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Article ; Online: The role of risk scores for prediction of adverse events in patients undergoing PCI.

Vlachojannis, Georgios J

European journal of clinical investigation

2020 Volume 50, Issue 11, Page(s) e13298

MeSH term(s)	Humans ; Percutaneous Coronary Intervention ; Risk Assessment ; Risk Factors
Language	English
Publishing date	2020-10-02
Publishing country	England
Document type	Editorial ; Comment
ZDB-ID	186196-7
ISSN	1365-2362 ; 0014-2972 ; 0960-135X
ISSN (online)	1365-2362
ISSN	0014-2972 ; 0960-135X
DOI	10.1111/eci.13298
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Book ; Thesis: Regulation der sekretorischen Phospholipase A2 Typ IIA durch Glukose in Zytokin-stimulierten glomerulären Rattenmesangiumzellkulturen sowie in Nieren diabetischer Ratten

Vlachojannis, Georgios J.

2003

Author's details	vorgelegt von Georgios J. Vlachojannis
Language	German
Size	112 S. : Ill., graph. Darst.
Publishing country	Germany
Document type	Book ; Thesis
Thesis / German Habilitation thesis	Frankfurt (Main), Univ., Diss., 2005
HBZ-ID	HT014541750
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Article ; Online: Evaluating the Arteriotomy Size of a New Sutureless Coronary Anastomosis Using a Finite Volume Approach.

Crielaard, Hanneke / Hoogewerf, Marieke / van Putte, Bart P / van de Vosse, Frans N / Vlachojannis, Georgios J / Stecher, David / Stijnen, Marco / Doevendans, Pieter A

Journal of cardiovascular translational research

2023 Volume 16, Issue 4, Page(s) 916–926

Abstract: Objectives: The ELANA® Heart Bypass creates a standardized sutureless anastomosis. Hereby, we investigate the influence of arteriotomy and graft size on coronary hemodynamics.: Methods: A computational fluid dynamics (CFD) model was developed. ... ...

Abstract	Objectives: The ELANA® Heart Bypass creates a standardized sutureless anastomosis. Hereby, we investigate the influence of arteriotomy and graft size on coronary hemodynamics. Methods: A computational fluid dynamics (CFD) model was developed. Arteriotomy size (standard 1.43 mm Results: The current size ELANA (arteriotomy 1.43 mm Conclusion: The ratio between the required minimal coronary diameter for application and the ELANA arteriotomy size effectuates a pressure drop that could be clinically relevant. Additional research and eventual lengthening of the anastomosis is advised.
MeSH term(s)	Humans ; Fractional Flow Reserve, Myocardial ; Coronary Angiography ; Coronary Artery Bypass/adverse effects ; Hemodynamics ; Anastomosis, Surgical ; Coronary Stenosis ; Coronary Vessels/diagnostic imaging ; Coronary Vessels/surgery
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2422411-X
ISSN	1937-5395 ; 1937-5387
ISSN (online)	1937-5395
ISSN	1937-5387
DOI	10.1007/s12265-023-10367-9
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Article ; Online: Prehospital crushed versus integral prasugrel loading dose in STEMI patients with a large myocardial area.

Wilschut, Jeroen M / Vogel, Rosanne F / Elscot, Jacob J / Delewi, Ronak / Lemmert, Miguel E / van der Waarden, Nancy W P L / Nuis, Rutger-Jan / Paradies, Valeria / Alexopoulos, Dimitrios / Zijlstra, Felix / Montalescot, Gilles / Angiolillo, Dominick J / Krucoff, Mitchell W / Smits, Pieter C / Vlachojannis, Georgios J / Van Mieghem, Nicolas M / Diletti, Roberto

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology

2024 Volume 20, Issue 7, Page(s) e436–e444

Abstract: Background: The effect of administering a crushed prasugrel loading dose is uncertain in patients presenting with a large myocardial infarction and ST-segment elevation myocardial infarction (STEMI).: Aims: The aim of this study was to investigate if ...

Abstract	Background: The effect of administering a crushed prasugrel loading dose is uncertain in patients presenting with a large myocardial infarction and ST-segment elevation myocardial infarction (STEMI). Aims: The aim of this study was to investigate if patients with a large myocardial infarction may benefit from prehospital administration of a crushed prasugrel loading dose. Methods: Patients from the CompareCrush trial with an available ambulance electrocardiography (ECG) were included in the study. An independent core laboratory confirmed a prehospital large myocardial area. We compared pre- and postprocedural angiographic markers, including Thrombolysis in Myocardial Infarction (TIMI) 3 flow in the infarct-related artery, high thrombus burden, and myocardial blush grade 3, in STEMI patients with and without a prehospital large myocardial area. Results: Ambulance ECG was available for 532 patients, of whom 331 patients were identified with a prehospital large myocardial area at risk. Crushed prasugrel significantly improved postprocedural TIMI 3 flow rates in STEMI patients with a prehospital large myocardial area at risk (92% vs 79%, odds ratio [OR] 3.00, 95% confidence interval [CI]: 1.50-6.00) but not in STEMI patients without a prehospital large myocardial area at risk (91% vs 95%, OR 0.47, 95% CI: 0.14-1.57; p Conclusions: Administration of crushed prasugrel may improve postprocedural TIMI 3 flow in STEMI patients with signs of a large myocardial area at risk on the ambulance ECG. The practice of crushing tablets of prasugrel loading dose might, therefore, represent a safe, fast and cost-effective strategy to improve myocardial reperfusion in this high-risk STEMI subgroup undergoing primary percutaneous coronary intervention.
MeSH term(s)	Humans ; Emergency Medical Services ; Myocardial Infarction/drug therapy ; Percutaneous Coronary Intervention/adverse effects ; Platelet Aggregation Inhibitors/therapeutic use ; Prasugrel Hydrochloride/therapeutic use ; ST Elevation Myocardial Infarction/drug therapy ; Treatment Outcome
Chemical Substances	Platelet Aggregation Inhibitors ; Prasugrel Hydrochloride (G89JQ59I13)
Language	English
Publishing date	2024-04-01
Publishing country	France
Document type	Comparative Study ; Journal Article
ZDB-ID	2457174-X
ISSN	1969-6213 ; 1774-024X
ISSN (online)	1969-6213
ISSN	1774-024X
DOI	10.4244/EIJ-D-23-00618
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Zs.A 6680: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 571: Show issues

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Article ; Online: Post TAVI paravalvular regurgitation: can we stop the leak?

Vlachojannis, Georgios J / Mehran, Roxana

Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions

2011 Volume 78, Issue 3, Page(s) 444–445

MeSH term(s)	Aortic Valve Insufficiency/etiology ; Aortic Valve Insufficiency/therapy ; Aortic Valve Stenosis/therapy ; Cardiac Catheterization/adverse effects ; Cardiac Catheterization/instrumentation ; Catheterization ; Female ; Heart Valve Prosthesis ; Heart Valve Prosthesis Implantation/adverse effects ; Heart Valve Prosthesis Implantation/instrumentation ; Humans ; Male
Language	English
Publishing date	2011-09-01
Publishing country	United States
Document type	Comment ; Editorial ; Research Support, Non-U.S. Gov't
ZDB-ID	1459995-8
ISSN	1522-726X ; 1522-1946
ISSN (online)	1522-726X
ISSN	1522-1946
DOI	10.1002/ccd.23317
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Article: Impact of recurrent ischaemic and bleeding events on quality of life in patients with acute coronary syndrome: Insights from the FORCE-ACS registry.

van der Sangen, Niels M R / Azzahhafi, Jaouad / Chan Pin Yin, Dean R P P / Rayhi, Senna / van Weede, Victoria M / Walhout, Ronald J / Tjon Joe Gin, Melvyn / Pisters, Ron / Nicastia, Deborah M / Langerveld, Jorina / Vlachojannis, Georgios J / van Bommel, Rutger J / Appelman, Yolande / Henriques, José P S / Ten Berg, Jurriën / Kikkert, Wouter

Open heart

2023 Volume 10, Issue 2

Abstract: Objective: Patients with acute coronary syndrome (ACS) remain at high risk for recurrent ischaemic and bleeding events during follow-up. Our study aimed to quantify and compare the impact of these adverse events on quality of life (QoL).: Methods: ... ...

Abstract	Objective: Patients with acute coronary syndrome (ACS) remain at high risk for recurrent ischaemic and bleeding events during follow-up. Our study aimed to quantify and compare the impact of these adverse events on quality of life (QoL). Methods: Data from patients with ACS prospectively enrolled in the FORCE-ACS registry between January 2015 and December 2019 were used for this study. The primary ischaemic and bleeding events of interest were hospital readmission for ACS and Bleeding Academic Research Consortium type 2 or 3 bleeding during 12 months follow-up. QoL was measured using the EQ-5D Visual Analogue Scale (VAS) score and the 12-item Short Form Survey version 2 derived Physical Component Summary (PCS) and Mental Health Component Summary (MCS) scores at 12 months follow-up. Results: In total, 3339 patients (mean age 66.8 years, 27.9% women) were included. During follow-up, ischaemic events occurred in 202 patients (6.0%) and bleeding events in 565 patients (16.9%). After adjustment for demographic and clinical characteristics, ischaemic events remained independently associated with lower QoL regardless of metric used. Bleeding was also independently associated with lower EQ-5D VAS and PCS scores, but not with a lower MCS score. The QoL decrement associated with ischaemic events was numerically larger than the decrement associated with bleeding. Conclusions: Ischaemic and bleeding events remain prevalent and are independently associated with lower QoL at 12 months follow-up in patients previously admitted for ACS. The incidence and impact of these adverse events should be considered when balancing individual ischaemic and bleeding risks.
MeSH term(s)	Humans ; Female ; Aged ; Male ; Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/therapy ; Acute Coronary Syndrome/epidemiology ; Quality of Life ; Prospective Studies ; Hemorrhage/epidemiology ; Hemorrhage/etiology ; Registries
Language	English
Publishing date	2023-08-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2747269-3
ISSN	2053-3624
ISSN	2053-3624
DOI	10.1136/openhrt-2023-002405
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Article: A Multicenter Comparison of 2 Point-of-Care Activated Clotting Time Test Systems.

Kemna, Evelien W M / Schellings, Mark W M / Vlachojannis, Georgios J / Falter, Florian / Milané-Santman, Antoinette / Hesselink, Tim / Scholten, Marcoen / Krabbe, Johannes G

The journal of applied laboratory medicine

2019 Volume 4, Issue 3, Page(s) 468–470

MeSH term(s)	Humans ; Point-of-Care Systems ; Point-of-Care Testing ; Reproducibility of Results ; Sensitivity and Specificity ; Whole Blood Coagulation Time/methods ; Whole Blood Coagulation Time/standards
Language	English
Publishing date	2019-08-23
Publishing country	England
Document type	Letter ; Multicenter Study
ISSN	2576-9456
ISSN	2576-9456
DOI	10.1373/jalm.2019.029066
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Article: Direct Stenting versus Conventional Stenting in Patients with ST-Segment Elevation Myocardial Infarction-A COMPARE CRUSH Sub-Study.

Vogel, Rosanne F / Delewi, Ronak / Wilschut, Jeroen M / Lemmert, Miguel E / Diletti, Roberto / van Vliet, Ria / van der Waarden, Nancy W P L / Nuis, Rutger-Jan / Paradies, Valeria / Alexopoulos, Dimitrios / Zijlstra, Felix / Montalescot, Gilles / Angiolillo, Dominick J / Krucoff, Mitchell W / Van Mieghem, Nicolas M / Smits, Pieter C / Vlachojannis, Georgios J

Journal of clinical medicine

2023 Volume 12, Issue 20

Abstract: Background: Direct stenting (DS) compared with conventional stenting (CS) after balloon predilatation may reduce distal embolization during percutaneous coronary intervention (PCI), thereby improving tissue reperfusion. In contrast, DS may increase the ... ...

Abstract	Background: Direct stenting (DS) compared with conventional stenting (CS) after balloon predilatation may reduce distal embolization during percutaneous coronary intervention (PCI), thereby improving tissue reperfusion. In contrast, DS may increase the risk of stent underexpansion and target lesion failure. Methods: In this sub-study of the randomized COMPARE CRUSH trial (NCT03296540), we reviewed the efficacy of DS versus CS in a cohort of contemporary, pretreated ST-segment elevation myocardial infarction (STEMI) patients undergoing primary PCI. We compared DS versus CS, assessing (1) stent diameter in the culprit lesion, (2) thrombolysis in myocardial infarction (TIMI) flow in the infarct-related artery post-PCI and complete ST-segment resolution (STR) one-hour post-PCI, and (3) target lesion failure at one year. For proportional variables, propensity score weighting was applied to account for potential treatment selection bias. Results: This prespecified sub-study included 446 patients, of whom 189 (42%) were treated with DS. Stent diameters were comparable between groups (3.2 ± 0.5 vs. 3.2 ± 0.5 mm, Conclusion: In this contemporary pretreated STEMI cohort, we found no difference in early myocardial reperfusion outcomes between DS and CS. Moreover, DS seemed comparable to CS in terms of stent diameter and one-year vessel patency.
Language	English
Publishing date	2023-10-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662592-1
ISSN	2077-0383
ISSN	2077-0383
DOI	10.3390/jcm12206645
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Article ; Online: Very Late Scaffold Thrombosis in Absorb BVS: Association With DAPT Termination?

Felix, Cordula M / Vlachojannis, Georgios J / IJsselmuiden, Alexander J / Onuma, Yoshinobu / van Geuns, Robert Jan M

JACC. Cardiovascular interventions

2017 Volume 10, Issue 6, Page(s) 625–626

MeSH term(s)	Absorbable Implants ; Coronary Artery Disease/diagnostic imaging ; Coronary Artery Disease/surgery ; Coronary Thrombosis/diagnostic imaging ; Coronary Thrombosis/etiology ; Coronary Thrombosis/therapy ; Drug Administration Schedule ; Drug Therapy, Combination ; Female ; Humans ; Male ; Middle Aged ; Percutaneous Coronary Intervention/adverse effects ; Percutaneous Coronary Intervention/instrumentation ; Platelet Aggregation Inhibitors/administration & dosage ; Risk Factors ; ST Elevation Myocardial Infarction/etiology ; Time Factors ; Treatment Outcome
Chemical Substances	Platelet Aggregation Inhibitors
Language	English
Publishing date	2017-02-10
Publishing country	United States
Document type	Case Reports ; Letter
ZDB-ID	2452157-7
ISSN	1876-7605 ; 1936-8798
ISSN (online)	1876-7605
ISSN	1936-8798
DOI	10.1016/j.jcin.2017.01.015
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Article ; Online: Abluminal biodegradable polymer biolimus-eluting versus durable polymer everolimus-eluting stent in patients with diabetes mellitus: 5 years follow-up from the COMPARE II trial.

Paradies, Valeria / Vlachojannis, Georgios J / Royaards, Kees-Jan / Wassing, Jochem / van der Ent, Martin / Smits, Pieter C

International journal of cardiology

2019 Volume 290, Page(s) 40–44

Abstract: Background: Drug eluting stents with biodegradable polymers have been developed to address the risk of very late adverse events. Long-term comparison data between the biodegradable polymer-coated biolimus-eluting stent (BES; Nobori®) and the second- ... ...

Abstract	Background: Drug eluting stents with biodegradable polymers have been developed to address the risk of very late adverse events. Long-term comparison data between the biodegradable polymer-coated biolimus-eluting stent (BES; Nobori®) and the second-generation durable polymer-coated everolimus-eluting stent (EES; XIENCE V® or XIENCE PRIME® or PROMUS™) in diabetic patients are scarce. Methods: The COMPARE II trial was an investigator-initiated, multicenter, open-label, randomized, all-comers trial which assigned patients undergoing percutaneous coronary intervention (PCI) in a 2:1 fashion to either BES or EES. We analyzed the safety and efficacy outcomes in diabetic patients at 5 year follow-up. The primary pre-specified composite endpoint major adverse cardiac event (MACE) was defined as cardiac death, non-fatal target-vessel myocardial infarction (TV-MI), or clinically indicated target vessel revascularization (CD-TVR). Results: Out of 2707 study patients, 588 were diabetics (21.7%) of whom 391 were treated with BES and 197 with EES. At 5 years follow-up, MACE occurred in 87 patients (22.2%) in the BES group and in 34 patients (17.2%) in the EES group (p = .34). Other safety and efficacy endpoints did not differ between stent groups. Conclusions: At 5 years follow-up, no differences in terms of MACE as well as all analyzed safety and efficacy measures, including stent thrombosis, between the biodegradable polymer-coated BES and the durable polymer-coated EES in diabetic patients were observed.
MeSH term(s)	Absorbable Implants/trends ; Aged ; Aged, 80 and over ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/epidemiology ; Diabetes Mellitus/therapy ; Drug-Eluting Stents/trends ; Everolimus/administration & dosage ; Female ; Follow-Up Studies ; Humans ; Immunosuppressive Agents/administration & dosage ; Male ; Middle Aged ; Percutaneous Coronary Intervention/instrumentation ; Percutaneous Coronary Intervention/methods ; Percutaneous Coronary Intervention/trends ; Polymers ; Sirolimus/administration & dosage ; Sirolimus/analogs & derivatives ; Time Factors
Chemical Substances	Immunosuppressive Agents ; Polymers ; Everolimus (9HW64Q8G6G) ; umirolimus (U36PGF65JH) ; Sirolimus (W36ZG6FT64)
Language	English
Publishing date	2019-05-03
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	779519-1
ISSN	1874-1754 ; 0167-5273
ISSN (online)	1874-1754
ISSN	0167-5273
DOI	10.1016/j.ijcard.2019.04.054
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