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Article ; Online: Student Preferences for Virtual or In-Person Interprofessional Education Simulations.

Rigby, Justin H / Canham, Sarah L / Farrell, Timothy W / Zeljkovic, Arminka / Hobson, Wendy L

2024 Volume 53, Issue 1, Page(s) e55–e59

Abstract: ... students preferred a virtual platform in academic year 2021-2022 than the previous year (p<0.001). Students ...

Abstract	The COVID-19 pandemic created a shift in interprofessional education (IPE) courses, causing programs to change pedagogical approaches. We sought to examine student preferences for taking IPE simulations. On post-simulation surveys from two courses (n=844 students, 2020-2022 academic years), we asked students if they preferred to take the simulation through a synchronous in-person or virtual format. More students preferred a virtual platform in academic year 2021-2022 than the previous year (p<0.001). Students who chose the virtual format believed it was more convenient, reduced COVID-19 transmission, and eased interprofessional collaboration. The downsides to in-person simulations included travel logistics and technical challenges in the simulation lab. Students suggested that in-person simulations more closely resembled 'real life' and that communication and body language are easier to convey in person.
MeSH term(s)	Humans ; Interprofessional Relations ; Interprofessional Education ; Pandemics ; Students, Health Occupations
Language	English
Publishing date	2024-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	197884-6
ISSN	1945-404X ; 0090-7421
ISSN (online)	1945-404X
ISSN	0090-7421
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Article ; Online: People with obsessive-compulsive disorder often remain symptomatic following psychological treatment: A clinical significance analysis of manualised psychological interventions.

Fisher, P L / Cherry, M G / Stuart, T / Rigby, J W / Temple, J

Journal of affective disorders

2020 Volume 275, Page(s) 94–108

Abstract: Background: Previous meta-analyses conclude that efficacious psychological treatments for obsessive-compulsive disorder (OCD) exist. However, determining the efficacy of psychological treatments requires multiple forms of assessment. We conducted an ... ...

Abstract	Background: Previous meta-analyses conclude that efficacious psychological treatments for obsessive-compulsive disorder (OCD) exist. However, determining the efficacy of psychological treatments requires multiple forms of assessment. We conducted an individual patient data meta-analysis of randomised controlled trials (RCTs) of manualised psychological therapy for adults with OCD. Methods: Four electronic databases were searched from their inception until July 2019. IPD were available for 24 (n = 1626) of 43 (n = 2455) eligible RCTs. Treatment efficacy was evaluated using clinical significance analyses (using standardised Jacobson methodology) and standardised mean difference within-group effect-size analyses. Outcomes were Yale-Brown Obsessive Compulsive Scale (Y-BOCS) scores at post-treatment and follow-up. Results: At follow-up, large within-group effect sizes were found for treated patients (g = 1.45) and controls (g = 0.90). Treated patients were significantly more likely than controls to recover, but recovery rates were low; post-intervention, only 32% of treated patients and 3% of controls recovered; rising to 38% and 21% respectively at follow-up. Regardless of allocation, only 20% of patients were asymptomatic at follow-up. Individual cognitive therapy (CT) was most efficacious, followed by group CT plus exposure and response prevention. Self-help interventions were generally less efficacious than face-to-face approaches. Limitations: Data were analysed from 24 of the 43 eligible RCTs. We were unable to consider the long-term efficacy of treatments because only two RCTs provided long-term (> 12 month) follow-up data. Conclusion: Almost 80% of treated patients remain symptomatic. The efficacy of psychological interventions for patients with OCD must be enhanced.
MeSH term(s)	Adult ; Cognitive Behavioral Therapy ; Humans ; Obsessive-Compulsive Disorder/therapy ; Psychosocial Intervention ; Psychotherapy ; Treatment Outcome
Language	English
Publishing date	2020-06-25
Publishing country	Netherlands
Document type	Journal Article ; Meta-Analysis ; Review
ZDB-ID	135449-8
ISSN	1573-2517 ; 0165-0327
ISSN (online)	1573-2517
ISSN	0165-0327
DOI	10.1016/j.jad.2020.06.019
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Zs.A 1485: Show issues

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Article ; Online: Efficient NADPH-dependent dehalogenation afforded by a self-sufficient reductive dehalogenase.

Fisher, Karl / Halliwell, Tom / Payne, Karl A P / Ragala, Gabriel / Hay, Sam / Rigby, Stephen E J / Leys, David

The Journal of biological chemistry

2023 Volume 299, Issue 9, Page(s) 105086

Abstract: ... debromination activity is readily observed, and when the enzyme is expressed in E. coli strain W, supports ...

Abstract	Reductive dehalogenases are corrinoid and iron-sulfur cluster-containing enzymes that catalyze the reductive removal of a halogen atom. The oxygen-sensitive and membrane-associated nature of the respiratory reductive dehalogenases has hindered their detailed kinetic study. In contrast, the evolutionarily related catabolic reductive dehalogenases are oxygen tolerant, with those that are naturally fused to a reductase domain with similarity to phthalate dioxygenase presenting attractive targets for further study. We present efficient heterologous expression of a self-sufficient catabolic reductive dehalogenase from Jhaorihella thermophila in Escherichia coli. Combining the use of maltose-binding protein as a solubility-enhancing tag with the btuCEDFB cobalamin uptake system affords up to 40% cobalamin occupancy and a full complement of iron-sulfur clusters. The enzyme is able to efficiently perform NADPH-dependent dehalogenation of brominated and iodinated phenolic compounds, including the flame retardant tetrabromobisphenol, under both anaerobic and aerobic conditions. NADPH consumption is tightly coupled to product formation. Surprisingly, corresponding chlorinated compounds only act as competitive inhibitors. Electron paramagnetic resonance spectroscopy reveals loss of the Co(II) signal observed in the resting state of the enzyme under steady-state conditions, suggesting accumulation of Co(I)/(III) species prior to the rate-limiting step. In vivo reductive debromination activity is readily observed, and when the enzyme is expressed in E. coli strain W, supports growth on 3-bromo-4-hydroxyphenylacetic as a sole carbon source. This demonstrates the potential for catabolic reductive dehalogenases for future application in bioremediation.
MeSH term(s)	Escherichia coli/genetics ; NADP/metabolism ; Oxygen/chemistry ; Vitamin B 12/metabolism ; Phenols/chemistry ; Phenols/metabolism ; Electron Spin Resonance Spectroscopy ; Hydrolases/chemistry ; Hydrolases/genetics ; Hydrolases/isolation & purification ; Hydrolases/metabolism ; Rhodobacteraceae/enzymology ; Rhodobacteraceae/genetics ; Protein Structure, Tertiary ; Models, Molecular ; Maltose-Binding Proteins/genetics ; Maltose-Binding Proteins/metabolism ; Recombinant Fusion Proteins/metabolism ; Coenzymes/metabolism
Chemical Substances	NADP (53-59-8) ; Oxygen (S88TT14065) ; Vitamin B 12 (P6YC3EG204) ; Phenols ; tetrabromobisphenol A (FQI02RFC3A) ; Hydrolases (EC 3.-) ; Maltose-Binding Proteins ; Recombinant Fusion Proteins ; Coenzymes
Language	English
Publishing date	2023-07-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.105086
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Article ; Online: Are non-invasive estimations of plasma volume an accurate measure of congestion in patients with chronic heart failure?

Cuthbert, J J / Pellicori, P / Rigby, A S / Abel, A A I / Kalvickbacka-Bennet, A / Shah, P / Kearsley, J W / Kazmi, S / Cleland, J G F / Clark, A L

European heart journal. Quality of care & clinical outcomes

2022 Volume 9, Issue 3, Page(s) 281–292

Abstract: ... hazard ratio (HR) per unitary increase = 1.02 (1.01-1.03); P < 0.001]. In cohort 2, HPVS was associated ... with B-line count (HR) = 1.05 [95% confidence interval (CI) (1.01-1.08); P = 0.02] and DPVS ... with the composite outcome [HR = 1.26 (1.01-1.58); P = 0.04]. HPVS and DPVS were strongly related to haemoglobin ...

Abstract	Aims: We report associations between different formulae for estimating plasma volume status (PVS) and clinical and ultrasound markers of congestion in patients with chronic heart failure (CHF) enrolled in the Hull Lifelab registry. Methods and results: Cohort 1 comprised patients with data on signs and symptoms at initial evaluation (n = 3505). Cohort 2 included patients with ultrasound assessment of congestion [lung B-line count, inferior vena cava (IVC) diameter, jugular vein distensibility (JVD) ratio] (N = 341). Two formulae for PVS were used: (a) Hakim (HPVS) and (b) Duarte (DPVS). Results were compared with clinical and ultrasound markers of congestion. Outcomes assessed were mortality and the composite of heart failure (HF) hospitalisation and all-cause mortality. In cohort 1, HPVS was associated with mortality [hazard ratio (HR) per unitary increase = 1.02 (1.01-1.03); P < 0.001]. In cohort 2, HPVS was associated with B-line count (HR) = 1.05 [95% confidence interval (CI) (1.01-1.08); P = 0.02] and DPVS with the composite outcome [HR = 1.26 (1.01-1.58); P = 0.04]. HPVS and DPVS were strongly related to haemoglobin concentration and HPVS to weight. After multivariable analysis, there were no strong or consistent associations between PVS and measures of congestion, severity of symptoms, or outcome. By contrast, log[NTproBNP] was strongly associated with all three. Conclusion: Amongst patients with CHF, HPVS and DPVS are not strongly or consistently associated with clinical or ultrasound evidence of congestion, nor clinical outcomes after multivariable adjustment. They appear only to be surrogates of the variables from which they are calculated with no intrinsic clinical utility.
MeSH term(s)	Humans ; Plasma Volume ; Heart Failure/complications ; Heart Failure/diagnosis ; Chronic Disease ; Hospitalization
Language	English
Publishing date	2022-07-13
Publishing country	England
Document type	Journal Article
ZDB-ID	2823451-0
ISSN	2058-1742 ; 2058-5225
ISSN (online)	2058-1742
ISSN	2058-5225
DOI	10.1093/ehjqcco/qcac035
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Article: Acute Supplementation with Cannabidiol Does Not Attenuate Inflammation or Improve Measures of Performance following Strenuous Exercise.

Crossland, Brett W / Rigby, B Rhett / Duplanty, Anthony A / King, George A / Juma, Shanil / Levine, Nicholas A / Clark, Cayla E / Ramirez, Kyndall P / Varone, Nicole L

Healthcare (Basel, Switzerland)

2022 Volume 10, Issue 6

Abstract: Supplementation with cannabidiol (CBD) may expedite recovery when consumed after exercise. The purpose of this study was to determine if supplementation with CBD reduces inflammation and enhances performance following strenuous eccentric exercise in ... ...

Abstract	Supplementation with cannabidiol (CBD) may expedite recovery when consumed after exercise. The purpose of this study was to determine if supplementation with CBD reduces inflammation and enhances performance following strenuous eccentric exercise in collegiate athletes. Twenty-four well-trained females (age = 21.2 ± 1.8 years, height = 166.4 ± 8 cm, weight = 64.9 ± 9.1 kg) completed 100 repetitions of unilateral eccentric leg extension to induce muscle damage. In this crossover design, participants were randomized to receive 5 mg/kg of CBD in pill form or a placebo 2 h prior to, immediately following, and 10 h following muscle damage. Blood was collected, and performance and fatigue were measured prior to, and 4 h, 24 h, and 48 h following the muscle damage. Approximately 28 days separated treatment administration to control for the menstrual cycle. No significant differences were observed between the treatments for inflammation, muscle damage, or subjective fatigue. Peak torque at 60°/s (
Language	English
Publishing date	2022-06-17
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2721009-1
ISSN	2227-9032
ISSN	2227-9032
DOI	10.3390/healthcare10061133
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Article ; Online: Volume-outcome relationships in laryngeal trauma processes of care: a retrospective cohort study.

Forner, David / Noel, Christopher W / Guttman, Matthew P / Haas, Barbara / Enepekides, Danny / Rigby, Matthew H / Taylor, S Mark / Nathens, Avery B / Eskander, Antoine

European journal of trauma and emergency surgery : official publication of the European Trauma Society

2022 Volume 48, Issue 5, Page(s) 4131–4141

Abstract: Purpose: The extent to which patients with laryngeal trauma undergo investigation and intervention is largely unknown. The objective of this study was to therefore determine the association between hospital volume and processes of care in patients ... ...

Abstract	Purpose: The extent to which patients with laryngeal trauma undergo investigation and intervention is largely unknown. The objective of this study was to therefore determine the association between hospital volume and processes of care in patients sustaining laryngeal trauma. Methods: This retrospective cohort study used the American College of Surgeons Trauma Quality Improvement Program database. Adult patients (≥ 18) who sustained traumatic laryngeal injuries between 2012 and 2016 were eligible. The exposure of interest was average annual laryngeal trauma volume categorized into quartiles. The primary and secondary outcomes of interest were the performances of diagnostic and therapeutic laryngeal procedures respectively. Multivariable logistic regression under a generalized estimating equations approach was utilized. Results: In total, 1164 patients were included. The average number of laryngeal trauma cases per hospital ranged from 0.2 to 7.2 per year. Diagnostic procedures were performed in 31% of patients and therapeutic in 19%. In patients with severe laryngeal injuries, diagnostic procedures were performed on a higher proportion of patients at high volume centers than low volume centers (46% vs 25%). In adjusted analysis, volume was not associated with the performance of diagnostic procedures. Patients treated at centers in the second (OR 1.94 [95% CI 1.29-2.90]) and third (OR 1.67 [95% CI 1.08-2.57]) volume quartiles had higher odds of undergoing a therapeutic procedure compared to the lowest volume quartile. Conclusion: Hospital volume may be associated with processes of care in laryngeal trauma. Additional research is required to investigate how these findings relate to patient and health system outcomes.
MeSH term(s)	Adult ; Databases, Factual ; Hospital Mortality ; Humans ; Logistic Models ; Quality Improvement ; Retrospective Studies ; Trauma Centers
Language	English
Publishing date	2022-03-23
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2275480-5
ISSN	1863-9941 ; 1863-9933
ISSN (online)	1863-9941
ISSN	1863-9933
DOI	10.1007/s00068-022-01950-x
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Zs.A 1221: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Investigation of spatial and temporal variability in lower tropospheric ozone from RAL Space UV–Vis satellite products

R. J. Pope / B. J. Kerridge / R. Siddans / B. G. Latter / M. P. Chipperfield / W. Feng / M. A. Pimlott / S. S. Dhomse / C. Retscher / R. Rigby

Atmospheric Chemistry and Physics, Vol 23, Pp 14933-

2023 Volume 14947

Abstract: Ozone is a potent air pollutant in the lower troposphere and an important short-lived climate forcer (SLCF) in the upper troposphere. Studies using satellite data to investigate spatiotemporal variability of troposphere ozone (TO 3 ) have predominantly ... ...

Abstract	Ozone is a potent air pollutant in the lower troposphere and an important short-lived climate forcer (SLCF) in the upper troposphere. Studies using satellite data to investigate spatiotemporal variability of troposphere ozone (TO 3 ) have predominantly focussed on the tropospheric column metric. This is the first study to investigate long-term spatiotemporal variability in lower tropospheric column ozone (LTCO 3 , surface–450 hPa sub-column) by merging multiple European Space Agency–Climate Change Initiative (ESA-CCI) products produced by the Rutherford Appleton Laboratory (RAL) Space. We find that in the LTCO 3 , the degree of freedom of signal (DOFS) from these products varies with latitude range and season and is up to 0.8, indicating that the retrievals contain useful information on lower TO 3 . The spatial and seasonal variation of the RAL Space products are in good agreement with each other, but there are systematic offsets of up to 3.0–5.0 DU between them. Comparison with ozonesondes shows that the Global Ozone Monitoring Experiment (GOME-1, 1996–2003), the SCanning Imaging Absorption spectroMeter for Atmospheric CartograpHY (SCIAMACHY, 2003–2010) and the Ozone Monitoring Instrument (OMI, 2005–2017) have stable LTCO 3 records over their respective periods, which can be merged together. However, GOME-2 (2008–2018) shows substantial drift in its bias with respect to ozonesondes. We have therefore constructed a robust merged data set of LTCO 3 from GOME-1, SCIAMACHY and OMI between 1996 and 2017. Comparing the LTCO 3 differences between the 1996–2000 and 2013–2017 5-year averages, we find sizeable positive increases (3.0–5.0 DU) in the tropics/sub-tropics, while in the northern mid-latitudes, we find small-scale differences in LTCO 3 . Therefore, we conclude that there has been a substantial increase in tropical/sub-tropical LTCO 3 during the satellite era, which is consistent with tropospheric column ozone (TCO 3 ) records from overlapping time periods (e.g. 2005–2016).
Keywords	Physics ; QC1-999 ; Chemistry ; QD1-999
Subject code	290
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	Copernicus Publications
Document type	Article ; Online
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Article: Transcriptome Response of Atlantic Salmon (

Samsing, Francisca / Alexandre, Pamela / Rigby, Megan / Taylor, Richard S / Chong, Roger / Wynne, James W

Pathogens (Basel, Switzerland)

2020 Volume 9, Issue 10

Abstract: Pilchard orthomyxovirus (POMV) is an emerging pathogen of concern to the salmon industry in Australia. To explore the molecular events that underpin POMV infection, we challenged Atlantic salmon ( ...

Abstract	Pilchard orthomyxovirus (POMV) is an emerging pathogen of concern to the salmon industry in Australia. To explore the molecular events that underpin POMV infection, we challenged Atlantic salmon (
Language	English
Publishing date	2020-09-30
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2695572-6
ISSN	2076-0817
ISSN	2076-0817
DOI	10.3390/pathogens9100807
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Article ; Online: Blunt Versus Penetrating Neck Trauma: A Retrospective Cohort Study.

Forner, David / Noel, Christopher W / Guttman, Matthew P / Haas, Barbara / Enepekides, Danny / Rigby, Matthew H / Nathens, Avery B / Eskander, Antoine

The Laryngoscope

2020 Volume 131, Issue 4, Page(s) E1109–E1116

Abstract: ... neck injuries compared to penetrating injuries (4.9% vs. 6.0%, P < .01), while length of hospital stay was ... similar (median 9.9 vs. 10.2, P = 0.06). In adjusted analysis, blunt neck injuries were associated ...

Abstract	Objectives/hypothesis: Despite being common, neck injuries have received relatively little attention for important quality of care metrics. This study sought to determine the association between blunt and penetrating neck injuries on mortality and length of stay, and to identify additional patient and hospital-level characteristics that impact these outcomes. Study design: Retrospective cohort study utilizing the American College of Surgeons Trauma Quality Improvement Program database. Methods: Adult patients (≥18) who sustained traumatic injuries involving the soft tissues of the neck between 2012 and 2016 were eligible. Multiple imputation was used to account for missing data. Logistic regression and negative binomial models were used to analyze 1) in-hospital mortality and 2) length of stay respectively while adjusting for potential confounders and accounting for clustering at the hospital level. Results: In a cohort of 20,285 patients, the crude mortality rate was lower in those sustaining blunt neck injuries compared to penetrating injuries (4.9% vs. 6.0%, P < .01), while length of hospital stay was similar (median 9.9 vs. 10.2, P = 0.06). In adjusted analysis, blunt neck injuries were associated with a reduced odds of mortality during hospital admission (odds ratio: 0.66, 95% confidence intervals [0.564, 0.788]), as well as significant reductions in length of stay (rate ratio: 0.92, 95% confidence intervals [0.880, 0.954]). Conclusions: Blunt neck injuries are associated with lower mortality and length of stay compared to penetrating injuries. Areas of future study have been identified, including elucidation of processes of care in specific organs of injury. Level of evidence: Level 3 Laryngoscope, 131:E1109-E1116, 2021.
MeSH term(s)	Adult ; Female ; Glasgow Coma Scale ; Hospital Mortality ; Humans ; Injury Severity Score ; Length of Stay/statistics & numerical data ; Male ; Middle Aged ; Neck Injuries/mortality ; Neck Injuries/surgery ; Retrospective Studies ; Wounds, Nonpenetrating/mortality ; Wounds, Nonpenetrating/surgery ; Wounds, Penetrating/mortality ; Wounds, Penetrating/surgery
Keywords	covid19
Language	English
Publishing date	2020-09-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	80180-x
ISSN	1531-4995 ; 0023-852X
ISSN (online)	1531-4995
ISSN	0023-852X
DOI	10.1002/lary.29088
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Article: Comparative laboratory and field evaluation of repellent formulations containing deet and lemon eucalyptus oil against mosquitoes in Queensland, Australia.

Frances, S P / Rigby, L M / Chow, W K

Journal of the American Mosquito Control Association

2014 Volume 30, Issue 1, Page(s) 65–67

Abstract: A field trial comparing a formulation containing 40% deet (N,N-diethyl-3-methyl benzamide) in ethanol (Bushman) and 32% lemon eucalyptus oil (LEO; Mosi-guard) as protection against mosquitoes at Redcliffe, Queensland, Australia, was conducted in February ...

Abstract	A field trial comparing a formulation containing 40% deet (N,N-diethyl-3-methyl benzamide) in ethanol (Bushman) and 32% lemon eucalyptus oil (LEO; Mosi-guard) as protection against mosquitoes at Redcliffe, Queensland, Australia, was conducted in February 2012 and February 2013. The 40% deet formulation provided 100% protection against mosquitoes for 7 h, while the 32% LEO provided >95% protection for 3 h.
MeSH term(s)	Animals ; Culicidae ; DEET ; Insect Repellents ; Mosquito Control/methods ; Plant Oils ; Queensland ; Species Specificity
Chemical Substances	Insect Repellents ; Plant Oils ; DEET (134-62-3)
Language	English
Publishing date	2014-03
Publishing country	United States
Document type	Comparative Study ; Evaluation Studies ; Journal Article
ZDB-ID	632618-3
ISSN	8756-971X
ISSN	8756-971X
DOI	10.2987/13-6366.1
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