LIVIVO - Search results -

Search results

Result 1 - 10 of total 400

Search options

Article: Sarcoidosis presenting as a loss of weight with preserved appetite.

Goonetilleke, Asitha / Matthias, Anne Thushara

2023 Volume 11, Page(s) 2050313X231195248

Abstract: Sarcoidosis is a multisystem inflammatory disorder of unknown aetiology affecting a wide range of organs and is characterised by the presence of noncaseating granulomas. It has rarely been reported in Sri Lanka. This case describes a 36-year-old male ... ...

Abstract	Sarcoidosis is a multisystem inflammatory disorder of unknown aetiology affecting a wide range of organs and is characterised by the presence of noncaseating granulomas. It has rarely been reported in Sri Lanka. This case describes a 36-year-old male presenting with a loss of weight despite a preserved appetite. He had evidence of sarcoidosis with pulmonary, lymph node, eye, hepatosplenomegaly, thyroid and parotid gland involvement with hypercalcaemia. He was successfully treated with glucocorticoids.
Language	English
Publishing date	2023-08-21
Publishing country	England
Document type	Case Reports
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313X231195248
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: Case report of scrub typhus with bilateral acute sensorineural hearing loss and cerebral salt-wasting disease.

Goonetilleke, Asitha / Silva, Shehan

Tropical doctor

2023 Volume 54, Issue 1, Page(s) 69–71

Abstract: Scrub typhus is a re-emerging and endemic disease in the Asia Pacific region caused ... ...

Abstract	Scrub typhus is a re-emerging and endemic disease in the Asia Pacific region caused by
MeSH term(s)	Male ; Humans ; Aged ; Scrub Typhus/complications ; Scrub Typhus/diagnosis ; Scrub Typhus/drug therapy ; Hyponatremia ; Typhus, Epidemic Louse-Borne ; Orientia tsutsugamushi ; Neuromuscular Diseases ; Hearing Loss, Sensorineural/diagnosis ; Hearing Loss, Sensorineural/drug therapy ; Hearing Loss, Sensorineural/etiology ; Wasting Syndrome
Language	English
Publishing date	2023-09-06
Publishing country	England
Document type	Case Reports ; Journal Article
ZDB-ID	193169-6
ISSN	1758-1133 ; 0049-4755
ISSN (online)	1758-1133
ISSN	0049-4755
DOI	10.1177/00494755231195933
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1056: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Colchicine in atherosclerotic cardiovascular disease.

Tucker, Bradley / Goonetilleke, Neil / Patel, Sanjay / Keech, Anthony

Heart (British Cardiac Society)

2024 Volume 110, Issue 9, Page(s) 618–625

Abstract: Inflammation has a direct role in the development of atherosclerotic vascular disease, and oral colchicine displays broad anti-inflammatory properties. Several large, randomised controlled trials (RCTs) have evaluated colchicine's impact on ... ...

Abstract	Inflammation has a direct role in the development of atherosclerotic vascular disease, and oral colchicine displays broad anti-inflammatory properties. Several large, randomised controlled trials (RCTs) have evaluated colchicine's impact on cardiovascular outcomes. Results from a meta-analysis of these trials demonstrate that colchicine reduces the risk of recurrent major adverse cardiovascular events (MACEs) by 25%, leading to its recent approval by the Food and Drug Administration for the treatment and prevention of cardiovascular disease. Despite this, colchicine has not been shown to confer any survival benefit in these trials. The non-significant reduction in cardiovascular death of 18% (95% CI: 45% decrease to 23% increase) is outweighed by a more prominent, borderline non-significant increase in the risk of non-cardiovascular death by 38% (95% CI: 1% decrease to 92% increase). Key populations including those with heart failure, those undergoing surgical revascularisation, women, elderly individuals and non-Caucasians are under-represented in completed trials, which limits generalisability. C reactive protein has been proposed as a biomarker for colchicine response and shows promise for identifying a high-risk population where the benefit on MACE reduction and specifically reduced cardiovascular death might outweigh any real increased risk of non-cardiovascular death; however, this approach is still to be validated in ongoing RCTs. In conclusion, while colchicine shows promise in reducing MACE, its net risk-benefit profile requires further elucidation before its widespread adoption into clinical practice for the secondary prevention of atherosclerotic cardiovascular disease. Much more large-scale, long-term trial data are still needed in this space.
MeSH term(s)	Aged ; Female ; Humans ; Anti-Inflammatory Agents/therapeutic use ; Atherosclerosis/drug therapy ; Atherosclerosis/prevention & control ; Cardiovascular Diseases/drug therapy ; Cardiovascular Diseases/prevention & control ; Colchicine/therapeutic use ; Inflammation/drug therapy ; Male
Chemical Substances	Anti-Inflammatory Agents ; Colchicine (SML2Y3J35T)
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Meta-Analysis ; Journal Article ; Review
ZDB-ID	1303417-0
ISSN	1468-201X ; 1355-6037
ISSN (online)	1468-201X
ISSN	1355-6037
DOI	10.1136/heartjnl-2023-323177
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Ui IV Zs.40: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 112: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: Coeliac lymph node abscess: A case report of a rare manifestation of extrapulmonary tuberculosis.

Goonetilleke, Asitha / Nandasena, Malith / Fernandopulle, Nilesh / Matthias, Anne Thushara

SAGE open medical case reports

2024 Volume 12, Page(s) 2050313X241229640

Abstract: Tuberculosis is a leading cause of death worldwide, especially in developing countries. It can affect any site in the body and have a myriad of presentations making diagnosis challenging. Tuberculous lymphadenitis in the abdomen is rare. We present a ... ...

Abstract	Tuberculosis is a leading cause of death worldwide, especially in developing countries. It can affect any site in the body and have a myriad of presentations making diagnosis challenging. Tuberculous lymphadenitis in the abdomen is rare. We present a case of a 42-year-old man who presented with non-specific abdominal symptoms and was found to have an intraabdominal abscess on computed tomography scan of the abdomen. Endoscopic ultrasound-guided aspiration was performed, and tuberculosis was confirmed. This case highlights the importance of having a high clinical suspicion of tuberculosis even with vague symptoms in tuberculosis endemic countries. This would prevent unnecessary surgery as tuberculosis is responsive to anti-tuberculosis drugs.
Language	English
Publishing date	2024-02-06
Publishing country	England
Document type	Case Reports
ZDB-ID	2736953-5
ISSN	2050-313X
ISSN	2050-313X
DOI	10.1177/2050313X241229640
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Immunomodulation with IL-7 and IL-15 in HIV-1 infection.

Gunst, Jesper D / Goonetilleke, Nilu / Rasmussen, Thomas A / Søgaard, Ole S

Journal of virus eradication

2023 Volume 9, Issue 3, Page(s) 100347

Abstract: Immunomodulating agents are substances that modify the host immune responses in diseases such as infections, autoimmune conditions and cancers. Immunomodulators can be divided into two main groups: 1) immunostimulators that activate the immune system ... ...

Abstract	Immunomodulating agents are substances that modify the host immune responses in diseases such as infections, autoimmune conditions and cancers. Immunomodulators can be divided into two main groups: 1) immunostimulators that activate the immune system such as cytokines, toll-like receptor agonists and immune checkpoint blockers; and 2) immunosuppressors that dampen an overactive immune system such as corticosteroids and cytokine-blocking antibodies. In this review, we have focussed on the two primarily T and natural killer (NK) cell homeostatic cytokines: interleukin-7 (IL-7) and -15 (IL-15). These cytokines are immunostimulators which act on immune cells independently of the presence or absence of antigen.
Language	English
Publishing date	2023-09-05
Publishing country	England
Document type	Journal Article
ZDB-ID	2868549-0
ISSN	2055-6659 ; 2055-6640
ISSN (online)	2055-6659
ISSN	2055-6640
DOI	10.1016/j.jve.2023.100347
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article: Determinants of self-efficacy of driving behavior among young adults in the UAE: Impact of gender, culture, and varying environmental conditions in a simulated environment.

Maghelal, Praveen Kumar / Lara, Juan Carlos Flores / Goonetilleke, Ravindra S / Luximon, Ameersing

Heliyon

2023 Volume 9, Issue 3, Page(s) e13993

Abstract: Research on traffic accidents have acknowledged that human error is the leading cause of road accidents around the world. In the UAE, those aged between 18 and 30 years are involved in the most accidents. As a result, this study examines the perception, ... ...

Abstract	Research on traffic accidents have acknowledged that human error is the leading cause of road accidents around the world. In the UAE, those aged between 18 and 30 years are involved in the most accidents. As a result, this study examines the perception, attitude and driving behavior of young adults in the UAE. Virtual Reality (VR) was used to examine driving behavior because it offers alternatives to assess driving behavior with a high degree of immersive experience in a safe and replicable environment. Participants drove through a virtual environment that resembled the urban environment of Abu Dhabi in the UAE, which included six traffic events. A sample of 12 females and 27 males also completed a pre and post-simulation questionnaire to report and evaluate their personal driving experience in Abu Dhabi. The volunteer group represented young drivers with limited driving experience and diverse cultural backgrounds. Results indicated that male drivers were less adhering to safe driving behavior compared to females. Even though both males and females exceeded the designated speed limit, males traveled longer distances over the limit. Additionally, it was found that young drivers tend to overestimate their skills with factors like gender, cultural background, and driving experience being key contributors. The results indicate that traffic authorities should take into consideration different approaches in the formulation of policies related to young drivers with periodic reassessment of skills and training to enhance the safety of driving in the UAE and the region.
Language	English
Publishing date	2023-02-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2835763-2
ISSN	2405-8440
ISSN	2405-8440
DOI	10.1016/j.heliyon.2023.e13993
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Influence of landscape patterns on nitrate and particulate organic nitrogen inputs to urban stormwater runoff.

Hou, Yifan / Wang, Shihui / Ma, Yukun / Shen, Zhenyao / Goonetilleke, Ashantha

Journal of environmental management

2023 Volume 348, Page(s) 119190

Abstract: This study investigated the effect of the landscape pattern of permeable/impermeable patches on ... ...

Abstract	This study investigated the effect of the landscape pattern of permeable/impermeable patches on NO
MeSH term(s)	Nitrates/analysis ; Nitrogen/analysis ; Environmental Monitoring/methods ; Water Movements ; Water Pollutants, Chemical/analysis ; Rain ; Organic Chemicals/analysis ; Dust
Chemical Substances	Nitrates ; Nitrogen (N762921K75) ; Water Pollutants, Chemical ; Organic Chemicals ; Dust
Language	English
Publishing date	2023-10-12
Publishing country	England
Document type	Journal Article
ZDB-ID	184882-3
ISSN	1095-8630 ; 0301-4797
ISSN (online)	1095-8630
ISSN	0301-4797
DOI	10.1016/j.jenvman.2023.119190
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Bonn / Germany

Z 7556: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾

Article ; Online: Efficacy of information extraction from bar, line, circular, bubble and radar graphs.

Abeynayake, Hiddadura Isura Malinda Mendis / Goonetilleke, Ravindra S / Wijeweera, Albert / Reischl, Uwe

Applied ergonomics

2023 Volume 109, Page(s) 103996

Abstract: With the emergence of enormous amounts of data, numerous ways to visualize such data have been used. Bar, circular, line, radar and bubble graphs that are ubiquitous were investigated for their effectiveness. Fourteen participants performed four types of ...

Abstract	With the emergence of enormous amounts of data, numerous ways to visualize such data have been used. Bar, circular, line, radar and bubble graphs that are ubiquitous were investigated for their effectiveness. Fourteen participants performed four types of evaluations: between categories (cities), within categories (transport modes within a city), all categories, and a direct reading within a category from a graph. The representations were presented in random order and participants were asked to respond to sixteen questions to the best of their ability after visually scanning the related graph. There were two trials on two separate days for each participant. Eye movements were recorded using an eye tracker. Bar and line graphs show superiority over circular and radial graphs in effectiveness, efficiency, and perceived ease of use primarily due to eye saccades. The radar graph had the worst performance. "Vibration-type" fill pattern could be improved by adding colors and symbolic fills. Design guidelines are proposed for the effective representation of data so that the presentation and communication of information are effective.
MeSH term(s)	Humans ; Radar ; Eye Movements ; Saccades ; Communication ; Information Storage and Retrieval
Language	English
Publishing date	2023-02-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2003513-5
ISSN	1872-9126 ; 0003-6870
ISSN (online)	1872-9126
ISSN	0003-6870
DOI	10.1016/j.apergo.2023.103996
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Inherent and external factors influencing the distribution of PAHs, hydroxy-PAHs, carbonyl-PAHs and nitro-PAHs in urban road dust.

Gbeddy, Gustav / Egodawatta, Prasanna / Akortia, Eric / Goonetilleke, Ashantha

Environmental pollution (Barking, Essex : 1987)

2022 Volume 308, Page(s) 119705

Abstract: The distribution and fate of hazardous polycyclic aromatic hydrocarbons (PAHs) and their associated transformed PAHs products (TPPs) notably carbonyl-PAHs (CPAHs), hydroxy-PAHs (HoPAHs), and nitro-PAHs (NPAHs) on urban road surfaces are influenced by ... ...

Abstract	The distribution and fate of hazardous polycyclic aromatic hydrocarbons (PAHs) and their associated transformed PAHs products (TPPs) notably carbonyl-PAHs (CPAHs), hydroxy-PAHs (HoPAHs), and nitro-PAHs (NPAHs) on urban road surfaces are influenced by diverse factors to varying extent. The pollutants are eventually transported to urban receiving waters via stormwater runoff posing risks to human and ecosystem health. In order to formulate an effective mitigation strategy, it is essential to comprehensively examine the role of both inherent and external factors in the distribution and fate of these hazardous pollutants, and thus, the need for this study. The research study showed that commercial land use has the highest cumulative concentration of PAHs and TPPs. Antecedent dry days (ADDs) has an inverse influence on the distribution of the total concentrations of low-molecular weight PAHs (LMW-PAHs), PAHs, and (PAHs + TPPs) irrespective of the type of land use, whilst there was no major influence on the total concentrations of high molecular weight PAHs (HMW-PAHs), and TPPs. The high volatility of LMW-PAHs compared to HMW-PAHs is considered to account for the decreasing concentration of LMW-PAH with increasing ADD. Particle size range has significant inverse influence on the cumulative concentration of pollutants across all land uses, since smaller particles are characteristically associated with larger surface area leading to the higher sorption of pollutants. Multivariate analysis of the influential factors indicated that two particle size ranges (0.45-150 μm and 150-425 μm) constitute the major influential factors on the distribution and fate of PAHs and TPPs in urban road dust. Greater quantum of pollutants are sorbed to the 0.45-150 μm particles due to the relatively higher specific surface area (SSA), concentration of total organic carbon (TOC) and total suspended solids (TSS) concentration. Therefore, it is critical to effectively remove finer particles from road surfaces in order to reduce exposure to hazardous pollutants.
MeSH term(s)	Dust/analysis ; Ecosystem ; Environmental Monitoring ; Environmental Pollutants/analysis ; Humans ; Polycyclic Aromatic Hydrocarbons/analysis
Chemical Substances	Dust ; Environmental Pollutants ; Polycyclic Aromatic Hydrocarbons
Language	English
Publishing date	2022-07-04
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2022.119705
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 2599: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: OMIP-087: Thirty-two parameter mass cytometry panel to assess human CD4 and CD8 T cell activation, memory subsets, and helper subsets.

Sponaugle, Alexis / Abad-Fernandez, Maria / Goonetilleke, Nilu

Cytometry. Part A : the journal of the International Society for Analytical Cytology

2022 Volume 103, Issue 3, Page(s) 184–188

Abstract: We developed a highly reproducible 32-marker mass cytometry panel able to measure all canonical immune lineages and perform detailed characterization of both CD4 and CD8 T cells in human peripheral blood mononuclear cells. In this panel, we identify six ... ...

Abstract	We developed a highly reproducible 32-marker mass cytometry panel able to measure all canonical immune lineages and perform detailed characterization of both CD4 and CD8 T cells in human peripheral blood mononuclear cells. In this panel, we identify six different T cell memory subsets, as well as markers of activation, cell cycling, and survival. In addition, this panel classifies all major CD4 T cell helper subsets. This panel enables detailed monitoring of CD4 and CD8 T cells in the context of infectious disease, cancer or autoimmunity with limited patient sample use. Detailed methods for standardization and optimization of the panel can be found in Supporting Information.
MeSH term(s)	Humans ; Leukocytes, Mononuclear ; CD8-Positive T-Lymphocytes ; T-Lymphocyte Subsets ; T-Lymphocytes, Helper-Inducer ; Lymphocyte Activation ; Flow Cytometry/methods ; CD4-Positive T-Lymphocytes
Language	English
Publishing date	2022-12-05
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2099868-5
ISSN	1552-4930 ; 0196-4763 ; 1552-4922
ISSN (online)	1552-4930
ISSN	0196-4763 ; 1552-4922
DOI	10.1002/cyto.a.24707
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1688: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 68: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito