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Article: Mechanisms of Epigenomic and Functional Convergence Between Glucocorticoid- and IL4-Driven Macrophage Programming.

Deochand, Dinesh K / Dacic, Marija / Bale, Michael J / Daman, Andrew W / Josefowicz, Steven Z / Oliver, David / Chinenov, Yurii / Rogatsky, Inez

bioRxiv : the preprint server for biology

2024

Abstract: Macrophages adopt distinct phenotypes in response to environmental cues, with type-2 cytokine interleukin-4 promoting a tissue-repair homeostatic state ( ... ...

Abstract	Macrophages adopt distinct phenotypes in response to environmental cues, with type-2 cytokine interleukin-4 promoting a tissue-repair homeostatic state (M2
Language	English
Publishing date	2024-02-18
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.02.16.580560
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Article ; Online: Evaluation of functional and oncological outcomes of localized prostate cancer after different minimally invasive therapeutic methods: A single center experience.

Chinenov, D V / Shpot, E V / Chernov, Y N / Gerasimov, A N / Kazachevskaya, L Y / Lyapichev, K A / Ismailov, H M / Tsukkiev, Z K / Korolev, D O / Rapoport, L M

Urologia

2024 , Page(s) 3915603231226366

Abstract: Objectives: To study the functional and oncological results of minimally invasive treatment methods: cryoablation, brachytherapy, and high-intensity focused ultrasound (HIFU) therapy of localized prostate cancer in a single hospital.: Methods: One ... ...

Abstract	Objectives: To study the functional and oncological results of minimally invasive treatment methods: cryoablation, brachytherapy, and high-intensity focused ultrasound (HIFU) therapy of localized prostate cancer in a single hospital. Methods: One hundred sixty patients with localized prostate cancer were treated with minimally invasive methods (53, 52, 55 patients with cryoablation, brachytherapy and HIFU therapy, respectively). Prostate-specific antigen and evaluation of post-procedure biopsies were used as an assessment. The review of functional indicators and quality of life was made with International Index of Erectile Function (IIEF-5), International Prostate Symptom Score (IPSS), maximum urinary flow rate (Qmax), quality of life (QoL) questionnaires. Results: Patients after cryoablation showed worse results of oncological control according to positive repeat biopsies, best indicators were observed after brachytherapy. When considering the IPSS results, there were statistically significantly worse scores in the brachytherapy group in the early postoperative period, these differences do not reach statistical significance in the late period in the brachytherapy and cryoablation groups. Patients in the cryoablation group showed worse indicators of IIEF-5; in the early postoperative period; in the late follow-up period, the indicators of erectile function in patients in the cryoablation group did not statistically significantly differ from those in patients after brachytherapy. Patients after HIFU therapy showed fewer cases of de novo erectile dysfunction during the follow-up period of 3 years, higher average IIEF-5 scores, lower IPSS scores and better QoL results. Conclusion: The recurrence of prostate cancer was statistically significantly higher in the International Society of Urological Pathology (ISUP) 3 grade group. HIFU therapy had better urination indicators compared to other groups, that can be associated with the laser enucleation of prostatic hyperplasia. The advantage was noted in patients after HIFU therapy when comparing the parameters to the IIEF-5 thus, HIFU treatment had a better impact on patients' QoL with localized prostate cancer.
Language	English
Publishing date	2024-01-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	204043-8
ISSN	1724-6075 ; 0376-0057 ; 0391-5603
ISSN (online)	1724-6075
ISSN	0376-0057 ; 0391-5603
DOI	10.1177/03915603231226366
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Article ; Online: A Prospective Comparison of Transrectal Standard, Cognitive, Transperineal Fusion, and Mapping Prostate Biopsy for Cancer Detection.

Petov, Vladislav / Bazarkin, Andrey / Morozov, Andrey / Taratkin, Mark / Ganzha, Timur / Danilov, Sergey / Chernov, Yaroslav / Chinenov, Denis / Rzayev, Ramin / Suvorov, Alexander / Amosov, Alexander / Fajkovic, Harun / Enikeev, Dmitry / Krupinov, German

Journal of endourology

2023 Volume 37, Issue 8, Page(s) 940–947

Abstract: Purpose: ...

Abstract	Purpose:
MeSH term(s)	Male ; Humans ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology ; Magnetic Resonance Imaging/methods ; Image-Guided Biopsy/methods ; Cognition
Language	English
Publishing date	2023-06-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	356931-7
ISSN	1557-900X ; 0892-7790
ISSN (online)	1557-900X
ISSN	0892-7790
DOI	10.1089/end.2022.0780
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Zs.A 2628: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article: [Minimizing the number of trocars during laparoscopic partial nephrectomy. Surgical technique].

Kurbanov A, A / Chernov Ya, N / Chinenov D, V / Tsukkiev Z, K / Votyakov A, Yu / Lerner Yu, V / Sutugin K, E / Shpot E, V

Urologiia (Moscow, Russia : 1999)

2023 , Issue 6, Page(s) 102–107

Abstract: Introduction: During last 20 years in urology there has been a number of significant advancements, which were due to the introduction into practice and improvement of minimally invasive techniques. Development of laparoscopic surgery allowed to actively ...

Abstract	Introduction: During last 20 years in urology there has been a number of significant advancements, which were due to the introduction into practice and improvement of minimally invasive techniques. Development of laparoscopic surgery allowed to actively introduce these procedures in various kidney disorders, including renal tumors. Laparoscopic partial nephrectomy is also undergoing changes in order to improve the technique. Standard technique requires four or more trocars, where fourth (additional) trocar is put for the assistant. However, there is an opinion that in most cases it is possible to perform partial nephrectomy without an assistant trocar, while maintaining the safety and efficiency of the procedure and improving some perioperative outcomes. The aim of our study was to compare the safety and efficiency of the three-trocar and four-trocar techniques during transperitoneal partial nephrectomy. This article also presents the technical features of laparoscopic partial nephrectomy. Materials and methods: Between 2021 and 2023, a total of 200 patients were included in the study comparing three- and four-trocar partial nephrectomy. Results: There was no difference in the rate of achieving renal trifecta between the two groups. In the three-trocar group, 94 cases of renal trifecta were found, while in the four-trocar group, there were 95 patients with renal trifecta. Conclusions: The three-trocar technique is not inferior in safety and efficiency to the standard four-trocar technique. The main advantages of the three-trocar technique are less pain, cost and post-operative scarring.
MeSH term(s)	Humans ; Laparoscopy/methods ; Nephrectomy/methods ; Kidney ; Kidney Neoplasms/surgery ; Surgical Instruments ; Retrospective Studies
Language	Russian
Publishing date	2023-12-29
Publishing country	Russia (Federation)
Document type	English Abstract ; Journal Article
ZDB-ID	43204-0
ISSN	1728-2985 ; 0042-1154
ISSN	1728-2985 ; 0042-1154
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Article: MALT Lymphoma of the Urinary Bladder Shows a Dramatic Female Predominance, Uneven Geographic Distribution, and Possible Infectious Etiology.

Lyapichev, Kirill A / Ivashkevich, Yana / Chernov, Yaroslav / Chinenov, Denis / Shpot, Evgeniy / Bessonov, Alexander A / Dabaja, Bouthaina S / Konoplev, Sergej

Research and reports in urology

2021 Volume 13, Page(s) 49–62

Abstract: Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the urinary bladder is an extremely rare entity accounting for 0.2% of all malignant urinary bladder neoplasms, and the diagnosis could be challenging. We present ... ...

Abstract	Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) of the urinary bladder is an extremely rare entity accounting for 0.2% of all malignant urinary bladder neoplasms, and the diagnosis could be challenging. We present here a patient with urinary bladder MALT lymphoma and review of all published case reports in the literature. We summarized the reported immunophenotype of the neoplasm, ancillary studies, therapy, and follow-up for all 59 patients in the table. The median patients' age was 57 years-old (range, 17 to 88), with female predominance in 50 of 59 patients representing a 1:5.6 ratio. Geographical distribution of the reported patients was as follows: 22 from Asia, of which more than a half (16) originated from Japan; 28 from Europe, of which 19 reported from the United Kingdom, and 3 patients were reported from the United States (including our patient). Twenty-three (77%) of 30 patients, for whom their clinical presentation was recorded, had symptoms of cystitis;
Language	English
Publishing date	2021-02-05
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2649530-2
ISSN	2253-2447
ISSN	2253-2447
DOI	10.2147/RRU.S283366
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Article ; Online: Glucocorticoid Signaling: An Update from a Genomic Perspective.

Sacta, Maria A / Chinenov, Yurii / Rogatsky, Inez

Annual review of physiology

2016 Volume 78, Page(s) 155–180

Abstract: Glucocorticoid hormones (GC) regulate essential physiological functions including energy homeostasis, embryonic and postembryonic development, and the stress response. From the biomedical perspective, GC have garnered a tremendous amount of attention as ... ...

Abstract	Glucocorticoid hormones (GC) regulate essential physiological functions including energy homeostasis, embryonic and postembryonic development, and the stress response. From the biomedical perspective, GC have garnered a tremendous amount of attention as highly potent anti-inflammatory and immunosuppressive medications indispensable in the clinic. GC signal through the GC receptor (GR), a ligand-dependent transcription factor whose structure, DNA binding, and the molecular partners that it employs to regulate transcription have been under intense investigation for decades. In particular, next-generation sequencing-based approaches have revolutionized the field by introducing a unified platform for a simultaneous genome-wide analysis of cellular activities at the level of RNA production, binding of transcription factors to DNA and RNA, and chromatin landscape and topology. Here we describe fundamental concepts of GC/GR function as established through traditional molecular and in vivo approaches and focus on the novel insights of GC biology that have emerged over the last 10 years from the rapidly expanding arsenal of system-wide genomic methodologies.
MeSH term(s)	Animals ; Genome/genetics ; Genomics/methods ; Glucocorticoids/genetics ; Glucocorticoids/metabolism ; Humans ; Receptors, Glucocorticoid/genetics ; Receptors, Glucocorticoid/metabolism ; Signal Transduction/physiology ; Transcription Factors/genetics ; Transcription Factors/metabolism
Chemical Substances	Glucocorticoids ; Receptors, Glucocorticoid ; Transcription Factors
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Review
ZDB-ID	207933-1
ISSN	1545-1585 ; 0066-4278
ISSN (online)	1545-1585
ISSN	0066-4278
DOI	10.1146/annurev-physiol-021115-105323
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Article: [Prospective comparison of cognitive and mpMR/US fusion biopsy for prostate cancer detection].

Petov, V S / Bazarkin, A K / Morozov, A O / Taratkin, M S / Ganzha, T M / Danilov, S P / Chernov, Y N / Chinenov, D V / Amosov, A V / Enikeev, D V / Krupinov, G E

Urologiia (Moscow, Russia : 1999)

2022 , Issue 4, Page(s) 38–43

Abstract: Introduction: According to the recommendations of the European Association of Urology the presence of a suspicious lesion on MRI is an indication for both primary and secondary MR-targeted biopsies. At the same time, the Russian Society of Urologists ... ...

Abstract	Introduction: According to the recommendations of the European Association of Urology the presence of a suspicious lesion on MRI is an indication for both primary and secondary MR-targeted biopsies. At the same time, the Russian Society of Urologists recommends to perform mpMR/US fusion biopsy only in patients with a prior negative biopsy. In clinical practice, mpMR/US fusion and cognitive biopsies are the most frequently performed. However, when comparing them, contradictory data on detection of clinically significant prostate cancer is obtained. Objective: to compare the detection rate of clinically significant prostate cancer performing cognitive and mpMR/US fusion biopsies. Materials and methods: Inclusion criteria: PSA >2 ng/mL and/or a positive DRE, and/or a suspicious lesion on TRUS, and PI-RADSv2.1 lesion more or equal 3. At first, "unblinded" urologist performed a transperineal mpMR/ultrasound fusion and saturation biopsy. Then "blinded" urologist obtained transrectal cognitive biopsy Clinically significant cancer was defined as ISUP more or equal 2. Results: We enrolled 96 patients. Median age was 63 years, prostate volume - 47 cm3 and PSA - 6.82 ng/mL. MpMR/US fusion and cognitive biopsies were comparable in regard to the detection rate of clinically significant (32.3% vs 25.0%; p=0.264), clinically insignificant cancer (25.0% and 26.0%; p=0.869) and overall detection rate (57.3% and 51%;p=0.385). Both biopsies missed clinically significant cancer with equal frequency (5.2%; p=0.839). Histological efficacy also was comparable. The number of positive cores between mpMR/US fusion and cognitive biopsy was equal (34.1% and 31.1% respectively; p= 0.415). At the same time, no statistically significant difference was found with respect to maximum cancer core length (53.1% vs 47.7%, respectively; p=0.293). Conclusion: The results suggest that both cognitive and mpMR/US fusion biopsies are equally accurate diagnostic methods for clinically significant prostate cancer detection, thus their wider introduction into clinical practice is necessary.
MeSH term(s)	Cognition ; Humans ; Image-Guided Biopsy/methods ; Male ; Middle Aged ; Prostate/diagnostic imaging ; Prostate/pathology ; Prostate-Specific Antigen ; Prostatic Neoplasms/diagnostic imaging ; Prostatic Neoplasms/pathology
Chemical Substances	Prostate-Specific Antigen (EC 3.4.21.77)
Language	Russian
Publishing date	2022-09-01
Publishing country	Russia (Federation)
Document type	Journal Article
ZDB-ID	43204-0
ISSN	1728-2985 ; 0042-1154
ISSN	1728-2985 ; 0042-1154
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Article: A second catalytic domain in the Elp3 histone acetyltransferases: a candidate for histone demethylase activity?

Chinenov, Yurii

Trends in biochemical sciences

2002 Volume 27, Issue 3, Page(s) 115–117

Abstract: A new subfamily of two-domain histone acetyltransferases (HATs) related to Elp3 has been identified. In addition to a HAT domain in the C terminus, these proteins have an N-terminal domain similar to the catalytic domain of S-adenosylmethionine radical ... ...

Abstract	A new subfamily of two-domain histone acetyltransferases (HATs) related to Elp3 has been identified. In addition to a HAT domain in the C terminus, these proteins have an N-terminal domain similar to the catalytic domain of S-adenosylmethionine radical enzymes. Two-domain organization is preserved in evolution, suggesting that both enzymatic activities are functionally or mechanistically coupled and directed towards highly conserved substrates. The functional implications of this similarity and a possible role for Elp3-related proteins as histone demethylases are discussed.
MeSH term(s)	Acetyltransferases/chemistry ; Acetyltransferases/genetics ; Acetyltransferases/metabolism ; Amino Acid Sequence ; Animals ; Binding Sites ; Catalysis ; Catalytic Domain/physiology ; Histone Acetyltransferases ; Histones/chemistry ; Histones/metabolism ; Humans ; Methylation ; Molecular Sequence Data ; Multigene Family ; Saccharomyces cerevisiae Proteins ; Sequence Homology, Amino Acid
Chemical Substances	Histones ; Saccharomyces cerevisiae Proteins ; Acetyltransferases (EC 2.3.1.-) ; Histone Acetyltransferases (EC 2.3.1.48)
Language	English
Publishing date	2002-03
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	194216-5
ISSN	1362-4326 ; 0968-0004 ; 0376-5067
ISSN (online)	1362-4326
ISSN	0968-0004 ; 0376-5067
DOI	10.1016/s0968-0004(02)02058-3
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Article: Unusual Case of Anaplastic Large Cell Lymphoma Presenting as a Breast Mass in a Patient with no History of Breast Implants.

Ivashkevich, Yana / Chernov, Yaroslav / Chinenov, Denis / Shpot, Evgeniy / Bessonov, Alexander A / Yoga, Arthy / Lyapichev, Kirill A / Konoplev, Sergej

Case reports in pathology

2020 Volume 2020, Page(s) 7543836

Abstract: Adenocarcinoma is the most common malignant neoplasm involving breast tissue. In contrast to carcinomas, the other types of malignant neoplasms involving the breast are relatively uncommon. One of the examples of this rare entity is lymphoma. ... ...

Abstract	Adenocarcinoma is the most common malignant neoplasm involving breast tissue. In contrast to carcinomas, the other types of malignant neoplasms involving the breast are relatively uncommon. One of the examples of this rare entity is lymphoma. Traditionally, non-Hodgkin lymphomas (NHL) involving the breast are divided into primary lymphoma of the breast and systemic lymphoma, although the distinction could be challenging. Most of NHL involving breast tissue have B cell origin; T cell NHL represents less than 20% of all lymphoma cases. Anaplastic large cell lymphomas (ALCL) involving the breast accounts for even lower percentage of cases. Similar to ALCL involving other sites, there are several main types of ALCL identified: primary cutaneous ALCL and systemic ALCL, which is subdivided into ALK positive and ALK negative subtypes. Relatively recently, an additional distinct subtype of ALK-negative ALCL was described, which is associated with textured breast implants and needs to be considered as a differential diagnosis if patient has a history of breast implants. Here, we report a case of ALCL presented as a breast mass without history of breast implant and discuss similar cases published in the literature.
Language	English
Publishing date	2020-07-23
Publishing country	United States
Document type	Case Reports
ZDB-ID	2648758-5
ISSN	2090-679X ; 2090-6781
ISSN (online)	2090-679X
ISSN	2090-6781
DOI	10.1155/2020/7543836
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Article ; Online: Correction: Transcription cofactor GRIP1 differentially affects myeloid cell-driven neuroinflammation and response to IFN-β therapy.

Mimouna, Sanda / Rollins, David A / Shibu, Gayathri / Tharmalingam, Bowranigan / Deochand, Dinesh K / Chen, Xi / Oliver, David / Chinenov, Yurii / Rogatsky, Inez

The Journal of experimental medicine

2020 Volume 218, Issue 1

Language	English
Publishing date	2020-11-23
Publishing country	United States
Document type	Journal Article ; Published Erratum
ZDB-ID	218343-2
ISSN	1540-9538 ; 0022-1007
ISSN (online)	1540-9538
ISSN	0022-1007
DOI	10.1084/jem.2019238611162020C
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Zs.MG 45: Show issues

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