comment ; Journal Article
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-0753
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  3. Article ; Online: Clonality and anatomic distribution on the skin of antibiotic resistant and sensitive Propionibacterium acnes.

    Lomholt, Hans B / Kilian, Mogens

    Acta dermato-venereologica

    2014  Volume 94, Issue 5, Page(s) 534–538

    Abstract: Increasing antibiotic resistance in the population of Propionibacterium acnes is a major concern. Our aims were to examine the clonal relationships and anatomical distribution of resistant and sensitive P. acnes. A collection of 350 P. acnes isolates was ...

    Abstract Increasing antibiotic resistance in the population of Propionibacterium acnes is a major concern. Our aims were to examine the clonal relationships and anatomical distribution of resistant and sensitive P. acnes. A collection of 350 P. acnes isolates was therefore used to determine the minimum inhibitory concentration of tetracycline, erythro-mycin and clindamycin, multilocus sequence type, and the identity of genetic resistance markers. Two hitherto unknown resistance mutations were detected. Resistant P. acnes mainly belonged to clonal clusters in division I-1a frequently isolated from skin and associated with moderate to severe acne. All high-level tetracycline resistant strains were members of a single clone. Multiple isolates from distinct anatomic areas of surface skin and follicles of 2 acne patients revealed substantial clonal diversity between areas and co-existence of resistant and sensitive clones. Fifty-two percent of Danish acne patients and 43% of controls carried at least one resistant P. acnes strain, resistance to clindamycin being most frequent followed by tetracycline and erythromycin. Resistance to tetracycline was detected exclusively among isolates from acne patients. In conclusion, antibiotic resistance is associated with particular evolutionary clades of P. acnes and a substantial part is due to a single geographically widespread clone (ST3). Individuals carry a strikingly complex population of P. acnes with distinct virulence potential and antibiotic resistance.
    MeSH term(s) Acne Vulgaris/drug therapy ; Acne Vulgaris/microbiology ; Anti-Bacterial Agents/therapeutic use ; Case-Control Studies ; Denmark ; Drug Resistance, Multiple, Bacterial ; Gram-Positive Bacterial Infections/drug therapy ; Gram-Positive Bacterial Infections/genetics ; Humans ; Propionibacterium acnes/genetics ; Propionibacterium acnes/isolation & purification
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2014-09
    Publishing country Sweden
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80007-7
    ISSN 1651-2057 ; 0001-5555
    ISSN (online) 1651-2057
    ISSN 0001-5555
    DOI 10.2340/00015555-1794
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  4. Article ; Online: Systemic allergic dermatitis presumably caused by formaldehyde derived from aspartame.

    Veien, Niels K / Lomholt, Hans B

    Contact dermatitis

    2012  Volume 67, Issue 5, Page(s) 315–316

    MeSH term(s) Adult ; Aspartame/adverse effects ; Aspartame/metabolism ; Dermatitis, Allergic Contact/etiology ; Facial Dermatoses/chemically induced ; Female ; Foot Dermatoses/chemically induced ; Formaldehyde/adverse effects ; Formaldehyde/metabolism ; Humans
    Chemical Substances Formaldehyde (1HG84L3525) ; Aspartame (Z0H242BBR1)
    Language English
    Publishing date 2012-11
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 193121-0
    ISSN 1600-0536 ; 0105-1873
    ISSN (online) 1600-0536
    ISSN 0105-1873
    DOI 10.1111/j.1600-0536.2012.02147.x
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  5. Article: Propionibacterium Acnes

    Petersen, Rolf L W / Scholz, Christian F P / Jensen, Anders / Brüggemann, Holger / Lomholt, Hans B

    European journal of microbiology & immunology

    2017  Volume 7, Issue 1, Page(s) 37–45

    Abstract: Progressive macular hypomelanosis (PMH) is a skin disorder that is characterized by hypopigmented macules and usually seen in young adults. The skin microbiota, in particular the ... ...

    Abstract Progressive macular hypomelanosis (PMH) is a skin disorder that is characterized by hypopigmented macules and usually seen in young adults. The skin microbiota, in particular the bacterium
    Language English
    Publishing date 2017-02-27
    Publishing country Hungary
    Document type Journal Article
    ZDB-ID 2652327-9
    ISSN 2062-8633 ; 2062-509X
    ISSN (online) 2062-8633
    ISSN 2062-509X
    DOI 10.1556/1886.2016.00040
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  6. Article: Draft Genome Sequences of Two Propionibacterium acnes Strains Isolated from Progressive Macular Hypomelanosis Lesions of Human Skin.

    Petersen, Rolf / Lomholt, Hans B / Scholz, Christian F P / Brüggemann, Holger

    Genome announcements

    2015  Volume 3, Issue 6

    Abstract: Propionibacterium acnes is a Gram-positive bacterium that is prevalent on human skin. It has been associated with skin disorders such as acne vulgaris and progressive macular hypomelanosis (PMH). Here, we report draft genome sequences of two type III P. ... ...

    Abstract Propionibacterium acnes is a Gram-positive bacterium that is prevalent on human skin. It has been associated with skin disorders such as acne vulgaris and progressive macular hypomelanosis (PMH). Here, we report draft genome sequences of two type III P. acnes strains, PMH5 and PMH7, isolated from PMH skin lesions.
    Language English
    Publishing date 2015-11-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2704277-7
    ISSN 2169-8287
    ISSN 2169-8287
    DOI 10.1128/genomeA.01250-15
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  7. Article ; Online: Population genetic analysis of Propionibacterium acnes identifies a subpopulation and epidemic clones associated with acne.

    Lomholt, Hans B / Kilian, Mogens

    PloS one

    2010  Volume 5, Issue 8, Page(s) e12277

    Abstract: The involvement of Propionibacterium acnes in the pathogenesis of acne is controversial, mainly owing to its dominance as an inhabitant of healthy skin. This study tested the hypothesis that specific evolutionary lineages of the species are associated ... ...

    Abstract The involvement of Propionibacterium acnes in the pathogenesis of acne is controversial, mainly owing to its dominance as an inhabitant of healthy skin. This study tested the hypothesis that specific evolutionary lineages of the species are associated with acne while others are compatible with health. Phylogenetic reconstruction based on nine housekeeping genes was performed on 210 isolates of P. acnes from well-characterized patients with acne, various opportunistic infections, and from healthy carriers. Although evidence of recombination was observed, the results showed a basically clonal population structure correlated with allelic variation in the virulence genes tly and camp5, with pulsed field gel electrophoresis (PFGE)- and biotype, and with expressed putative virulence factors. An unexpected geographically and temporal widespread dissemination of some clones was demonstrated. The population comprised three major divisions, one of which, including an epidemic clone, was strongly associated with moderate to severe acne while others were associated with health and opportunistic infections. This dichotomy correlated with previously observed differences in in vitro inflammation-inducing properties. Comparison of five genomes representing acne- and health-associated clones revealed multiple both cluster- and strain-specific genes that suggest major differences in ecological preferences and redefines the spectrum of disease-associated virulence factors. The results of the study indicate that particular clones of P. acnes play an etiologic role in acne while others are associated with health.
    MeSH term(s) Acne Vulgaris/epidemiology ; Acne Vulgaris/microbiology ; Alleles ; Cloning, Molecular ; Disease Outbreaks ; Electrophoresis, Gel, Pulsed-Field ; Evolution, Molecular ; Genes, Bacterial/genetics ; Humans ; Multigene Family ; Opportunistic Infections/microbiology ; Phenotype ; Phylogeny ; Polymorphism, Genetic ; Propionibacterium acnes/classification ; Propionibacterium acnes/genetics ; Propionibacterium acnes/pathogenicity ; Propionibacterium acnes/physiology ; Recombination, Genetic ; Sequence Analysis, DNA ; Skin/microbiology
    Language English
    Publishing date 2010-08-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1932-6203
    ISSN (online) 1932-6203
    DOI 10.1371/journal.pone.0012277
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  8. Article: The flexible gene pool of Propionibacterium acnes.

    Brüggemann, Holger / Lomholt, Hans B / Kilian, Mogens

    Mobile genetic elements

    2012  Volume 2, Issue 3, Page(s) 145–148

    Abstract: Propionibacterium acnes is a Gram-positive bacterium that is intimately associated with humans. The nature and consequences of this symbiosis are poorly understood; it might comprise both mutualistic and parasitic properties. Recent advances in ... ...

    Abstract Propionibacterium acnes is a Gram-positive bacterium that is intimately associated with humans. The nature and consequences of this symbiosis are poorly understood; it might comprise both mutualistic and parasitic properties. Recent advances in distinguishing phylotypes of P. acnes have revealed that certain type I lineages are predominantly associated with acne vulgaris. Genome analyses revealed a highly conserved core genome and the existence of island-like genomic regions and possible mobile genetic elements as part of the flexible gene pool. The analysis of clustered regularly interspaced short palindromic repeats (CRISPR), found exclusively in type II P. acnes, recently revealed the presence of CRISPR spacers that derived from mobile genetic elements. These elements are present in a subset of P. acnes type I lineages. Their significance for type-specific host-interacting properties and their contribution to pathogenicity is currently under investigation.
    Language English
    Publishing date 2012-08-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2682444-9
    ISSN 2159-256X ; 2159-2543
    ISSN (online) 2159-256X
    ISSN 2159-2543
    DOI 10.4161/mge.21204
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  9. Article ; Online: Validity and reliability of the Rosacea Area and Severity Index: A novel scoring system for clinical assessment of rosacea severity.

    Wienholtz, Nita Katarina Frifelt / Thyssen, Jacob P / Christensen, Casper Emil / Thomsen, Simon Francis / Karmisholt, Katrine Elisabeth / Jemec, Gregor B E / Lomholt, Hans B / Heidenheim, Michael / Simonsen, Anne Birgitte / Sand, Carsten / Vestergaard, Christian / Kaur-Knudsen, Diljit / Ammitzbøll, Elisabeth / Lørup, Erik / Danielsen, Anne G / Strauss, Gitte / Skov, Lone / Andersen, Peter H / Hald, Marianne /
    Idorn, Luise W / Ashina, Messoud / Zachariae, Claus / Egeberg, Alexander

    Journal of the European Academy of Dermatology and Venereology : JEADV

    2022  Volume 37, Issue 3, Page(s) 573–580

    Abstract: Background: Rosacea is a common chronic inflammatory facial skin disorder. Standardized evaluation of the severity and extent of rosacea is important for baseline assessment and treatment effect. The currently used Investigator's Global Assessment (IGA) ...

    Abstract Background: Rosacea is a common chronic inflammatory facial skin disorder. Standardized evaluation of the severity and extent of rosacea is important for baseline assessment and treatment effect. The currently used Investigator's Global Assessment (IGA) is unspecific and fails to consider subtypes/phenotypes of rosacea and area involvement. The Rosacea Area and Severity Index (RASI) was developed to give a more nuanced evaluation of rosacea features in four facial skin areas adjusted to the relative importance of each area of the face to obtain an overall severity score.
    Objectives: To validate RASI against the IGA and to assess the inter- and intraobserver reliability for RASI.
    Methods: Sixteen dermatologists evaluated photographs of 60 adult patients with rosacea (3 photographs per patient, one from the front and one from each side). IGA and RASI scores were performed for interobserver reliability assessment. To determine intraobserver reliability, 14 dermatologists evaluated 10 other patients twice with at least 1 week interval.
    Results: The IGA and RASI correlated well (Spearman correlation coefficient (SCC) = 0.75, 95% confidence interval (CI) = 0.72-0.78). Interobserver reliability was moderate for RASI and poor to moderate for IGA. Reliability was strongest for rhinophyma, followed by papules/pustules and erythema, and rather weak for telangiectasia. For area scores, interobserver reliability was strongest for cheeks, followed by nose, chin and forehead. We found a moderate-to-strong intraobserver agreement both for IGA and RASI.
    Conclusions: We have designed a new practical tool to examine clinical severity of rosacea. RASI proved simple and reliable in scoring clinical severity of rosacea with an agreement comparable to the currently used IGA although RASI will provide a more nuanced view of the current rosacea extent and severity. We suggest that RASI is used in the daily clinical setting as well as in clinical studies assessing the efficacy of rosacea therapies.
    MeSH term(s) Humans ; Reproducibility of Results ; Rosacea/diagnosis ; Rosacea/drug therapy ; Skin ; Erythema ; Immunoglobulin A ; Severity of Illness Index
    Chemical Substances Immunoglobulin A
    Language English
    Publishing date 2022-11-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 1128828-0
    ISSN 1468-3083 ; 0926-9959
    ISSN (online) 1468-3083
    ISSN 0926-9959
    DOI 10.1111/jdv.18721
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    Zs.MO 413: Show issues

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  10. Article ; Online: Multilocus sequence typing and phylogenetic analysis of Propionibacterium acnes.

    Kilian, Mogens / Scholz, Christian F P / Lomholt, Hans B

    Journal of clinical microbiology

    2012  Volume 50, Issue 4, Page(s) 1158–1165

    Abstract: Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris, in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies ... ...

    Abstract Propionibacterium acnes is a commensal of human skin but is also implicated in the pathogenesis of acne vulgaris, in biofilm-associated infections of medical devices and endophthalmitis, and in infections of bone and dental root canals. Recent studies associate P. acnes with prostate cancer. As the species includes evolutionary lineages with distinct association with health and disease, there is a need for a high-resolution typing scheme. Recently, two multilocus sequence typing (MLST) schemes were reported, one based on nine and one based on seven housekeeping genes. In the present study, the two schemes were compared with reference to a phylogenetic tree based on 78 P. acnes genomes and their gene contents. Further support for a basically clonal population structure of P. acnes and a scenario of the global spread of epidemic clones of P. acnes was obtained. Compared to the Belfast scheme, the Aarhus MLST scheme (http://pacnes.mlst.net/), which is based on nine genes, offers significantly enhanced resolution and phylogenetic inferences more concordant with analyses based on a comprehensive sampling of the entire genomes, their gene contents, and their putative pathogenic potential.
    MeSH term(s) Algorithms ; Bacterial Typing Techniques/methods ; Genes, Bacterial ; Genes, Essential ; Humans ; Models, Genetic ; Multilocus Sequence Typing/methods ; Phenotype ; Phylogeny ; Propionibacterium acnes/classification ; Propionibacterium acnes/genetics
    Language English
    Publishing date 2012-01-18
    Publishing country United States
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 390499-4
    ISSN 1098-660X ; 0095-1137
    ISSN (online) 1098-660X
    ISSN 0095-1137
    DOI 10.1128/JCM.r06129-11
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