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  1. Article ; Online: Closed for business: The mortality impact of business closures during the Covid-19 pandemic.

    Bongaerts, Dion / Mazzola, Francesco / Wagner, Wolf

    PloS one

    2021  Volume 16, Issue 5, Page(s) e0251373

    Abstract: We investigate the effectiveness of business shutdowns to contain the Covid-19 disease. In March 2020, Italy shut down operations in selected sectors of its economy. Using a difference-in-differences approach, we find that municipalities with higher ... ...

    Abstract We investigate the effectiveness of business shutdowns to contain the Covid-19 disease. In March 2020, Italy shut down operations in selected sectors of its economy. Using a difference-in-differences approach, we find that municipalities with higher exposure to closed sectors experienced subsequently lower mortality rates. The implied life savings exceed 9,400 people over a period of less than a month. We also find that business closures exhibited rapidly diminishing returns and had large effects outside the closed businesses themselves, including spillovers to other municipalities. Overall, the results suggest business shutdowns are effective, but should be selectively implemented and centrally coordinated.
    MeSH term(s) COVID-19/epidemiology ; COVID-19/mortality ; COVID-19/prevention & control ; COVID-19/virology ; Commerce ; Humans ; Italy/epidemiology ; Mortality/trends ; Pandemics/prevention & control ; Quarantine/methods ; SARS-CoV-2
    Language English
    Publishing date 2021-05-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0251373
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Closed for business

    Dion Bongaerts / Francesco Mazzola / Wolf Wagner

    PLoS ONE, Vol 16, Iss 5, p e

    The mortality impact of business closures during the Covid-19 pandemic.

    2021  Volume 0251373

    Abstract: We investigate the effectiveness of business shutdowns to contain the Covid-19 disease. In March 2020, Italy shut down operations in selected sectors of its economy. Using a difference-in-differences approach, we find that municipalities with higher ... ...

    Abstract We investigate the effectiveness of business shutdowns to contain the Covid-19 disease. In March 2020, Italy shut down operations in selected sectors of its economy. Using a difference-in-differences approach, we find that municipalities with higher exposure to closed sectors experienced subsequently lower mortality rates. The implied life savings exceed 9,400 people over a period of less than a month. We also find that business closures exhibited rapidly diminishing returns and had large effects outside the closed businesses themselves, including spillovers to other municipalities. Overall, the results suggest business shutdowns are effective, but should be selectively implemented and centrally coordinated.
    Keywords Medicine ; R ; Science ; Q
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Public Library of Science (PLoS)
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Book ; Online: Alternatives for issuer-paid credit rating agencies

    Bongaerts, Dion

    (Working paper series / European Central Bank ; 1703)

    2014  

    Author's details Dion Bongaerts
    Series title Working paper series / European Central Bank ; 1703
    Language English
    Size Online-Ressource (48 S.)
    Publisher European Central Bank
    Publishing place Frankfurt am Main
    Document type Book ; Online
    ISBN 9789289911115 ; 9289911115
    Database ECONomics Information System

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  4. Book ; Online: Green certificates

    Bongaerts, Dion / Schoenmaker, Dirk

    A better version of green bonds

    2020  

    Abstract: The market for green bonds is growing rapidly and has been boosted by the European Commission's plan to raise through green bonds 30 percent of the up to €750 billion that will be borrowed under the Next Generation EU coronavirus economic recovery ... ...

    Abstract -The market for green bonds is growing rapidly and has been boosted by the European Commission's plan to raise through green bonds 30 percent of the up to €750 billion that will be borrowed under the Next Generation EU coronavirus economic recovery programme. But while green bonds can reduce the financing costs of green projects and technologies, their current design means they fall short of fulfilling their full potential. Issuing green bonds alongside regular bonds fragments bond issues, reducing liquidity and thus increasing financing costs. Moreover, green bond prices reflect liquidity, credit risk and environmental performance jointly, which makes it difficult to isolate the part of the return on the bonds that relates to environmental performance. -We propose an alternative: issuance of regular bonds with attached green certificates that ensure earmarking for green purposes. The new design would lead to more liquid securities (as only regular bonds are issued), which would reduce financing costs and in turn would provide incentives to start a greater number of environmentally-friendly projects. The new design would also make market prices more informative about environmental performance. In addition, green certificates would address the criticism that green bonds are used mostly for refinancing existing green projects rather than for new projects. -Sovereigns are among the largest issuers of bonds and are therefore natural candidates for implementation of green certificates. The European Commission could also issue regular bonds and green certificates to finance the European Union's recovery package, and should include green certificates in the under-preparation EU Green Bond standard. Commission issuance of green certificates would give a major boost to EU bonds as liquid safe assets while promoting green investment.
    Keywords ddc:330
    Subject code 710
    Language English
    Publisher Brussels: Bruegel
    Publishing country de
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Uveal Melanoma Patients Have a Distinct Metabolic Phenotype in Peripheral Blood.

    de Bruyn, Daniël P / Bongaerts, Michiel / Bonte, Ramon / Vaarwater, Jolanda / Meester-Smoor, Magda A / Verdijk, Robert M / Paridaens, Dion / Naus, Nicole C / de Klein, Annelies / Ruijter, George J G / Kiliç, Emine / Brosens, Erwin

    International journal of molecular sciences

    2023  Volume 24, Issue 6

    Abstract: Uveal melanomas (UM) are detected earlier. Consequently, tumors are smaller, allowing for novel eye-preserving treatments. This reduces tumor tissue available for genomic profiling. Additionally, these small tumors can be hard to differentiate from nevi, ...

    Abstract Uveal melanomas (UM) are detected earlier. Consequently, tumors are smaller, allowing for novel eye-preserving treatments. This reduces tumor tissue available for genomic profiling. Additionally, these small tumors can be hard to differentiate from nevi, creating the need for minimally invasive detection and prognostication. Metabolites show promise as minimally invasive detection by resembling the biological phenotype. In this pilot study, we determined metabolite patterns in the peripheral blood of UM patients (n = 113) and controls (n = 46) using untargeted metabolomics. Using a random forest classifier (RFC) and leave-one-out cross-validation, we confirmed discriminatory metabolite patterns in UM patients compared to controls with an area under the curve of the receiver operating characteristic of 0.99 in both positive and negative ion modes. The RFC and leave-one-out cross-validation did not reveal discriminatory metabolite patterns in high-risk versus low-risk of metastasizing in UM patients. Ten-time repeated analyses of the RFC and LOOCV using 50% randomly distributed samples showed similar results for UM patients versus controls and prognostic groups. Pathway analysis using annotated metabolites indicated dysregulation of several processes associated with malignancies. Consequently, minimally invasive metabolomics could potentially allow for screening as it distinguishes metabolite patterns that are putatively associated with oncogenic processes in the peripheral blood plasma of UM patients from controls at the time of diagnosis.
    MeSH term(s) Humans ; Pilot Projects ; Melanoma/genetics ; Uveal Neoplasms/diagnosis ; Uveal Neoplasms/genetics ; Phenotype
    Language English
    Publishing date 2023-03-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms24065077
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: An asset pricing approach to liquidity effects in corporate bond markets

    Bongaerts, Dion / Driessen, Joost / Jong, Frank de

    The review of financial studies Vol. 30, No. 4 , p. 1229-1269

    2017  Volume 30, Issue 4, Page(s) 1229–1269

    Author's details Dion Bongaerts, Frank de Jong, Joost Driessen
    Keywords Unternehmensanleihe ; CAPM ; Liquidität ; Risiko ; Transaktionskosten ; Risikoprämie ; USA
    Language English
    Publisher Oxford Univ. Press
    Publishing place Cary, NC
    Document type Article
    ZDB-ID 1043666-2 ; 1467494-4
    ISSN 1465-7368 ; 0893-9454
    ISSN (online) 1465-7368
    ISSN 0893-9454
    Database ECONomics Information System

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  7. Article ; Online: Uveal Melanoma Patients Have a Distinct Metabolic Phenotype in Peripheral Blood

    Daniël P. de Bruyn / Michiel Bongaerts / Ramon Bonte / Jolanda Vaarwater / Magda A. Meester-Smoor / Robert M. Verdijk / Dion Paridaens / Nicole C. Naus / Annelies de Klein / George J. G. Ruijter / Emine Kiliç / Erwin Brosens

    International Journal of Molecular Sciences, Vol 24, Iss 5077, p

    2023  Volume 5077

    Abstract: Uveal melanomas (UM) are detected earlier. Consequently, tumors are smaller, allowing for novel eye-preserving treatments. This reduces tumor tissue available for genomic profiling. Additionally, these small tumors can be hard to differentiate from nevi, ...

    Abstract Uveal melanomas (UM) are detected earlier. Consequently, tumors are smaller, allowing for novel eye-preserving treatments. This reduces tumor tissue available for genomic profiling. Additionally, these small tumors can be hard to differentiate from nevi, creating the need for minimally invasive detection and prognostication. Metabolites show promise as minimally invasive detection by resembling the biological phenotype. In this pilot study, we determined metabolite patterns in the peripheral blood of UM patients (n = 113) and controls (n = 46) using untargeted metabolomics. Using a random forest classifier (RFC) and leave-one-out cross-validation, we confirmed discriminatory metabolite patterns in UM patients compared to controls with an area under the curve of the receiver operating characteristic of 0.99 in both positive and negative ion modes. The RFC and leave-one-out cross-validation did not reveal discriminatory metabolite patterns in high-risk versus low-risk of metastasizing in UM patients. Ten-time repeated analyses of the RFC and LOOCV using 50% randomly distributed samples showed similar results for UM patients versus controls and prognostic groups. Pathway analysis using annotated metabolites indicated dysregulation of several processes associated with malignancies. Consequently, minimally invasive metabolomics could potentially allow for screening as it distinguishes metabolite patterns that are putatively associated with oncogenic processes in the peripheral blood plasma of UM patients from controls at the time of diagnosis.
    Keywords noninvasive ; prognostication ; biomarker ; metabolomics ; liquid biopsy ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
    Subject code 610
    Language English
    Publishing date 2023-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  8. Book ; Online: Private Equity and Regulatory Capital

    Bongaerts, Dion / Charlier, Erwin

    (Discussion Paper / CentER for Economic Research ; 2008,52)

    2008  

    Author's details by By Dion Bongaerts, Erwin Charlier
    Series title Discussion Paper / CentER for Economic Research ; 2008,52
    Keywords Private Equity ; Kapitalbedarf ; Basler Akkord ; Portfolio-Management ; Anlageverhalten ; Optionspreistheorie ; Theorie
    Language English
    Size Online-Ressource (PDF-Datei: 34 S.), graph. Darst.
    Publisher Center for Economic Research
    Publishing place Tilburg
    Document type Book ; Online
    Note IMD-Felder maschinell generiert
    Database ECONomics Information System

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  9. Article: Private equity and regulatory capital

    Bongaerts, Dion / Charlier, Erwin

    Journal of banking & finance Vol. 33, No. 7 , p. 1211-1220

    2009  Volume 33, Issue 7, Page(s) 1211–1220

    Author's details Dion Bongaerts; Erwin Charlier
    Keywords Private Equity ; Kapitalbedarf ; Basler Akkord ; Portfolio-Management ; Anlageverhalten ; Optionspreistheorie ; Risikomanagement ; Theorie
    Language English
    Size graph. Darst.
    Publisher Elsevier
    Publishing place Amsterdam [u.a.]
    Document type Article
    ZDB-ID 752905-3 ; 1460614-8
    ISSN 1872-6372 ; 0378-4266
    ISSN (online) 1872-6372
    ISSN 0378-4266
    Database ECONomics Information System

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  10. Book: Multiple ratings and credit spreads

    Bongaerts, Dion / Cremers, Martijn K. J / Goetzmann, William N

    (NBER working paper series ; 15331)

    2009  

    Author's details Dion Bongaerts; K. J. Martijn Cremers; William N. Goetzmann
    Series title NBER working paper series ; 15331
    Keywords Unternehmensanleihe ; Kreditwürdigkeit ; Ratingagentur ; Informationswert ; USA
    Language English
    Size 44 S., graph. Darst.
    Publishing place Cambridge, Mass
    Document type Book
    Database ECONomics Information System

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